{"id":"https://openalex.org/W7166318133","doi":"https://doi.org/10.1002/advs.76255","title":"Targeting WDR12 Unleashes T\u2010Cell\u2010Mediated Antitumor Activity in Melanoma by Destabilizing CD276","display_name":"Targeting WDR12 Unleashes T\u2010Cell\u2010Mediated Antitumor Activity in Melanoma by Destabilizing CD276","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166318133","doi":"https://doi.org/10.1002/advs.76255","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363820"},"language":"en","primary_location":{"id":"doi:10.1002/advs.76255","doi":"https://doi.org/10.1002/advs.76255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.76255","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.76255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139499678","display_name":"Jie Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Pan","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007426136","display_name":"Ruimin Chang","orcid":"https://orcid.org/0000-0003-3237-6478","observed_orcids":["https://orcid.org/0000-0003-3237-6478"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruimin Chang","raw_affiliation_strings":["National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","The Department of Thoracic Surgery Xiangya Hospital Central South University  Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"The Department of Thoracic Surgery Xiangya Hospital Central South University  Changsha Hunan China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132643971","display_name":"M Zhang","orcid":"https://orcid.org/0009-0008-2206-1265","observed_orcids":["https://orcid.org/0009-0008-2206-1265","https://orcid.org/0000-0002-4389-760X","https://orcid.org/0009-0000-0298-9754","https://orcid.org/0009-0001-2007-8126","https://orcid.org/0009-0009-3883-061X"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zhang","raw_affiliation_strings":["The Department of Thoracic Surgery Xiangya Hospital Central South University  Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Thoracic Surgery Xiangya Hospital Central South University  Changsha Hunan China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124766065","display_name":"Qian Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Dong","raw_affiliation_strings":["State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences \u2010 Beijing Beijing Institute of Lifeomics  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences \u2010 Beijing Beijing Institute of Lifeomics  Beijing China","institution_ids":["https://openalex.org/I4210149540","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030664371","display_name":"Guanxiong Zhang","orcid":"https://orcid.org/0000-0003-4819-6543","observed_orcids":["https://orcid.org/0000-0003-4819-6543"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanxiong Zhang","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":"https://orcid.org/0000-0003-4819-6543","affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139486260","display_name":"Xiang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055412197","display_name":"M Chen","orcid":"https://orcid.org/0009-0002-4323-669X","observed_orcids":["https://orcid.org/0009-0002-4323-669X","https://orcid.org/0009-0008-8474-255X"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingliang Chen","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109256658","display_name":"l Zhi-Bing Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixia Lu","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaowei Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaowei Liang","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112010630","display_name":"Guo Y","orcid":"https://orcid.org/0000-0001-7468-8061","observed_orcids":["https://orcid.org/0000-0001-7468-8061","https://orcid.org/0009-0001-6992-3650"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yeye Guo","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123617125","display_name":"J R Su","orcid":"https://orcid.org/0009-0006-6415-0683","observed_orcids":["https://orcid.org/0009-0006-6415-0683","https://orcid.org/0009-0006-2272-591X"]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Su","raw_affiliation_strings":["Furong Labratory  Changsha Hunan China","Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","The Department of Dermatology Xiangya Hospital Central South University  Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Furong Labratory  Changsha Hunan China","institution_ids":[]},{"raw_affiliation_string":"Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital  Changsha China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China","institution_ids":[]},{"raw_affiliation_string":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China","institution_ids":["https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112010630","https://openalex.org/A5123617125"],"corresponding_institution_ids":["https://openalex.org/I4210159865"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47259378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"52","first_page":"e76255","last_page":"e76255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wdr12","display_name":"WDR12","score":0.9549999833106995},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.6449999809265137},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/immune-checkpoint-evasion","display_name":"immune checkpoint evasion","score":0.5339999794960022},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8130999803543091},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7217000126838684},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7080000042915344},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6948000192642212},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6779000163078308},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6413000226020813},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5497000217437744},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3917999863624573},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.38679999113082886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.373199999332428},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.36500000953674316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35510000586509705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.31189998984336853},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2526000142097473},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060887","descriptor_name":"B7 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060887","descriptor_name":"B7 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/advs.76255","doi":"https://doi.org/10.1002/advs.76255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.76255","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42363820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0e608d290ca3447a9d918886acff56fc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0e608d290ca3447a9d918886acff56fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Science, Vol 13, Iss 52, Pp n/a-n/a (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13337114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13337114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.76255","doi":"https://doi.org/10.1002/advs.76255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.76255","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3433690606","display_name":null,"funder_award_id":"82403284","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3932304680","display_name":null,"funder_award_id":"82503382","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4607223381","display_name":null,"funder_award_id":"82273215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6962721379","display_name":null,"funder_award_id":"2024JJ6648","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G726808725","display_name":null,"funder_award_id":"82441043","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1972959233","https://openalex.org/W2010966202","https://openalex.org/W2111515566","https://openalex.org/W2118534577","https://openalex.org/W2153574614","https://openalex.org/W2156337883","https://openalex.org/W2336130220","https://openalex.org/W2587048937","https://openalex.org/W2602350547","https://openalex.org/W2725962181","https://openalex.org/W2752528156","https://openalex.org/W2761872853","https://openalex.org/W2791483720","https://openalex.org/W2801777436","https://openalex.org/W2898830231","https://openalex.org/W2936623055","https://openalex.org/W2952365924","https://openalex.org/W2967805215","https://openalex.org/W2971445256","https://openalex.org/W2971738181","https://openalex.org/W3012308970","https://openalex.org/W3015265197","https://openalex.org/W3015860015","https://openalex.org/W3134262902","https://openalex.org/W3157185054","https://openalex.org/W3203575974","https://openalex.org/W3213884117","https://openalex.org/W4200468913","https://openalex.org/W4308061573","https://openalex.org/W4310424284","https://openalex.org/W4312019583","https://openalex.org/W4385956055","https://openalex.org/W4389280613","https://openalex.org/W4402905469","https://openalex.org/W4414163970"],"related_works":[],"abstract_inverted_index":{"Melanoma":[0],"is":[1,44],"the":[2,8,66,71],"deadliest":[3],"skin":[4],"cancer,":[5],"and":[6,48,57,83,108,122,125,144],"despite":[7],"success":[9],"of":[10,17,39],"immune":[11,72,85,140],"checkpoint":[12,73],"blockade,":[13,121],"a":[14,37,95,135,152],"substantial":[15],"fraction":[16],"patients":[18],"fail":[19],"to":[20,119],"respond.":[21],"Tumors":[22],"can":[23],"evade":[24],"cytotoxic":[25,59],"lymphocytes":[26],"by":[27],"upregulating":[28],"multiple":[29],"inhibitory":[30],"checkpoints.":[31],"Here":[32],"we":[33,91],"identify":[34,92],"WDR12":[35,42,97,101,115,146],"as":[36,94,151],"determinant":[38],"immunotherapy":[40],"resistance:":[41],"expression":[43],"elevated":[45],"in":[46,63,142],"nonresponders,":[47],"its":[49],"genetic":[50],"inhibition":[51,147],"increases":[52],"intratumoral":[53],"CD8+":[54],"T-cell":[55,81,111],"infiltration":[56],"enhances":[58],"function.":[60],"Mechanistically,":[61],"WDR12,":[62],"cooperation":[64],"with":[65,102,148],"chaperonin":[67],"subunit":[68],"CCT7,":[69],"stabilizes":[70],"CD276":[74,106],"(B7-H3)":[75],"on":[76],"tumor":[77],"cells,":[78],"thereby":[79],"suppressing":[80],"activity":[82],"promoting":[84],"escape.":[86],"To":[87],"translate":[88],"these":[89],"findings,":[90],"SU14813":[93,124],"small-molecule":[96],"inhibitor":[98],"that":[99,138],"binds":[100],"high":[103],"specificity,":[104],"reduces":[105],"stability,":[107],"relieves":[109],"CD276-mediated":[110],"suppression.":[112],"In":[113],"vivo,":[114],"targeting":[116],"sensitizes":[117],"tumors":[118],"PD-1":[120,149],"combined":[123],"anti-PD-1":[126],"therapy":[127],"produces":[128],"superior":[129],"antitumor":[130],"efficacy.":[131],"These":[132],"results":[133],"define":[134],"WDR12-CCT7-CD276":[136],"axis":[137],"sustains":[139],"resistance":[141],"melanoma":[143],"nominate":[145],"blockade":[150],"promising":[153],"therapeutic":[154],"strategy.":[155]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2026-06-28T00:00:00"}