{"id":"https://openalex.org/W7166326311","doi":"https://doi.org/10.1016/j.cca.2026.121204","title":"Presepsin outperforms conventional biomarkers for Sepsis diagnosis and 30-day mortality prediction: A multicenter prospective study in a north African ICU cohort","display_name":"Presepsin outperforms conventional biomarkers for Sepsis diagnosis and 30-day mortality prediction: A multicenter prospective study in a north African ICU cohort","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166326311","doi":"https://doi.org/10.1016/j.cca.2026.121204","pmid":"https://pubmed.ncbi.nlm.nih.gov/42364890"},"language":"en","primary_location":{"id":"doi:10.1016/j.cca.2026.121204","doi":"https://doi.org/10.1016/j.cca.2026.121204","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2026.121204","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112513274","display_name":"Ines Allam","orcid":"https://orcid.org/0000-0001-6399-9593","observed_orcids":["https://orcid.org/0000-0001-6399-9593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ines Allam","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139474481","display_name":"Amel Derdoum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amel Derdoum","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139472741","display_name":"Ali Said","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Said","raw_affiliation_strings":["Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128596210","display_name":"Hadia Boussaha","orcid":"https://orcid.org/0009-0005-5549-0814","observed_orcids":["https://orcid.org/0009-0005-5549-0814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hadia Boussaha","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002462389","display_name":"Fatma Merah","orcid":"https://orcid.org/0009-0008-9287-4886","observed_orcids":["https://orcid.org/0009-0008-9287-4886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Merah","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029961005","display_name":"Brahim Belaid","orcid":"https://orcid.org/0000-0001-7618-4051","observed_orcids":["https://orcid.org/0000-0001-7618-4051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brahim Belaid","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139491345","display_name":"Nour Ouchene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nour Ouchene","raw_affiliation_strings":["Department of Intensive Care Unit, Beni Messous University Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Unit, Beni Messous University Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139352876","display_name":"Asma Kassoul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asma Kassoul","raw_affiliation_strings":["Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009421205","display_name":"Ly\u00e8ce Yargui","orcid":"https://orcid.org/0000-0003-1239-7159","observed_orcids":["https://orcid.org/0000-0003-1239-7159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ly\u00e8ce Yargui","raw_affiliation_strings":["Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Mustapha University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108906956","display_name":"Souhila Sadat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Souhila Sadat","raw_affiliation_strings":["Department of Intensive Care Unit, Zeralda Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Unit, Zeralda Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007555318","display_name":"R\u00e9da Malek Hamidi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reda Malek Hamidi","raw_affiliation_strings":["Department of Intensive Care Unit, Beni Messous University Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Unit, Beni Messous University Hospital, Faculty of Medicine, University of Health Sciences, Algiers, Algeria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057925637","display_name":"R\u00e9da Djidjik","orcid":"https://orcid.org/0000-0003-0820-692X","observed_orcids":["https://orcid.org/0000-0003-0820-692X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Reda Djidjik","raw_affiliation_strings":["Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria. Electronic address: r.djidjik@univ-alger.dz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Beni Messous University Hospital, Faculty of Pharmacy, University of Health Sciences, Algiers, Algeria. Electronic address: r.djidjik@univ-alger.dz","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057925637"],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"592","issue":null,"first_page":"121204","last_page":"121204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presepsin","display_name":"presepsin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sepsis-diagnosis","display_name":"sepsis diagnosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8769999742507935},{"id":"https://openalex.org/keywords/30-day-mortality-prediction","display_name":"30-day mortality prediction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.656000018119812},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.6460000276565552},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.5680000185966492},{"id":"https://openalex.org/keywords/sepsis-3-criteria","display_name":"Sepsis-3 criteria","score":0.8100000023841858},{"id":"https://openalex.org/keywords/north-africa","display_name":"North Africa","score":0.4269999861717224},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8985999822616577},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.7914000153541565},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7782999873161316},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5630000233650208},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5103999972343445},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4916999936103821},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4255000054836273},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.3776000142097473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2842999994754791},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cca.2026.121204","doi":"https://doi.org/10.1016/j.cca.2026.121204","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2026.121204","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:42364890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42364890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2054699814","https://openalex.org/W2100259646","https://openalex.org/W2282181907","https://openalex.org/W2942645055","https://openalex.org/W2947062919","https://openalex.org/W2947375759","https://openalex.org/W2949537508","https://openalex.org/W2952580254","https://openalex.org/W3036684707","https://openalex.org/W3114428276","https://openalex.org/W3170770952","https://openalex.org/W4205238243","https://openalex.org/W4223627523","https://openalex.org/W4307840692","https://openalex.org/W4385553286","https://openalex.org/W4400131515","https://openalex.org/W4400974215","https://openalex.org/W4402106125","https://openalex.org/W4406599712","https://openalex.org/W4407989435","https://openalex.org/W4408414387","https://openalex.org/W4408414575","https://openalex.org/W4409214289","https://openalex.org/W4409362388","https://openalex.org/W4413217278","https://openalex.org/W4413348741","https://openalex.org/W4415228080","https://openalex.org/W4415240019"],"related_works":["https://openalex.org/W4378531243","https://openalex.org/W2800856862","https://openalex.org/W2140532535","https://openalex.org/W2100259646","https://openalex.org/W4293809725","https://openalex.org/W4407135190","https://openalex.org/W2922064524","https://openalex.org/W2474470608","https://openalex.org/W2732552819","https://openalex.org/W2962344342"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-06-28T00:00:00"}
