{"id":"https://openalex.org/W7166324086","doi":"https://doi.org/10.1186/s43556-026-00508-2","title":"Maternal separation-induced changes in breast milk fatty acid composition are associated with altered gut microbiota and serotonergic gene expression in neonatal mice","display_name":"Maternal separation-induced changes in breast milk fatty acid composition are associated with altered gut microbiota and serotonergic gene expression in neonatal mice","publication_year":2026,"publication_date":"2026-06-28","ids":{"openalex":"https://openalex.org/W7166324086","doi":"https://doi.org/10.1186/s43556-026-00508-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365549"},"language":"en","primary_location":{"id":"doi:10.1186/s43556-026-00508-2","doi":"https://doi.org/10.1186/s43556-026-00508-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00508-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00508-2.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00508-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040615023","display_name":"Eman A. Mady","orcid":"https://orcid.org/0000-0002-6518-3990","observed_orcids":["https://orcid.org/0000-0002-6518-3990"]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]},{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["EG","JP"],"is_corresponding":false,"raw_author_name":"Eman A. Mady","raw_affiliation_strings":["Department of Animal Hygiene, Behavior, and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, 13736, Egypt","Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Hygiene, Behavior, and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, 13736, Egypt","institution_ids":["https://openalex.org/I207547235"]},{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109597113","display_name":"Hussein M. El\u2010Husseiny","orcid":"https://orcid.org/0000-0003-1143-4018","observed_orcids":["https://orcid.org/0000-0003-1143-4018"]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]},{"id":"https://openalex.org/I4405268571","display_name":"Institute of Global Innovation Research (Tokyo University of Agriculture and Technology)","ror":"https://ror.org/01bwqe616","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405268571"]},{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["EG","JP"],"is_corresponding":false,"raw_author_name":"Hussein M. El-Husseiny","raw_affiliation_strings":["Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, Egypt","Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-Cho, Fuchu-Shi, Tokyo, 183-8538, Japan","Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, Egypt","institution_ids":["https://openalex.org/I207547235"]},{"raw_affiliation_string":"Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-Cho, Fuchu-Shi, Tokyo, 183-8538, Japan","institution_ids":["https://openalex.org/I4405268571","https://openalex.org/I92614990"]},{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033804743","display_name":"Jun Kambe","orcid":"https://orcid.org/0009-0006-9279-4961","observed_orcids":["https://orcid.org/0009-0006-9279-4961"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Kambe","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098967247","display_name":"Sora Masukado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sora Masukado","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033261663","display_name":"Shiho Miyata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiho Miyata","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002175179","display_name":"Taiki Terajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiki Terajima","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139483680","display_name":"Hong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126138032","display_name":"Ryo Inoue","orcid":"https://orcid.org/0000-0002-7233-366X","observed_orcids":["https://orcid.org/0000-0002-7233-366X"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Inoue","raw_affiliation_strings":["Laboratory of Animal Science, Department of Applied Biological Science, Setsunan University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Science, Department of Applied Biological Science, Setsunan University, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139499262","display_name":"Chunmei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunmei Li","raw_affiliation_strings":["College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139497781","display_name":"Yuki Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Yamamoto","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044345304","display_name":"Kentaro Nagaoka","orcid":"https://orcid.org/0000-0003-1038-1380","observed_orcids":["https://orcid.org/0000-0003-1038-1380"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Nagaoka","raw_affiliation_strings":["Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan. nagaokak@cc.tuat.ac.jp"],"raw_orcid":"https://orcid.org/0000-0003-1038-1380","affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan. nagaokak@cc.tuat.ac.jp","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044345304"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42115599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.2159000039100647,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-separation","display_name":"maternal separation","score":1.0},{"id":"https://openalex.org/keywords/early-life-stress","display_name":"early life stress","score":0.9380000233650208},{"id":"https://openalex.org/keywords/breast-milk-fatty-acids","display_name":"breast milk fatty acids","score":0.8460000157356262},{"id":"https://openalex.org/keywords/myristic-acid","display_name":"myristic acid","score":0.871999979019165},{"id":"https://openalex.org/keywords/inosine","display_name":"inosine","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9419999718666077},{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":0.949999988079071},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tryptophan-hydroxylase-2","display_name":"tryptophan hydroxylase 2","score":0.8349999785423279},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/5-ht1b-receptor","display_name":"5-HT1B receptor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neonatal-mice","display_name":"neonatal mice","score":0.7900000214576721},{"id":"https://openalex.org/keywords/serum-metabolites","display_name":"serum metabolites","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2778483698","wikidata":"https://www.wikidata.org/wiki/Q422658","display_name":"Myristic acid","level":4,"score":0.6991000175476074},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.6866000294685364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6694999933242798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5216000080108643},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5026999711990356},{"id":"https://openalex.org/C6977687","wikidata":"https://www.wikidata.org/wiki/Q781350","display_name":"Lipoteichoic acid","level":4,"score":0.4611999988555908},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4440000057220459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4309000074863434},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.40950000286102295},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.3873000144958496},{"id":"https://openalex.org/C2779999352","wikidata":"https://www.wikidata.org/wiki/Q18049432","display_name":"TPH2","level":5,"score":0.3790999948978424},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C2781003072","wikidata":"https://www.wikidata.org/wiki/Q422627","display_name":"Lauric acid","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C2909748322","wikidata":"https://www.wikidata.org/wiki/Q255933","display_name":"Inosine monophosphate","level":4,"score":0.3142000138759613},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C2779164789","wikidata":"https://www.wikidata.org/wiki/Q238532","display_name":"5-Hydroxyindoleacetic acid","level":4,"score":0.30000001192092896},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.29510000348091125},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.2637999951839447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008426","descriptor_name":"Maternal Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008426","descriptor_name":"Maternal Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008426","descriptor_name":"Maternal Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s43556-026-00508-2","doi":"https://doi.org/10.1186/s43556-026-00508-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00508-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00508-2.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},{"id":"pmid:42365549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13310859","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310859/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310859/pdf/43556_2026_Article_508.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Biomed","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3d5c65675864495396b19d142c9d76e9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3d5c65675864495396b19d142c9d76e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biomedicine, Vol 7, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43556-026-00508-2","doi":"https://doi.org/10.1186/s43556-026-00508-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-026-00508-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-026-00508-2.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41373446583747864}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3911498701","display_name":null,"funder_award_id":"JPMJOP1833","funder_id":"https://openalex.org/F4320338123","funder_display_name":"Program on Open Innovation Platform with Enterprises, Research Institute and Academia"}],"funders":[{"id":"https://openalex.org/F4320338123","display_name":"Program on Open Innovation Platform with Enterprises, Research Institute and Academia","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166324086.pdf","grobid_xml":"https://content.openalex.org/works/W7166324086.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1969144895","https://openalex.org/W1972237932","https://openalex.org/W2036878287","https://openalex.org/W2061951616","https://openalex.org/W2066642662","https://openalex.org/W2107999816","https://openalex.org/W2123116671","https://openalex.org/W2126688003","https://openalex.org/W2139817708","https://openalex.org/W2149617947","https://openalex.org/W2231115651","https://openalex.org/W2343547480","https://openalex.org/W2499348334","https://openalex.org/W2567044834","https://openalex.org/W2606997239","https://openalex.org/W2613015861","https://openalex.org/W2734690070","https://openalex.org/W2778056352","https://openalex.org/W2796215289","https://openalex.org/W2802384692","https://openalex.org/W2896729655","https://openalex.org/W2916858609","https://openalex.org/W2936180285","https://openalex.org/W2963276645","https://openalex.org/W2972820854","https://openalex.org/W2999988859","https://openalex.org/W3044698562","https://openalex.org/W3111723999","https://openalex.org/W3117213742","https://openalex.org/W3118759601","https://openalex.org/W3120745389","https://openalex.org/W3134035023","https://openalex.org/W3173403511","https://openalex.org/W3174610032","https://openalex.org/W3189091825","https://openalex.org/W3195932210","https://openalex.org/W4200474644","https://openalex.org/W4281478418","https://openalex.org/W4297497367","https://openalex.org/W4304689737","https://openalex.org/W4307449358","https://openalex.org/W4307758059","https://openalex.org/W4366825169","https://openalex.org/W4392715882","https://openalex.org/W4392962544","https://openalex.org/W4394575192","https://openalex.org/W4394576408","https://openalex.org/W4394578957","https://openalex.org/W4396829484","https://openalex.org/W4399245755","https://openalex.org/W4408974838","https://openalex.org/W4413964183"],"related_works":[],"abstract_inverted_index":{"Maternal":[0],"separation":[1],"(MS)":[2],"is":[3],"a":[4,27,164,176],"widely":[5],"used":[6],"model":[7],"of":[8],"early-life":[9],"stress,":[10],"yet":[11],"the":[12,46,56,79,112,135,223],"biological":[13,29],"pathways":[14],"transmitting":[15],"maternal":[16,199],"stress":[17],"signals":[18],"to":[19],"offspring":[20,43,67,105,205],"remain":[21],"incompletely":[22],"understood.":[23],"Breast":[24],"milk":[25,39,58,201],"represents":[26],"primary":[28],"interface":[30],"between":[31,167,179],"mother":[32],"and":[33,35,60,74,98,118,128,131,149,171,175,182,210],"infant,":[34],"stress-induced":[36,200],"changes":[37,63],"in":[38,78,87,101,111,121,126,134,142],"composition":[40],"may":[41],"influence":[42],"development":[44],"through":[45],"gut":[47,68,206],"microbiota-brain":[48],"axis.":[49,226],"Here,":[50],"we":[51,89],"investigated":[52],"whether":[53,61],"MS":[54,92,104],"alters":[55],"breast":[57,102],"metabolome":[59],"such":[62],"are":[64],"associated":[65],"with":[66],"microbiota":[69],"composition,":[70],"serum":[71],"metabolite":[72],"profiles,":[73],"serotonin-related":[75,211],"gene":[76,212],"expression":[77,133],"prefrontal":[80,136,183],"cortex.":[81,137],"Using":[82],"an":[83,215],"integrated":[84],"multi-omics":[85],"approach":[86],"mice,":[88],"found":[90],"that":[91],"dams":[93],"had":[94],"elevated":[95,115],"myristic":[96,116,139,169],"acid":[97,117,140,170,203],"ethanolamine":[99],"levels":[100],"milk.":[103],"exhibited":[106],"reduced":[107,129,145],"A.":[108,146],"muciniphila":[109,147],"abundance":[110],"cecal":[113,122,168,172,180],"microbiota,":[114,207],"decreased":[119,124],"inosine":[120,125,150,173,181],"contents,":[123],"serum,":[127],"Tph2":[130,184],"Htr1b":[132],"Oral":[138],"supplementation":[141,151],"neonatal":[143],"pups":[144],"abundance,":[148],"selectively":[152],"increased":[153],"Htr1a":[154],"expression.":[155],"Spearman":[156],"correlation":[157,178],"analyses":[158],"using":[159],"paired":[160],"individual":[161],"data":[162],"revealed":[163],"negative":[165],"association":[166],"levels,":[174],"positive":[177],"expression,":[185,213],"supporting":[186],"quantitative":[187],"links":[188],"among":[189,198],"these":[190,193],"components.":[191],"Collectively,":[192],"findings":[194],"identify":[195],"coordinated":[196],"associations":[197],"fatty":[202],"changes,":[204],"microbial":[208],"metabolites,":[209],"providing":[214],"exploratory":[216],"framework":[217],"for":[218],"understanding":[219],"milk-mediated":[220],"effects":[221],"on":[222],"developing":[224],"gut-brain":[225]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-06-28T00:00:00"}