{"id":"https://openalex.org/W7166156808","doi":"https://doi.org/10.1093/gbe/evag159","title":"A Reassessment of Positive Growth Effects of Expressed Random Sequence Clones in E. coli Suggests Direct Adaptive Functions","display_name":"A Reassessment of Positive Growth Effects of Expressed Random Sequence Clones in E. coli Suggests Direct Adaptive Functions","publication_year":2026,"publication_date":"2026-06-25","ids":{"openalex":"https://openalex.org/W7166156808","doi":"https://doi.org/10.1093/gbe/evag159","pmid":"https://pubmed.ncbi.nlm.nih.gov/42360890"},"language":"en","primary_location":{"id":"doi:10.1093/gbe/evag159","doi":"https://doi.org/10.1093/gbe/evag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evag159","pdf_url":null,"source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/gbe/evag159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006941807","display_name":"Sven K\u00fcnzel","orcid":"https://orcid.org/0000-0003-4992-5963","observed_orcids":["https://orcid.org/0000-0003-4992-5963"]},"institutions":[{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven K\u00fcnzel","raw_affiliation_strings":["Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,"],"raw_orcid":"https://orcid.org/0000-0003-4992-5963","affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,","institution_ids":["https://openalex.org/I4210152351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114394516","display_name":"Carla Borisch","orcid":"https://orcid.org/0009-0002-2337-1034","observed_orcids":["https://orcid.org/0009-0002-2337-1034"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carla Borish","raw_affiliation_strings":["Hannover Medical School (MHH), Institute of Molecular and Translational Therapeutic Strategies (IMTTS) , Hannover 30625 ,","Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,"],"raw_orcid":"https://orcid.org/0009-0002-2337-1034","affiliations":[{"raw_affiliation_string":"Hannover Medical School (MHH), Institute of Molecular and Translational Therapeutic Strategies (IMTTS) , Hannover 30625 ,","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,","institution_ids":["https://openalex.org/I4210152351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133316814","display_name":"Cornelia Burghardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Burghardt","raw_affiliation_strings":["Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,","institution_ids":["https://openalex.org/I4210152351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133382211","display_name":"Corinna Heidinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Corinna Heidinger","raw_affiliation_strings":["Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,","institution_ids":["https://openalex.org/I4210152351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018355185","display_name":"Diethard Tautz","orcid":"https://orcid.org/0000-0002-0460-5344","observed_orcids":["https://orcid.org/0000-0002-0460-5344"]},"institutions":[{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Diethard Tautz","raw_affiliation_strings":["Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,"],"raw_orcid":"https://orcid.org/0000-0002-0460-5344","affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Evolutionary Biology , Department Evolutionary Genetics, Pl\u00f6n 24306 ,","institution_ids":["https://openalex.org/I4210152351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018355185"],"corresponding_institution_ids":["https://openalex.org/I4210152351"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46307732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fitness-effects","display_name":"fitness effects","score":0.5230000019073486},{"id":"https://openalex.org/keywords/adaptive-evolution","display_name":"adaptive evolution","score":0.5429999828338623},{"id":"https://openalex.org/keywords/selection-coefficients","display_name":"selection coefficients","score":0.6159999966621399},{"id":"https://openalex.org/keywords/non-coding-sequences","display_name":"non-coding sequences","score":0.6240000128746033},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9088000059127808},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.633400022983551},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5353999733924866},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.534600019454956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5189999938011169},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.5121999979019165},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5062999725341797},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.46459999680519104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43869999051094055},{"id":"https://openalex.org/C186515451","wikidata":"https://www.wikidata.org/wiki/Q228191","display_name":"Random sequence","level":3,"score":0.42179998755455017},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38909998536109924},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.3882000148296356},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.38429999351501465},{"id":"https://openalex.org/C2986302931","wikidata":"https://www.wikidata.org/wiki/Q764759","display_name":"Positive selection","level":3,"score":0.36570000648498535},{"id":"https://openalex.org/C2992278830","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Adaptive evolution","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.28060001134872437},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.26179999113082886},{"id":"https://openalex.org/C138405894","wikidata":"https://www.wikidata.org/wiki/Q3179949","display_name":"Multivariate random variable","level":3,"score":0.25}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gbe/evag159","doi":"https://doi.org/10.1093/gbe/evag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evag159","pdf_url":null,"source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:42360890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42360890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13361975","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42360890/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13361975/pdf/evag159.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biol Evol","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_3727457","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0013-788A-9","pdf_url":"https://hdl.handle.net/21.11116/0000-0013-788C-7","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology and Evolution","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/gbe/evag159","doi":"https://doi.org/10.1093/gbe/evag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evag159","pdf_url":null,"source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1902451327","https://openalex.org/W1973094248","https://openalex.org/W2005869314","https://openalex.org/W2036073976","https://openalex.org/W2058587250","https://openalex.org/W2059223767","https://openalex.org/W2179438025","https://openalex.org/W2223866672","https://openalex.org/W2232609933","https://openalex.org/W2275779322","https://openalex.org/W2609769603","https://openalex.org/W2735379537","https://openalex.org/W2750286977","https://openalex.org/W2805188346","https://openalex.org/W2806354673","https://openalex.org/W2945066961","https://openalex.org/W2948098754","https://openalex.org/W3118982697","https://openalex.org/W3216849316","https://openalex.org/W4224237071","https://openalex.org/W4225659342","https://openalex.org/W4324311049","https://openalex.org/W4388522901","https://openalex.org/W4401206157","https://openalex.org/W4405335480","https://openalex.org/W4406917203","https://openalex.org/W4407741954","https://openalex.org/W4415223239","https://openalex.org/W4416797678","https://openalex.org/W7125919523"],"related_works":[],"abstract_inverted_index":{"De":[0],"novo":[1],"gene":[2],"emergence":[3],"from":[4,68],"noncoding":[5],"sequences":[6,18,205,229],"is":[7],"an":[8],"important":[9],"evolutionary":[10],"mechanism,":[11],"yet":[12],"the":[13,35,58,69,118,121,225,236],"functional":[14],"potential":[15,54],"of":[16,26,37,57,83,90,120,128,186,203,227],"random":[17,27,84,145,187,204,228],"remains":[19],"debated.":[20],"Previous":[21],"experiments":[22],"suggested":[23],"that":[24,168,182],"expression":[25],"sequence":[28,85,146,188],"clones":[29,86,147,164,189],"in":[30,215],"Escherichia":[31],"coli":[32],"can":[33,41],"enhance":[34],"growth":[36,77,100,115,184],"cells,":[38],"ie":[39],"they":[40,169],"provide":[42,221],"a":[43,62,80,88,201],"direct":[44],"fitness":[45,91,208],"advantage.":[46],"However,":[47],"these":[48,154],"findings":[49,220],"have":[50],"been":[51],"questioned,":[52],"regarding":[53],"confounding":[55],"effects":[56,159,185,234],"clone":[59,194],"mixtures":[60],"and":[61,105,112,131,196],"possibly":[63],"negatively":[64],"acting":[65],"peptide":[66],"expressed":[67],"cloning":[70],"vector.":[71],"Here,":[72],"we":[73],"performed":[74],"controlled":[75],"competitive":[76],"assays":[78],"using":[79],"defined":[81],"subset":[82,202],"representing":[87],"spectrum":[89],"effects.":[92],"Experiments":[93],"across":[94],"multiple":[95],"conditions,":[96],"including":[97],"two":[98],"different":[99],"cycle":[101],"durations,":[102],"induction":[103],"states,":[104],"replicate":[106],"sets,":[107],"showed":[108],"high":[109],"technical":[110],"reproducibility":[111],"consistent":[113],"clone-specific":[114],"trajectories":[116],"for":[117,124,137,224],"majority":[119],"clones,":[122],"but":[123],"some,":[125],"also":[126],"influences":[127],"genomic":[129],"background":[130],"experimental":[132,216,222],"conditions.":[133],"While":[134],"previous":[135],"results":[136,180],"vector-derived":[138],"control":[139],"constructs":[140],"could":[141],"be":[142,191],"confirmed,":[143],"several":[144],"exhibited":[148],"higher":[149],"positive":[150,183],"selection":[151],"coefficients":[152],"than":[153],"vector":[155,197],"constructs.":[156],"These":[157,219],"relative":[158],"persisted":[160],"even":[161],"when":[162],"negative":[163,177],"were":[165],"excluded,":[166],"indicating":[167],"are":[170],"not":[171],"driven":[172],"by":[173,193],"competition":[174],"dynamics":[175],"with":[176],"clones.":[178],"Our":[179],"demonstrate":[181],"cannot":[190],"explained":[192],"mixture":[195],"artifacts":[198],"alone.":[199],"Instead,":[200],"confers":[206],"genuine":[207],"advantages":[209],"comparable":[210],"to":[211,230,238],"beneficial":[212],"mutations":[213],"observed":[214],"evolution":[217],"studies.":[218],"support":[223],"capacity":[226],"directly":[231],"generate":[232],"adaptive":[233,241],"without":[235],"necessity":[237],"acquire":[239],"additional":[240],"mutations.":[242]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-06-27T00:00:00"}
