{"id":"https://openalex.org/W7166316450","doi":"https://doi.org/10.1093/nar/gkag648","title":"Persistence of large mtDNA rearrangements linked to premature aging in Pol \u03b3 exonuclease-deficient mice","display_name":"Persistence of large mtDNA rearrangements linked to premature aging in Pol \u03b3 exonuclease-deficient mice","publication_year":2026,"publication_date":"2026-06-16","ids":{"openalex":"https://openalex.org/W7166316450","doi":"https://doi.org/10.1093/nar/gkag648","pmid":"https://pubmed.ncbi.nlm.nih.gov/42363763"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkag648","doi":"https://doi.org/10.1093/nar/gkag648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag648","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkag648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083795656","display_name":"Shilan Wu","orcid":"https://orcid.org/0009-0007-5121-9036","observed_orcids":["https://orcid.org/0009-0007-5121-9036"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilan Wu","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,"],"raw_orcid":"https://orcid.org/0009-0007-5121-9036","affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072131585","display_name":"Scott A. Lujan","orcid":"https://orcid.org/0000-0003-2400-8325","observed_orcids":["https://orcid.org/0000-0003-2400-8325"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A Lujan","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health, , Research Triangle Park, NC 27709,"],"raw_orcid":"https://orcid.org/0000-0003-2400-8325","affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health, , Research Triangle Park, NC 27709,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077612907","display_name":"Adam Burkholder","orcid":"https://orcid.org/0000-0002-0237-6920","observed_orcids":["https://orcid.org/0000-0002-0237-6920"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam B Burkholder","raw_affiliation_strings":["Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021711176","display_name":"Nadee Nissanka","orcid":"https://orcid.org/0000-0002-4639-7192","observed_orcids":["https://orcid.org/0000-0002-4639-7192"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadee Nissanka","raw_affiliation_strings":["Department of Neurology, University of Miami Miller School of Medicine , Miami, FL 33136,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Miami Miller School of Medicine , Miami, FL 33136,","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058936762","display_name":"Matthew J. Longley","orcid":"https://orcid.org/0000-0002-9352-2814","observed_orcids":["https://orcid.org/0000-0002-9352-2814"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Longley","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090151610","display_name":"Piotr A. Mieczkowski","orcid":"https://orcid.org/0000-0003-2418-0096","observed_orcids":["https://orcid.org/0000-0003-2418-0096"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Mieczkowski","raw_affiliation_strings":["Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7264 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599-7264 ,","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054055369","display_name":"Thomas A. Kunkel","orcid":"https://orcid.org/0000-0002-9900-1788","observed_orcids":["https://orcid.org/0000-0002-9900-1788"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A Kunkel","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health, , Research Triangle Park, NC 27709,"],"raw_orcid":"https://orcid.org/0000-0002-9900-1788","affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, DNA Replication Fidelity Group, National Institute of Environmental Health Sciences, National Institutes of Health, , Research Triangle Park, NC 27709,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060561492","display_name":"Carlos Torres Moraes","orcid":"https://orcid.org/0000-0002-8077-7092","observed_orcids":["https://orcid.org/0000-0002-8077-7092"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos T Moraes","raw_affiliation_strings":["Department of Neurology, University of Miami Miller School of Medicine , Miami, FL 33136,"],"raw_orcid":"https://orcid.org/0000-0002-8077-7092","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Miami Miller School of Medicine , Miami, FL 33136,","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075186269","display_name":"William C. Copeland","orcid":"https://orcid.org/0000-0002-0359-0953","observed_orcids":["https://orcid.org/0000-0002-0359-0953"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C Copeland","raw_affiliation_strings":["Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,"],"raw_orcid":"https://orcid.org/0000-0002-0359-0953","affiliations":[{"raw_affiliation_string":"Genome Integrity and Structural Biology Laboratory, Mitochondrial DNA Replication Group, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna-rearrangement","display_name":"mitochondrial genome rearrangement","score":0.8980000019073486},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dna-polymerase-gamma","display_name":"DNA polymerase gamma","score":0.7419999837875366},{"id":"https://openalex.org/keywords/exonuclease-proofreading","display_name":"exonuclease proofreading","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9509999752044678},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.8776000142097473},{"id":"https://openalex.org/C119054055","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"Indel","level":5,"score":0.8263000249862671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7250999808311462},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6258999705314636},{"id":"https://openalex.org/C2910714999","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"INDEL Mutation","level":5,"score":0.6107000112533569},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.5604000091552734},{"id":"https://openalex.org/C19811304","wikidata":"https://www.wikidata.org/wiki/Q6930378","display_name":"mtDNA control region","level":5,"score":0.5236999988555908},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5117999911308289},{"id":"https://openalex.org/C170748874","wikidata":"https://www.wikidata.org/wiki/Q21117977","display_name":"Proofreading","level":4,"score":0.49160000681877136},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.35839998722076416},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.337799996137619},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.3352999985218048},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C169802333","wikidata":"https://www.wikidata.org/wiki/Q424473","display_name":"Repeated sequence","level":4,"score":0.32280001044273376},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.31790000200271606},{"id":"https://openalex.org/C166252455","wikidata":"https://www.wikidata.org/wiki/Q6736610","display_name":"Trinucleotide repeat expansion","level":4,"score":0.3165000081062317},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C2781243718","wikidata":"https://www.wikidata.org/wiki/Q5420625","display_name":"Exonuclease III","level":4,"score":0.28850001096725464},{"id":"https://openalex.org/C198268994","wikidata":"https://www.wikidata.org/wiki/Q3774404","display_name":"D-loop","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.2667999863624573},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C2778090637","wikidata":"https://www.wikidata.org/wiki/Q1154619","display_name":"Werner syndrome","level":5,"score":0.26260000467300415},{"id":"https://openalex.org/C2910240311","wikidata":"https://www.wikidata.org/wiki/Q5418641","display_name":"Mutation Accumulation","level":4,"score":0.2615000009536743},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.2538999915122986},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.25220000743865967}],"mesh":[{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkag648","doi":"https://doi.org/10.1093/nar/gkag648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag648","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:42363763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13309792","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42363763/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkag648","doi":"https://doi.org/10.1093/nar/gkag648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag648","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2214148588","display_name":null,"funder_award_id":"Z01 ES065080","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4000056634","display_name":null,"funder_award_id":"1R01NS079965","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4715629133","display_name":null,"funder_award_id":"Z01 ES065078","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5103124042","display_name":"Structure-Function Studies Of DNA Replication Fidelity","funder_award_id":"Z01ES065070","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7678110179","display_name":null,"funder_award_id":"W911NF-21-1-0248","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G9000186942","display_name":null,"funder_award_id":"Z01 ES065078","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1521947818","https://openalex.org/W1703028909","https://openalex.org/W1967253002","https://openalex.org/W1980960847","https://openalex.org/W1982439221","https://openalex.org/W1987207427","https://openalex.org/W1994496497","https://openalex.org/W1995706959","https://openalex.org/W1996813968","https://openalex.org/W1998344938","https://openalex.org/W2000730064","https://openalex.org/W2005953994","https://openalex.org/W2012998724","https://openalex.org/W2016800407","https://openalex.org/W2036897871","https://openalex.org/W2041419523","https://openalex.org/W2044897807","https://openalex.org/W2053666250","https://openalex.org/W2060626022","https://openalex.org/W2062920562","https://openalex.org/W2063450941","https://openalex.org/W2069501159","https://openalex.org/W2074140784","https://openalex.org/W2074303856","https://openalex.org/W2076704428","https://openalex.org/W2077577291","https://openalex.org/W2091701724","https://openalex.org/W2098992864","https://openalex.org/W2103776029","https://openalex.org/W2115638153","https://openalex.org/W2140888103","https://openalex.org/W2147828523","https://openalex.org/W2153029275","https://openalex.org/W2156144742","https://openalex.org/W2156603613","https://openalex.org/W2256578114","https://openalex.org/W2511456620","https://openalex.org/W2591957352","https://openalex.org/W2792098864","https://openalex.org/W2806941167","https://openalex.org/W2809681489","https://openalex.org/W2895492780","https://openalex.org/W2900457101","https://openalex.org/W2903298309","https://openalex.org/W2911505657","https://openalex.org/W3085465284","https://openalex.org/W4290989098","https://openalex.org/W4311448318","https://openalex.org/W4321478233","https://openalex.org/W4391429754","https://openalex.org/W4392388298","https://openalex.org/W4400871790","https://openalex.org/W4407054220"],"related_works":[],"abstract_inverted_index":{"Mitochondrial":[0],"DNA":[1,16,161],"(mtDNA)":[2],"mutations":[3],"are":[4,140],"hallmarks":[5],"of":[6,90,113,181],"aging.":[7],"mtDNA":[8,37,56,91,101,167],"in":[9,119,126,133],"all":[10],"opisthokonts":[11],"is":[12],"replicated":[13],"exclusively":[14],"by":[15,22,76,142,184],"Polymerase":[17],"\u03b3":[18,28],"(Pol":[19],"\u03b3;":[20],"encoded":[21],"POLG).":[23],"PolgD257A/D257A":[24],"mice,":[25],"lacking":[26,106],"Pol":[27],"exonuclease":[29,79],"proofreading":[30],"(exo-),":[31],"exhibit":[32],"premature":[33,197],"aging":[34,198],"and":[35,47,59,70,78,128,135,139,144,174],"higher":[36],"mutation":[38],"rates":[39],"than":[40],"Polgwt/wt":[41],"(exo+)":[42],"mice.":[43],"Using":[44],"short-read":[45,152],"sequencing":[46,150],"the":[48,159,196],"ultra-sensitive":[49],"LostArc":[50],"indel-junction":[51],"detection":[52],"pipeline,":[53],"we":[54],"analyzed":[55],"from":[57],"exo-":[58,129],"exo+":[60,127],"mice":[61],"across":[62],"10":[63],"tissues.":[64,121],"Indel-junction":[65],"frequency,":[66],"endpoint":[67,123,156],"sequence":[68,124],"context,":[69],"inferred":[71],"indel":[72,146],"size":[73],"varied":[74],"systematically":[75],"tissue":[77],"state.":[80],"Exo-":[81],"tissues,":[82,85],"especially":[83],"post-mitotic":[84,120],"evidenced":[86],"exceptionally":[87],"high":[88],"burdens":[89],"large":[92],"indels":[93],"(mtDNALIs).":[94],"These":[95],"create":[96],"covalently":[97],"closed,":[98],"circular,":[99],"double-stranded":[100,116],"that":[102],"persists":[103],"despite":[104],"often":[105],"replication":[107],"origins.":[108],"This":[109],"suggests":[110],"limited":[111],"removal":[112],"aberrant":[114,191],"circular":[115,190],"DNA,":[117],"particularly":[118],"mtDNALI":[122],"contexts":[125],"tissues":[130],"mimic":[131],"those":[132],"young":[134],"elderly":[136],"human":[137],"muscle":[138],"dominated":[141],"sequence-dependent":[143],"-independent":[145],"mechanisms,":[147],"respectively.":[148],"Long-read":[149],"recapitulated":[151],"junction":[153],"patterns,":[154],"including":[155,172],"concentration":[157],"near":[158],"7S":[160],"3'":[162],"end,":[163],"but":[164],"also":[165],"revealed":[166],"circles":[168],"with":[169],"multiple":[170],"mtDNALIs,":[171,182],"deletions":[173],"duplications.":[175],"Together,":[176],"these":[177],"results":[178],"implicate":[179],"accumulation":[180],"compounded":[183],"insufficient":[185],"mechanisms":[186],"for":[187],"eliminating":[188],"closed":[189],"mtDNA,":[192],"as":[193],"contributing":[194],"to":[195],"phenotype.":[199]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-06-28T00:00:00"}