{"id":"https://openalex.org/W7166321184","doi":"https://doi.org/10.1111/fcp.70104","title":"Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis\u2010 and Angiogenesis\u2010Related Proteins","display_name":"Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis\u2010 and Angiogenesis\u2010Related Proteins","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166321184","doi":"https://doi.org/10.1111/fcp.70104","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363632"},"language":"en","primary_location":{"id":"doi:10.1111/fcp.70104","doi":"https://doi.org/10.1111/fcp.70104","is_oa":false,"landing_page_url":"https://doi.org/10.1111/fcp.70104","pdf_url":null,"source":{"id":"https://openalex.org/S35226884","display_name":"Fundamental and Clinical Pharmacology","issn_l":"0767-3981","issn":["0767-3981","1472-8206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075278753","display_name":"Ecem Kaya\u2010Sezginer","orcid":"https://orcid.org/0000-0002-8490-6293","observed_orcids":["https://orcid.org/0000-0002-8490-6293"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ecem Kaya\u2010Sezginer","raw_affiliation_strings":["Department of Biochemistry Faculty of Pharmacy, Ankara University  Ankara T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-8490-6293","affiliations":[{"raw_affiliation_string":"Department of Biochemistry Faculty of Pharmacy, Ankara University  Ankara T\u00fcrkiye","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054028405","display_name":"Filiz Bakar\u2010Ates","orcid":"https://orcid.org/0000-0003-2809-8946","observed_orcids":["https://orcid.org/0000-0003-2809-8946"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Filiz Bakar\u2010Ates","raw_affiliation_strings":["Department of Biochemistry Faculty of Pharmacy, Ankara University  Ankara T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-2809-8946","affiliations":[{"raw_affiliation_string":"Department of Biochemistry Faculty of Pharmacy, Ankara University  Ankara T\u00fcrkiye","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149218525"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42110498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"4","first_page":"e70104","last_page":"e70104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.2223999947309494,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.1386999934911728,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probucol","display_name":"probucol","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9200000166893005},{"id":"https://openalex.org/keywords/g0-g1-arrest","display_name":"G0/G1 arrest","score":0.8769999742507935},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9419999718666077},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776167589","wikidata":"https://www.wikidata.org/wiki/Q10354103","display_name":"Probucol","level":3,"score":0.9746999740600586},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6593000292778015},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6172999739646912},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.616100013256073},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.614300012588501},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5985000133514404},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5853000283241272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.54830002784729},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5156000256538391},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46369999647140503},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4415999948978424},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43140000104904175},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41920000314712524},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3628000020980835},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25920000672340393}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011341","descriptor_name":"Probucol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/fcp.70104","doi":"https://doi.org/10.1111/fcp.70104","is_oa":false,"landing_page_url":"https://doi.org/10.1111/fcp.70104","pdf_url":null,"source":{"id":"https://openalex.org/S35226884","display_name":"Fundamental and Clinical Pharmacology","issn_l":"0767-3981","issn":["0767-3981","1472-8206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:42363632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8590797781944275}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W242291106","https://openalex.org/W1968719918","https://openalex.org/W1979853854","https://openalex.org/W1995068068","https://openalex.org/W1995803823","https://openalex.org/W1999748605","https://openalex.org/W2004463632","https://openalex.org/W2005627263","https://openalex.org/W2010077871","https://openalex.org/W2015132580","https://openalex.org/W2017735458","https://openalex.org/W2028403331","https://openalex.org/W2045192469","https://openalex.org/W2071876872","https://openalex.org/W2078363421","https://openalex.org/W2080646870","https://openalex.org/W2082095383","https://openalex.org/W2103541397","https://openalex.org/W2151935839","https://openalex.org/W2157942810","https://openalex.org/W2185726806","https://openalex.org/W2195422959","https://openalex.org/W2272811657","https://openalex.org/W2288903023","https://openalex.org/W2415790086","https://openalex.org/W2612373740","https://openalex.org/W2729021745","https://openalex.org/W2762043727","https://openalex.org/W2919016311","https://openalex.org/W2930771079","https://openalex.org/W3021839250","https://openalex.org/W4200173014","https://openalex.org/W4393935425","https://openalex.org/W4403342587","https://openalex.org/W4409234191","https://openalex.org/W4414883681","https://openalex.org/W4415042531","https://openalex.org/W4416016311"],"related_works":[],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,39,61,217],"remains":[2],"one":[3],"of":[4,8,55,162,170,180],"the":[5,13,52,66,142,178],"leading":[6],"causes":[7],"cancer-related":[9],"mortality":[10],"worldwide,":[11],"highlighting":[12],"need":[14],"for":[15,238],"novel":[16],"therapeutic":[17],"agents":[18],"with":[19,28,81,146],"multitarget":[20,244],"anticancer":[21,213],"activity.":[22],"Probucol":[23,127,232],"is":[24],"a":[25,133,202,235,242],"phenolic":[26],"compound":[27],"well-established":[29],"antioxidant":[30],"and":[31,63,75,91,103,108,136,151,156,189,195,225,228],"anti-inflammatory":[32],"properties;":[33],"however,":[34],"its":[35],"effects":[36,54,214],"on":[37,57,71,215],"colorectal":[38,60,216,247],"cells":[40,62,79,218],"have":[41],"not":[42],"been":[43],"fully":[44],"elucidated.":[45],"The":[46,160],"present":[47],"study":[48],"aimed":[49],"to":[50,64,85],"investigate":[51],"antitumor":[53],"probucol":[56,82,147,175,210],"SW480":[58,78],"human":[59],"explore":[65],"underlying":[67],"molecular":[68,230],"mechanisms":[69],"focusing":[70],"cell":[72,96,130,138,154,221],"cycle,":[73],"apoptosis-,":[74],"angiogenesis-associated":[76,181],"proteins.":[77],"treated":[80],"were":[83,93],"subjected":[84],"MTT":[86],"analysis.":[87],"Cell":[88],"cycle":[89,97,139],"distribution":[90],"apoptosis":[92],"evaluated":[94],"using":[95],"assay,":[98,102],"Annexin":[99],"V":[100],"binding":[101],"multicaspase":[104,158],"activity":[105],"assay.":[106],"Apoptosis-":[107],"angiogenesis-related":[109],"protein":[110,165],"expression":[111,121,179],"was":[112,122,166],"analyzed":[113],"by":[114,124,168,219],"western":[115],"blot,":[116],"matrix":[117],"metalloproteinase-9":[118],"(MMP-9)":[119],"mRNA":[120,199],"quantified":[123],"real-time":[125],"PCR.":[126],"significantly":[128,176],"reduced":[129],"viability":[131],"in":[132,246],"dose-dependent":[134],"manner":[135],"induced":[137],"arrest":[140],"at":[141],"G0/G1":[143],"phase.":[144],"Treatment":[145],"markedly":[148],"increased":[149],"early":[150],"late":[152],"apoptotic":[153],"populations":[155],"enhanced":[157],"activation.":[159],"upregulation":[161],"pro-apoptotic":[163],"Bax":[164],"accompanied":[167],"downregulation":[169],"antiapoptotic":[171],"Bcl-2.":[172],"In":[173],"addition,":[174],"suppressed":[177],"proteins,":[182],"including":[183],"vascular":[184],"endothelial":[185,190],"growth":[186],"factor":[187],"(VEGF)":[188],"nitric":[191],"oxide":[192],"synthase":[193],"(eNOS)":[194],"also":[196],"decreased":[197],"MMP-9":[198],"expression,":[200],"indicating":[201],"potential":[203,243],"antimetastatic":[204],"effect.":[205],"These":[206],"findings":[207],"demonstrate":[208],"that":[209],"exerts":[211],"significant":[212],"inhibiting":[220],"proliferation,":[222],"inducing":[223],"apoptosis,":[224],"suppressing":[226],"angiogenesis-":[227],"metastasis-related":[229],"markers.":[231],"may":[233],"represent":[234],"promising":[236],"candidate":[237],"further":[239],"investigation":[240],"as":[241],"agent":[245],"cancer.":[248]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-06-28T00:00:00"}