{"id":"https://openalex.org/W7166007671","doi":"https://doi.org/10.1016/j.envint.2026.110390","title":"Integrative network toxicology and single-cell analysis implicates a potential TGFBR1-centered fibroblast remodeling axis in Benzo[a]pyrene-related atrial fibrillation","display_name":"Integrative network toxicology and single-cell analysis implicates a potential TGFBR1-centered fibroblast remodeling axis in Benzo[a]pyrene-related atrial fibrillation","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166007671","doi":"https://doi.org/10.1016/j.envint.2026.110390","pmid":"https://pubmed.ncbi.nlm.nih.gov/42364542"},"language":"en","primary_location":{"id":"doi:10.1016/j.envint.2026.110390","doi":"https://doi.org/10.1016/j.envint.2026.110390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110390","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.envint.2026.110390","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121497005","display_name":"Qianchen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianchen Wang","raw_affiliation_strings":["First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121495662","display_name":"Jiejie Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiejie Wu","raw_affiliation_strings":["First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shaoyu Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoyu Qi","raw_affiliation_strings":["First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139399610","display_name":"Jingwen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210159257","display_name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/052q26725","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159257"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingwen Zhang","raw_affiliation_strings":["Department of Cardiovascular Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China. Electronic address: 15665651870@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China. Electronic address: 15665651870@163.com","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210159257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100644814","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0002-1312-0146","observed_orcids":["https://orcid.org/0000-0002-1312-0146","https://orcid.org/0000-0002-3304-6713","https://orcid.org/0000-0001-5521-2316","https://orcid.org/0000-0001-6047-0731","https://orcid.org/0000-0001-7110-127X","https://orcid.org/0000-0001-8931-9656","https://orcid.org/0000-0001-9021-734X","https://orcid.org/0000-0002-1202-6174","https://orcid.org/0000-0002-4892-2309","https://orcid.org/0000-0002-5453-5604","https://orcid.org/0000-0002-7078-0757","https://orcid.org/0000-0003-0856-9632","https://orcid.org/0009-0001-7592-8036","https://orcid.org/0009-0002-2379-6323","https://orcid.org/0009-0002-4529-3647","https://orcid.org/0009-0002-5970-2376","https://orcid.org/0009-0002-6927-8134","https://orcid.org/0009-0004-1884-7581","https://orcid.org/0009-0006-7576-9131","https://orcid.org/0009-0006-9053-2634","https://orcid.org/0000-0002-8951-2648","https://orcid.org/0000-0001-5718-7804","https://orcid.org/0000-0001-6752-080X","https://orcid.org/0000-0001-7291-2242","https://orcid.org/0000-0001-7352-8955","https://orcid.org/0000-0001-7472-0287","https://orcid.org/0000-0001-7505-9718","https://orcid.org/0000-0001-8052-9200","https://orcid.org/0000-0001-8824-4007","https://orcid.org/0000-0001-8956-8214","https://orcid.org/0000-0001-9147-1059","https://orcid.org/0000-0001-9178-2340","https://orcid.org/0000-0001-9683-9123","https://orcid.org/0000-0001-9958-2757","https://orcid.org/0000-0001-9973-3498","https://orcid.org/0000-0002-0028-9102","https://orcid.org/0000-0002-0166-6942","https://orcid.org/0000-0002-0203-5018","https://orcid.org/0000-0002-0303-8499","https://orcid.org/0000-0002-0702-5636","https://orcid.org/0000-0002-0779-1488","https://orcid.org/0000-0002-0966-9646","https://orcid.org/0000-0002-1192-8328","https://orcid.org/0000-0002-1372-3078","https://orcid.org/0000-0002-1674-849X","https://orcid.org/0000-0002-1771-6342","https://orcid.org/0000-0002-1862-3121","https://orcid.org/0000-0002-2740-9362","https://orcid.org/0000-0002-3084-3864","https://orcid.org/0000-0002-3401-2566","https://orcid.org/0000-0002-3413-5013","https://orcid.org/0000-0002-4367-5097","https://orcid.org/0000-0002-4619-5099","https://orcid.org/0000-0002-5500-1946","https://orcid.org/0000-0002-5547-5893","https://orcid.org/0000-0002-5922-2156","https://orcid.org/0000-0002-5978-1150","https://orcid.org/0000-0002-6182-3786","https://orcid.org/0000-0002-6260-5289","https://orcid.org/0000-0002-6570-1735","https://orcid.org/0000-0002-6676-7832","https://orcid.org/0000-0002-6801-3444","https://orcid.org/0000-0002-6837-5015","https://orcid.org/0000-0002-6973-1480","https://orcid.org/0000-0002-7786-7361","https://orcid.org/0000-0002-7957-2487","https://orcid.org/0000-0002-8076-1904","https://orcid.org/0000-0002-8135-5369","https://orcid.org/0000-0002-9340-9205","https://orcid.org/0000-0002-9522-8651","https://orcid.org/0000-0002-9653-073X","https://orcid.org/0000-0003-1006-7842","https://orcid.org/0000-0003-1126-9841","https://orcid.org/0000-0003-1392-4432","https://orcid.org/0000-0003-1683-0255","https://orcid.org/0000-0003-1698-5783","https://orcid.org/0000-0003-1890-2793","https://orcid.org/0000-0003-1916-0349","https://orcid.org/0000-0003-2166-6365","https://orcid.org/0000-0003-2211-3535","https://orcid.org/0000-0003-2402-7841","https://orcid.org/0000-0003-2854-4061","https://orcid.org/0000-0003-2988-8843","https://orcid.org/0000-0003-3033-8873","https://orcid.org/0000-0003-3977-2481","https://orcid.org/0000-0003-4022-1249","https://orcid.org/0000-0003-4352-5774","https://orcid.org/0000-0003-4851-9488","https://orcid.org/0009-0000-4198-1579","https://orcid.org/0009-0000-4270-037X","https://orcid.org/0009-0000-4555-9586","https://orcid.org/0009-0000-5683-0159","https://orcid.org/0009-0000-6526-2376","https://orcid.org/0009-0000-6537-2815","https://orcid.org/0009-0000-8388-5374","https://orcid.org/0009-0000-9480-3987","https://orcid.org/0009-0001-1520-5215","https://orcid.org/0009-0001-2200-9562","https://orcid.org/0009-0001-5124-2865","https://orcid.org/0009-0001-6153-9435","https://orcid.org/0009-0001-6264-7630","https://orcid.org/0009-0001-6789-7591","https://orcid.org/0009-0001-7939-3120","https://orcid.org/0009-0001-8413-5150","https://orcid.org/0009-0001-9185-7637","https://orcid.org/0009-0001-9193-5391","https://orcid.org/0009-0002-3016-8624","https://orcid.org/0009-0002-3372-8703","https://orcid.org/0009-0002-3648-0803","https://orcid.org/0009-0002-4131-0737","https://orcid.org/0009-0002-5011-747X","https://orcid.org/0009-0002-5673-1809","https://orcid.org/0009-0003-0315-8145","https://orcid.org/0009-0003-0513-8607","https://orcid.org/0009-0003-0974-0275","https://orcid.org/0009-0003-5873-7232","https://orcid.org/0009-0003-7278-1635","https://orcid.org/0009-0003-9004-3353","https://orcid.org/0009-0003-9712-0219","https://orcid.org/0009-0004-0701-6926","https://orcid.org/0009-0004-1003-9360","https://orcid.org/0009-0004-3276-669X","https://orcid.org/0009-0004-4664-5637","https://orcid.org/0009-0004-7250-4811","https://orcid.org/0009-0004-8646-4996","https://orcid.org/0009-0005-1157-766X","https://orcid.org/0009-0005-2432-2236","https://orcid.org/0009-0005-7087-9430","https://orcid.org/0009-0005-8646-706X","https://orcid.org/0009-0006-0914-3368","https://orcid.org/0009-0006-3337-0886","https://orcid.org/0009-0006-4523-0805","https://orcid.org/0009-0006-5263-3661","https://orcid.org/0009-0006-5598-8601","https://orcid.org/0009-0006-7671-6728","https://orcid.org/0009-0006-9998-5891","https://orcid.org/0009-0007-1265-6006","https://orcid.org/0009-0007-2774-7103","https://orcid.org/0009-0007-3440-6139","https://orcid.org/0009-0007-5649-1776","https://orcid.org/0009-0007-6047-9104","https://orcid.org/0009-0007-6737-5965","https://orcid.org/0009-0007-7716-183X","https://orcid.org/0009-0007-7804-9030","https://orcid.org/0009-0007-9840-8723","https://orcid.org/0009-0008-2508-3750","https://orcid.org/0009-0008-3280-5272","https://orcid.org/0009-0008-4626-8754","https://orcid.org/0009-0008-4942-7052","https://orcid.org/0009-0008-5265-0511","https://orcid.org/0009-0008-7270-5794","https://orcid.org/0009-0008-7339-4756","https://orcid.org/0009-0009-0324-9665","https://orcid.org/0009-0009-0882-6222","https://orcid.org/0009-0009-1650-9542","https://orcid.org/0009-0009-2145-518X","https://orcid.org/0009-0009-3681-4843","https://orcid.org/0009-0009-4613-2985","https://orcid.org/0009-0009-5810-0235","https://orcid.org/0009-0009-6677-8724","https://orcid.org/0009-0009-7252-646X","https://orcid.org/0009-0009-7330-7904","https://orcid.org/0009-0009-9227-7122","https://orcid.org/0009-0009-9548-6675","https://orcid.org/0009-0004-8595-4352"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210159257","display_name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/052q26725","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159257"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Cardiovascular Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China. Electronic address: liuyangtcm@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China. Electronic address: liuyangtcm@126.com","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210159257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100644814","https://openalex.org/A5139399610"],"corresponding_institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210159257"],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":{"value":4750,"currency":"USD","value_usd":4750},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51508707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"214","issue":null,"first_page":"110390","last_page":"110390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.3240000009536743,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9760000109672546},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-receptor-1","display_name":"TGFBR1","score":0.953000009059906},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.878000020980835},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6019999980926514},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.6230000257492065},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6150000095367432},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.574999988079071},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8460000157356262},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/virtual-knockout","display_name":"virtual knockout","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.48899999260902405},{"id":"https://openalex.org/keywords/molecular-toxicology","display_name":"molecular toxicology","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7031000256538391},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6730999946594238},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6438000202178955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5906999707221985},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5817000269889832},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.47290000319480896},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.451200008392334},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4440000057220459},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4253000020980835},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.41370001435279846},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.40880000591278076},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4020000100135803},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39969998598098755},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39640000462532043},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.38350000977516174},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38269999623298645},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.33899998664855957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.323199987411499},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2752000093460083},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26829999685287476},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.257099986076355},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.25519999861717224}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.envint.2026.110390","doi":"https://doi.org/10.1016/j.envint.2026.110390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110390","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},{"id":"pmid:42364542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42364542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.envint.2026.110390","doi":"https://doi.org/10.1016/j.envint.2026.110390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2026.110390","pdf_url":null,"source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.8576186299324036}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8018938404","display_name":null,"funder_award_id":"ZR2021LZY011","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1995869884","https://openalex.org/W2104916446","https://openalex.org/W2155048725","https://openalex.org/W2158118095","https://openalex.org/W2165956438","https://openalex.org/W2209078408","https://openalex.org/W2568675678","https://openalex.org/W2611425558","https://openalex.org/W2765726697","https://openalex.org/W2800787044","https://openalex.org/W2883576516","https://openalex.org/W2942610007","https://openalex.org/W2944617715","https://openalex.org/W2949177718","https://openalex.org/W2959103028","https://openalex.org/W2969658635","https://openalex.org/W2984472267","https://openalex.org/W3027341006","https://openalex.org/W3037623356","https://openalex.org/W3082188176","https://openalex.org/W3090880001","https://openalex.org/W3092861045","https://openalex.org/W3092980867","https://openalex.org/W3108776726","https://openalex.org/W3116086463","https://openalex.org/W3121058838","https://openalex.org/W3132661792","https://openalex.org/W3135327518","https://openalex.org/W3164831205","https://openalex.org/W3168436232","https://openalex.org/W3177828909","https://openalex.org/W3182546273","https://openalex.org/W3196799816","https://openalex.org/W3211713257","https://openalex.org/W4206428122","https://openalex.org/W4220916725","https://openalex.org/W4224269882","https://openalex.org/W4225426244","https://openalex.org/W4281741468","https://openalex.org/W4281742670","https://openalex.org/W4281792218","https://openalex.org/W4285078579","https://openalex.org/W4286561118","https://openalex.org/W4313472109","https://openalex.org/W4321793895","https://openalex.org/W4360603634","https://openalex.org/W4376631479","https://openalex.org/W4377819329","https://openalex.org/W4384155285","https://openalex.org/W4385249280","https://openalex.org/W4385955506","https://openalex.org/W4386328101","https://openalex.org/W4389619430","https://openalex.org/W4390499803","https://openalex.org/W4391654821","https://openalex.org/W4392902402","https://openalex.org/W4394728248","https://openalex.org/W4395447849","https://openalex.org/W4399654534","https://openalex.org/W4400107658","https://openalex.org/W4402490040","https://openalex.org/W4402710322","https://openalex.org/W4404695486","https://openalex.org/W4404756574","https://openalex.org/W4404771327","https://openalex.org/W4404928944","https://openalex.org/W4404992810","https://openalex.org/W4405177115","https://openalex.org/W4405668672","https://openalex.org/W4405945827","https://openalex.org/W4406420875","https://openalex.org/W4408413331","https://openalex.org/W4408814506","https://openalex.org/W4409486874","https://openalex.org/W4409738410","https://openalex.org/W4410511259","https://openalex.org/W4412789792","https://openalex.org/W4413110670","https://openalex.org/W4414703565","https://openalex.org/W4416927591","https://openalex.org/W4417259518","https://openalex.org/W7117534803","https://openalex.org/W7118761123","https://openalex.org/W7124434410","https://openalex.org/W7130414356"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Benzo[a]pyrene":[1],"(BaP),":[2],"an":[3],"air":[4],"pollution-related":[5],"polycyclic":[6],"aromatic":[7],"hydrocarbon,":[8],"may":[9,261],"intersect":[10,262],"with":[11,32,93,116,159,263],"molecular":[12,33],"pathways":[13],"relevant":[14],"to":[15,216],"atrial":[16,41,210,277,299],"fibrillation":[17],"(AF),":[18],"but":[19],"this":[20,273],"relationship":[21],"remains":[22],"unclear.":[23],"OBJECTIVES:":[24],"To":[25],"examine":[26],"whether":[27],"predicted":[28,78,161],"BaP":[29,77,160,282],"targets":[30,79,101,151],"overlap":[31,92],"and":[34,48,59,89,109,135,143,163,171,197,220,225,284,298],"cellular":[35,144],"remodeling":[36,176,266],"features":[37],"in":[38,168,267,275,292],"human":[39,73,209],"AF-related":[40,208],"datasets.":[42,76],"METHODS:":[43],"Five":[44],"AF":[45,74,193],"microarray":[46],"datasets":[47],"one":[49],"single-cell":[50,136,239],"RNA":[51,131],"sequencing":[52],"(scRNA-seq)":[53],"dataset":[54],"were":[55,80,152,166],"analyzed.":[56],"Differential":[57],"expression":[58],"weighted":[60],"gene":[61],"co-expression":[62],"network":[63],"analysis":[64],"(WGCNA)":[65],"defined":[66,97],"AF-associated":[67,94,156,222],"key":[68,95,157],"genes":[69,96,158,215],"directly":[70,236],"observed":[71],"from":[72],"transcriptomic":[75],"computationally":[81],"obtained":[82],"using":[83],"ChEMBL,":[84],"Similarity":[85],"Ensemble":[86],"Approach":[87],"(SEA),":[88],"PharmMapper;":[90],"their":[91],"inferred":[98,148],"BaP-AF":[99,149],"candidate":[100,150],"for":[102],"Gene":[103],"Ontology":[104],"(GO)/Kyoto":[105],"Encyclopedia":[106],"of":[107,207,295],"Genes":[108],"Genomes":[110],"(KEGG)":[111],"enrichment.":[112],"Machine":[113],"learning":[114],"(ML)":[115],"SHapley":[117],"Additive":[118],"exPlanations":[119],"(SHAP)":[120],"prioritized":[121],"hub":[122,214],"genes.":[123],"Cell-type":[124],"Identification":[125],"By":[126],"Estimating":[127],"Relative":[128],"Subsets":[129],"Of":[130],"Transcripts":[132],"(CIBERSORT),":[133],"docking,":[134],"analyses":[137,206],"assessed":[138],"immune":[139,223],"patterns,":[140],"structural":[141],"plausibility,":[142],"context.":[145],"RESULTS:":[146],"Eighteen":[147],"identified":[153],"by":[154,230,291],"overlapping":[155],"targets,":[162],"these":[164],"candidates":[165],"enriched":[167],"oxidative":[169],"stress/inflammation":[170],"transforming":[172],"growth":[173],"factor-beta":[174],"(TGF-\u03b2)-related":[175],"pathways.":[177],"Elastic":[178],"Net":[179],"yielded":[180],"a":[181,254],"final":[182],"hub-gene":[183],"signature":[184],"(PPP3CA,":[185],"ERBB4,":[186],"PSAP,":[187],"LAMP1,":[188],"PPARA,":[189],"HSP90AB1,":[190],"TGFBR1,":[191],"KCNA5).":[192],"exhibited":[194],"increased":[195],"neutrophils":[196],"reduced":[198],"M2":[199],"macrophages/T":[200],"follicular":[201],"helper":[202],"(Tfh)":[203],"cells.":[204],"Single-cell":[205],"tissue":[211],"localized":[212],"the":[213],"major":[217],"cell":[218,278],"populations":[219],"revealed":[221],"expansion":[224],"fibroblast-centered":[226],"TGF-\u03b2":[227],"signaling,":[228],"dominated":[229],"TGFB1-(TGFBR1":[231],"+":[232],"TGFBR2),":[233],"rather":[234],"than":[235],"measuring":[237],"BaP-induced":[238],"remodeling.scTenifoldKnk-based":[240],"TGFBR1":[241,285],"virtual":[242],"knockout":[243],"highlighted":[244],"perturbations":[245,260],"(ABCA8,":[246],"CD9,":[247],"IFI44L,":[248],"BGN).":[249],"CONCLUSION:":[250],"These":[251],"findings":[252],"nominate":[253],"testable":[255],"hypothesis":[256,274],"that":[257],"BaP-related":[258],"target":[259],"TGFBR1-associated":[264],"fibroblast":[265,296],"AF.":[268],"Future":[269],"studies":[270],"should":[271],"evaluate":[272],"exposure-relevant":[276],"models":[279],"through":[280],"controlled":[281],"exposure":[283],"gain-":[286],"or":[287],"loss-of-function":[288],"experiments,":[289],"followed":[290],"vivo":[293],"validation":[294],"activation":[297],"remodeling.":[300]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-06-27T00:00:00"}