{"id":"https://openalex.org/W7166326347","doi":"https://doi.org/10.2139/ssrn.7000379","title":"Transcriptome-guided systems pharmacology reveals potential nephroprotective mechanisms of Myrica esculenta against oxaliplatin-induced renal injury","display_name":"Transcriptome-guided systems pharmacology reveals potential nephroprotective mechanisms of Myrica esculenta against oxaliplatin-induced renal injury","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7166326347","doi":"https://doi.org/10.2139/ssrn.7000379"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.7000379","doi":"https://doi.org/10.2139/ssrn.7000379","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7000379","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7166326347"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.7000379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020578949","display_name":"Ananya Chetia","orcid":"https://orcid.org/0009-0001-3286-567X","observed_orcids":["https://orcid.org/0009-0001-3286-567X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ananya Chetia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-3286-567X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107298516","display_name":"Leena Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leena Das","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016108948","display_name":"Momita Rani Baro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Momita  Rani Baro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063733298","display_name":"M Venkat Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138537684","display_name":"Gauhati University","ror":"https://ror.org/01ppj9r51","country_code":"IN","type":"education","lineage":["https://openalex.org/I138537684"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manas Das","raw_affiliation_strings":["Gauhati University, Guwahati, Assam, 789970, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gauhati University, Guwahati, Assam, 789970, India","institution_ids":["https://openalex.org/I138537684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063733298"],"corresponding_institution_ids":["https://openalex.org/I138537684"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myrica-esculenta","display_name":"Myrica esculenta","score":1.0},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rhamnetin","display_name":"rhamnetin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.9850000143051147},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9559999704360962},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5683000087738037},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.5679000020027161},{"id":"https://openalex.org/C2778989860","wikidata":"https://www.wikidata.org/wiki/Q311617","display_name":"Myrica rubra","level":2,"score":0.5440000295639038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217999815940857},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.3815999925136566},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.35850000381469727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35530000925064087},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.32820001244544983},{"id":"https://openalex.org/C2991844318","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"Renal injury","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3073999881744385},{"id":"https://openalex.org/C14314382","wikidata":"https://www.wikidata.org/wiki/Q1943386","display_name":"Molecular Pharmacology","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2720000147819519},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.7000379","doi":"https://doi.org/10.2139/ssrn.7000379","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7000379","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.7000379","doi":"https://doi.org/10.2139/ssrn.7000379","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7000379","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163896734","https://openalex.org/W4413939800","https://openalex.org/W7165036418","https://openalex.org/W4385461618","https://openalex.org/W7142372293","https://openalex.org/W2092525168","https://openalex.org/W4392137736","https://openalex.org/W4307234931","https://openalex.org/W7222784132","https://openalex.org/W4410975340"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-06-28T00:00:00"}
