{"id":"https://openalex.org/W7166330658","doi":"https://doi.org/10.1038/s41598-026-56507-4","title":"The effect of simvastatin on orthopaedic biomaterial induced inflammation","display_name":"The effect of simvastatin on orthopaedic biomaterial induced inflammation","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166330658","doi":"https://doi.org/10.1038/s41598-026-56507-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365036"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-56507-4","doi":"https://doi.org/10.1038/s41598-026-56507-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-56507-4","pdf_url":"https://www.nature.com/articles/s41598-026-56507-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-56507-4_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064392848","display_name":"Sami A. Anjum","orcid":"https://orcid.org/0000-0002-3466-1048","observed_orcids":["https://orcid.org/0000-0002-3466-1048"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sami A. Anjum","raw_affiliation_strings":["Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK. sami.anjum@newcastle.ac.uk","Newcastle University, Third Floor William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, England, UK. sami.anjum@newcastle.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK. sami.anjum@newcastle.ac.uk","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Newcastle University, Third Floor William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, England, UK. sami.anjum@newcastle.ac.uk","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028478090","display_name":"Shannon Jamieson","orcid":"https://orcid.org/0009-0000-7990-7702","observed_orcids":["https://orcid.org/0009-0000-7990-7702"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shannon Jamieson","raw_affiliation_strings":["Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137212823","display_name":"David J. Deehan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Deehan","raw_affiliation_strings":["Musculoskeletal Unit, Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Unit, Department of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043822035","display_name":"John Andrew Kirby","orcid":"https://orcid.org/0000-0003-2543-4131","observed_orcids":["https://orcid.org/0000-0003-2543-4131"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John A. Kirby","raw_affiliation_strings":["Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071424712","display_name":"Alison Jane Tyson-Capper","orcid":"https://orcid.org/0000-0002-4778-1946","observed_orcids":["https://orcid.org/0000-0002-4778-1946"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Tyson-Capper","raw_affiliation_strings":["Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 4HH, England, UK","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064392848"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52512716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8510000109672546},{"id":"https://openalex.org/keywords/orthopedic-biomaterials","display_name":"orthopedic biomaterials","score":0.9120000004768372},{"id":"https://openalex.org/keywords/aseptic-loosening","display_name":"aseptic loosening","score":0.8019999861717224},{"id":"https://openalex.org/keywords/revision-arthroplasty","display_name":"revision arthroplasty","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cobalt","display_name":"cobalt","score":0.6150000095367432},{"id":"https://openalex.org/keywords/zirconia","display_name":"zirconia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9620000123977661},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ccl3","display_name":"CCL3","score":0.871999979019165},{"id":"https://openalex.org/keywords/ccl20","display_name":"CCL20","score":0.9729999899864197},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/particulate-debris","display_name":"particulate debris","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9488000273704529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7236999869346619},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6399999856948853},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4562000036239624},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4284000098705292},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.40299999713897705},{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.4025000035762787},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3968999981880188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.385699987411499},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C2778417548","wikidata":"https://www.wikidata.org/wiki/Q417942","display_name":"Fluvastatin","level":3,"score":0.32829999923706055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3041999936103821},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.25}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-026-56507-4","doi":"https://doi.org/10.1038/s41598-026-56507-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-56507-4","pdf_url":"https://www.nature.com/articles/s41598-026-56507-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42365036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:895c11aca4b943bb99f534df06706517","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/895c11aca4b943bb99f534df06706517","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-56507-4","doi":"https://doi.org/10.1038/s41598-026-56507-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-56507-4","pdf_url":"https://www.nature.com/articles/s41598-026-56507-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320014","display_name":"Royal College of Surgeons of England","ror":"https://ror.org/02qrg5a24"},{"id":"https://openalex.org/F4320320242","display_name":"Royal College of Surgeons of Edinburgh","ror":"https://ror.org/021a7d287"},{"id":"https://openalex.org/F4320327444","display_name":"Versus Arthritis","ror":"https://ror.org/02jkpm469"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166330658.pdf","grobid_xml":"https://content.openalex.org/works/W7166330658.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0,56],"most":[1],"common":[2],"indications":[3],"for":[4,165,179],"lower":[5,40],"limb":[6,41],"revision":[7,180],"arthroplasty":[8,42,181],"are":[9,24,152],"aseptic":[10],"loosening":[11],"of":[12,22,58,66,122,146,175],"the":[13,50,64,173],"implant":[14],"and":[15,79,86,112,124,158],"adverse":[16],"reactions":[17],"to":[18,30,62,107,168,171],"particulate":[19],"debris,":[20],"both":[21],"which":[23],"driven":[25],"by":[26,77,84],"host":[27],"immune":[28],"responses":[29],"orthopaedic":[31,69,143],"biomaterials.":[32],"Pharmacoepidemiologic":[33],"studies":[34],"suggest":[35],"that":[36,138],"statins":[37,139,151,170],"may":[38],"improve":[39],"survival,":[43],"potentially":[44],"through":[45],"pleiotropic":[46],"anti-inflammatory":[47],"effects,":[48],"but":[49],"biology":[51],"underpinning":[52],"this":[53,59,160],"remains":[54],"unclear.":[55],"aim":[57],"study":[60],"was":[61,75,82],"investigate":[63],"effect":[65],"simvastatin":[67,96],"on":[68,182],"bio-material-induced":[70],"inflammation":[71],"in-vitro.":[72,149],"Gene":[73],"expression":[74,104,145],"measured":[76,83],"qPCR":[78],"protein":[80,114],"secretion":[81],"ELISA":[85],"Meso":[87],"scale":[88],"discovery":[89],"assays.":[90],"In":[91],"THP-1":[92],"macrophages,":[93],"co-culture":[94],"with":[95],"significantly":[97,141],"abrogated":[98],"cobalt-mediated":[99],"increases":[100,131],"in":[101,105,132,155],"IL-8":[102],"gene":[103],"addition":[106],"IL-8,":[108],"IL-1\u03b2,":[109],"CCL3,":[110],"CCL4":[111],"CCL20":[113],"secretion.":[115],"Simvastatin":[116],"also":[117],"inhibited":[118],"zirconium":[119],"oxide-mediated":[120,130],"levels":[121],"CCL2":[123],"CCL4,":[125],"as":[126,128],"well":[127],"alumina":[129],"CCL2.":[133],"These":[134],"novel":[135],"findings":[136],"demonstrate":[137],"can":[140],"reduce":[142,172],"biomaterial-induced":[144],"pro-inflammatory":[147],"cytokines":[148],"As":[150],"widely":[153],"used":[154],"clinical":[156],"practice":[157],"inexpensive,":[159],"provides":[161],"an":[162],"exciting":[163],"basis":[164],"future":[166],"work":[167],"leverage":[169],"impact":[174],"a":[176],"burgeoning":[177],"demand":[178],"patients.":[183]},"counts_by_year":[],"updated_date":"2026-09-30T09:27:27.532063","created_date":"2026-06-28T00:00:00"}