{"id":"https://openalex.org/W7166322143","doi":"https://doi.org/10.4103/bbrj.bbrj_25_26","title":"In silico Guided Design of a Synthetic Peptide Vaccine Construct from Intrinsically Disordered Regions of the Group Specific Antigen Polyprotein","display_name":"In silico Guided Design of a Synthetic Peptide Vaccine Construct from Intrinsically Disordered Regions of the Group Specific Antigen Polyprotein","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7166322143","doi":"https://doi.org/10.4103/bbrj.bbrj_25_26"},"language":"en","primary_location":{"id":"doi:10.4103/bbrj.bbrj_25_26","doi":"https://doi.org/10.4103/bbrj.bbrj_25_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/bbrj.bbrj_25_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210183705","display_name":"Biomedical and Biotechnology Research Journal (BBRJ)","issn_l":"2588-9834","issn":["2588-9834","2588-9842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and Biotechnology Research Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/bbrj.bbrj_25_26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139478935","display_name":"Gwyneth Anne A. Rabanal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103193709","display_name":"Adamson University","ror":"https://ror.org/00xbjad38","country_code":"PH","type":"education","lineage":["https://openalex.org/I103193709"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Gwyneth Anne A. Rabanal","raw_affiliation_strings":["Immunoinformatics and Novel Synthetic Peptide Immunogens Research (INSPIRe) Group, Department of Chemistry, College of Science, Adamson University, Manila, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoinformatics and Novel Synthetic Peptide Immunogens Research (INSPIRe) Group, Department of Chemistry, College of Science, Adamson University, Manila, Philippines","institution_ids":["https://openalex.org/I103193709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092032912","display_name":"Arturo Lano Gaitano","orcid":"https://orcid.org/0000-0001-7526-1692","observed_orcids":["https://orcid.org/0000-0001-7526-1692"]},"institutions":[{"id":"https://openalex.org/I103193709","display_name":"Adamson University","ror":"https://ror.org/00xbjad38","country_code":"PH","type":"education","lineage":["https://openalex.org/I103193709"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Arturo Lano Gaitano","raw_affiliation_strings":["Immunoinformatics and Novel Synthetic Peptide Immunogens Research (INSPIRe) Group, Department of Chemistry, College of Science, Adamson University, Manila, Philippines"],"raw_orcid":"https://orcid.org/0000-0001-7526-1692","affiliations":[{"raw_affiliation_string":"Immunoinformatics and Novel Synthetic Peptide Immunogens Research (INSPIRe) Group, Department of Chemistry, College of Science, Adamson University, Manila, Philippines","institution_ids":["https://openalex.org/I103193709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092032912"],"corresponding_institution_ids":["https://openalex.org/I103193709"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"2","first_page":"121","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-gag-polyprotein","display_name":"HIV-1 Gag polyprotein","score":0.9150000214576721},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9649999737739563},{"id":"https://openalex.org/keywords/synthetic-peptide-vaccine","display_name":"synthetic peptide vaccine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":0.890999972820282},{"id":"https://openalex.org/keywords/cytotoxic-t-cell-epitopes","display_name":"cytotoxic T cell epitopes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/immunoinformatics","display_name":"immunoinformatics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/epitope-prediction","display_name":"epitope prediction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9682000279426575},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.830299973487854},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.5396999716758728},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5390999913215637},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5284000039100647},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5029000043869019},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49810001254081726},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4936000108718872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4596000015735626},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44620001316070557},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.42289999127388},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37450000643730164},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.33799999952316284},{"id":"https://openalex.org/C78598654","wikidata":"https://www.wikidata.org/wiki/Q17140316","display_name":"Linear epitope","level":4,"score":0.3379000127315521},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.3228999972343445},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.28130000829696655}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4103/bbrj.bbrj_25_26","doi":"https://doi.org/10.4103/bbrj.bbrj_25_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/bbrj.bbrj_25_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210183705","display_name":"Biomedical and Biotechnology Research Journal (BBRJ)","issn_l":"2588-9834","issn":["2588-9834","2588-9842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and Biotechnology Research Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:588e6b43c7c54238846ad9194d380693","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/588e6b43c7c54238846ad9194d380693","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical and Biotechnology Research Journal, Vol 10, Iss 2, Pp 121-130 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/bbrj.bbrj_25_26","doi":"https://doi.org/10.4103/bbrj.bbrj_25_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/bbrj.bbrj_25_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210183705","display_name":"Biomedical and Biotechnology Research Journal (BBRJ)","issn_l":"2588-9834","issn":["2588-9834","2588-9842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and Biotechnology Research Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1768303176","https://openalex.org/W2512372054","https://openalex.org/W2804822363","https://openalex.org/W2884282168","https://openalex.org/W2949683836","https://openalex.org/W2992070886","https://openalex.org/W4200295529","https://openalex.org/W4210308892","https://openalex.org/W4284888448","https://openalex.org/W4291161865","https://openalex.org/W4295419295","https://openalex.org/W4308256044","https://openalex.org/W4310222901","https://openalex.org/W4318046849","https://openalex.org/W4353074900","https://openalex.org/W4378529013","https://openalex.org/W4381708431","https://openalex.org/W4388798411","https://openalex.org/W4391135050","https://openalex.org/W4391429141","https://openalex.org/W4392696664","https://openalex.org/W4393150833","https://openalex.org/W4399777819","https://openalex.org/W4399998927","https://openalex.org/W4402315765","https://openalex.org/W4402783441","https://openalex.org/W4402917611","https://openalex.org/W4408472312","https://openalex.org/W4408813343","https://openalex.org/W4409365727","https://openalex.org/W4410968588","https://openalex.org/W4411437420","https://openalex.org/W4411437550","https://openalex.org/W4411891294","https://openalex.org/W4412520952","https://openalex.org/W4414242549"],"related_works":["https://openalex.org/W3011348226","https://openalex.org/W2980046512","https://openalex.org/W7128495478","https://openalex.org/W4377984315","https://openalex.org/W115240908","https://openalex.org/W2198157849","https://openalex.org/W3163720137","https://openalex.org/W1882915604","https://openalex.org/W7208748742","https://openalex.org/W6976718071"],"abstract_inverted_index":{"Background:":[0],"The":[1,57],"group":[2],"specific":[3],"antigen":[4],"(Gag)":[5],"polyprotein":[6,47],"of":[7,18,32,138,164,202,246],"human":[8],"immunodeficiency":[9],"virus-1":[10],"is":[11],"an":[12],"essential":[13],"protein":[14],"for":[15,27,98,132],"the":[16,45,91,177,247],"formation":[17],"virus":[19],"particles":[20],"and":[21,36,53,75,83,103,113,128,130,141,154,176,186,189,194,210,221,252],"has":[22],"emerged":[23],"as":[24,147,206,208],"a":[25,64,122,165],"target":[26],"potential":[28,133],"therapeutic":[29],"interventions.":[30],"Identification":[31],"viable":[33,148],"linear":[34],"B-Cell":[35,74,82,140,156,193,220],"cytotoxic":[37,76,84,203],"T-Cell":[38,77,85,143,152,197,204,222],"epitopes":[39,59,78,144,153,157,223],"within":[40,44],"intrinsically":[41],"disordered":[42,160,226],"regions":[43,227],"Gag":[46],"can":[48,60],"be":[49,61],"achieved":[50],"through":[51,81],"immunoinformatics":[52],"related":[54],"computational":[55],"tools.":[56],"identified":[58,80,146],"incorporated":[62],"into":[63,121],"synthetic":[65,215],"peptide":[66,216],"vaccine":[67,123,166,217,248],"construct":[68,124,167,218,249],"designed":[69,235],"in":[70,90,106,159,191,225,232,236,250,253],"silico.":[71],"Methods:":[72],"Linear":[73],"were":[79,96,119,145],"epitope":[86],"prediction":[87],"tools":[88],"found":[89,158,224],"Immune":[92],"Epitope":[93],"Database.":[94],"These":[95,118],"assessed":[97],"antigenicity,":[99],"allergenicity,":[100],"toxicity,":[101],"cross-reactivity,":[102],"sequence":[104],"conservation":[105],"silico":[107,237],".":[108,238,255],"Disorder":[109],"analysis":[110],"was":[111,234],"conducted":[112],"cross-referenced":[114],"with":[115,126,150,182,199],"predicted":[116],"epitopes.":[117],"combined":[120],"along":[125],"adjuvants":[127],"linkers":[129,179],"tested":[131],"immunogenicity.":[134],"Results:":[135],"A":[136,214],"total":[137],"9":[139],"2":[142],"candidates,":[149],"both":[151],"7":[155],"regions.":[161],"Different":[162],"portions":[163],"containing":[168],"these":[169],"epitopes,":[170],"RS09,":[171],"pan":[172],"HLA":[173],"DR-binding":[174],"epitope,":[175],"appropriate":[178],"binds":[180],"spontaneously":[181],"Toll-like":[183],"receptor":[184],"4":[185],"induced":[187],"increases":[188,201],"maintenance":[190],"memory":[192,195],"helper":[196],"populations,":[198],"corresponding":[200],"populations":[205],"well":[207],"antibody":[209],"cytokine":[211],"concentrations.":[212],"Conclusions:":[213],"from":[219],"that":[228],"induces":[229],"immune":[230],"responses":[231],"simulations":[233],"As":[239],"such,":[240],"this":[241],"could":[242],"warrant":[243],"further":[244],"investigations":[245],"vitro":[251],"vivo":[254]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2026-06-28T00:00:00"}