{"id":"https://openalex.org/W7166298629","doi":"https://doi.org/10.30978/mg-2026-2-61","title":"The role of the gut microbiome and metabolome in potentializing metabolic health disorders. Review","display_name":"The role of the gut microbiome and metabolome in potentializing metabolic health disorders. Review","publication_year":2026,"publication_date":"2026-06-22","ids":{"openalex":"https://openalex.org/W7166298629","doi":"https://doi.org/10.30978/mg-2026-2-61"},"language":"en","primary_location":{"id":"doi:10.30978/mg-2026-2-61","doi":"https://doi.org/10.30978/mg-2026-2-61","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2026-2-61","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.30978/mg-2026-2-61","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065826467","display_name":"G. D. Fadieienko","orcid":"https://orcid.org/0000-0003-0881-6541","observed_orcids":["https://orcid.org/0000-0003-0881-6541"]},"institutions":[{"id":"https://openalex.org/I4210090156","display_name":"L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/00afzhq19","country_code":"UA","type":"government","lineage":["https://openalex.org/I4210090156","https://openalex.org/I4210144782"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"G.\u2006D. Fadieienko","raw_affiliation_strings":["\u0414\u0423 \u00ab\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0456\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0435\u0440\u0430\u043f\u0456\u0457 \u0456\u043c\u0435\u043d\u0456\u00a0\u041b.\u00a0\u0422.\u00a0\u041c\u0430\u043b\u043e\u0457 \u041d\u0410\u041c\u041d\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb, \u0425\u0430\u0440\u043a\u0456\u0432"],"raw_orcid":"https://orcid.org/0000-0003-0881-6541","affiliations":[{"raw_affiliation_string":"\u0414\u0423 \u00ab\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0456\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0435\u0440\u0430\u043f\u0456\u0457 \u0456\u043c\u0435\u043d\u0456\u00a0\u041b.\u00a0\u0422.\u00a0\u041c\u0430\u043b\u043e\u0457 \u041d\u0410\u041c\u041d\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb, \u0425\u0430\u0440\u043a\u0456\u0432","institution_ids":["https://openalex.org/I4210090156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013313586","display_name":"Oleksiy Gridnyev","orcid":"https://orcid.org/0000-0003-4716-3520","observed_orcids":["https://orcid.org/0000-0003-4716-3520"]},"institutions":[{"id":"https://openalex.org/I4210090156","display_name":"L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/00afzhq19","country_code":"UA","type":"government","lineage":["https://openalex.org/I4210090156","https://openalex.org/I4210144782"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"O.\u2006Y. Gridnyev","raw_affiliation_strings":["\u0414\u0423 \u00ab\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0456\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0435\u0440\u0430\u043f\u0456\u0457 \u0456\u043c\u0435\u043d\u0456\u00a0\u041b.\u00a0\u0422.\u00a0\u041c\u0430\u043b\u043e\u0457 \u041d\u0410\u041c\u041d\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb, \u0425\u0430\u0440\u043a\u0456\u0432"],"raw_orcid":"https://orcid.org/0000-0003-4716-3520","affiliations":[{"raw_affiliation_string":"\u0414\u0423 \u00ab\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0456\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0435\u0440\u0430\u043f\u0456\u0457 \u0456\u043c\u0435\u043d\u0456\u00a0\u041b.\u00a0\u0422.\u00a0\u041c\u0430\u043b\u043e\u0457 \u041d\u0410\u041c\u041d\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb, \u0425\u0430\u0440\u043a\u0456\u0432","institution_ids":["https://openalex.org/I4210090156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210090156"],"apc_list":null,"apc_paid":null,"fwci":1.3452,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72165518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":"2","first_page":"61","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gut-metabolome","display_name":"gut metabolome","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.8320000171661377},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.878000020980835},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.878000020980835},{"id":"https://openalex.org/keywords/phenylacetylglutamine","display_name":"phenylacetylglutamine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":1.0},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9459999799728394},{"id":"https://openalex.org/keywords/microplastics","display_name":"microplastics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.949999988079071},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.46399998664855957},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5879999995231628},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/virome","display_name":"virome","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8830999732017517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6836000084877014},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.682699978351593},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.41909998655319214},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C2908713948","wikidata":"https://www.wikidata.org/wiki/Q104117645","display_name":"Intestinal Microbiome","level":3,"score":0.38769999146461487},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.383899986743927},{"id":"https://openalex.org/C190743605","wikidata":"https://www.wikidata.org/wiki/Q17027885","display_name":"Human virome","level":4,"score":0.37400001287460327},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.36730000376701355},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3010999858379364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29910001158714294},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2946999967098236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2915000021457672},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C2780241833","wikidata":"https://www.wikidata.org/wiki/Q6556375","display_name":"Lipidome","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.30978/mg-2026-2-61","doi":"https://doi.org/10.30978/mg-2026-2-61","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2026-2-61","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:ojs.journals.uran.ua:article/365252","doi":null,"is_oa":true,"landing_page_url":"https://sgastro.com.ua/article/download/365252/350776","pdf_url":null,"source":{"id":"https://openalex.org/S4210228265","display_name":"The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy","issn_l":"2311-6382","issn":["2311-6382","2415-3605"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310322067","host_organization_name":"Ternopil Volodymyr Hnatiuk National Pedagogical University","host_organization_lineage":["https://openalex.org/P4310322067"],"host_organization_lineage_names":["Ternopil Volodymyr Hnatiuk National Pedagogical University"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1727-5725","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.30978/mg-2026-2-61","doi":"https://doi.org/10.30978/mg-2026-2-61","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2026-2-61","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7105701134","https://openalex.org/W2899852374","https://openalex.org/W2600254651","https://openalex.org/W2965140029","https://openalex.org/W3117428187","https://openalex.org/W1923006901","https://openalex.org/W2729975070","https://openalex.org/W2088529660","https://openalex.org/W3161113126","https://openalex.org/W4280582856"],"abstract_inverted_index":{"The":[0,159,249],"article":[1],"presents":[2],"data":[3],"on":[4,81,99],"the":[5,10,16,25,29,32,42,46,66,70,82,87,100,107,121,145,149,169,195,198,205,220,229,232,238,253,260,269,280,288,296,299,303,327],"features":[6],"of":[7,28,72,84,102,109,113,142,161,197,200,231,240,252,255,258,271,282,291,298,305,329],"changes":[8,85,218],"in":[9,15,49,75,86,92,106,168,187,219,228,295,319,326],"intestinal":[11,88,103,146,221,233,261,300],"microbiome":[12,89,147,222,301],"and":[13,56,90,115,118,131,148,185,213,215,223,268,279,302,317,324,338],"metabolome":[14],"most":[17],"common":[18],"metabolic-associated":[19,93,241,244,330],"diseases.":[20],"Attention":[21,135,190],"is":[22,60,125,136,175,191,285],"drawn":[23],"to":[24,51,69,127,138,164,194,225,237],"significant":[26],"role":[27,83],"liver":[30,246],"as":[31],"first":[33],"organ":[34],"that":[35,62,308],"comes":[36],"into":[37],"contact":[38],"with":[39,211,276],"blood":[40],"from":[41,45,65,207],"mesenteric":[43],"outflow":[44],"intestine,":[47],"which,":[48],"addition":[50],"nutrients,":[52],"may":[53],"contain":[54],"toxins":[55],"other":[57,139],"components.":[58],"It":[59],"noted":[61],"microbial":[63],"translocation":[64],"intestine":[67],"contributes":[68],"development":[71,108,239,254],"inflammatory":[73],"processes":[74],"adipose":[76],"tissue.":[77],"Data":[78,95],"are":[79,96,321],"provided":[80,98],"virome":[91,264],"pathologies.":[94],"also":[97,192],"activity":[101],"microbiota":[104],"metabolites":[105],"heart":[110],"failure,":[111],"disorders":[112],"glucose":[114],"lipid":[116],"metabolism,":[117],"others.":[119],"Among":[120],"metabolites,":[122],"special":[123,250],"attention":[124],"paid":[126,137,193],"trimethylamine":[128],"oxide,":[129],"phenylacetylglutamine,":[130],"short-chain":[132],"fatty":[133],"acids.":[134],"signaling":[140],"pathways":[141],"interaction":[143],"between":[144],"human":[150],"body,":[151],"namely":[152],"bioactive":[153],"molecules":[154],"\u2014":[155],"extracellular":[156,162,273],"bacterial":[157],"vesicles.":[158],"ability":[160],"vesicles":[163],"overcome":[165],"biological":[166],"barriers":[167],"\u00abhost\u00bb":[170],"organism":[171],"(intestinal,":[172],"endothelial,":[173],"etc.)":[174],"emphasized,":[176],"even":[177],"if":[178],"they":[179],"do":[180],"not":[181,310],"have":[182,309],"impaired":[183],"permeability":[184,230],"accumulate":[186],"internal":[188],"organs.":[189],"problem":[196],"impact":[199],"microplastics,":[201],"which":[202],"can":[203],"enter":[204],"body":[206],"\u00abfood\u00bb":[208],"plastic":[209],"containers":[210],"water":[212],"food":[214],"provoke":[216],"dysbiotic":[217],"contribute":[224],"an":[226],"increase":[227],"barrier,":[234],"respectively,":[235],"contributing":[236],"diseases":[242,331],"(obesity,":[243,332],"steatotic":[245],"disease,":[247],"etc.).":[248],"relevance":[251],"new":[256,293],"methods":[257],"influencing":[259],"microbiome,":[262],"(fecal":[263],"transplantation,":[265],"phage":[266],"therapy":[267],"use":[270,281],"modified":[272],"vesicles)":[274],"along":[275],"dietary":[277],"interventions":[278],"various":[283],"\u00abbiotics\u00bb":[284],"indicated.":[286],"Despite":[287],"limited":[289],"application":[290,318],"these":[292],"developments":[294],"modification":[297],"presence":[304],"many":[306],"questions":[307],"yet":[311],"been":[312],"answered,":[313],"their":[314],"further":[315],"study":[316],"humans":[320],"very":[322],"relevant":[323],"promising":[325],"treatment":[328],"type":[333],"2":[334],"diabetes,":[335],"arterial":[336],"hypertension":[337],"others).":[339]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-06-28T00:00:00"}
