{"id":"https://openalex.org/W7165947153","doi":"https://doi.org/10.1002/tkm2.70069","title":"Maoto Is Associated With Partial Recovery of Autophagic Flux in Influenza Virus\u2010Infected A549 Cells","display_name":"Maoto Is Associated With Partial Recovery of Autophagic Flux in Influenza Virus\u2010Infected A549 Cells","publication_year":2026,"publication_date":"2026-06-25","ids":{"openalex":"https://openalex.org/W7165947153","doi":"https://doi.org/10.1002/tkm2.70069"},"language":"en","primary_location":{"id":"doi:10.1002/tkm2.70069","doi":"https://doi.org/10.1002/tkm2.70069","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.70069","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Atsuhiko Sakamoto","orcid":"https://orcid.org/0000-0002-4178-8661","observed_orcids":["https://orcid.org/0000-0002-4178-8661"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsuhiko Sakamoto","raw_affiliation_strings":["Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","Department of Microbiology and Immunology, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":"https://orcid.org/0000-0002-4178-8661","affiliations":[{"raw_affiliation_string":"Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034156879","display_name":"Yusuke Sechi","orcid":"https://orcid.org/0009-0006-5554-5261","observed_orcids":["https://orcid.org/0009-0006-5554-5261"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Sechi","raw_affiliation_strings":["Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089016584","display_name":"Aya Fujikane","orcid":"https://orcid.org/0000-0002-6888-926X","observed_orcids":["https://orcid.org/0000-0002-6888-926X"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Fujikane","raw_affiliation_strings":["Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049906111","display_name":"Tetsuya Hiyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Hiyoshi","raw_affiliation_strings":["Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002232148","display_name":"Kenji Hiromatsu","orcid":"https://orcid.org/0000-0002-3496-6087","observed_orcids":["https://orcid.org/0000-0002-3496-6087"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Hiromatsu","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060842834","display_name":"Shigeki Nabeshima","orcid":"https://orcid.org/0000-0001-6250-3162","observed_orcids":["https://orcid.org/0000-0001-6250-3162"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Nabeshima","raw_affiliation_strings":["Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan","institution_ids":["https://openalex.org/I31784960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I31784960"],"apc_list":{"value":2870,"currency":"USD","value_usd":2870},"apc_paid":null,"fwci":4.4714,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95066694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"13","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.08349999785423279,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.800000011920929},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autophagosome-lysosome-fusion","display_name":"autophagosome-lysosome fusion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.949999988079071},{"id":"https://openalex.org/keywords/atg14","display_name":"ATG14","score":0.9990000128746033},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9337999820709229},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.736299991607666},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.605400025844574},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6046000123023987},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5598999857902527},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.475600004196167},{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.4609000086784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4345000088214874},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.387800008058548},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.37299999594688416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.365200012922287},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35510000586509705},{"id":"https://openalex.org/C68434959","wikidata":"https://www.wikidata.org/wiki/Q1908996","display_name":"Viral matrix protein","level":3,"score":0.3495999872684479},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.3174999952316284},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C2994541485","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral infection","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.28130000829696655},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2736999988555908},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.25619998574256897},{"id":"https://openalex.org/C2779626144","wikidata":"https://www.wikidata.org/wiki/Q403356","display_name":"Kampo","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/tkm2.70069","doi":"https://doi.org/10.1002/tkm2.70069","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.70069","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6719022393226624,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323314","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1613566907","https://openalex.org/W1990437594","https://openalex.org/W2041995729","https://openalex.org/W2064381459","https://openalex.org/W2148281700","https://openalex.org/W2749857261","https://openalex.org/W3041314293"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Aim":[1],"Influenza":[2,125],"A":[3],"virus":[4,46,56,126,181],"subverts":[5],"host":[6],"autophagy":[7,43,101,171,187],"by":[8,68,134],"impairing":[9],"autophagosome\u2013lysosome":[10],"fusion,":[11],"a":[12,19,58],"strategy":[13],"that":[14,168],"supports":[15],"viral":[16,112,123],"replication.":[17],"Maoto,":[18],"traditional":[20,204],"Kampo":[21],"medicine,":[22],"exhibits":[23],"antiviral":[24,104,160,175,200],"activity":[25,161,176],"against":[26],"influenza":[27,45,54,180],"through":[28],"multiple":[29],"mechanisms.":[30],"This":[31],"study":[32],"aimed":[33],"to":[34,96,102,173],"examine":[35],"whether":[36],"maoto":[37,178],"is":[38],"associated":[39],"with":[40,53],"modulation":[41,169],"of":[42,60,62,89,100,106,130,136,149,162,170,177,185,192,202],"during":[44,118,179],"infection.":[47,182],"Methods":[48],"A549":[49],"cells":[50],"were":[51,66,77],"infected":[52],"A/PR8":[55],"at":[57],"multiplicity":[59],"infection":[61,127],"1.":[63],"Viral":[64],"titers":[65,113],"quantified":[67],"TCID":[69],"50":[70],"assays":[71],"using":[72,79],"MDCK":[73],"cells.":[74],"Autophagy\u2010related":[75],"processes":[76],"analyzed":[78],"GFP\u2010LC3,":[80],"Lysotracker":[81],"staining,":[82],"and":[83,92],"LC3":[84],"turnover":[85],"assays.":[86],"siRNA\u2010mediated":[87],"knockdown":[88],"Beclin":[90,150],"1":[91,151],"Atg14":[93,153],"was":[94],"performed":[95],"assess":[97],"the":[98,103,119,159,174,193,198],"contribution":[99],"effects":[105,201],"maoto.":[107,163],"Results":[108],"Maoto":[109,139],"significantly":[110],"reduced":[111],"when":[114],"administered":[115],"before":[116],"or":[117,152],"early":[120],"phase":[121],"after":[122],"entry.":[124],"induced":[128],"perturbations":[129],"autophagic":[131,146],"flux,":[132],"characterized":[133],"accumulation":[135],"immature":[137],"autophagosomes.":[138],"treatment":[140],"partially":[141],"counteracted":[142],"these":[143],"alterations":[144],"in":[145],"flux.":[147],"Knockdown":[148],"attenuated,":[154],"but":[155],"did":[156],"not":[157],"abolish,":[158],"Conclusion":[164],"These":[165],"findings":[166],"suggest":[167],"contributes":[172],"Partial":[183],"alleviation":[184],"virus\u2010induced":[186],"impairment":[188],"may":[189],"represent":[190],"one":[191],"complementary":[194],"host\u2010directed":[195],"mechanisms":[196],"underlying":[197],"multifaceted":[199],"this":[203],"medicine.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-06-26T00:00:00"}
