{"id":"https://openalex.org/W7166317049","doi":"https://doi.org/10.1016/j.nxnano.2026.100584","title":"Neuro-tumoral dialogue: A comprehensive review of molecular mechanisms, clinical heterogeneity, and therapeutic frontiers","display_name":"Neuro-tumoral dialogue: A comprehensive review of molecular mechanisms, clinical heterogeneity, and therapeutic frontiers","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166317049","doi":"https://doi.org/10.1016/j.nxnano.2026.100584"},"language":"en","primary_location":{"id":"doi:10.1016/j.nxnano.2026.100584","doi":"https://doi.org/10.1016/j.nxnano.2026.100584","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nxnano.2026.100584","pdf_url":null,"source":{"id":"https://openalex.org/S4387288079","display_name":"Next Nanotechnology","issn_l":"2949-8295","issn":["2949-8295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Next Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.nxnano.2026.100584","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006879075","display_name":"Farah Djelti","orcid":"https://orcid.org/0000-0002-5081-2280","observed_orcids":["https://orcid.org/0000-0002-5081-2280","https://orcid.org/0000-0002-8753-6443"]},"institutions":[{"id":"https://openalex.org/I233209018","display_name":"University of Abou Bekr Belka\u00efd","ror":"https://ror.org/00jsjm362","country_code":"DZ","type":"education","lineage":["https://openalex.org/I233209018"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Farah Djelti","raw_affiliation_strings":["CancerLabN\u00b030 Research Laboratory, University of Tlemcen, 13000, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CancerLabN\u00b030 Research Laboratory, University of Tlemcen, 13000, Algeria","institution_ids":["https://openalex.org/I233209018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012175668","display_name":"Mostefa Hani","orcid":"https://orcid.org/0000-0002-1540-6113","observed_orcids":["https://orcid.org/0000-0002-1540-6113"]},"institutions":[{"id":"https://openalex.org/I116970179","display_name":"University of Jijel","ror":"https://ror.org/03kkfk814","country_code":"DZ","type":"education","lineage":["https://openalex.org/I116970179"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Mostefa Hani","raw_affiliation_strings":["Faculty of Sciences and Technology, University of Jijel, Jijel 18000, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sciences and Technology, University of Jijel, Jijel 18000, Algeria","institution_ids":["https://openalex.org/I116970179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092846474","display_name":"Yazid Chetbani","orcid":"https://orcid.org/0009-0002-5877-2196","observed_orcids":["https://orcid.org/0009-0002-5877-2196"]},"institutions":[{"id":"https://openalex.org/I4405259121","display_name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques","ror":"https://ror.org/01s3bfe44","country_code":"DZ","type":"other","lineage":["https://openalex.org/I4405259121"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Yazid Chetbani","raw_affiliation_strings":["Centre de Recherche scientifique et Technique en Analyses Physico-Chimiques CRAPC, BP 384, Bou-Ismail, Tipaza RP 42004, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche scientifique et Technique en Analyses Physico-Chimiques CRAPC, BP 384, Bou-Ismail, Tipaza RP 42004, Algeria","institution_ids":["https://openalex.org/I4405259121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034364859","display_name":"Ahmed Belaadi","orcid":"https://orcid.org/0000-0002-6059-3974","observed_orcids":["https://orcid.org/0000-0002-6059-3974"]},"institutions":[{"id":"https://openalex.org/I98962006","display_name":"University of Skikda","ror":"https://ror.org/02571vj15","country_code":"DZ","type":"education","lineage":["https://openalex.org/I98962006"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Ahmed Belaadi","raw_affiliation_strings":["University of August 20, 1955-Skikda, 21000, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of August 20, 1955-Skikda, 21000, Algeria","institution_ids":["https://openalex.org/I98962006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034364859"],"corresponding_institution_ids":["https://openalex.org/I98962006"],"apc_list":{"value":1280,"currency":"USD","value_usd":1280},"apc_paid":{"value":1280,"currency":"USD","value_usd":1280},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51080517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"100584","last_page":"100584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-neuroscience","display_name":"cancer neuroscience","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-neuron-interaction","display_name":"tumor-neuron interaction","score":0.6029999852180481},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.9520000219345093},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.8679999709129333},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neural-markers","display_name":"neural markers","score":0.5699999928474426},{"id":"https://openalex.org/keywords/spatial-multi-omics","display_name":"spatial multi-omics","score":0.7390000224113464},{"id":"https://openalex.org/keywords/intertumoral-heterogeneity","display_name":"intertumoral heterogeneity","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5910999774932861},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37040001153945923},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.24889999628067017},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23829999566078186},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.20800000429153442},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.20759999752044678},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.20550000667572021},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.20509999990463257}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.nxnano.2026.100584","doi":"https://doi.org/10.1016/j.nxnano.2026.100584","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nxnano.2026.100584","pdf_url":null,"source":{"id":"https://openalex.org/S4387288079","display_name":"Next Nanotechnology","issn_l":"2949-8295","issn":["2949-8295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Next Nanotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.nxnano.2026.100584","doi":"https://doi.org/10.1016/j.nxnano.2026.100584","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nxnano.2026.100584","pdf_url":null,"source":{"id":"https://openalex.org/S4387288079","display_name":"Next Nanotechnology","issn_l":"2949-8295","issn":["2949-8295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Next Nanotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1996048876","https://openalex.org/W1999263375","https://openalex.org/W2008388798","https://openalex.org/W2137004657","https://openalex.org/W2279910164","https://openalex.org/W2306715392","https://openalex.org/W2787816121","https://openalex.org/W2927114316","https://openalex.org/W2973455289","https://openalex.org/W2973686658","https://openalex.org/W2980389467","https://openalex.org/W3016787828","https://openalex.org/W3021642983","https://openalex.org/W3035853891","https://openalex.org/W3096139666","https://openalex.org/W3111161421","https://openalex.org/W3112258248","https://openalex.org/W3112735128","https://openalex.org/W3119733694","https://openalex.org/W3191029526","https://openalex.org/W4210378222","https://openalex.org/W4221019666","https://openalex.org/W4221126471","https://openalex.org/W4283770669","https://openalex.org/W4285007928","https://openalex.org/W4308862625","https://openalex.org/W4317358738","https://openalex.org/W4318826548","https://openalex.org/W4362458198","https://openalex.org/W4365446430","https://openalex.org/W4367839828","https://openalex.org/W4376133598","https://openalex.org/W4380550728","https://openalex.org/W4385175586","https://openalex.org/W4388275106","https://openalex.org/W4388687641","https://openalex.org/W4388693109","https://openalex.org/W4388744807","https://openalex.org/W4389080714","https://openalex.org/W4390733477","https://openalex.org/W4390741732","https://openalex.org/W4393868596","https://openalex.org/W4396931696","https://openalex.org/W4399212947","https://openalex.org/W4400831045","https://openalex.org/W4402315428","https://openalex.org/W4402711539","https://openalex.org/W4402926891","https://openalex.org/W4406300708","https://openalex.org/W4406489185","https://openalex.org/W4406661086","https://openalex.org/W4407225532","https://openalex.org/W4409533874","https://openalex.org/W4412707641","https://openalex.org/W4413345515","https://openalex.org/W4414409642"],"related_works":[],"abstract_inverted_index":{"Cancer":[0],"neuroscience":[1],"has":[2],"fundamentally":[3],"redefined":[4],"malignancy,":[5],"repositioning":[6],"the":[7,29,53,79,126,142,179,186,196,202,210,217],"nervous":[8,54,86],"system":[9,87],"from":[10],"a":[11,25,106,152,224],"passive":[12],"structural":[13],"element":[14],"to":[15,66,167,170,188,215],"an":[16,135],"integral":[17],"driver":[18],"of":[19,28,75,144,155,181,198,204,212,220,227],"tumor":[20,137],"progression.":[21],"This":[22,148],"review":[23],"provides":[24],"systematic":[26],"examination":[27],"dynamic,":[30],"bidirectional":[31],"dialogue":[32],"between":[33,83,109],"neurons":[34],"and":[35,44,61,70,101,112,115,139,163,178,209],"cancer":[36,221,229],"cells,":[37],"dissecting":[38],"its":[39],"molecular":[40],"foundations,":[41],"context-dependent":[42],"heterogeneity,":[43],"emerging":[45],"therapeutic":[46],"vulnerabilities.":[47],"We":[48],"detail":[49],"how":[50],"tumors":[51,88,169],"exploit":[52],"system\u2019s":[55],"signaling":[56],"architecture":[57],"co-opting":[58],"neurotransmitters,":[59],"neurotrophins,":[60],"developmental":[62],"axon":[63],"guidance":[64],"programs":[65],"promote":[67],"their":[68],"proliferation":[69],"dissemination.":[71],"A":[72],"central":[73,85],"thesis":[74],"this":[76,192],"work":[77],"is":[78],"crucial":[80],"mechanistic":[81],"divergence":[82],"malignancies:":[84],"establish":[89],"functional":[90],"synaptic":[91],"integration":[92],"with":[93],"neural":[94,132,200],"circuits,":[95],"whereas":[96],"peripheral":[97],"cancers":[98],"like":[99],"pancreatic":[100],"prostate":[102],"are":[103],"characterized":[104],"by":[105],"complex":[107],"interplay":[108],"autonomic":[110],"(sympathetic":[111],"parasympathetic)":[113],"remodeling":[114],"sensory":[116],"nerve":[117],"activation,":[118],"including":[119,158],"aggressive":[120],"perineural":[121],"invasion.":[122],"Furthermore,":[123],"we":[124],"explore":[125],"critical":[127],"neuroimmune":[128],"crosstalk,":[129],"through":[130],"which":[131],"signals":[133],"orchestrate":[134],"immunosuppressive":[136],"microenvironment":[138],"thereby":[140],"undermine":[141],"efficacy":[143],"immune":[145],"checkpoint":[146],"blockade.":[147],"evolving":[149],"understanding":[150],"unlocks":[151],"new":[153,225],"class":[154],"oncologic":[156],"strategies,":[157],"pharmacological":[159],"receptor":[160],"blockade,":[161],"denervation,":[162],"combination":[164],"therapies":[165],"designed":[166],"resensitize":[168],"immunotherapy.":[171],"However,":[172],"significant":[173],"barriers,":[174],"particularly":[175],"inter-tumoral":[176],"heterogeneity":[177],"limitations":[180],"current":[182],"preclinical":[183],"models,":[184],"challenge":[185],"path":[187],"clinical":[189],"application.":[190],"Advancing":[191],"frontier":[193],"will":[194],"necessitate":[195],"establishment":[197],"validated":[199],"biomarkers,":[201],"development":[203],"sophisticated":[205],"patient-derived":[206],"co-culture":[207],"systems,":[208],"application":[211],"spatial":[213],"multi-omics":[214],"translate":[216],"foundational":[218],"principles":[219],"neurobiology":[222],"into":[223],"generation":[226],"effective":[228],"treatments.":[230]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-06-28T00:00:00"}