{"id":"https://openalex.org/W7166118372","doi":"https://doi.org/10.1158/2159-8290.cd-24-1908","title":"Tumor Microbial Burden Drives Immune Responses through Regulation of Interferon Signaling","display_name":"Tumor Microbial Burden Drives Immune Responses through Regulation of Interferon Signaling","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166118372","doi":"https://doi.org/10.1158/2159-8290.cd-24-1908","pmid":"https://pubmed.ncbi.nlm.nih.gov/42360233"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-24-1908","doi":"https://doi.org/10.1158/2159-8290.cd-24-1908","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-24-1908","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/2159-8290.cd-24-1908","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101731301","display_name":"Haoyue Liu","orcid":"https://orcid.org/0000-0003-0498-2796","observed_orcids":["https://orcid.org/0000-0003-0498-2796"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoyue Liu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-0498-2796","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086296734","display_name":"Jeong\u2010Hoon Jang","orcid":"https://orcid.org/0000-0002-5925-6524","observed_orcids":["https://orcid.org/0000-0002-5925-6524"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I39705031","display_name":"Daegu Catholic University","ror":"https://ror.org/04fxknd68","country_code":"KR","type":"education","lineage":["https://openalex.org/I39705031"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Jeong-Hoon Jang","raw_affiliation_strings":["4College of Pharmacy, Daegu Catholic University, Gyeongsan-si, South Korea","The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-5925-6524","affiliations":[{"raw_affiliation_string":"4College of Pharmacy, Daegu Catholic University, Gyeongsan-si, South Korea","institution_ids":["https://openalex.org/I39705031"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030580072","display_name":"Fuduan Peng","orcid":"https://orcid.org/0000-0003-4068-530X","observed_orcids":["https://orcid.org/0000-0003-4068-530X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuduan Peng","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 5 Genomic Medicine, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-4068-530X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 5 Genomic Medicine, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039567508","display_name":"Hajar Rajaei","orcid":"https://orcid.org/0000-0002-8803-8841","observed_orcids":["https://orcid.org/0000-0002-8803-8841"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajar Rajaei","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-8803-8841","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012332252","display_name":"Vidhi Chandra","orcid":"https://orcid.org/0000-0003-3642-2144","observed_orcids":["https://orcid.org/0000-0003-3642-2144"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidhi Chandra","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-3642-2144","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847187","display_name":"Li Li","orcid":"https://orcid.org/0009-0003-4636-9487","observed_orcids":["https://orcid.org/0009-0003-4636-9487","https://orcid.org/0000-0003-4909-9796","https://orcid.org/0000-0001-5324-2271","https://orcid.org/0000-0002-3616-8206","https://orcid.org/0000-0003-0472-7314","https://orcid.org/0000-0002-2999-2344","https://orcid.org/0000-0002-7039-2404","https://orcid.org/0000-0002-9477-7093","https://orcid.org/0000-0001-5097-9972","https://orcid.org/0000-0001-7553-6916","https://orcid.org/0000-0001-8630-1098","https://orcid.org/0000-0001-9817-7661","https://orcid.org/0000-0002-5090-1793","https://orcid.org/0000-0002-5117-9739","https://orcid.org/0000-0002-8600-4461","https://orcid.org/0000-0003-0141-2798","https://orcid.org/0009-0000-6405-425X","https://orcid.org/0009-0001-7598-4855","https://orcid.org/0009-0005-0369-2705","https://orcid.org/0009-0005-7059-7417","https://orcid.org/0009-0009-4221-2793","https://orcid.org/0009-0009-8079-9812","https://orcid.org/0000-0002-2803-3803","https://orcid.org/0000-0001-5100-734X","https://orcid.org/0000-0001-5230-3749","https://orcid.org/0000-0001-5478-5681","https://orcid.org/0000-0001-5575-0894","https://orcid.org/0000-0001-5711-8681","https://orcid.org/0000-0001-5887-370X","https://orcid.org/0000-0001-5977-4754","https://orcid.org/0000-0001-6579-249X","https://orcid.org/0000-0001-7541-7570","https://orcid.org/0000-0001-7688-6141","https://orcid.org/0000-0001-7699-4484","https://orcid.org/0000-0001-7738-6464","https://orcid.org/0000-0001-8089-9164","https://orcid.org/0000-0001-8285-0671","https://orcid.org/0000-0001-8297-309X","https://orcid.org/0000-0001-8877-9052","https://orcid.org/0000-0001-8941-7336","https://orcid.org/0000-0001-9461-596X","https://orcid.org/0000-0001-9978-6346","https://orcid.org/0000-0002-0062-1742","https://orcid.org/0000-0002-0208-7475","https://orcid.org/0000-0002-0412-7565","https://orcid.org/0000-0002-1171-1858","https://orcid.org/0000-0002-2444-6694","https://orcid.org/0000-0002-2511-0156","https://orcid.org/0000-0002-3036-0934","https://orcid.org/0000-0002-3391-5608","https://orcid.org/0000-0002-3414-5561","https://orcid.org/0000-0002-3770-5675","https://orcid.org/0000-0002-4977-9137","https://orcid.org/0000-0002-5021-2648","https://orcid.org/0000-0002-6308-7524","https://orcid.org/0000-0002-6569-6008","https://orcid.org/0000-0002-7163-6263","https://orcid.org/0000-0002-7213-023X","https://orcid.org/0000-0002-8321-8480","https://orcid.org/0000-0002-8633-6028","https://orcid.org/0000-0002-8866-296X","https://orcid.org/0000-0002-9127-7763","https://orcid.org/0000-0002-9428-1960","https://orcid.org/0000-0002-9833-2294","https://orcid.org/0000-0002-9861-9789","https://orcid.org/0000-0003-0358-3929","https://orcid.org/0000-0003-0426-6546","https://orcid.org/0000-0003-0685-3189","https://orcid.org/0000-0003-0861-7366","https://orcid.org/0000-0003-0996-6787","https://orcid.org/0000-0003-1041-4533","https://orcid.org/0000-0003-1052-1566","https://orcid.org/0000-0003-1163-5733","https://orcid.org/0000-0003-1381-0654","https://orcid.org/0000-0003-1669-3094","https://orcid.org/0000-0003-1912-3556","https://orcid.org/0000-0003-2411-3846","https://orcid.org/0000-0003-2667-2166","https://orcid.org/0000-0003-2948-6561","https://orcid.org/0000-0003-3294-0219","https://orcid.org/0000-0003-3371-7561","https://orcid.org/0000-0003-3932-1998","https://orcid.org/0000-0003-4026-7984","https://orcid.org/0000-0003-4597-2017","https://orcid.org/0000-0003-4841-2330","https://orcid.org/0009-0000-0354-3615","https://orcid.org/0009-0000-0455-7365","https://orcid.org/0009-0000-2920-9543","https://orcid.org/0009-0000-7908-4793","https://orcid.org/0009-0000-8822-7960","https://orcid.org/0009-0000-9009-559X","https://orcid.org/0009-0000-9267-9839","https://orcid.org/0009-0000-9836-9276","https://orcid.org/0009-0001-2591-0858","https://orcid.org/0009-0001-3077-8273","https://orcid.org/0009-0001-6164-9992","https://orcid.org/0009-0001-6878-197X","https://orcid.org/0009-0001-7914-129X","https://orcid.org/0009-0002-0454-4008","https://orcid.org/0009-0002-2093-3468","https://orcid.org/0009-0002-2480-9077","https://orcid.org/0009-0002-2923-0275","https://orcid.org/0009-0002-3113-416X","https://orcid.org/0009-0002-4593-0159","https://orcid.org/0009-0002-5375-0211","https://orcid.org/0009-0002-5635-8186","https://orcid.org/0009-0002-7738-9096","https://orcid.org/0009-0003-0140-1690","https://orcid.org/0009-0003-5388-6212","https://orcid.org/0009-0003-7390-0237","https://orcid.org/0009-0003-8161-0272","https://orcid.org/0009-0004-1604-4697","https://orcid.org/0009-0004-1781-813X","https://orcid.org/0009-0004-2664-0732","https://orcid.org/0009-0004-4258-2229","https://orcid.org/0009-0004-5134-5030","https://orcid.org/0009-0004-7487-5640","https://orcid.org/0009-0004-7713-0660","https://orcid.org/0009-0004-8085-1717","https://orcid.org/0009-0004-9166-8328","https://orcid.org/0009-0005-1130-6755","https://orcid.org/0009-0005-3688-1852","https://orcid.org/0009-0005-5281-369X","https://orcid.org/0009-0005-6906-455X","https://orcid.org/0009-0006-2746-320X","https://orcid.org/0009-0006-3290-5447","https://orcid.org/0009-0006-5037-7318","https://orcid.org/0009-0006-7748-1107","https://orcid.org/0009-0007-6253-0284","https://orcid.org/0009-0007-6472-0436","https://orcid.org/0009-0007-7646-4177","https://orcid.org/0009-0007-8202-7475","https://orcid.org/0009-0007-8390-5903","https://orcid.org/0009-0007-9875-8459","https://orcid.org/0009-0008-5637-2600","https://orcid.org/0009-0008-7735-8437","https://orcid.org/0009-0008-7767-6208","https://orcid.org/0009-0009-1716-7484","https://orcid.org/0009-0009-1849-3003","https://orcid.org/0009-0009-2531-1159","https://orcid.org/0009-0009-2538-9685","https://orcid.org/0009-0009-3460-7541","https://orcid.org/0009-0009-5814-908X","https://orcid.org/0009-0009-9973-1746","https://orcid.org/0009-0007-6072-4026"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le Li","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0009-0001-3077-8273","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076888203","display_name":"Dhwani N. Rupani","orcid":"https://orcid.org/0000-0003-2325-4057","observed_orcids":["https://orcid.org/0000-0003-2325-4057"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhwani N. Rupani","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-2325-4057","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 3 Department of Clinical Cancer Prevention, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047140019","display_name":"Sedigheh Taghinezhad\u2010S","orcid":"https://orcid.org/0000-0002-4497-4427","observed_orcids":["https://orcid.org/0000-0002-4497-4427"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sedigheh Taghinezhadsaroukalaei","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-4497-4427","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058319210","display_name":"Yuehui Zhao","orcid":"https://orcid.org/0000-0002-9496-0023","observed_orcids":["https://orcid.org/0000-0002-9496-0023"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuehui Zhao","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 6 Department of Systems Biology, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-9496-0023","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 6 Department of Systems Biology, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022792492","display_name":"Erika Yanil Faraoni","orcid":"https://orcid.org/0000-0003-0731-2122","observed_orcids":["https://orcid.org/0000-0003-0731-2122"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Y. Faraoni","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-0731-2122","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077740608","display_name":"Thais Fernanda Bartelli","orcid":"https://orcid.org/0000-0002-1373-0112","observed_orcids":["https://orcid.org/0000-0002-1373-0112"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thais F. Bartelli","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-1373-0112","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084916598","display_name":"Olivereen Le Roux","orcid":"https://orcid.org/0000-0003-1882-879X","observed_orcids":["https://orcid.org/0000-0003-1882-879X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivereen Le Roux","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-1882-879X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102807355","display_name":"Virginia Tahan","orcid":"https://orcid.org/0009-0006-8326-3536","observed_orcids":["https://orcid.org/0009-0006-8326-3536"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Tahan","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0009-0006-8326-3536","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132878442","display_name":"Fernando Jimenez-Arancon","orcid":"https://orcid.org/0009-0009-7880-589X","observed_orcids":["https://orcid.org/0009-0009-7880-589X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando Jimenez-Arancon","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0009-0009-7880-589X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053367421","display_name":"Seyda Baydogan","orcid":"https://orcid.org/0000-0002-9455-640X","observed_orcids":["https://orcid.org/0000-0002-9455-640X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seyda Baydogan","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-9455-640X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016322563","display_name":"Amir Hossein Mohseni","orcid":"https://orcid.org/0000-0003-0320-9523","observed_orcids":["https://orcid.org/0000-0003-0320-9523"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Hossein Mohseni","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-0320-9523","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069469851","display_name":"Javier A. Gomez","orcid":"https://orcid.org/0000-0002-6579-744X","observed_orcids":["https://orcid.org/0000-0002-6579-744X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier A. Gomez","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 7 Department of Leukemia, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-6579-744X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 7 Department of Leukemia, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066945125","display_name":"Mitesh Patel","orcid":"https://orcid.org/0000-0001-6724-9183","observed_orcids":["https://orcid.org/0000-0001-6724-9183"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitesh Patel","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York"],"raw_orcid":"https://orcid.org/0000-0001-6724-9183","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008665039","display_name":"Jared K. Burks","orcid":"https://orcid.org/0000-0002-6173-9074","observed_orcids":["https://orcid.org/0000-0002-6173-9074"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared K. Burks","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 7 Department of Leukemia, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-6173-9074","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 7 Department of Leukemia, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041691279","display_name":"Barbara Mino","orcid":"https://orcid.org/0000-0001-9217-8719","observed_orcids":["https://orcid.org/0000-0001-9217-8719"]},"institutions":[{"id":"https://openalex.org/I133599470","display_name":"Universidad del Desarrollo","ror":"https://ror.org/05y33vv83","country_code":"CL","type":"education","lineage":["https://openalex.org/I133599470"]},{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Barbara Mi\u00f1o Galvez","raw_affiliation_strings":["Cl\u00ednica Alemana 9 , Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0001-9217-8719","affiliations":[{"raw_affiliation_string":"Cl\u00ednica Alemana 9 , Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile","institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023461112","display_name":"Daniel Carvajal","orcid":"https://orcid.org/0000-0003-1742-729X","observed_orcids":["https://orcid.org/0000-0003-1742-729X"]},"institutions":[{"id":"https://openalex.org/I133599470","display_name":"Universidad del Desarrollo","ror":"https://ror.org/05y33vv83","country_code":"CL","type":"education","lineage":["https://openalex.org/I133599470"]},{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Daniel E. Carvajal-Hausdorf","raw_affiliation_strings":["Cl\u00ednica Alemana 9 , Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0003-1742-729X","affiliations":[{"raw_affiliation_string":"Cl\u00ednica Alemana 9 , Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile","institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004540435","display_name":"Erika Ru\u00edz\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-0446-123X","observed_orcids":["https://orcid.org/0000-0002-0446-123X"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Erika Ruiz-Garc\u00eda","raw_affiliation_strings":["Instituto Nacional de Cancerolog\u00eda 10 Departamento de Tumores de Tubo Digestivo, Laboratorio de Medicina Traslacional, , Ciudad de M\u00e9xico, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-0446-123X","affiliations":[{"raw_affiliation_string":"Instituto Nacional de Cancerolog\u00eda 10 Departamento de Tumores de Tubo Digestivo, Laboratorio de Medicina Traslacional, , Ciudad de M\u00e9xico, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033310896","display_name":"Edith Araceli Fern\u00e1ndez-Figueroa","orcid":"https://orcid.org/0000-0002-5159-8300","observed_orcids":["https://orcid.org/0000-0002-5159-8300"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Edith A. Fernandez-Figueroa","raw_affiliation_strings":["Instituto Nacional de Medicina Gen\u00f3mica 11 N\u00facleo B de Innovaci\u00f3n en Medicina de Precisi\u00f3n, , Ciudad de M\u00e9xico, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-5159-8300","affiliations":[{"raw_affiliation_string":"Instituto Nacional de Medicina Gen\u00f3mica 11 N\u00facleo B de Innovaci\u00f3n en Medicina de Precisi\u00f3n, , Ciudad de M\u00e9xico, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006348751","display_name":"Scott Kopetz","orcid":"https://orcid.org/0000-0001-9647-3416","observed_orcids":["https://orcid.org/0000-0001-9647-3416"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Kopetz","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 12 Department of Gastrointestinal Medical Oncology, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0001-9647-3416","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 12 Department of Gastrointestinal Medical Oncology, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053992102","display_name":"Steven Brad Maron","orcid":"https://orcid.org/0000-0002-8794-130X","observed_orcids":["https://orcid.org/0000-0002-8794-130X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven B. Maron","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-8794-130X","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031539570","display_name":"Andrea Cercek","orcid":"https://orcid.org/0000-0002-5054-8192","observed_orcids":["https://orcid.org/0000-0002-5054-8192"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Cercek","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-5054-8192","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066180141","display_name":"Erick Marcelo Riquelme","orcid":"https://orcid.org/0000-0002-2696-7995","observed_orcids":["https://orcid.org/0000-0002-2696-7995"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Erick M. Riquelme","raw_affiliation_strings":["Pontifical Catholic University of Chile 13 Respiratory Diseases Department, Faculty of Medicine, , Santiago, Chile"],"raw_orcid":"https://orcid.org/0000-0002-2696-7995","affiliations":[{"raw_affiliation_string":"Pontifical Catholic University of Chile 13 Respiratory Diseases Department, Faculty of Medicine, , Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063693068","display_name":"Nicholas E. Navin","orcid":"https://orcid.org/0000-0002-2106-8624","observed_orcids":["https://orcid.org/0000-0002-2106-8624"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Navin","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 6 Department of Systems Biology, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-2106-8624","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 6 Department of Systems Biology, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048216930","display_name":"James Robert White","orcid":"https://orcid.org/0000-0002-7535-9179","observed_orcids":["https://orcid.org/0000-0002-7535-9179"]},"institutions":[{"id":"https://openalex.org/I4210158189","display_name":"Resphera Biosciences","ror":"https://ror.org/0519z1231","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210158189"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Robert White","raw_affiliation_strings":["14Resphera Biosciences LLC, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-7535-9179","affiliations":[{"raw_affiliation_string":"14Resphera Biosciences LLC, Baltimore, Maryland","institution_ids":["https://openalex.org/I4210158189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182441","display_name":"Linghua Wang","orcid":"https://orcid.org/0000-0001-9380-0266","observed_orcids":["https://orcid.org/0000-0001-9380-0266"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linghua Wang","raw_affiliation_strings":["15Institute for Data Science in Oncology (IDSO), Houston, Texas","The University of Texas MD Anderson Cancer Center 16 James P. Allison Institute (JPAI), , Houston, Texas","The University of Texas MD Anderson Cancer Center 5 Genomic Medicine, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0001-9380-0266","affiliations":[{"raw_affiliation_string":"15Institute for Data Science in Oncology (IDSO), Houston, Texas","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 16 James P. Allison Institute (JPAI), , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 5 Genomic Medicine, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050789569","display_name":"Luis Alberto Diaz","orcid":"https://orcid.org/0000-0002-7079-8914","observed_orcids":["https://orcid.org/0000-0002-7079-8914"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis A. Diaz","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-7079-8914","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center 8 Division of Solid Tumor Oncology, , New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047609850","display_name":"Florencia M. McAllister","orcid":"https://orcid.org/0000-0002-9915-0943","observed_orcids":["https://orcid.org/0000-0002-9915-0943"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Florencia McAllister","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","The University of Texas MD Anderson Cancer Center 12 Department of Gastrointestinal Medical Oncology, , Houston, Texas","The University of Texas MD Anderson Cancer Center 17 Department of Immunology, , Houston, Texas","The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-9915-0943","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 1 Department of Genetics, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 12 Department of Gastrointestinal Medical Oncology, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 17 Department of Immunology, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center 2 Tumor Ecosystems Center, , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5047609850"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45219804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OF1","last_page":"OF18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microbiota","display_name":"tumor microbiome","score":0.878000020980835},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.9800000190734863},{"id":"https://openalex.org/keywords/interferon-related-genes","display_name":"interferon-related genes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.8429999947547913},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.859000027179718},{"id":"https://openalex.org/keywords/adar1","display_name":"ADAR1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7836999893188477},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7687000036239624},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6916000247001648},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6227999925613403},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5672000050544739},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5087000131607056},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.48249998688697815},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47999998927116394},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4733999967575073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46389999985694885},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4399000108242035},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4162999987602234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4156000018119812},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.3986999988555908},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.38690000772476196},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3824999928474426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37779998779296875},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3594000041484833},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2578999996185303},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.cd-24-1908","doi":"https://doi.org/10.1158/2159-8290.cd-24-1908","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-24-1908","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"pmid:42360233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42360233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.cd-24-1908","doi":"https://doi.org/10.1158/2159-8290.cd-24-1908","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-24-1908","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7501395344734192}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2192699636","display_name":"Modulating the Gut- Tumor Microbial Axis to Reverse Pancreatic Cancer Immunosuooression","funder_award_id":"RP200173","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G2955680221","display_name":null,"funder_award_id":"1R37CA237384","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000841871","display_name":null,"funder_award_id":"13723124","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000843144","display_name":null,"funder_award_id":"SU2C-AACR-PS-29","funder_id":"https://openalex.org/F4320332898","funder_display_name":"Stand Up To Cancer"},{"id":"https://openalex.org/G9000843250","display_name":null,"funder_award_id":"1RO1CA282786","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320313428","display_name":"Andrew Sabin Family Foundation","ror":"https://ror.org/02h7p8r46"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320332898","display_name":"Stand Up To Cancer","ror":"https://ror.org/01dmpb598"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"microbes":[2,90,173],"are":[3],"increasingly":[4],"recognized":[5],"for":[6],"modulating":[7],"tumor":[8,89,101,104,161,177],"behavior":[9],"and":[10,25,32,43,91,137,153],"therapy":[11,144,185],"responses.":[12,145,186],"Intratumoral":[13],"microbial":[14,105,126],"burden":[15],"(ITMB)":[16],"analysis":[17],"across":[18],"cancers":[19],"revealed":[20,54],"regulation":[21,42],"of":[22,56,116,171],"immune":[23,85,154],"pathways":[24],"activated":[26],"mast":[27,93],"cells,":[28],"mostly":[29],"in":[30,49,118,174],"colorectal":[31,36,63],"gastric":[33],"cancers.":[34],"High-ITMB":[35],"cancer":[37,120],"leads":[38],"to":[39,142,151,159,163,183],"interferon":[40],"(IFN)":[41],"is":[44,149],"associated":[45],"with":[46,81],"improved":[47],"outcomes":[48],"advanced":[50],"disease.":[51],"Single-cell":[52],"sequencing":[53],"induction":[55],"IFN-related":[57],"genes":[58],"(IRG)":[59],"within":[60],"microbe-containing":[61,92],"human":[62],"cancer.":[64],"Gastrointestinal-luminal":[65],"mismatch":[66],"repair\u2013deficient":[67],"(MMRd)":[68],"tumors":[69],"had":[70],"higher":[71],"ITMB":[72,148],"than":[73],"proficient":[74],"tumors.":[75],"In":[76,96],"a":[77],"rectal":[78],"MMRd":[79,100],"cohort":[80],"100%":[82],"remission":[83],"after":[84],"checkpoint":[86],"blockade":[87],"(ICB),":[88],"cells":[94,121],"increased.":[95],"ICB-sensitive":[97],"syngeneic":[98],"murine":[99],"models,":[102],"local":[103],"depletion":[106],"impaired":[107],"ICB":[108],"efficacy":[109],"while":[110],"downregulating":[111],"IFN":[112],"signaling.":[113],"Forced":[114],"upregulation":[115],"IRGs":[117],"ADAR1-deficient":[119],"restored":[122],"immunotherapy":[123],"responses":[124],"during":[125],"ablation.":[127],"These":[128,165],"data":[129],"highlight":[130,167],"dynamic":[131],"interplay":[132],"among":[133],"ITMB,":[134],"host":[135],"defense,":[136],"immunogenicity,":[138],"which":[139,179],"seems":[140],"key":[141,169],"determine":[143,160],"Significance:":[146],"The":[147],"linked":[150],"transcriptional":[152],"functional":[155],"changes":[156],"that":[157],"seem":[158],"sensitivity":[162],"immunotherapy.":[164],"findings":[166],"the":[168,176],"role":[170],"tumor-resident":[172],"shaping":[175],"ecosystem,":[178],"could":[180],"be":[181],"targeted":[182],"modulate":[184]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-06-27T00:00:00"}
