{"id":"https://openalex.org/W7166166176","doi":"https://doi.org/10.1007/s40618-026-02967-4","title":"Late-onset hypogonadism and lower limb vascular complications in men with type 2 diabetes: an observational study in a tertiary care centre","display_name":"Late-onset hypogonadism and lower limb vascular complications in men with type 2 diabetes: an observational study in a tertiary care centre","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166166176","doi":"https://doi.org/10.1007/s40618-026-02967-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42360633"},"language":"en","primary_location":{"id":"doi:10.1007/s40618-026-02967-4","doi":"https://doi.org/10.1007/s40618-026-02967-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-026-02967-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-026-02967-4.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40618-026-02967-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040917945","display_name":"Rita Matrone","orcid":"https://orcid.org/0009-0006-1308-0769","observed_orcids":["https://orcid.org/0009-0006-1308-0769"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Matrone","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":"https://orcid.org/0009-0006-1308-0769","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054748643","display_name":"Paola Caruso","orcid":"https://orcid.org/0000-0002-4756-2022","observed_orcids":["https://orcid.org/0000-0002-4756-2022"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Caruso","raw_affiliation_strings":["Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy. paola.caruso@unicampania.it"],"raw_orcid":"https://orcid.org/0000-0002-4756-2022","affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy. paola.caruso@unicampania.it","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005827466","display_name":"Miriam Longo","orcid":"https://orcid.org/0000-0002-6459-5854","observed_orcids":["https://orcid.org/0000-0002-6459-5854"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Miriam Longo","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6459-5854","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113682510","display_name":"Alessandro Pontillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Pontillo","raw_affiliation_strings":["Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112876770","display_name":"Carla Carbone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Carbone","raw_affiliation_strings":["Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044203595","display_name":"Paolo Cirillo","orcid":"https://orcid.org/0000-0003-1732-6819","observed_orcids":["https://orcid.org/0000-0003-1732-6819"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Cirillo","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017701173","display_name":"Chiara Porcellini","orcid":"https://orcid.org/0009-0004-3567-2349","observed_orcids":["https://orcid.org/0009-0004-3567-2349"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Porcellini","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068675003","display_name":"Maria Tomasuolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Tomasuolo","raw_affiliation_strings":["Department of Experimental Medicine, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039806023","display_name":"Lorenzo Scappaticcio","orcid":"https://orcid.org/0000-0003-2972-9551","observed_orcids":["https://orcid.org/0000-0003-2972-9551","https://orcid.org/0009-0007-7628-2226"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Scappaticcio","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":"https://orcid.org/0009-0007-7628-2226","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043443418","display_name":"Maria Ida Maiorino","orcid":"https://orcid.org/0000-0003-4659-7546","observed_orcids":["https://orcid.org/0000-0003-4659-7546"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Ida Maiorino","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025735798","display_name":"Giuseppe Bellastella","orcid":"https://orcid.org/0000-0002-4748-321X","observed_orcids":["https://orcid.org/0000-0002-4748-321X"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Bellastella","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4748-321X","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052044111","display_name":"Katherine Esposito","orcid":"https://orcid.org/0000-0002-3652-5154","observed_orcids":["https://orcid.org/0000-0002-3652-5154"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Katherine Esposito","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3652-5154","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolic Diseases, University of Campania \"Luigi Vanvitelli\", Piazza Luigi Miraglia 2, 80138, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054748643"],"corresponding_institution_ids":["https://openalex.org/I197809005"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48353384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andropause","display_name":"andropause","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5860000252723694},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/amputation","display_name":"amputation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.753000020980835},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.8759999871253967},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9314000010490417},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6330999732017517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5878999829292297},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.5687000155448914},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.542900025844574},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5351999998092651},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5198000073432922},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49160000681877136},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4442000091075897},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41040000319480896},{"id":"https://openalex.org/C2778144972","wikidata":"https://www.wikidata.org/wiki/Q52859","display_name":"Diabetic foot ulcer","level":4,"score":0.37880000472068787},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36160001158714294},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.3172000050544739},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.31540000438690186},{"id":"https://openalex.org/C2778848681","wikidata":"https://www.wikidata.org/wiki/Q6725716","display_name":"Macrovascular disease","level":4,"score":0.31209999322891235},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C2991842025","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Tertiary care","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C2779881954","wikidata":"https://www.wikidata.org/wiki/Q1097957","display_name":"Intermittent claudication","level":4,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s40618-026-02967-4","doi":"https://doi.org/10.1007/s40618-026-02967-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-026-02967-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-026-02967-4.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},{"id":"pmid:42360633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42360633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s40618-026-02967-4","doi":"https://doi.org/10.1007/s40618-026-02967-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-026-02967-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-026-02967-4.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8294473886489868,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325777","display_name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166166176.pdf","grobid_xml":"https://content.openalex.org/works/W7166166176.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1499736081","https://openalex.org/W1966196166","https://openalex.org/W1975704047","https://openalex.org/W1986638597","https://openalex.org/W1987977957","https://openalex.org/W1995336189","https://openalex.org/W2043854359","https://openalex.org/W2068420355","https://openalex.org/W2092048322","https://openalex.org/W2098247759","https://openalex.org/W2111728603","https://openalex.org/W2160140561","https://openalex.org/W2160377398","https://openalex.org/W2161417745","https://openalex.org/W2171835594","https://openalex.org/W2296297527","https://openalex.org/W2566604658","https://openalex.org/W2762293522","https://openalex.org/W2767825002","https://openalex.org/W2770250917","https://openalex.org/W2808755202","https://openalex.org/W2904342773","https://openalex.org/W2937652406","https://openalex.org/W2965524715","https://openalex.org/W2997862629","https://openalex.org/W3205163456","https://openalex.org/W3217631576","https://openalex.org/W4206754574","https://openalex.org/W4211201846","https://openalex.org/W4220750946","https://openalex.org/W4293168498","https://openalex.org/W4313332416","https://openalex.org/W4313488014","https://openalex.org/W4323807307","https://openalex.org/W4376614009","https://openalex.org/W4385897619","https://openalex.org/W4401013264","https://openalex.org/W4401226065","https://openalex.org/W4401402771","https://openalex.org/W4406255636","https://openalex.org/W4410193944","https://openalex.org/W4417121491"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,106],"aim":[2],"of":[3,115,117,148,178,192,202,213,234],"this":[4],"study":[5,34,107],"was":[6,48],"to":[7,51,94],"evaluate":[8,95],"the":[9,96,190],"relationship":[10],"between":[11,43,98,141],"late":[12],"onset":[13],"hypogonadism":[14,206,230],"(LOH)":[15],"with":[16,24,37,112,133,162,174,189,204,209,225],"inflammation":[17],"and":[18,45,53,56,67,85,102,125,128,167,194,215,227],"lower-limb":[19,155],"vascular":[20,73,103,235],"complications":[21,137,156],"in":[22,150,160],"men":[23,36,120,161,203],"type":[25],"2":[26],"diabetes":[27],"(T2D).":[28],"METHODS:":[29],"This":[30],"single-centre,":[31],"retrospective":[32],"observational":[33],"included":[35,109],"T2D":[38],"who":[39],"underwent":[40],"hormonal":[41],"evaluation":[42],"2020":[44],"2024.":[46],"LOH":[47,116],"diagnosed":[49],"according":[50],"SIAMS/SIE":[52],"EAU":[54],"guidelines":[55],"participants":[57],"were":[58,70,87,92,157,172,222],"classified":[59],"as":[60,231],"hypogonadal":[61,151],"or":[62],"eugonadal.":[63],"Demographic,":[64],"metabolic,":[65],"inflammatory,":[66],"haematological":[68],"parameters":[69],"collected.":[71],"Lower-limb":[72],"complications,":[74],"including":[75,164],"peripheral":[76],"artery":[77],"disease":[78],"(PAD),":[79],"diabetic":[80],"foot":[81],"ulcer":[82],"(DFU),":[83],"osteomyelitis":[84],"amputation,":[86,228],"assessed.":[88],"Logistic":[89],"regression":[90],"analyses":[91],"performed":[93],"association":[97],"testosterone":[99],"(T)":[100],"levels":[101,127,171,185,221],"complications.":[104,218],"RESULTS:":[105],"population":[108],"155":[110],"men,":[111],"a":[113,145,175,232],"prevalence":[114,147],"50.3%.":[118],"Hypogonadal":[119],"showed":[121],"significantly":[122],"lower":[123,195,216],"haemoglobin":[124],"haematocrit":[126],"higher":[129,146],"inflammatory":[130],"markers":[131],"compared":[132],"eugonadal":[134],"subjects.":[135],"Microvascular":[136],"did":[138],"not":[139],"differ":[140],"groups,":[142],"except":[143],"for":[144],"DFU":[149],"men.":[152],"Conversely,":[153],"macrovascular":[154,214],"more":[158],"frequent":[159],"LOH,":[163],"PAD,":[165],"osteomyelitis,":[166],"amputation.":[168,197],"Higher":[169],"T":[170,184,220],"associated":[173,188,208,224],"reduced":[176],"number":[177],"these":[179],"outcomes.":[180],"After":[181],"multivariable":[182],"adjustment,":[183],"remained":[186],"independently":[187,223],"risk":[191],"PAD":[193,226],"limb":[196,217],"CONCLUSION:":[198],"In":[199],"our":[200],"cohort":[201],"T2D,":[205],"is":[207],"an":[210],"increased":[211],"burden":[212],"Lower":[219],"supporting":[229],"marker":[233],"impairment.":[236]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-06-27T00:00:00"}