{"id":"https://openalex.org/W7166313801","doi":"https://doi.org/10.1038/s41598-026-59835-7","title":"Differences in follicular fluid kynurenic acid and 9,10-DiHOME levels between controlled ovarian stimulation and modified natural ART cycles","display_name":"Differences in follicular fluid kynurenic acid and 9,10-DiHOME levels between controlled ovarian stimulation and modified natural ART cycles","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166313801","doi":"https://doi.org/10.1038/s41598-026-59835-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365102"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-59835-7","doi":"https://doi.org/10.1038/s41598-026-59835-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59835-7","pdf_url":"https://www.nature.com/articles/s41598-026-59835-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-59835-7_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037317327","display_name":"Sanja Devi\u0107 Pavli\u0107","orcid":"https://orcid.org/0000-0001-8440-1722","observed_orcids":["https://orcid.org/0000-0001-8440-1722"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Sanja Devi\u0107 Pavli\u0107","raw_affiliation_strings":["Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083921319","display_name":"Emilia Fornal","orcid":"https://orcid.org/0000-0002-0503-0706","observed_orcids":["https://orcid.org/0000-0002-0503-0706"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Emilia Fornal","raw_affiliation_strings":["Department of Bioanalytics, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioanalytics, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020983122","display_name":"Anna Stachniuk","orcid":"https://orcid.org/0000-0001-6384-1999","observed_orcids":["https://orcid.org/0000-0001-6384-1999"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Stachniuk","raw_affiliation_strings":["Department of Bioanalytics, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioanalytics, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050538759","display_name":"Hanna Nikolaichuk","orcid":"https://orcid.org/0000-0001-6292-483X","observed_orcids":["https://orcid.org/0000-0001-6292-483X"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Hanna Nikolaichuk","raw_affiliation_strings":["Department of Bioanalytics, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioanalytics, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114991193","display_name":"Ewa Paszkowska","orcid":"https://orcid.org/0000-0002-5063-1500","observed_orcids":["https://orcid.org/0000-0002-5063-1500"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Paszkowska","raw_affiliation_strings":["Department of Bioanalytics, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioanalytics, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029327615","display_name":"Nada Birki\u0107","orcid":"https://orcid.org/0000-0003-2215-4126","observed_orcids":["https://orcid.org/0000-0003-2215-4126"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Nada Birkic","raw_affiliation_strings":["Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139491772","display_name":"Christian A. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Christian A. Reynolds","raw_affiliation_strings":["Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045611159","display_name":"Tea Mladeni\u0107","orcid":"https://orcid.org/0000-0001-7631-9411","observed_orcids":["https://orcid.org/0000-0001-7631-9411"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Tea Mladeni\u0107","raw_affiliation_strings":["Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029548355","display_name":"Neda Smiljan Severinski","orcid":"https://orcid.org/0000-0002-2241-0268","observed_orcids":["https://orcid.org/0000-0002-2241-0268"]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Neda Smiljan Severinski","raw_affiliation_strings":["Clinic for Gynecology and Obstetrics, Department of Human Reproduction, Clinical Hospital Center Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Gynecology and Obstetrics, Department of Human Reproduction, Clinical Hospital Center Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062236936","display_name":"Tina Su\u0161anj \u0160epi\u0107","orcid":"https://orcid.org/0000-0002-5110-3830","observed_orcids":["https://orcid.org/0000-0002-5110-3830"]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Tina Su\u0161anj \u0160epi\u0107","raw_affiliation_strings":["Clinic for Gynecology and Obstetrics, Department of Human Reproduction, Clinical Hospital Center Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Gynecology and Obstetrics, Department of Human Reproduction, Clinical Hospital Center Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053341491","display_name":"An\u0111elka Radoj\u010di\u0107 Badovinac","orcid":"https://orcid.org/0000-0001-5949-5245","observed_orcids":["https://orcid.org/0000-0001-5949-5245"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"An\u0111elka Radoj\u010di\u0107 Badovinac","raw_affiliation_strings":["Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069648600","display_name":"Lara Safti\u0107 Martinovi\u0107","orcid":"https://orcid.org/0000-0001-5637-4659","observed_orcids":["https://orcid.org/0000-0001-5637-4659"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Lara Safti\u0107 Martinovi\u0107","raw_affiliation_strings":["Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia. lara.saftic.martinovic@medri.uniri.hr"],"raw_orcid":"https://orcid.org/0000-0001-5637-4659","affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Genetics, Faculty of medicine, University of Rijeka, Rijeka, Croatia. lara.saftic.martinovic@medri.uniri.hr","institution_ids":["https://openalex.org/I154347574"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069648600"],"corresponding_institution_ids":["https://openalex.org/I154347574"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49246338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.14159999787807465,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kynurenic-acid","display_name":"kynurenic acid","score":0.9200000166893005},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.8370000123977661},{"id":"https://openalex.org/keywords/oxylipins","display_name":"oxylipins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/follicular-fluid","display_name":"follicular fluid","score":0.8790000081062317},{"id":"https://openalex.org/keywords/controlled-ovarian-stimulation","display_name":"controlled ovarian stimulation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/modified-natural-cycle","display_name":"modified natural cycle","score":0.9800000190734863},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.8259999752044678},{"id":"https://openalex.org/keywords/kynurenine-aminotransferase","display_name":"kynurenine aminotransferase","score":0.871999979019165},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2776841986","wikidata":"https://www.wikidata.org/wiki/Q642217","display_name":"Kynurenic acid","level":4,"score":0.8968999981880188},{"id":"https://openalex.org/C2776188440","wikidata":"https://www.wikidata.org/wiki/Q3746826","display_name":"Follicular fluid","level":4,"score":0.8859999775886536},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.864799976348877},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7408999800682068},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6938999891281128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6872000098228455},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.6855000257492065},{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.6779999732971191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.450300008058548},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3709000051021576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3578000068664551},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3003000020980835},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.28630000352859497},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.2635999917984009}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-026-59835-7","doi":"https://doi.org/10.1038/s41598-026-59835-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59835-7","pdf_url":"https://www.nature.com/articles/s41598-026-59835-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42365102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ab4efeb2c646462297342ba80175a738","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ab4efeb2c646462297342ba80175a738","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-59835-7","doi":"https://doi.org/10.1038/s41598-026-59835-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59835-7","pdf_url":"https://www.nature.com/articles/s41598-026-59835-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7622403727","display_name":null,"funder_award_id":"100.24.0007","funder_id":"https://openalex.org/F1002590718","funder_display_name":"Sveu\u010dili\u0161te u Rijeci"}],"funders":[{"id":"https://openalex.org/F1002590718","display_name":"Sveu\u010dili\u0161te u Rijeci","ror":"https://ror.org/05r8dqr10"},{"id":"https://openalex.org/F4320326535","display_name":"Uniwersytet Medyczny w Lublinie","ror":"https://ror.org/016f61126"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166313801.pdf","grobid_xml":"https://content.openalex.org/works/W7166313801.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1],"investigates":[2],"the":[3,69,106,154,164,174],"impact":[4],"of":[5,51,111,117,129,143,156,177],"assisted":[6],"reproductive":[7,53,184],"technology":[8],"(ART)":[9],"protocols,":[10],"specifically":[11],"modified":[12],"natural":[13],"cycle":[14],"(MNC)":[15],"and":[16,24,43,82,88,133,145,183],"controlled":[17],"ovarian":[18,157],"stimulation":[19,158],"(COS),":[20],"on":[21],"Kynurenine":[22,74,100],"metabolism":[23],"bioactive":[25],"lipid":[26],"mediators.":[27],"Follicular":[28],"fluid":[29],"(FF)":[30],"samples":[31,123],"from":[32],"28":[33],"participants":[34],"(MNC:":[35],"14,":[36],"COS:":[37],"14)":[38],"were":[39,91],"analyzed":[40],"using":[41],"targeted":[42,109],"untargeted":[44],"liquid":[45],"chromatography-tandem":[46],"mass":[47],"spectrometry,":[48],"alongside":[49],"evaluation":[50],"baseline":[52],"hormones.":[54],"A":[55,108],"significant":[56,115,138],"reduction":[57,142],"in":[58,68,98,121,147,153,163],"Kynurenic":[59],"acid":[60,119],"(KA)":[61],"levels":[62,128],"(p":[63,124],"=":[64],"0.0088)":[65],"was":[66],"observed":[67],"COS":[70,122,148],"group,":[71],"while":[72],"other":[73],"pathway":[75,103],"metabolites":[76],"such":[77],"as":[78],"L-Kynurenine":[79],"(Kyn),":[80],"3-Hydroxykynurenine,":[81],"Tryptophan":[83],"(Trp)":[84],"remained":[85],"unchanged.":[86],"KA/Kyn":[87],"KA/Trp":[89],"ratios":[90],"also":[92],"unchanged,":[93],"suggesting":[94],"no":[95,137],"major":[96],"alteration":[97],"overall":[99],"aminotransferase":[101],"(KAT)-associated":[102],"activity":[104],"between":[105],"groups.":[107],"analysis":[110],"oxylipins":[112],"revealed":[113],"a":[114],"decrease":[116],"9,10-dihydroxy-12-octadecenoic":[118],"(9,10-DiHOME)":[120],"<":[125],"0.0001),":[126],"whereas":[127],"12,13-DiHOME,":[130],"13-HODE,":[131],"DiHETEs,":[132],"8-Iso-prostaglandin":[134],"E\u2082":[135],"showed":[136],"differences.":[139],"The":[140],"parallel":[141],"KA":[144],"9,10-DiHOME":[146],"cycles":[149],"indicates":[150],"that":[151],"differences":[152],"intensity":[155],"are":[159],"associated":[160],"with":[161],"alterations":[162],"follicular":[165],"immunometabolic":[166],"environment.":[167],"Further":[168],"research":[169],"is":[170],"needed":[171],"to":[172],"evaluate":[173],"functional":[175],"relevance":[176],"these":[178],"changes":[179],"for":[180],"oocyte":[181],"quality":[182],"outcomes.":[185]},"counts_by_year":[],"updated_date":"2026-09-30T09:27:27.532063","created_date":"2026-06-28T00:00:00"}