{"id":"https://openalex.org/W7166322432","doi":"https://doi.org/10.1177/03000605261463139","title":"Monitoring and analysis of drug therapy in a patient with drug reaction with eosinophilia and systemic symptoms syndrome caused by pantoprazole: A case report","display_name":"Monitoring and analysis of drug therapy in a patient with drug reaction with eosinophilia and systemic symptoms syndrome caused by pantoprazole: A case report","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7166322432","doi":"https://doi.org/10.1177/03000605261463139","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363799"},"language":"en","primary_location":{"id":"doi:10.1177/03000605261463139","doi":"https://doi.org/10.1177/03000605261463139","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03000605261463139","pdf_url":null,"source":{"id":"https://openalex.org/S62018274","display_name":"Journal of International Medical Research","issn_l":"0300-0605","issn":["0300-0605","1473-2300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/03000605261463139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027394014","display_name":"G Chen","orcid":"https://orcid.org/0000-0002-4706-1260","observed_orcids":["https://orcid.org/0000-0002-4706-1260","https://orcid.org/0000-0003-1962-1360","https://orcid.org/0009-0004-5908-2028"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Hui Chen","raw_affiliation_strings":["Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China"],"raw_orcid":"https://orcid.org/0009-0004-5908-2028","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102880515","display_name":"Haibo Lei","orcid":"https://orcid.org/0000-0002-7258-6106","observed_orcids":["https://orcid.org/0000-0002-7258-6106","https://orcid.org/0009-0002-0221-5286"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Bo Lei","raw_affiliation_strings":["Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China"],"raw_orcid":"https://orcid.org/0009-0002-0221-5286","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102819128","display_name":"Xiang Liu","orcid":"https://orcid.org/0009-0008-9958-745X","observed_orcids":["https://orcid.org/0009-0008-9958-745X"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Liu","raw_affiliation_strings":["Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China"],"raw_orcid":"https://orcid.org/0009-0008-9958-745X","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University), China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057663111","display_name":"Zheng Yun-hua","orcid":"https://orcid.org/0009-0007-6398-4907","observed_orcids":["https://orcid.org/0009-0007-6398-4907"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]},{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun-Hua Zheng","raw_affiliation_strings":["Department of Quality Evaluation and Medical Record Management, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, China","NHC Key Laboratory of Chronobiology, Sichuan University, China","Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, China","West China Second University Hospital, Sichuan University"],"raw_orcid":"https://orcid.org/0009-0007-6398-4907","affiliations":[{"raw_affiliation_string":"Department of Quality Evaluation and Medical Record Management, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, China","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]},{"raw_affiliation_string":"NHC Key Laboratory of Chronobiology, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057663111"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228","https://openalex.org/I4210093384","https://openalex.org/I4800084"],"apc_list":{"value":4155,"currency":"USD","value_usd":4155},"apc_paid":{"value":4155,"currency":"USD","value_usd":4155},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48934939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"6","first_page":"3000605261463139","last_page":"3000605261463139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-reaction-with-eosinophilia-and-systemic-symptoms","display_name":"DRESS syndrome","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pantoprazole","display_name":"pantoprazole","score":1.0},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/adverse-cutaneous-drug-reactions","display_name":"adverse cutaneous drug reactions","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pharmacist-intervention","display_name":"pharmacist intervention","score":0.6340000033378601},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stress-ulcer-prophylaxis","display_name":"stress ulcer prophylaxis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/t-cell-mediated-hypersensitivity","display_name":"T-cell-mediated hypersensitivity","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9754999876022339},{"id":"https://openalex.org/C2781315423","wikidata":"https://www.wikidata.org/wiki/Q286846","display_name":"Pantoprazole","level":3,"score":0.7346000075340271},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7064999938011169},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.6292999982833862},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.5228000283241272},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.491100013256073},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.4767000079154968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45980000495910645},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4458000063896179},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4185999929904938},{"id":"https://openalex.org/C2779060952","wikidata":"https://www.wikidata.org/wiki/Q2068896","display_name":"Drug allergy","level":3,"score":0.41200000047683716},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.4104999899864197},{"id":"https://openalex.org/C2778062832","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Drug withdrawal","level":3,"score":0.40389999747276306},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C2780664588","wikidata":"https://www.wikidata.org/wiki/Q1878682","display_name":"Toxic epidermal necrolysis","level":2,"score":0.38929998874664307},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.3709000051021576},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36239999532699585},{"id":"https://openalex.org/C2778784858","wikidata":"https://www.wikidata.org/wiki/Q1363741","display_name":"Erythroderma","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C2779515644","wikidata":"https://www.wikidata.org/wiki/Q718675","display_name":"Drug eruption","level":3,"score":0.32760000228881836},{"id":"https://openalex.org/C2993280485","wikidata":"https://www.wikidata.org/wiki/Q5958765","display_name":"Hypersensitivity reaction","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.30959999561309814},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30550000071525574},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000077402","descriptor_name":"Pantoprazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077402","descriptor_name":"Pantoprazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077402","descriptor_name":"Pantoprazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077402","descriptor_name":"Pantoprazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D063926","descriptor_name":"Drug Hypersensitivity Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/03000605261463139","doi":"https://doi.org/10.1177/03000605261463139","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03000605261463139","pdf_url":null,"source":{"id":"https://openalex.org/S62018274","display_name":"Journal of International Medical Research","issn_l":"0300-0605","issn":["0300-0605","1473-2300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Medical Research","raw_type":"journal-article"},{"id":"pmid:42363799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of international medical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13310318","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310318/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310318/pdf/10.1177_03000605261463139.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Int Med Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1177/03000605261463139","doi":"https://doi.org/10.1177/03000605261463139","is_oa":true,"landing_page_url":"https://doi.org/10.1177/03000605261463139","pdf_url":null,"source":{"id":"https://openalex.org/S62018274","display_name":"Journal of International Medical Research","issn_l":"0300-0605","issn":["0300-0605","1473-2300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.835939347743988}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1901880560","https://openalex.org/W2026294611","https://openalex.org/W2034248719","https://openalex.org/W2065699704","https://openalex.org/W2066724445","https://openalex.org/W2086043303","https://openalex.org/W2086521259","https://openalex.org/W2152558879","https://openalex.org/W2416065713","https://openalex.org/W2730833249","https://openalex.org/W2891315877","https://openalex.org/W2898389841","https://openalex.org/W2904000232","https://openalex.org/W2974966193","https://openalex.org/W2980816248","https://openalex.org/W2987348835","https://openalex.org/W3037735708","https://openalex.org/W3094612534","https://openalex.org/W3129853886","https://openalex.org/W3199203413","https://openalex.org/W3217092116","https://openalex.org/W4210811883","https://openalex.org/W4213370560","https://openalex.org/W4383722242","https://openalex.org/W4385296908","https://openalex.org/W4385698924","https://openalex.org/W4388670111","https://openalex.org/W4388695067","https://openalex.org/W4390532452","https://openalex.org/W4405273318","https://openalex.org/W4409531170"],"related_works":[],"abstract_inverted_index":{"Drug":[0],"reaction":[1,15],"with":[2,35,102,143,186],"eosinophilia":[3],"and":[4,20,44,78,104,126,150,166,182,196],"systemic":[5],"symptoms":[6],"(DRESS)":[7],"syndrome":[8,43],"is":[9,28],"a":[10,76],"severe":[11],"T-cell-mediated":[12],"adverse":[13],"cutaneous":[14],"characterized":[16],"by":[17,31,75],"rash,":[18,139,165],"fever,":[19],"visceral":[21],"involvement":[22],"following":[23],"prolonged":[24],"drug":[25,176,195],"use.":[26],"It":[27],"rarely":[29],"induced":[30],"proton":[32],"pump":[33],"inhibitors,":[34],"no":[36],"prior":[37],"reports":[38],"documenting":[39],"pharmacist-identified":[40],"pantoprazole-related":[41],"DRESS":[42,187,209],"subsequent":[45,151],"intervention.":[46],"A":[47],"female":[48],"in":[49,69,156],"her":[50,105],"early":[51],"60s":[52],"(Han":[53],"Chinese":[54],"ethnicity)":[55],"was":[56,80,141],"admitted":[57],"to":[58,111],"the":[59,87,96,136,144,164,179,189,193],"intensive":[60],"care":[61],"unit":[62],"of":[63,116,129,138,153,163,168,175,192],"Xiangtan":[64],"Central":[65],"Hospital":[66],"(Xiangtan,":[67],"China)":[68],"mid-2024":[70],"for":[71,82,205],"thoracoabdominal":[72],"pain":[73],"caused":[74],"fall,":[77],"pantoprazole":[79,94,154],"initiated":[81],"stress":[83],"ulcer":[84],"prophylaxis":[85],"on":[86,208],"hospital":[88],"day":[89],"2.":[90],"Twenty-six":[91],"days":[92,115,134,174],"after":[93,113,135],"initiation,":[95],"patient":[97],"developed":[98],"diffuse":[99],"macular":[100],"erythema":[101],"desquamation,":[103],"eosinophil":[106,145],"percentage":[107,146],"increased":[108],"from":[109],"0.5%":[110],"7.8%":[112],"2":[114],"rash":[117],"onset.":[118],"The":[119],"clinical":[120,203],"pharmacist":[121],"initially":[122],"suspected":[123,194],"meropenem":[124],"hypersensitivity":[125],"recommended":[127],"discontinuation":[128,152],"this":[130],"agent;":[131],"however,":[132],"5":[133],"onset":[137],"leucopenia":[140],"observed":[142],"peaking":[147],"at":[148],"18.4%,":[149],"resulted":[155],"defervescence":[157],"within":[158,171],"48":[159],"h,":[160],"gradual":[161],"resolution":[162],"normalization":[167],"blood":[169],"counts":[170],"approximately":[172],"10":[173],"cessation.":[177],"Despite":[178],"complex":[180],"pathophysiology":[181],"diagnostic":[183],"challenges":[184],"associated":[185],"syndrome,":[188],"pharmacist's":[190],"identification":[191],"targeted":[197],"intervention":[198],"achieved":[199],"favorable":[200],"outcomes,":[201],"providing":[202],"reference":[204],"further":[206],"research":[207],"syndrome.":[210]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-06-28T00:00:00"}