{"id":"https://openalex.org/W7166319927","doi":"https://doi.org/10.1002/ijc.70618","title":"Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival","display_name":"Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166319927","doi":"https://doi.org/10.1002/ijc.70618","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363768"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.70618","doi":"https://doi.org/10.1002/ijc.70618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.70618","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/ijc.70618","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021729508","display_name":"Luca Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Luca Li","raw_affiliation_strings":["Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902366","display_name":"Elaheh Zarean","orcid":"https://orcid.org/0000-0002-2227-8949","observed_orcids":["https://orcid.org/0000-0002-2227-8949","https://orcid.org/0000-0002-0246-9529"]},"institutions":[{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elaheh Zarean","raw_affiliation_strings":["Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060133950","display_name":"Danmeng Lily Li","orcid":"https://orcid.org/0009-0006-7799-819X","observed_orcids":["https://orcid.org/0009-0006-7799-819X"]},"institutions":[{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Danmeng Lily Li","raw_affiliation_strings":["Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139477454","display_name":"Yiyue Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yiyue Zhu","raw_affiliation_strings":["Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424111","display_name":"Shuai Li","orcid":"https://orcid.org/0000-0002-8696-8594","observed_orcids":["https://orcid.org/0000-0002-8696-8594","https://orcid.org/0000-0002-9574-9609","https://orcid.org/0009-0005-7872-8194"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shuai Li","raw_affiliation_strings":["Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":"https://orcid.org/0000-0002-8696-8594","affiliations":[{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135389296","display_name":"Enes Makalic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Enes Makalic","raw_affiliation_strings":["Department of Data Science and AI, Faculty of Information Technology Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science and AI, Faculty of Information Technology Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054461576","display_name":"Catriona McLean","orcid":"https://orcid.org/0000-0002-0302-5727","observed_orcids":["https://orcid.org/0000-0002-0302-5727"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catriona McLean","raw_affiliation_strings":["Anatomical Pathology Alfred Health, The Alfred Hospital  Melbourne Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Pathology Alfred Health, The Alfred Hospital  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019133187","display_name":"Graham G. Giles","orcid":"https://orcid.org/0000-0003-4946-9099","observed_orcids":["https://orcid.org/0000-0003-4946-9099"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196466984","display_name":"Cancer Council Victoria","ror":"https://ror.org/023m51b03","country_code":"AU","type":"funder","lineage":["https://openalex.org/I196466984"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Graham G. Giles","raw_affiliation_strings":["Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I196466984"]},{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139979845","display_name":"Roger L. Milne","orcid":"https://orcid.org/0000-0001-5764-7268","observed_orcids":["https://orcid.org/0000-0001-5764-7268"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196466984","display_name":"Cancer Council Victoria","ror":"https://ror.org/023m51b03","country_code":"AU","type":"funder","lineage":["https://openalex.org/I196466984"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roger L. Milne","raw_affiliation_strings":["Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I196466984"]},{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089741432","display_name":"Melissa C. Southey","orcid":"https://orcid.org/0000-0002-6313-9005","observed_orcids":["https://orcid.org/0000-0002-6313-9005"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196466984","display_name":"Cancer Council Victoria","ror":"https://ror.org/023m51b03","country_code":"AU","type":"funder","lineage":["https://openalex.org/I196466984"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Melissa C. Southey","raw_affiliation_strings":["Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I196466984"]},{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016432397","display_name":"Pierre\u2010Antoine Dugu\u00e9","orcid":"https://orcid.org/0000-0003-2736-3023","observed_orcids":["https://orcid.org/0000-0003-2736-3023"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196466984","display_name":"Cancer Council Victoria","ror":"https://ror.org/023m51b03","country_code":"AU","type":"funder","lineage":["https://openalex.org/I196466984"]},{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Pierre\u2010Antoine Dugu\u00e9","raw_affiliation_strings":["Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"],"raw_orcid":"https://orcid.org/0000-0003-2736-3023","affiliations":[{"raw_affiliation_string":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I196466984"]},{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne  Parkville Victoria Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia","institution_ids":["https://openalex.org/I4210121067","https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016432397"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196466984","https://openalex.org/I4210121067","https://openalex.org/I56590836"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":{"value":5030,"currency":"USD","value_usd":5030},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42108798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"159","issue":"10","first_page":"2452","last_page":"2462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6480000019073486},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9110000133514404},{"id":"https://openalex.org/keywords/btec","display_name":"BTEC","score":0.7450000047683716},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.9459999799728394},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.996999979019165},{"id":"https://openalex.org/keywords/dunedinpace","display_name":"DunedinPACE","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogen-receptor-status","display_name":"estrogen receptor status","score":0.9350000023841858},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8733000159263611},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7563999891281128},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6992999911308289},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6220999956130981},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5551000237464905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5498999953269958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4855000078678131},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.446399986743927},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.40849998593330383},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4027000069618225},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.3806000053882599},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3707999885082245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3490000069141388},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.31610000133514404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C190789776","wikidata":"https://www.wikidata.org/wiki/Q767511","display_name":"Genetic marker","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2779880527","wikidata":"https://www.wikidata.org/wiki/Q4959796","display_name":"Breast disease","level":4,"score":0.2777999937534332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.2581000030040741},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.2556999921798706}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.70618","doi":"https://doi.org/10.1002/ijc.70618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.70618","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:42363768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13595474","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13595474/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ijc.70618","doi":"https://doi.org/10.1002/ijc.70618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.70618","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6835014224052429,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2557843578","display_name":"Health 2020","funder_award_id":"396414","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G3677070516","display_name":"Methylation as a risk and prognostic factor for breast cancer","funder_award_id":"1011618","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6694426861","display_name":"Epidemiology of Chronic Disease, Health Interventions and DNA Studies","funder_award_id":"209057","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7291819673","display_name":"Precision Public Health for major cancers - novel approaches to building the genetic, epigenetic and lifestyle knowledge base for assessing risk and prognosis","funder_award_id":"1074383","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320592","display_name":"VicHealth","ror":"https://ror.org/02swcnz29"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334707","display_name":"Cancer Council Victoria","ror":"https://ror.org/023m51b03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1007659581","https://openalex.org/W1465453806","https://openalex.org/W1967997862","https://openalex.org/W1974047233","https://openalex.org/W1975528145","https://openalex.org/W1988007795","https://openalex.org/W1998137132","https://openalex.org/W2036986058","https://openalex.org/W2152656267","https://openalex.org/W2529317472","https://openalex.org/W2580601263","https://openalex.org/W2596440417","https://openalex.org/W2770929780","https://openalex.org/W2773327522","https://openalex.org/W2791168897","https://openalex.org/W2795120383","https://openalex.org/W2897814271","https://openalex.org/W2911952651","https://openalex.org/W2912654909","https://openalex.org/W2949100461","https://openalex.org/W2965994767","https://openalex.org/W3033207925","https://openalex.org/W3037887056","https://openalex.org/W3045418589","https://openalex.org/W3100302089","https://openalex.org/W3111895291","https://openalex.org/W3116143478","https://openalex.org/W3152823082","https://openalex.org/W4200612471","https://openalex.org/W4205358347","https://openalex.org/W4236743283","https://openalex.org/W4285587624","https://openalex.org/W4289783427","https://openalex.org/W4318754780","https://openalex.org/W4384820782","https://openalex.org/W4387692477","https://openalex.org/W4397022786","https://openalex.org/W4406302381","https://openalex.org/W4407607603","https://openalex.org/W4407870211","https://openalex.org/W4408007244","https://openalex.org/W4409147616","https://openalex.org/W7126261865"],"related_works":[],"abstract_inverted_index":{"Breast":[0],"cancer":[1,18,61,225],"remains":[2],"a":[3],"major":[4],"challenge":[5],"to":[6,13,110,179],"public":[7],"health.":[8],"Biomarkers":[9],"may":[10,235,246],"be":[11,253],"useful":[12],"improve":[14],"prediction":[15],"of":[16,23,77,87,97,114,150,193,219],"breast":[17,44,60,224],"survival.":[19,226],"Several":[20],"epigenetic":[21,41,116,221],"markers":[22,42,76,86,96,117,153,176,192,222,234],"cell":[24,78,151],"division":[25,79,152],"and":[26,46,69,83,92,94,103,134,144,211],"ageing":[27],"based":[28],"on":[29],"DNA":[30,54],"methylation":[31,55],"have":[32,236],"been":[33],"proposed.":[34],"In":[35],"this":[36],"study,":[37,147],"we":[38],"measured":[39,57],"these":[40,233],"in":[43,58],"tumours":[45,62],"assessed":[47],"their":[48],"prognostic":[49,238],"value.":[50,239],"We":[51,73],"used":[52,109],"genome-wide":[53],"data":[56],"1992":[59],"from":[63],"the":[64,112,205],"Melbourne":[65],"Collaborative":[66],"Cohort":[67],"Study":[68],"publicly":[70],"available":[71],"datasets.":[72],"calculated":[74],"four":[75,95],"(epiTOC2,":[80],"stemTOC,":[81],"MiAge":[82],"CellDRIFT),":[84],"two":[85],"chronological":[88,174],"age":[89,91,99,143,175,195],"(Horvath":[90],"BTEC),":[93],"biological":[98,194,249],"(PhenoAge,":[100],"GrimAge,":[101],"MRscore":[102],"DunedinPACE).":[104],"Cox":[105],"regression":[106],"models":[107],"were":[108,154,177,201,229],"assess":[111],"associations":[113,200,218,228,242],"age-adjusted":[115],"with":[118,122,156,223],"5-year":[119],"overall":[120],"survival,":[121],"adjustment":[123,141],"for":[124,142],"clinical":[125],"variables.":[126],"Effect":[127],"modification":[128],"by":[129,146,204],"estrogen":[130],"receptor":[131],"(ER)":[132],"status":[133],"molecular":[135],"subtype":[136],"was":[137],"also":[138],"investigated.":[139,255],"After":[140],"stratification":[145],"higher":[148,173],"levels":[149],"associated":[155],"poorer":[157],"survival":[158],"(e.g.,":[159,182],"epiTOC2:":[160],"per":[161],"one-standard-deviation":[162],"increase,":[163],"hazard":[164],"ratio":[165],"[HR]":[166],"=":[167,186],"1.14,":[168],"95%":[169,188],"CI:":[170,189],"1.03-1.27),":[171],"whereas":[172],"linked":[178],"better":[180],"prognosis":[181],"Horvath":[183],"age:":[184],"HR":[185],"0.70,":[187],"0.61-0.82).":[190],"Epigenetic":[191],"showed":[196],"variable":[197],"associations.":[198],"These":[199],"partly":[202],"explained":[203],"main":[206],"clinicopathological":[207],"variables":[208],"at":[209],"diagnosis":[210],"varied":[212],"across":[213],"subtypes.":[214],"Our":[215],"study":[216],"revealed":[217],"several":[220],"The":[227,240],"quite":[230],"weak,":[231],"suggesting":[232],"limited":[237],"varying":[241],"observed":[243],"among":[244],"subtypes":[245],"reflect":[247],"underlying":[248],"differences":[250],"that":[251],"should":[252],"further":[254]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-06-28T00:00:00"}
