{"id":"https://openalex.org/W7166330678","doi":"https://doi.org/10.1007/s00335-026-10253-0","title":"Neuroinflammation in glaucoma: a myriad of cellular pathways and players","display_name":"Neuroinflammation in glaucoma: a myriad of cellular pathways and players","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166330678","doi":"https://doi.org/10.1007/s00335-026-10253-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365203"},"language":"en","primary_location":{"id":"doi:10.1007/s00335-026-10253-0","doi":"https://doi.org/10.1007/s00335-026-10253-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00335-026-10253-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00335-026-10253-0.pdf","source":{"id":"https://openalex.org/S197264859","display_name":"Mammalian Genome","issn_l":"0938-8990","issn":["0938-8990","1432-1777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mammalian Genome","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00335-026-10253-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070311672","display_name":"Michael MacLean","orcid":"https://orcid.org/0000-0001-9685-3400","observed_orcids":["https://orcid.org/0000-0001-9685-3400"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael MacLean","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007410078","display_name":"Sean D. Lydon","orcid":"https://orcid.org/0000-0002-7565-5445","observed_orcids":["https://orcid.org/0000-0002-7565-5445"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean D. Lydon","raw_affiliation_strings":["Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA","Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA","The Center for Visual Sciences, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"The Center for Visual Sciences, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017720088","display_name":"C\u00e1tia Gomes","orcid":"https://orcid.org/0000-0001-8491-6822","observed_orcids":["https://orcid.org/0000-0001-8491-6822"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C\u00e1tia Gomes","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104291577","display_name":"Elizabeth M. Pizzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Pizzi","raw_affiliation_strings":["School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA","The Jackson Laboratory, Bar Harbor, ME, 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164784","display_name":"Cory A. Diemler","orcid":"https://orcid.org/0000-0003-0050-2716","observed_orcids":["https://orcid.org/0000-0003-0050-2716"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory A. Diemler","raw_affiliation_strings":["Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, 04469, USA","The Jackson Laboratory, Bar Harbor, ME, 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, 04469, USA","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078198107","display_name":"Sarah E. R. Yablonski","orcid":"https://orcid.org/0000-0002-9510-187X","observed_orcids":["https://orcid.org/0000-0002-9510-187X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. R. Yablonski","raw_affiliation_strings":["Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA","Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA","The Center for Visual Sciences, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"The Center for Visual Sciences, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018525513","display_name":"Gareth R. Howell","orcid":"https://orcid.org/0000-0003-0565-6474","observed_orcids":["https://orcid.org/0000-0003-0565-6474"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth R. Howell","raw_affiliation_strings":["Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, 04469, USA","School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA","The Jackson Laboratory, Bar Harbor, ME, 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, 04469, USA","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017293822","display_name":"Jason S. Meyer","orcid":"https://orcid.org/0000-0001-9037-6033","observed_orcids":["https://orcid.org/0000-0001-9037-6033"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason S. Meyer","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064072378","display_name":"Richard T. Libby","orcid":"https://orcid.org/0000-0003-2844-7632","observed_orcids":["https://orcid.org/0000-0003-2844-7632"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard T. Libby","raw_affiliation_strings":["Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA. richard_libby@urmc.rochester.edu","Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA. richard_libby@urmc.rochester.edu","The Center for Visual Sciences, University of Rochester, Rochester, NY, USA. richard_libby@urmc.rochester.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA. richard_libby@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY, USA. richard_libby@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"The Center for Visual Sciences, University of Rochester, Rochester, NY, USA. richard_libby@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064072378"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":7.505,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96746751,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"37","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.8730000257492065},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/innate-immune-cells","display_name":"innate immune cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/macroglia","display_name":"macroglia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glaucomatous-neurodegeneration","display_name":"glaucomatous neurodegeneration","score":0.8059999942779541},{"id":"https://openalex.org/keywords/peripheral-immune-cell-infiltration","display_name":"peripheral immune cell infiltration","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8888999819755554},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.8108999729156494},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6919999718666077},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6711999773979187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6399999856948853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6294999718666077},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49149999022483826},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.46630001068115234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40389999747276306},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.39239999651908875},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.39160001277923584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3366999924182892},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3131999969482422},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2777102633","wikidata":"https://www.wikidata.org/wiki/Q735343","display_name":"Muller glia","level":4,"score":0.27070000767707825},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25600001215934753},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00335-026-10253-0","doi":"https://doi.org/10.1007/s00335-026-10253-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00335-026-10253-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00335-026-10253-0.pdf","source":{"id":"https://openalex.org/S197264859","display_name":"Mammalian Genome","issn_l":"0938-8990","issn":["0938-8990","1432-1777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mammalian Genome","raw_type":"journal-article"},{"id":"pmid:42365203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mammalian genome : official journal of the International Mammalian Genome Society","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/57034","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/57034","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/f7bead31-6eda-4ead-963a-cdb0ee5e98bf/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13310235","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310235/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mamm Genome","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00335-026-10253-0","doi":"https://doi.org/10.1007/s00335-026-10253-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00335-026-10253-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00335-026-10253-0.pdf","source":{"id":"https://openalex.org/S197264859","display_name":"Mammalian Genome","issn_l":"0938-8990","issn":["0938-8990","1432-1777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mammalian Genome","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7141850590705872,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1248590197","display_name":null,"funder_award_id":"ShafGrnt2024GomesCat","funder_id":"https://openalex.org/F4320306709","funder_display_name":"Glaucoma Research Foundation"},{"id":"https://openalex.org/G1479571606","display_name":null,"funder_award_id":"R01EY035093","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3362248351","display_name":"Deciphering the role of the CDKN2B-AS region in glaucoma","funder_award_id":"G2020254","funder_id":"https://openalex.org/F4320308990","funder_display_name":"BrightFocus Foundation"},{"id":"https://openalex.org/G54426785","display_name":null,"funder_award_id":"K99EY038315","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000900531","display_name":"Establishing a human cellular model of retinal ganglion cell compartmentalization in neurodegeneration and neuroinflammation","funder_award_id":"R01EY033022","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G925511890","display_name":"The role of reactive astrocyte-associated complement C3 in glaucomatous neurodegeneration","funder_award_id":"G2022003F","funder_id":"https://openalex.org/F4320308990","funder_display_name":"BrightFocus Foundation"}],"funders":[{"id":"https://openalex.org/F4320306709","display_name":"Glaucoma Research Foundation","ror":"https://ror.org/05ez53b31"},{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166330678.pdf","grobid_xml":"https://content.openalex.org/works/W7166330678.grobid-xml"},"referenced_works_count":259,"referenced_works":["https://openalex.org/W235660785","https://openalex.org/W652700712","https://openalex.org/W785171792","https://openalex.org/W1034109569","https://openalex.org/W1529601180","https://openalex.org/W1545421865","https://openalex.org/W1547948326","https://openalex.org/W1553218248","https://openalex.org/W1563498244","https://openalex.org/W1568207206","https://openalex.org/W1583737662","https://openalex.org/W1770378670","https://openalex.org/W1843574900","https://openalex.org/W1934209312","https://openalex.org/W1963827203","https://openalex.org/W1964506812","https://openalex.org/W1967364872","https://openalex.org/W1968210590","https://openalex.org/W1977509321","https://openalex.org/W1983740408","https://openalex.org/W1984335578","https://openalex.org/W1990973189","https://openalex.org/W1993136367","https://openalex.org/W1993918206","https://openalex.org/W1994009311","https://openalex.org/W1996519889","https://openalex.org/W1996690280","https://openalex.org/W2005313696","https://openalex.org/W2009740514","https://openalex.org/W2010162134","https://openalex.org/W2017204654","https://openalex.org/W2019132331","https://openalex.org/W2019885109","https://openalex.org/W2021181758","https://openalex.org/W2021499247","https://openalex.org/W2022209206","https://openalex.org/W2022370855","https://openalex.org/W2025060864","https://openalex.org/W2029994336","https://openalex.org/W2030225419","https://openalex.org/W2031743055","https://openalex.org/W2036362108","https://openalex.org/W2036505824","https://openalex.org/W2047909825","https://openalex.org/W2048385853","https://openalex.org/W2050065221","https://openalex.org/W2050365557","https://openalex.org/W2050374811","https://openalex.org/W2051550352","https://openalex.org/W2052799596","https://openalex.org/W2055335620","https://openalex.org/W2056051498","https://openalex.org/W2062523245","https://openalex.org/W2063461910","https://openalex.org/W2063594243","https://openalex.org/W2064815984","https://openalex.org/W2066478570","https://openalex.org/W2068232370","https://openalex.org/W2070876833","https://openalex.org/W2072465036","https://openalex.org/W2073947789","https://openalex.org/W2074279418","https://openalex.org/W2078684091","https://openalex.org/W2081232316","https://openalex.org/W2081703291","https://openalex.org/W2081861923","https://openalex.org/W2082122713","https://openalex.org/W2094660330","https://openalex.org/W2096327192","https://openalex.org/W2101625094","https://openalex.org/W2101873043","https://openalex.org/W2108824480","https://openalex.org/W2110127308","https://openalex.org/W2110707863","https://openalex.org/W2111027046","https://openalex.org/W2120119175","https://openalex.org/W2124464421","https://openalex.org/W2126514593","https://openalex.org/W2135364731","https://openalex.org/W2135930638","https://openalex.org/W2138480916","https://openalex.org/W2144997370","https://openalex.org/W2145273997","https://openalex.org/W2147122728","https://openalex.org/W2148898943","https://openalex.org/W2150040640","https://openalex.org/W2153440518","https://openalex.org/W2154886355","https://openalex.org/W2158626764","https://openalex.org/W2160226180","https://openalex.org/W2160605010","https://openalex.org/W2191292005","https://openalex.org/W2193723006","https://openalex.org/W2194338638","https://openalex.org/W2252793112","https://openalex.org/W2257915098","https://openalex.org/W2301368457","https://openalex.org/W2305909828","https://openalex.org/W2310977865","https://openalex.org/W2314547812","https://openalex.org/W2317516423","https://openalex.org/W2343444117","https://openalex.org/W2398211621","https://openalex.org/W2461039837","https://openalex.org/W2478787406","https://openalex.org/W2482717739","https://openalex.org/W2498411827","https://openalex.org/W2510030592","https://openalex.org/W2511152819","https://openalex.org/W2519070410","https://openalex.org/W2530778444","https://openalex.org/W2535316919","https://openalex.org/W2552266513","https://openalex.org/W2557564964","https://openalex.org/W2560232547","https://openalex.org/W2567699986","https://openalex.org/W2572710398","https://openalex.org/W2590373630","https://openalex.org/W2591733518","https://openalex.org/W2596443765","https://openalex.org/W2604275021","https://openalex.org/W2605401453","https://openalex.org/W2605876272","https://openalex.org/W2608281831","https://openalex.org/W2615285606","https://openalex.org/W2742680365","https://openalex.org/W2761739377","https://openalex.org/W2785933318","https://openalex.org/W2803022315","https://openalex.org/W2806766888","https://openalex.org/W2811380413","https://openalex.org/W2884217857","https://openalex.org/W2887394562","https://openalex.org/W2893194701","https://openalex.org/W2904334833","https://openalex.org/W2905656859","https://openalex.org/W2907148266","https://openalex.org/W2917323190","https://openalex.org/W2921224315","https://openalex.org/W2921565902","https://openalex.org/W2926805808","https://openalex.org/W2945985580","https://openalex.org/W2951866836","https://openalex.org/W2952511722","https://openalex.org/W2954710602","https://openalex.org/W2960352676","https://openalex.org/W2975056325","https://openalex.org/W2975634552","https://openalex.org/W2990735871","https://openalex.org/W2999300346","https://openalex.org/W3006264708","https://openalex.org/W3034201929","https://openalex.org/W3037075657","https://openalex.org/W3038722185","https://openalex.org/W3040092474","https://openalex.org/W3044202555","https://openalex.org/W3048482917","https://openalex.org/W3082036436","https://openalex.org/W3091491962","https://openalex.org/W3094163967","https://openalex.org/W3096251629","https://openalex.org/W3102161185","https://openalex.org/W3111302746","https://openalex.org/W3121129716","https://openalex.org/W3136614944","https://openalex.org/W3145334405","https://openalex.org/W3171218066","https://openalex.org/W3192931997","https://openalex.org/W3206340131","https://openalex.org/W4200571393","https://openalex.org/W4206726949","https://openalex.org/W4213362614","https://openalex.org/W4221026990","https://openalex.org/W4224234656","https://openalex.org/W4226210469","https://openalex.org/W4240661191","https://openalex.org/W4283026839","https://openalex.org/W4288048244","https://openalex.org/W4292686117","https://openalex.org/W4301398089","https://openalex.org/W4308150510","https://openalex.org/W4308590016","https://openalex.org/W4309047635","https://openalex.org/W4309679211","https://openalex.org/W4310087933","https://openalex.org/W4316464559","https://openalex.org/W4321004307","https://openalex.org/W4321784450","https://openalex.org/W4324009105","https://openalex.org/W4362522101","https://openalex.org/W4366411702","https://openalex.org/W4367317533","https://openalex.org/W4376132416","https://openalex.org/W4381249137","https://openalex.org/W4381838933","https://openalex.org/W4382632577","https://openalex.org/W4385563821","https://openalex.org/W4385753923","https://openalex.org/W4386056671","https://openalex.org/W4386096524","https://openalex.org/W4386857262","https://openalex.org/W4387098638","https://openalex.org/W4387169052","https://openalex.org/W4387219455","https://openalex.org/W4387973622","https://openalex.org/W4389613158","https://openalex.org/W4389990122","https://openalex.org/W4390773218","https://openalex.org/W4391348413","https://openalex.org/W4392400555","https://openalex.org/W4398781639","https://openalex.org/W4399167645","https://openalex.org/W4399622714","https://openalex.org/W4400262621","https://openalex.org/W4400956453","https://openalex.org/W4401021339","https://openalex.org/W4401034774","https://openalex.org/W4401215945","https://openalex.org/W4401912842","https://openalex.org/W4401972042","https://openalex.org/W4403513715","https://openalex.org/W4404448370","https://openalex.org/W4404533072","https://openalex.org/W4406281465","https://openalex.org/W4406627870","https://openalex.org/W4407780825","https://openalex.org/W4408223476","https://openalex.org/W4408279709","https://openalex.org/W4408778463","https://openalex.org/W4408990057","https://openalex.org/W4409577673","https://openalex.org/W4409907418","https://openalex.org/W4410982099","https://openalex.org/W4411428008","https://openalex.org/W4411619940","https://openalex.org/W4411750391","https://openalex.org/W4412024169","https://openalex.org/W4412024286","https://openalex.org/W4412150460","https://openalex.org/W4412774943","https://openalex.org/W4414081690","https://openalex.org/W4414419845","https://openalex.org/W4414456917","https://openalex.org/W4414520840","https://openalex.org/W4414584919","https://openalex.org/W4415010678","https://openalex.org/W4415035255","https://openalex.org/W4417272601","https://openalex.org/W4417485926","https://openalex.org/W7117426074","https://openalex.org/W7119023918","https://openalex.org/W7122475911","https://openalex.org/W7127417741","https://openalex.org/W7127424311","https://openalex.org/W7127912418","https://openalex.org/W7127990048","https://openalex.org/W7130595607","https://openalex.org/W7133892406","https://openalex.org/W7155208195"],"related_works":[],"abstract_inverted_index":{"Glaucoma":[0],"is":[1,36,45,87,99,169,186],"a":[2,37,88],"complex":[3],"neurodegenerative":[4],"disease":[5],"with":[6,67],"multiple":[7],"subtypes,":[8],"yet":[9],"all":[10],"are":[11,74,154],"characterized":[12],"by":[13],"the":[14,112,129,195,209,224],"progressive":[15],"dysfunction":[16],"and":[17,30,62,82,109,131,138,152,174,223,232],"loss":[18],"of":[19,95,133,144,159,198,211,219],"retinal":[20],"ganglion":[21],"cells":[22],"(RGCs),":[23],"which":[24,116],"ultimately":[25],"results":[26],"in":[27,128,135,156,180,214],"vision":[28],"impairment":[29],"blindness.":[31],"Elevated":[32],"intraocular":[33],"pressure":[34],"(IOP)":[35],"major":[38],"risk":[39,81],"factor":[40],"for":[41,50,227],"glaucoma;":[42,216],"however,":[43],"it":[44],"neither":[46],"necessary":[47],"nor":[48],"sufficient":[49],"glaucomatous":[51,160],"neurodegeneration,":[52],"as":[53,103],"patients":[54,63],"can":[55,64],"exhibit":[56],"high":[57],"IOP":[58],"without":[59],"developing":[60],"glaucoma":[61,66,96,134,145,220],"develop":[65],"normal":[68],"IOP.":[69,84],"Yet":[70],"FDA-approved":[71],"treatment":[72],"options":[73],"largely":[75],"limited":[76],"to":[77,79,91,146,163,182,189,193],"approaches":[78],"minimize":[80],"reduce":[83],"Thus,":[85,184],"there":[86,168,185],"critical":[89,187],"need":[90,188],"target":[92],"other":[93],"aspects":[94],"pathophysiology.":[97],"Neuroinflammation":[98],"broadly":[100],"defined":[101],"here":[102],"immune-relevant":[104],"responses,":[105],"often":[106],"involving":[107],"microglia":[108,151],"astrocytes,":[110],"within":[111],"central":[113],"nervous":[114],"system":[115],"may":[117],"include":[118,194],"peripheral":[119],"immune":[120,230],"cell":[121,200],"infiltration.":[122],"Burgeoning":[123],"evidence":[124,171,210,225],"has":[125],"implicated":[126],"glia":[127,176],"development":[130],"progression":[132],"human":[136,173,199,215],"tissues":[137],"mouse":[139,142,175],"models.":[140,202],"Most":[141],"models":[143,218],"date":[147],"have":[148],"shown":[149],"that":[150,172],"astrocytes":[153],"reactive":[155],"early":[157],"stages":[158],"neurodegeneration":[161],"prior":[162],"overt":[164],"RGC":[165],"loss.":[166],"However,":[167],"growing":[170],"adopt":[177],"distinct":[178],"phenotypes":[179],"response":[181],"neurodegeneration.":[183],"expand":[190],"our":[191],"studies":[192],"new":[196],"generations":[197],"culture":[201],"In":[203],"this":[204],"review,":[205],"we":[206],"discuss:":[207],"1)":[208],"neuroinflammatory":[212],"processes":[213],"2)":[217],"relevant":[221],"neuroinflammation;":[222],"specifically":[226],"3)":[228],"innate":[229],"cell-driven":[231],"4)":[233],"macroglia-driven":[234],"processes.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-06-28T00:00:00"}
