{"id":"https://openalex.org/W7166326564","doi":"https://doi.org/10.1080/17460794.2026.2692828","title":"Antiviral efficacy of silver nanoparticles against herpes simplex virus type 1: a systematic review of in vitro studies","display_name":"Antiviral efficacy of silver nanoparticles against herpes simplex virus type 1: a systematic review of in vitro studies","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166326564","doi":"https://doi.org/10.1080/17460794.2026.2692828"},"language":"en","primary_location":{"id":"doi:10.1080/17460794.2026.2692828","doi":"https://doi.org/10.1080/17460794.2026.2692828","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460794.2026.2692828","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102523265","display_name":"Manoela Borges e Souza Marques","orcid":"https://orcid.org/0000-0002-8357-5875","observed_orcids":["https://orcid.org/0000-0002-8357-5875"]},"institutions":[{"id":"https://openalex.org/I4210158152","display_name":"Universidade de Uberaba","ror":"https://ror.org/05hzgxd58","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210158152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Manoela Borges e Souza Marques","raw_affiliation_strings":["University of Uberaba (UNIUBE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Uberaba (UNIUBE)","institution_ids":["https://openalex.org/I4210158152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093692576","display_name":"Jo\u00e3o Marcos Carvalho\u2010Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Marcos Carvalho-Silva","raw_affiliation_strings":["University of S\u00e3o Paulo (USP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo (USP)","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026652365","display_name":"Denise Tornavoi de Castro","orcid":"https://orcid.org/0000-0001-8180-7858","observed_orcids":["https://orcid.org/0000-0001-8180-7858"]},"institutions":[{"id":"https://openalex.org/I4210158152","display_name":"Universidade de Uberaba","ror":"https://ror.org/05hzgxd58","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210158152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Denise Tornavoi de Castro","raw_affiliation_strings":["University of Uberaba (UNIUBE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Uberaba (UNIUBE)","institution_ids":["https://openalex.org/I4210158152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080897349","display_name":"Jo\u00e3o Marcos Carvalho Silva","orcid":"https://orcid.org/0000-0002-4045-8791","observed_orcids":["https://orcid.org/0000-0002-4045-8791"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Andr\u00e9a C\u00e2ndido dos Reis","raw_affiliation_strings":["University of S\u00e3o Paulo (USP)"],"raw_orcid":"https://orcid.org/0000-0002-4045-8791","affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo (USP)","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080897349"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20158103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"7","first_page":"481","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silver-nanoparticles","display_name":"silver nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.968999981880188},{"id":"https://openalex.org/keywords/virucidal-activity","display_name":"virucidal activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/co-treatment","display_name":"co-treatment","score":0.6660000085830688},{"id":"https://openalex.org/keywords/pretreatment","display_name":"pretreatment","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.7239000201225281},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.723800003528595},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6434000134468079},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5723999738693237},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4099000096321106},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4074999988079071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38040000200271606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32249999046325684},{"id":"https://openalex.org/C36372059","wikidata":"https://www.wikidata.org/wiki/Q376492","display_name":"HSL and HSV","level":3,"score":0.2913999855518341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29100000858306885},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.25119999051094055},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/17460794.2026.2692828","doi":"https://doi.org/10.1080/17460794.2026.2692828","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460794.2026.2692828","pdf_url":null,"source":{"id":"https://openalex.org/S204562989","display_name":"Future Virology","issn_l":"1746-0794","issn":["1746-0794","1746-0808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Virology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1565131161","https://openalex.org/W1877152538","https://openalex.org/W1920887763","https://openalex.org/W1966758367","https://openalex.org/W1970507883","https://openalex.org/W1980111069","https://openalex.org/W2021238010","https://openalex.org/W2026890958","https://openalex.org/W2029146518","https://openalex.org/W2066855216","https://openalex.org/W2104154679","https://openalex.org/W2142693008","https://openalex.org/W2153349575","https://openalex.org/W2154442121","https://openalex.org/W2155014384","https://openalex.org/W2159334987","https://openalex.org/W2417296926","https://openalex.org/W2537605934","https://openalex.org/W2587194014","https://openalex.org/W2746379171","https://openalex.org/W2791285646","https://openalex.org/W2791362520","https://openalex.org/W2810943459","https://openalex.org/W2891921246","https://openalex.org/W2964941347","https://openalex.org/W3016655066","https://openalex.org/W3038406722","https://openalex.org/W3043121607","https://openalex.org/W3118615836","https://openalex.org/W3120589563","https://openalex.org/W3134199500","https://openalex.org/W3137436769","https://openalex.org/W3145063672","https://openalex.org/W3158777789","https://openalex.org/W3158874432","https://openalex.org/W3202390311","https://openalex.org/W3202818110","https://openalex.org/W3212929426","https://openalex.org/W3215787045","https://openalex.org/W4210415481","https://openalex.org/W4249760819","https://openalex.org/W4280498156","https://openalex.org/W4281701563","https://openalex.org/W4282832829","https://openalex.org/W4283815263","https://openalex.org/W4284701892","https://openalex.org/W4290724184","https://openalex.org/W4303646272","https://openalex.org/W4308118960","https://openalex.org/W4308476524","https://openalex.org/W4311020935","https://openalex.org/W4311888158","https://openalex.org/W4316464758","https://openalex.org/W4322741046","https://openalex.org/W4323568636","https://openalex.org/W4327945510","https://openalex.org/W4376643549","https://openalex.org/W4380148530","https://openalex.org/W4383217672","https://openalex.org/W4386178393","https://openalex.org/W4386780167","https://openalex.org/W4387338446","https://openalex.org/W4389145084","https://openalex.org/W4390674007","https://openalex.org/W4391053460","https://openalex.org/W4391354425","https://openalex.org/W4391915404","https://openalex.org/W4394932473","https://openalex.org/W4398232778","https://openalex.org/W4398255226","https://openalex.org/W4399730092","https://openalex.org/W4400465985","https://openalex.org/W4400618365","https://openalex.org/W4401842934","https://openalex.org/W4403173127","https://openalex.org/W4403977729","https://openalex.org/W4404140922","https://openalex.org/W4404412983","https://openalex.org/W4404645611","https://openalex.org/W4404700052","https://openalex.org/W4406152012","https://openalex.org/W4406682575","https://openalex.org/W4407708078","https://openalex.org/W4408907534"],"related_works":[],"abstract_inverted_index":{"Background":[0],"This":[1],"systematic":[2,108],"review":[3,109],"aimed":[4],"to":[5,40,45],"answer":[6],"the":[7,57,113],"following":[8],"question:":[9],"\u201cDo":[10],"silver":[11],"nanoparticles":[12],"(AgNPs)":[13],"exhibit":[14,95],"antiviral":[15,60,77,99],"and":[16,31,33,59,75,86,100],"virucidal":[17,58,73,101],"efficacy":[18],"against":[19,64,79,103],"herpes":[20],"simplex":[21],"type":[22],"1":[23],"(HSV-1)?.\u201dMethods":[24],"Five":[25],"databases":[26],"(PubMed/MEDLINE,":[27],"LILACS,":[28],"ScienceDirect,":[29],"Scopus,":[30],"Embase)":[32],"Google":[34],"Scholar":[35],"(gray":[36],"literature)":[37],"were":[38],"accessed":[39],"search":[41],"for":[42],"articles":[43],"up":[44],"20":[46],"September":[47],"2024.":[48],"Eligibility":[49],"criteria":[50],"included":[51],"in":[52,67,84,97],"vitro":[53,98],"experimental":[54],"studies":[55],"evaluating":[56],"activity":[61,74,78,102],"of":[62,106],"AgNPs":[63,70,94],"HSV-1,":[65],"published":[66],"peer-reviewed":[68],"journals.Results":[69],"demonstrated":[71],"high":[72],"moderate":[76],"different":[80,104],"HSV-1":[81],"strains,":[82],"especially":[83],"pre-treatment":[85],"co-treatment":[87],"assays.Discussion":[88],"The":[89],"available":[90],"evidence":[91],"indicates":[92],"that":[93],"potential":[96],"strains":[105],"HSV-1.This":[107],"was":[110],"registered":[111],"on":[112],"Open":[114],"Science":[115],"Framework":[116],"(OSF)":[117],"platform":[118],"(https://osf.io/xyj9d/).":[119]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-06-28T00:00:00"}