{"id":"https://openalex.org/W7166340373","doi":"https://doi.org/10.1021/acs.biomac.6c00502","title":"Engineering Coil-Coiled Domains for the Design of Modular Theranostic Agents: Galectin-3 as a Targeting Moiety","display_name":"Engineering Coil-Coiled Domains for the Design of Modular Theranostic Agents: Galectin-3 as a Targeting Moiety","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166340373","doi":"https://doi.org/10.1021/acs.biomac.6c00502","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363882"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biomac.6c00502","doi":"https://doi.org/10.1021/acs.biomac.6c00502","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.6c00502","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.biomac.6c00502","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093216681","display_name":"Chiara Burgio","orcid":"https://orcid.org/0009-0005-6450-4667","observed_orcids":["https://orcid.org/0009-0005-6450-4667"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Chiara Burgio","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology II, School of Pharmacy","Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","University of Granada"],"raw_orcid":"https://orcid.org/0009-0005-6450-4667","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology II, School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"University of Granada","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047498629","display_name":"Mar\u00eda Dolores Gir\u00f3n","orcid":"https://orcid.org/0000-0001-9638-988X","observed_orcids":["https://orcid.org/0000-0001-9638-988X"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria D. Giron","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology II, School of Pharmacy","Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","University of Granada"],"raw_orcid":"https://orcid.org/0000-0001-9638-988X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology II, School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"University of Granada","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019348005","display_name":"Mariano Ortega\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-2395-9391","observed_orcids":["https://orcid.org/0000-0002-2395-9391"]},"institutions":[{"id":"https://openalex.org/I1312106833","display_name":"Biotechnology Institute","ror":"https://ror.org/00s1jty20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1312106833"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Mariano Ortega-Mu\u00f1oz","raw_affiliation_strings":["Department of Organic Chemistry, School of Sciences, Biotechnology Institute","Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","University of Granada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, School of Sciences, Biotechnology Institute","institution_ids":["https://openalex.org/I1312106833"]},{"raw_affiliation_string":"Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"University of Granada","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895771","display_name":"Daniel Lucena","orcid":"https://orcid.org/0009-0005-1219-7087","observed_orcids":["https://orcid.org/0009-0005-1219-7087"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Lucena","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology II, School of Pharmacy","Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","University of Granada"],"raw_orcid":"https://orcid.org/0009-0005-1219-7087","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology II, School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"University of Granada","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000029388","display_name":"Rafael Salto","orcid":"https://orcid.org/0000-0002-7044-3611","observed_orcids":["https://orcid.org/0000-0002-7044-3611"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rafael Salto","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology II, School of Pharmacy","Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","University of Granada"],"raw_orcid":"https://orcid.org/0000-0002-7044-3611","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology II, School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Unit of Excellence in Chemistry Applied to Biomedicine and the Environment of the University of Granada","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"University of Granada","institution_ids":["https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000029388"],"corresponding_institution_ids":["https://openalex.org/I173304897"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42018853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"7","first_page":"4597","last_page":"4608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.3319999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.6919999718666077},{"id":"https://openalex.org/keywords/theranostic-agents","display_name":"theranostic agents","score":0.8560000061988831},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9010000228881836},{"id":"https://openalex.org/keywords/targeting-moieties","display_name":"targeting moieties","score":0.640999972820282},{"id":"https://openalex.org/keywords/maltose-binding-protein","display_name":"maltose-binding protein","score":0.8339999914169312},{"id":"https://openalex.org/keywords/streptavidin","display_name":"streptavidin","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.8880000114440918},{"id":"https://openalex.org/keywords/genetically-engineered-proteins","display_name":"genetically engineered proteins","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7488999962806702},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.739300012588501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6144999861717224},{"id":"https://openalex.org/C2776190903","wikidata":"https://www.wikidata.org/wiki/Q421817","display_name":"Streptavidin","level":3,"score":0.5321999788284302},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5238000154495239},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5128999948501587},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4749000072479248},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4447000026702881},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41290000081062317},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38850000500679016},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3799999952316284},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.37940001487731934},{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3481999933719635},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3278999924659729},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C2778839769","wikidata":"https://www.wikidata.org/wiki/Q12856814","display_name":"Sortase A","level":4,"score":0.30250000953674316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29739999771118164},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2526000142097473}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058619","descriptor_name":"Maltose-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biomac.6c00502","doi":"https://doi.org/10.1021/acs.biomac.6c00502","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.6c00502","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"pmid:42363882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"},{"id":"pmh:oai:digibug.ugr.es:10481/114766","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10481/114766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13370767","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363882/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomacromolecules","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.biomac.6c00502","doi":"https://doi.org/10.1021/acs.biomac.6c00502","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.6c00502","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8485207557678223,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2742661276","display_name":null,"funder_award_id":"A-CTS-186-UGR20","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"}],"funders":[{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1523714793","https://openalex.org/W1557376328","https://openalex.org/W1959914164","https://openalex.org/W1973008499","https://openalex.org/W1977709885","https://openalex.org/W1992046087","https://openalex.org/W2004818616","https://openalex.org/W2007927038","https://openalex.org/W2021635812","https://openalex.org/W2033232429","https://openalex.org/W2034711213","https://openalex.org/W2070563411","https://openalex.org/W2081497965","https://openalex.org/W2109785108","https://openalex.org/W2111789637","https://openalex.org/W2140728144","https://openalex.org/W2150280909","https://openalex.org/W2154683659","https://openalex.org/W2160898059","https://openalex.org/W2173047025","https://openalex.org/W2333380790","https://openalex.org/W2405122542","https://openalex.org/W2523808935","https://openalex.org/W2748278329","https://openalex.org/W2887132644","https://openalex.org/W2902946041","https://openalex.org/W2945567049","https://openalex.org/W2976094227","https://openalex.org/W3119402092","https://openalex.org/W3120497039","https://openalex.org/W3160992829","https://openalex.org/W3188464845","https://openalex.org/W4210762403","https://openalex.org/W4321372972","https://openalex.org/W4376115723","https://openalex.org/W4381516236","https://openalex.org/W4390941192","https://openalex.org/W4394843616","https://openalex.org/W4405037415","https://openalex.org/W4410837017","https://openalex.org/W4414757289"],"related_works":[],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"To":[7],"generate":[8],"drug-targeting":[9],"agents":[10],"with":[11],"a":[12,37,41,52,59,64,99],"modular":[13],"and":[14,51,58,120,141,151],"efficient":[15],"design":[16],"for":[17,32],"disease":[18],"treatments,":[19],"including":[20],"cancer,":[21],"we":[22],"used":[23],"protein":[24,54,57],"coil-coiled":[25],"dimerization":[26],"motifs":[27],"to":[28,46,73,87,109],"eliminate":[29],"the":[30,78,96,104,114,124,147],"need":[31],"chemical":[33],"conjugation":[34],"techniques,":[35],"generating":[36],"versatile":[38],"theranostic":[39],"system:":[40],"targeting":[42,79,105],"moiety":[43],"genetically":[44],"fused":[45],"an":[47],"E":[48],"3":[49,66],"coil":[50],"fusion":[53],"of":[55,117],"maltose-binding":[56],"monomeric":[60],"streptavidin":[61],"that":[62,133],"includes":[63],"K":[65],"coil.":[67],"The":[68,81],"system":[69,97],"can":[70],"be":[71],"directed":[72],"other":[74],"targets":[75],"by":[76],"changing":[77],"moiety.":[80],"second":[82],"component":[83],"enables":[84],"simultaneous":[85],"binding":[86],"two":[88],"different":[89],"ligands":[90,140],"(maltosylated":[91],"or":[92,135],"biotinylated).":[93],"We":[94],"tested":[95],"using":[98,130],"truncated":[100],"human":[101],"Galectin-3":[102,139],"as":[103,123],"moiety,":[106],"which":[107],"binds":[108],"\u03b2-galactoside-containing":[110],"oligosaccharides":[111],"overexpressed":[112],"on":[113],"plasma":[115],"membranes":[116],"tumor":[118],"cells,":[119],"biotinylated":[121],"doxorubicin":[122],"cargo":[125],"molecule.":[126],"In":[127],"vitro":[128],"experiments":[129],"cell":[131],"lines":[132],"express":[134,138],"do":[136],"not":[137],"in":[142],"vivo":[143],"mouse":[144],"xenografts":[145],"demonstrated":[146],"system\u2019s":[148],"capability,":[149],"specificity,":[150],"flexibility.":[152]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-06-28T00:00:00"}
