{"id":"https://openalex.org/W7166316601","doi":"https://doi.org/10.1007/s11302-026-10171-5","title":"The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis","display_name":"The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166316601","doi":"https://doi.org/10.1007/s11302-026-10171-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363991"},"language":"en","primary_location":{"id":"doi:10.1007/s11302-026-10171-5","doi":"https://doi.org/10.1007/s11302-026-10171-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11302-026-10171-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11302-026-10171-5.pdf","source":{"id":"https://openalex.org/S111106147","display_name":"Purinergic Signalling","issn_l":"1573-9538","issn":["1573-9538","1573-9546"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Purinergic Signalling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11302-026-10171-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028468781","display_name":"Luke Tattersall","orcid":"https://orcid.org/0000-0001-8835-0627","observed_orcids":["https://orcid.org/0000-0001-8835-0627"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luke Tattersall","raw_affiliation_strings":["School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060450259","display_name":"Qiguang Wang","orcid":"https://orcid.org/0000-0003-3040-5810","observed_orcids":["https://orcid.org/0000-0003-3040-5810"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Qiguang Wang","raw_affiliation_strings":["College of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610065, Sichuan, China","School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610065, Sichuan, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005287881","display_name":"Anna Lisa Giuliani","orcid":"https://orcid.org/0000-0003-4988-9181","observed_orcids":["https://orcid.org/0000-0003-4988-9181"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Lisa Giuliani","raw_affiliation_strings":["Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053938706","display_name":"Elena Adinolfi","orcid":"https://orcid.org/0000-0001-8129-9929","observed_orcids":["https://orcid.org/0000-0001-8129-9929"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Elena Adinolfi","raw_affiliation_strings":["Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy. elena.adinolfi@unife.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy. elena.adinolfi@unife.it","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039432402","display_name":"Alison Gartland","orcid":"https://orcid.org/0000-0002-3712-2437","observed_orcids":["https://orcid.org/0000-0002-3712-2437"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alison Gartland","raw_affiliation_strings":["School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK. a.gartland@sheffield.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, Division of Clinical Medicine, The Mellanby Centre for Musculoskeletal Research, The University of Sheffield, Sheffield, UK. a.gartland@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039432402","https://openalex.org/A5053938706"],"corresponding_institution_ids":["https://openalex.org/I201324441","https://openalex.org/I91136226"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":{"value":4690,"currency":"USD","value_usd":4690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43609807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8069999814033508},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gain-of-function","display_name":"gain-of-function","score":0.5379999876022339},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pore-formation","display_name":"pore formation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.828000009059906},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.6133000254631042},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5773000121116638},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5713000297546387},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5566999912261963},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5396000146865845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5321000218391418},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5270000100135803},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5268999934196472},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.501800000667572},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.49639999866485596},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4943000078201294},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.4717000126838684},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4447000026702881},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.4431999921798706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4368000030517578},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4293000102043152},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.41100001335144043},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38690000772476196},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.3718000054359436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3368000090122223},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.3230000138282776},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.31859999895095825},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11302-026-10171-5","doi":"https://doi.org/10.1007/s11302-026-10171-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11302-026-10171-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11302-026-10171-5.pdf","source":{"id":"https://openalex.org/S111106147","display_name":"Purinergic Signalling","issn_l":"1573-9538","issn":["1573-9538","1573-9546"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Purinergic Signalling","raw_type":"journal-article"},{"id":"pmid:42363991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Purinergic signalling","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:242690","doi":null,"is_oa":true,"landing_page_url":"https://eprints.whiterose.ac.uk/id/eprint/242690/1/s11302-026-10171-5.pdf","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/242690/1/s11302-026-10171-5.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13310211","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310211/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13310211/pdf/11302_2026_Article_10171.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Purinergic Signal","raw_type":"Text"},{"id":"pmh:oai:sfera.unife.it:11392/2633690","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11392/2633690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s11302-026-10171-5","doi":"https://doi.org/10.1007/s11302-026-10171-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11302-026-10171-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11302-026-10171-5.pdf","source":{"id":"https://openalex.org/S111106147","display_name":"Purinergic Signalling","issn_l":"1573-9538","issn":["1573-9538","1573-9546"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Purinergic Signalling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3960845196","display_name":null,"funder_award_id":"CA21130","funder_id":"https://openalex.org/F4320338111","funder_display_name":"Precursory Research for Embryonic Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320312958","display_name":"Bone Cancer Research Trust","ror":"https://ror.org/02gsmy581"},{"id":"https://openalex.org/F4320338111","display_name":"Precursory Research for Embryonic Science and Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166316601.pdf","grobid_xml":"https://content.openalex.org/works/W7166316601.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1481135965","https://openalex.org/W1970144926","https://openalex.org/W1971955679","https://openalex.org/W1985655794","https://openalex.org/W1992995639","https://openalex.org/W2035279478","https://openalex.org/W2038595980","https://openalex.org/W2048143272","https://openalex.org/W2065009203","https://openalex.org/W2078551078","https://openalex.org/W2085731175","https://openalex.org/W2094545851","https://openalex.org/W2124264362","https://openalex.org/W2132958789","https://openalex.org/W2137756761","https://openalex.org/W2146098291","https://openalex.org/W2147386725","https://openalex.org/W2151516998","https://openalex.org/W2171701555","https://openalex.org/W2327906024","https://openalex.org/W2333209163","https://openalex.org/W2466136947","https://openalex.org/W2524169823","https://openalex.org/W2585547361","https://openalex.org/W2586409573","https://openalex.org/W2613177040","https://openalex.org/W2791025399","https://openalex.org/W2795677294","https://openalex.org/W2905070817","https://openalex.org/W2948073747","https://openalex.org/W3008432224","https://openalex.org/W3085579791","https://openalex.org/W3093158551","https://openalex.org/W3130148755","https://openalex.org/W3206773065","https://openalex.org/W4223908211","https://openalex.org/W4233935843","https://openalex.org/W4313312708","https://openalex.org/W4367056755","https://openalex.org/W4399760499","https://openalex.org/W4406139057"],"related_works":[],"abstract_inverted_index":{"Bone":[0,285],"cells":[1,189],"are":[2,10],"known":[3],"to":[4,187,359],"express":[5],"multiple":[6,321],"purinergic":[7],"receptors.":[8],"These":[9],"involved":[11],"in":[12,27,38,52,66,166,248,275,301,315,342,352,375],"various":[13],"aspects":[14],"of":[15,49,80,85,133,143,175,269,339,349,378],"bone":[16,40,53,91,184,322,344,367,372,379],"physiology":[17],"depending":[18,324],"on":[19,74,138,325],"the":[20,39,47,67,75,98,113,139,144,200,210,218,222,227,276,302,316,337,340],"cell":[21,147,157,234,251,279,303],"type":[22,293],"and":[23,29,58,83,94,106,125,136,164,178,213,240,291,309,312,346,365],"receptor":[24,108],"involved,":[25],"both":[26,78,237],"normal":[28,140],"disease":[30],"states,":[31],"with":[32,88,198],"extracellular":[33],"ATP":[34],"being":[35],"particularly":[36],"abundant":[37],"microenvironment.":[41],"The":[42,110,131,170],"P2X7R":[43,341],"subtype":[44],"has":[45],"been":[46,64],"subject":[48],"in-depth":[50],"research":[51],"homeostasis.":[54],"Different":[55],"splice":[56],"isoforms":[57,135,177],"single":[59],"nucleotide":[60],"polymorphisms":[61,351],"(SNPs)":[62],"have":[63,71],"discovered":[65],"P2RX7":[68,176,350],"gene,":[69],"these":[70,134],"functional":[72],"implications":[73],"receptor,":[76],"conferring":[77],"gain":[79],"function":[81,86],"(GOF)":[82],"loss":[84],"(LOF),":[87],"consequences":[89],"for":[90,151],"phenotype,":[92],"turnover":[93],"mass.":[95],"We":[96],"examined":[97],"full":[99],"length":[100],"P2RX7A,":[101],"truncated":[102],"P2RX7B,":[103],"their":[104],"co-expression":[105],"different":[107],"SNPs.":[109],"SNPs":[111,137],"included":[112],"c.489C":[114],">":[115,121,127],"T":[116],"variant":[117,207],"(p.His155Tyr)":[118],"GOF,":[119],"c.946G":[120],"A":[122],"(p.Arg307Gln)":[123],"LOF":[124],"c.1513A":[126],"C":[128],"(p.Glu496Ala)":[129],"LOF.":[130,328],"effect":[132],"cellular":[141],"behaviour":[142],"TE85":[145,188,228],"osteoblastic":[146],"line":[148,235],"were":[149,299,313],"measured":[150],"intracellular":[152],"calcium":[153,196,243],"uptake,":[154],"pore":[155,204,238],"formation,":[156],"proliferation,":[158],"Alkaline":[159],"phosphatase":[160],"(ALP)":[161],"activity,":[162,256,311],"mineralisation,":[163],"changes":[165],"osteogenic":[167],"gene":[168,262],"expression.":[169],"results":[171],"demonstrate":[172],"that":[173,266,305],"transfection":[174],"SNP":[179,224,250],"variants":[180,192,225,304,364],"influenced":[181],"several":[182],"important":[183],"processes.":[185],"Compared":[186],"all":[190,249],"isoform":[191],"had":[193,209,236,306],"an":[194,241],"increased":[195,242,274,300],"response":[197],"only":[199,226],"co-transfected":[201,223],"P2RX7AB":[202],"having":[203],"formation.":[205],"This":[206],"also":[208],"highest":[211],"mineralisation":[212,308],"ALP":[214,255,290,310],"activity":[215],"but":[216],"was":[217,246,254,259],"least":[219],"proliferative.":[220],"Of":[221],"+":[229,231],"P2RX7B":[230],"155Y":[232],"GOF":[233,326],"formation":[239],"response.":[244],"Mineralisation":[245],"lower":[247],"lines":[252],"as":[253,284],"however,":[257],"proliferation":[258],"increased.":[260],"Mechanistically,":[261],"expression":[263],"arrays":[264],"showed":[265],"Nuclear":[267],"Factor":[268],"Activated":[270],"T-cells":[271],"1":[272,296],"(NFATc1)":[273],"highly":[277,317],"proliferative":[278,318],"variants.":[280],"Osteogenic":[281],"genes":[282],"such":[283],"morphogenetic":[286],"protein":[287],"2":[288],"(BMP2),":[289],"collagen":[292],"I":[294],"alpha":[295],"chain":[297],"(COL1A1)":[298],"high":[307],"decreased":[314],"variants,":[319],"demonstrating":[320],"phenotypes":[323],"or":[327,370],"In":[329,354],"conclusion,":[330],"this":[331,356],"study":[332],"extends":[333],"our":[334],"knowledge":[335],"into":[336],"role":[338],"maintaining":[343],"homeostasis":[345],"provides":[347],"assessment":[348],"osteoblasts.":[353],"future":[355],"could":[357],"help":[358],"identify":[360],"associations":[361],"between":[362],"specific":[363],"increased/reduced":[366],"mineral":[368],"density":[369],"accelerated":[371],"loss/fracture":[373],"risk":[374],"a":[376],"number":[377],"related":[380],"conditions.":[381]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-06-28T00:00:00"}