{"id":"https://openalex.org/W7166174685","doi":"https://doi.org/10.1038/s41467-026-74916-x","title":"Discovery of an isoflavone biosynthetic pathway in Iridaceae plants","display_name":"Discovery of an isoflavone biosynthetic pathway in Iridaceae plants","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166174685","doi":"https://doi.org/10.1038/s41467-026-74916-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/42362562"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-74916-x","doi":"https://doi.org/10.1038/s41467-026-74916-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-74916-x","pdf_url":"https://www.nature.com/articles/s41467-026-74916-x_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-74916-x_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062618737","display_name":"Yucheng Zhao","orcid":"https://orcid.org/0000-0002-8962-5212","observed_orcids":["https://orcid.org/0000-0002-8962-5212"]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Yucheng Zhao","raw_affiliation_strings":["Biochemistry and Metabolism Department, John Innes Centre, Norwich, UK. zhaoyucheng1986@126.com","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. zhaoyucheng1986@126.com"],"raw_orcid":"https://orcid.org/0000-0002-8962-5212","affiliations":[{"raw_affiliation_string":"Biochemistry and Metabolism Department, John Innes Centre, Norwich, UK. zhaoyucheng1986@126.com","institution_ids":["https://openalex.org/I100288624"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. zhaoyucheng1986@126.com","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139411224","display_name":"Xinyu Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Shi","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139447772","display_name":"Xiang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Zhang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006106050","display_name":"Xin\u2010Guang Zhu","orcid":"https://orcid.org/0000-0002-4435-130X","observed_orcids":["https://orcid.org/0000-0002-4435-130X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210139738","display_name":"Center for Excellence in Molecular Plant Sciences","ror":"https://ror.org/04ew43640","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Ju Amy Lyu","raw_affiliation_strings":["Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-4435-130X","affiliations":[{"raw_affiliation_string":"Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210139738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mei Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270420","display_name":"Institute of Botany, Jiangsu Province and Chinese Academy of Sciences","ror":"https://ror.org/00nqzn326","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210087707","https://openalex.org/I4405270420"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Tian","raw_affiliation_strings":["Jiangsu Key Laboratory for Conservation and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Conservation and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, China","institution_ids":["https://openalex.org/I4405270420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139433947","display_name":"Shuai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Li","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103731862","display_name":"Sun L","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanlan Sun","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100521844","display_name":"Yixuan Zhong","orcid":"https://orcid.org/0000-0001-7474-0536","observed_orcids":["https://orcid.org/0000-0001-7474-0536"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Zhong","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yiqun Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqun Dai","raw_affiliation_strings":["School of Pharmacy, Bengbu Medical University, Bengbu, China","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Bengbu Medical University, Bengbu, China","institution_ids":["https://openalex.org/I169351748"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139430605","display_name":"Huihui Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Zeng","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100961591","display_name":"Yan Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhu","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441779","display_name":"Guoyong Xie","orcid":"https://orcid.org/0000-0001-9956-302X","observed_orcids":["https://orcid.org/0000-0001-9956-302X","https://orcid.org/0000-0001-9572-8624"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoyong Xie","raw_affiliation_strings":["Medical Botanical Garden, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjin, China","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Botanical Garden, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjin, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianfang Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100288624","display_name":"John Innes Centre","ror":"https://ror.org/055zmrh94","country_code":"GB","type":"facility","lineage":["https://openalex.org/I100288624","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4210146959","display_name":"Beijing Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/04trzn023","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210146959"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Jianfang Bai","raw_affiliation_strings":["Beijing Key Laboratory of Molecular Genetics in Hybrid Wheat, Institute of Hybrid Wheat Beijing Academy of Agriculture and Forestry Sciences, Beijing, China","Biochemistry and Metabolism Department, John Innes Centre, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Molecular Genetics in Hybrid Wheat, Institute of Hybrid Wheat Beijing Academy of Agriculture and Forestry Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210146959"]},{"raw_affiliation_string":"Biochemistry and Metabolism Department, John Innes Centre, Norwich, UK","institution_ids":["https://openalex.org/I100288624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039661089","display_name":"X L Ma","orcid":"https://orcid.org/0000-0001-7004-8075","observed_orcids":["https://orcid.org/0000-0001-7004-8075","https://orcid.org/0000-0003-0279-8354"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Ma","raw_affiliation_strings":["State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025530383","display_name":"Lian\u2010Wen Qi","orcid":"https://orcid.org/0000-0003-0728-4475","observed_orcids":["https://orcid.org/0000-0003-0728-4475"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian-Wen Qi","raw_affiliation_strings":["School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, China. Qilw@cpu.edu.cn","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-0728-4475","affiliations":[{"raw_affiliation_string":"School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, China. Qilw@cpu.edu.cn","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041546573","display_name":"Minjian Qin","orcid":"https://orcid.org/0000-0001-8539-7649","observed_orcids":["https://orcid.org/0000-0001-8539-7649"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjian Qin","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. minjianqin@163.com"],"raw_orcid":"https://orcid.org/0000-0001-8539-7649","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. minjianqin@163.com","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41971079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.12939999997615814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflavone-biosynthesis","display_name":"isoflavone biosynthesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/iridaceae","display_name":"Iridaceae","score":0.9869999885559082},{"id":"https://openalex.org/keywords/isoflavone-synthase","display_name":"isoflavone synthase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/o-methyltransferase","display_name":"O-methyltransferase","score":0.781000018119812},{"id":"https://openalex.org/keywords/fabaceae","display_name":"Fabaceae","score":0.8309999704360962},{"id":"https://openalex.org/keywords/soybean","display_name":"soybean","score":0.8080000281333923},{"id":"https://openalex.org/keywords/plant-secondary-metabolites","display_name":"plant secondary metabolites","score":0.828000009059906},{"id":"https://openalex.org/keywords/land-plant-evolution","display_name":"land plant evolution","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2776337548","wikidata":"https://www.wikidata.org/wiki/Q155941","display_name":"Iridaceae","level":2,"score":0.640500009059906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4553999900817871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4099999964237213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4002000093460083},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.38929998874664307},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.25040000677108765},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24570000171661377}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027621","descriptor_name":"Iridaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41467-026-74916-x","doi":"https://doi.org/10.1038/s41467-026-74916-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-74916-x","pdf_url":"https://www.nature.com/articles/s41467-026-74916-x_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:42362562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42362562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bb4674476c834955960329d030287f79","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bb4674476c834955960329d030287f79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13454174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13454174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-74916-x","doi":"https://doi.org/10.1038/s41467-026-74916-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-74916-x","pdf_url":"https://www.nature.com/articles/s41467-026-74916-x_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.7100034356117249,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426670779","display_name":null,"funder_award_id":"XDB0630101","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G19326746","display_name":null,"funder_award_id":"81872958","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2528558203","display_name":null,"funder_award_id":"2060302","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5796164572","display_name":null,"funder_award_id":"SKLNMZZ2024JS37","funder_id":"https://openalex.org/F4320326988","funder_display_name":"State Key Laboratory of Natural Medicines"},{"id":"https://openalex.org/G7012955624","display_name":null,"funder_award_id":"32570471","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8385610713","display_name":null,"funder_award_id":"2060302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321542","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320325093","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470"},{"id":"https://openalex.org/F4320326988","display_name":"State Key Laboratory of Natural Medicines","ror":"https://ror.org/01as92r37"},{"id":"https://openalex.org/F4320327605","display_name":"Southern University of Science and Technology","ror":null},{"id":"https://openalex.org/F4320328111","display_name":"Chengdu University","ror":"https://ror.org/034z67559"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166174685.pdf","grobid_xml":"https://content.openalex.org/works/W7166174685.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Isoflavones,":[0],"characterized":[1],"by":[2],"their":[3,22],"distinctive":[4],"C6-C3-C6":[5],"skeleton,":[6],"represent":[7],"an":[8,48,58,87],"important":[9],"class":[10],"of":[11,123,138],"plant":[12,40],"secondary":[13],"metabolites":[14],"with":[15],"considerable":[16],"pharmacological":[17],"and":[18,73,89,144],"physiological":[19],"relevance.":[20],"Although":[21],"biosynthetic":[23,50,92,140],"pathways":[24],"have":[25,85],"been":[26],"extensively":[27],"elucidated":[28],"in":[29,38,52,99,120,126,142],"Fabaceae":[30],"species,":[31],"the":[32,134],"molecular":[33],"mechanisms":[34,141],"governing":[35],"isoflavone":[36,49,62,78,91,124,139],"production":[37],"other":[39],"families":[41],"remain":[42],"largely":[43],"unexplored.":[44],"Herein,":[45],"we":[46],"uncovered":[47],"pathway":[51,108],"Iridaceae":[53,84,127,143],"plants.":[54,101],"Notably,":[55],"it":[56],"involves":[57],"uncharacterized":[59],"CYP736D":[60],"family":[61],"synthase,":[63],"a":[64,74,96,106,117],"non-CYP450":[65],"(iso)flavone":[66],"6-hydroxylase,":[67],"two":[68],"cation-dependent":[69],"type":[70],"I":[71],"O-methyltransferases,":[72],"newly":[75],"identified":[76],"CYP75F":[77],"3'-hydroxylase.":[79],"Evolutionary":[80],"analyses":[81],"revealed":[82],"that":[83],"retained":[86],"ancient":[88],"conserved":[90],"pathway,":[93],"potentially":[94],"representing":[95],"prototypical":[97],"route":[98],"land":[100],"In":[102],"contrast,":[103],"soybean":[104],"utilizes":[105],"specialized":[107],"unique":[109],"to":[110],"Fabaceae.":[111,145],"Our":[112],"findings":[113],"not":[114],"only":[115],"resolve":[116],"long-standing":[118],"gap":[119],"our":[121],"understanding":[122],"biosynthesis":[125],"plants,":[128],"but":[129],"also":[130],"provide":[131],"insights":[132],"into":[133],"independent":[135],"evolutionary":[136],"trajectory":[137]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-06-27T00:00:00"}