{"id":"https://openalex.org/W7166318142","doi":"https://doi.org/10.1016/j.envint.2026.110396","title":"Maternal exposure to biosolids reshapes chemical burden and steroidogenic pathways to promote adipogenic differentiation in a sheep model","display_name":"Maternal exposure to biosolids reshapes chemical burden and steroidogenic pathways to promote adipogenic differentiation in a sheep model","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166318142","doi":"https://doi.org/10.1016/j.envint.2026.110396","pmid":"https://pubmed.ncbi.nlm.nih.gov/42385498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13590118"},"language":"en","primary_location":{"id":"doi:10.1016/j.envint.2026.110396","doi":"https://doi.org/10.1016/j.envint.2026.110396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110396","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.envint.2026.110396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062330563","display_name":"Katherine M. Littlefield","orcid":"https://orcid.org/0000-0002-0963-8620","observed_orcids":["https://orcid.org/0000-0002-0963-8620"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine M. Littlefield","raw_affiliation_strings":["Department of Pathology, University of Illinois Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0002-0963-8620","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Illinois Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046931094","display_name":"Michelle Bellingham","orcid":"https://orcid.org/0000-0002-3646-8989","observed_orcids":["https://orcid.org/0000-0002-3646-8989"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michelle Bellingham","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":"https://orcid.org/0000-0002-3646-8989","affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056961548","display_name":"Ravikumar Jagani","orcid":"https://orcid.org/0000-0002-7680-860X","observed_orcids":["https://orcid.org/0000-0002-7680-860X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravikumar Jagani","raw_affiliation_strings":["Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109265432","display_name":"H. M. Patel","orcid":"https://orcid.org/0009-0007-8973-4375","observed_orcids":["https://orcid.org/0009-0007-8973-4375"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiraj Patel","raw_affiliation_strings":["Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0009-0007-8973-4375","affiliations":[{"raw_affiliation_string":"Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051918069","display_name":"Richard Lea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Lea","raw_affiliation_strings":["University of Nottingham, Sutton Bonington Campus, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Sutton Bonington Campus, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043984013","display_name":"Kevin D. Sinclair","orcid":"https://orcid.org/0000-0002-6375-215X","observed_orcids":["https://orcid.org/0000-0002-6375-215X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin D. Sinclair","raw_affiliation_strings":["University of Nottingham, Sutton Bonington Campus, Loughborough, UK"],"raw_orcid":"https://orcid.org/0000-0002-6375-215X","affiliations":[{"raw_affiliation_string":"University of Nottingham, Sutton Bonington Campus, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050826731","display_name":"Neil P. Evans","orcid":"https://orcid.org/0000-0001-7395-3222","observed_orcids":["https://orcid.org/0000-0001-7395-3222"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil P. Evans","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":"https://orcid.org/0000-0001-7395-3222","affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139481824","display_name":"Richard Auchus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Auchus","raw_affiliation_strings":["Departments of Pharmacology & Internal Medicine, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Internal Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139489165","display_name":"Jose Villegas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Villegas","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Illinois Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Illinois Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036979172","display_name":"Syam S. Andra","orcid":"https://orcid.org/0000-0003-2839-6417","observed_orcids":["https://orcid.org/0000-0003-2839-6417"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Syam S. Andra","raw_affiliation_strings":["Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: syam.andra@mssm.edu"],"raw_orcid":"https://orcid.org/0000-0003-2839-6417","affiliations":[{"raw_affiliation_string":"Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: syam.andra@mssm.edu","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052065231","display_name":"Almudena Veiga\u2010Lopez","orcid":"https://orcid.org/0000-0002-0308-7231","observed_orcids":["https://orcid.org/0000-0002-0308-7231"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Almudena Veiga-Lopez","raw_affiliation_strings":["Department of Pathology, University of Illinois Chicago, IL, USA; The Chicago Center for Health and Environment, University of Illinois Chicago, Chicago, IL, USA. Electronic address: veiga@uic.edu"],"raw_orcid":"https://orcid.org/0000-0002-0308-7231","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Illinois Chicago, IL, USA; The Chicago Center for Health and Environment, University of Illinois Chicago, Chicago, IL, USA. Electronic address: veiga@uic.edu","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029119143","display_name":"Vasantha Padmanabhan","orcid":"https://orcid.org/0000-0002-8443-7212","observed_orcids":["https://orcid.org/0000-0002-8443-7212"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vasantha Padmanabhan","raw_affiliation_strings":["Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Electronic address: vasantha@umich.edu"],"raw_orcid":"https://orcid.org/0000-0002-8443-7212","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Electronic address: vasantha@umich.edu","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029119143","https://openalex.org/A5036979172","https://openalex.org/A5052065231"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I39422238","https://openalex.org/I98704320"],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":{"value":4750,"currency":"USD","value_usd":4750},"fwci":2.5352,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79795451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"214","issue":null,"first_page":"110396","last_page":"110396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosolids","display_name":"biosolids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/maternal-exposure","display_name":"maternal exposure","score":0.9390000104904175},{"id":"https://openalex.org/keywords/obesogens","display_name":"obesogens","score":0.8190000057220459},{"id":"https://openalex.org/keywords/perfluorinated-compounds","display_name":"perfluorinated compounds","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bisphenols","display_name":"bisphenols","score":0.8790000081062317},{"id":"https://openalex.org/keywords/phthalates","display_name":"phthalates","score":1.0},{"id":"https://openalex.org/keywords/parabens","display_name":"parabens","score":0.9670000076293945},{"id":"https://openalex.org/keywords/acetamiprid","display_name":"acetamiprid","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pfbs","display_name":"PFBS","score":0.8700000047683716},{"id":"https://openalex.org/keywords/steroid-profiling","display_name":"steroid profiling","score":0.5699999928474426},{"id":"https://openalex.org/keywords/pregnenolone","display_name":"pregnenolone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.6230000257492065},{"id":"https://openalex.org/keywords/metabolic-risk","display_name":"metabolic risk","score":0.4819999933242798},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777654200","wikidata":"https://www.wikidata.org/wiki/Q1776685","display_name":"Biosolids","level":2,"score":0.9168999791145325},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.6797999739646912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4544000029563904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3831000030040741},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2662999927997589},{"id":"https://openalex.org/C198408306","wikidata":"https://www.wikidata.org/wiki/Q4008388","display_name":"Exposure assessment","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.25529998540878296},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.25189998745918274}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.envint.2026.110396","doi":"https://doi.org/10.1016/j.envint.2026.110396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110396","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},{"id":"pmid:42385498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42385498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment international","raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:67271701","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110396","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:390295","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/view/journal_volume/Environment_International.html>,","pdf_url":"https://eprints.gla.ac.uk/390295/1/390295.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:13590118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13590118/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Environ Int","raw_type":"Text"},{"id":"pmh:oai:nottingham-repository.worktribe.com:67271701","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/67271701/1/Littlefield%20Et%20Al%202026","pdf_url":"https://nottingham-repository.worktribe.com/preview/67271728/Littlefield%20et%20al%202026.pdf","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.envint.2026.110396","doi":"https://doi.org/10.1016/j.envint.2026.110396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110396","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5682792106","display_name":"Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic health","funder_award_id":"R01ES030374","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000869895","display_name":"Environmental exposure modulation of the ovarian lipidome","funder_award_id":"1r21es037063-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000876201","display_name":"Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)","funder_award_id":"P30ES023515","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000880075","display_name":"Mount Sinai HHEAR Network Untargeted Lab Hub","funder_award_id":"U2CES030859","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000892405","display_name":"ChicAgo Center for Health and EnvironmenT (CACHET)","funder_award_id":"P30ES027792","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000898591","display_name":"Mount Sinai HHEAR Network Targeted Lab Hub","funder_award_id":"U2CES026561","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000914129","display_name":"Chemical exposure disruption of the placental circadian clock","funder_award_id":"R01ES035691","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166318142.pdf","grobid_xml":"https://content.openalex.org/works/W7166318142.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1988067304","https://openalex.org/W1993263557","https://openalex.org/W1995802297","https://openalex.org/W1996660089","https://openalex.org/W2004011863","https://openalex.org/W2010023375","https://openalex.org/W2034081958","https://openalex.org/W2039153579","https://openalex.org/W2068634056","https://openalex.org/W2144382327","https://openalex.org/W2162438732","https://openalex.org/W2173681478","https://openalex.org/W2537546128","https://openalex.org/W2551195925","https://openalex.org/W2684997942","https://openalex.org/W2754490565","https://openalex.org/W2789295608","https://openalex.org/W2811324844","https://openalex.org/W2884658619","https://openalex.org/W2914776112","https://openalex.org/W2929358998","https://openalex.org/W3013007519","https://openalex.org/W3113082615","https://openalex.org/W3137637730","https://openalex.org/W3178109793","https://openalex.org/W3188431036","https://openalex.org/W3193694995","https://openalex.org/W3213568821","https://openalex.org/W4223500776","https://openalex.org/W4224287862","https://openalex.org/W4283162474","https://openalex.org/W4283585315","https://openalex.org/W4313214663","https://openalex.org/W4321165590","https://openalex.org/W4368374042","https://openalex.org/W4377030299","https://openalex.org/W4385252864","https://openalex.org/W4386316647","https://openalex.org/W4386376695","https://openalex.org/W4387965431","https://openalex.org/W4388046252","https://openalex.org/W4388861438","https://openalex.org/W4389684505","https://openalex.org/W4390629601","https://openalex.org/W4400421706","https://openalex.org/W4402259750","https://openalex.org/W4404055601","https://openalex.org/W4404137738","https://openalex.org/W4404257971","https://openalex.org/W4404521890","https://openalex.org/W4406061905","https://openalex.org/W4406598560","https://openalex.org/W4408133672","https://openalex.org/W4408180963","https://openalex.org/W4408266046","https://openalex.org/W4408746581","https://openalex.org/W4411133550","https://openalex.org/W4413106855","https://openalex.org/W4416390198","https://openalex.org/W4416589192","https://openalex.org/W7160520314"],"related_works":["https://openalex.org/W4313214663","https://openalex.org/W4385252864","https://openalex.org/W2073957371","https://openalex.org/W4308141630","https://openalex.org/W4387433134","https://openalex.org/W4389684505","https://openalex.org/W4406061905","https://openalex.org/W4403148794","https://openalex.org/W4386376695","https://openalex.org/W2551195925"],"abstract_inverted_index":{"Biosolids,":[0],"a":[1],"by-product":[2],"of":[3,36,104,138,231],"wastewater":[4],"treatment,":[5],"are":[6],"widely":[7],"used":[8],"as":[9,21],"agricultural":[10],"fertilizers":[11],"and":[12,26,33,53,56,79,81,112,120,125,150,179,184,195,203,234],"contain":[13],"anthropogenically-derived":[14],"chemical":[15,39,52,106,194,216],"mixtures,":[16,40],"often":[17],"including":[18],"obesogens":[19],"such":[20],"perfluoroalkyl":[22],"substances":[23],"(PFAS),":[24],"bisphenols,":[25,111],"phthalates.":[27],"Given":[28],"the":[29,136,225,229],"potential":[30,236],"for":[31],"endocrine":[32],"metabolic":[34,239],"disruption":[35],"biosolids'":[37],"complex":[38],"we":[41,69],"hypothesized":[42],"that":[43,57,210],"maternal":[44],"exposure":[45,100,189],"to":[46,155,190,227,238],"biosolids-treated":[47,191],"pastures":[48,192],"would":[49],"alter":[50],"circulating":[51,211],"steroid":[54,196],"profiles":[55,197],"these":[58],"changes":[59],"could":[60],"influence":[61,219],"adipogenic":[62,205],"differentiation":[63,206],"in":[64,86,135,198,207],"preadipocytes.":[65],"To":[66],"test":[67],"this,":[68],"characterized":[70],"125":[71],"environmental":[72,215],"chemicals":[73],"across":[74],"16":[75],"classes":[76],"using":[77,84],"ID-LC-MS/MS":[78],"adrenal-":[80],"ovarian-derived":[82],"steroids":[83],"LC-MS/MS":[85],"plasma":[87,118,163,199],"from":[88,141,164,200],"pregnant":[89,201],"sheep":[90],"(n":[91],"=":[92],"6/group)":[93],"collected":[94],"at":[95],"gestational":[96],"day":[97],"30.":[98],"Biosolids":[99],"increased":[101,145,204],"total":[102],"concentrations":[103,183],"several":[105],"classes,":[107],"notably":[108],"phthalates,":[109],"parabens,":[110],"PFAS.":[113],"Steroid":[114],"profiling":[115],"revealed":[116,174],"lower":[117],"pregnenolone":[119],"higher":[121],"17-OH-pregnenolone,":[122],"DHEA,":[123],"17-OH-progesterone,":[124],"18-OH-corticosterone.":[126],"Adipogenic":[127],"effects":[128],"were":[129,160],"assessed":[130],"by":[131],"differentiating":[132],"3T3-L1":[133,146],"preadipocytes":[134],"presence":[137],"plasma.":[139,157],"Plasma":[140],"biosolids-exposed":[142],"females":[143,202],"significantly":[144],"lipid":[147,185],"droplet":[148],"count":[149],"BODIPY":[151],"staining":[152],"intensity":[153],"compared":[154],"control":[156],"No":[158],"differences":[159],"observed":[161],"between":[162,177],"pregnancies":[165],"with":[166,214],"male":[167],"vs.":[168],"female":[169],"fetuses.":[170],"Lastly,":[171],"LASSO":[172],"regression":[173],"positive":[175],"associations":[176],"acetamiprid":[178],"perfluorobutane":[180],"sulfonic":[181],"acid":[182],"accumulation.":[186],"In":[187],"conclusion,":[188],"altered":[193],"vitro,":[208],"suggesting":[209],"factors":[212],"associated":[213],"mixtures":[217],"may":[218],"adipose":[220],"development.":[221],"These":[222],"findings":[223],"highlight":[224],"need":[226],"evaluate":[228],"safety":[230],"biosolids":[232],"use":[233],"their":[235],"contribution":[237],"risk.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-06-28T00:00:00"}