{"id":"https://openalex.org/W7165924435","doi":"https://doi.org/10.35630/2026/16/iss.3.08","title":"PERIOPERATIVE AND NEOADJUVANT IMMUNOTHERAPY IN RESECTABLE NON-SMALL CELL LUNG CANCER: CURRENT EVIDENCE, BIOMARKERS AND FUTURE DIRECTIONS","display_name":"PERIOPERATIVE AND NEOADJUVANT IMMUNOTHERAPY IN RESECTABLE NON-SMALL CELL LUNG CANCER: CURRENT EVIDENCE, BIOMARKERS AND FUTURE DIRECTIONS","publication_year":2026,"publication_date":"2026-06-25","ids":{"openalex":"https://openalex.org/W7165924435","doi":"https://doi.org/10.35630/2026/16/iss.3.08"},"language":"en","primary_location":{"id":"doi:10.35630/2026/16/iss.3.08","doi":"https://doi.org/10.35630/2026/16/iss.3.08","is_oa":false,"landing_page_url":"https://doi.org/10.35630/2026/16/iss.3.08","pdf_url":null,"source":{"id":"https://openalex.org/S4210173642","display_name":"Archiv Euromedica","issn_l":"2193-3863","issn":["2193-3863","2199-885X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archiv Euromedica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133491472","display_name":"Paulina Klaudia Gryz","orcid":"https://orcid.org/0009-0009-5503-5992","observed_orcids":["https://orcid.org/0009-0009-5503-5992","https://orcid.org/0000-0003-4764-9192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulina Klaudia Gryz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5503-5992","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133558279","display_name":"Anna Baczy\u0144ska","orcid":"https://orcid.org/0009-0000-7597-7842","observed_orcids":["https://orcid.org/0009-0000-7597-7842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Baczy\u0144ska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7597-7842","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133509437","display_name":"B\u0142a\u017cej Boruszczak","orcid":"https://orcid.org/0009-0009-6559-2733","observed_orcids":["https://orcid.org/0009-0009-6559-2733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u0142a\u017cej Boruszczak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-6559-2733","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133551602","display_name":"Hubert Jaros\u0142aw \u0106wiek","orcid":"https://orcid.org/0009-0003-8152-4294","observed_orcids":["https://orcid.org/0009-0003-8152-4294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Jaros\u0142aw \u0106wiek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-8152-4294","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133510863","display_name":"Marta Ko\u0142odziej-Sieradz","orcid":"https://orcid.org/0009-0006-0051-6332","observed_orcids":["https://orcid.org/0009-0006-0051-6332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Ko\u0142odziej-Sieradz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-0051-6332","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133522578","display_name":"Kacper Komorowski","orcid":"https://orcid.org/0009-0008-3856-5150","observed_orcids":["https://orcid.org/0009-0008-3856-5150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kacper Komorowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-3856-5150","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133540299","display_name":"Karolina Jolanta Pilarska","orcid":"https://orcid.org/0009-0001-5475-5199","observed_orcids":["https://orcid.org/0009-0001-5475-5199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karolina Jolanta Pilarska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5475-5199","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133531265","display_name":"Adam Wiktor Ro\u017cenek","orcid":"https://orcid.org/0009-0008-3150-3117","observed_orcids":["https://orcid.org/0009-0008-3150-3117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Wiktor Ro\u017cenek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-3150-3117","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133494448","display_name":"Anna Aleksandra Szwankowska","orcid":"https://orcid.org/0009-0009-3942-6969","observed_orcids":["https://orcid.org/0009-0009-3942-6969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Aleksandra Szwankowska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-3942-6969","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5093511497","display_name":"Anna Magdalena Terlecka","orcid":"https://orcid.org/0009-0000-1900-7155","observed_orcids":["https://orcid.org/0009-0000-1900-7155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Magdalena Terlecka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-1900-7155","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.453900009393692,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/perioperative-immunotherapy","display_name":"perioperative immunotherapy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neoadjuvant-immunotherapy","display_name":"neoadjuvant immunotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/resectable-lung-cancer","display_name":"resectable lung cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pathological-response","display_name":"pathological response","score":0.6330000162124634},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.7440000176429749},{"id":"https://openalex.org/keywords/postoperative-recurrence","display_name":"postoperative recurrence","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9017999768257141},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.7786999940872192},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7038999795913696},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.636900007724762},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.6096000075340271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5544000267982483},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.43709999322891235},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4059999883174896},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3831000030040741},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C2777589429","wikidata":"https://www.wikidata.org/wiki/Q46565","display_name":"Pneumonectomy","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.2939999997615814},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.28130000829696655},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26080000400543213},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35630/2026/16/iss.3.08","doi":"https://doi.org/10.35630/2026/16/iss.3.08","is_oa":false,"landing_page_url":"https://doi.org/10.35630/2026/16/iss.3.08","pdf_url":null,"source":{"id":"https://openalex.org/S4210173642","display_name":"Archiv Euromedica","issn_l":"2193-3863","issn":["2193-3863","2199-885X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archiv Euromedica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313037203","https://openalex.org/W4391509144","https://openalex.org/W7130599344","https://openalex.org/W7166562223","https://openalex.org/W4290958826","https://openalex.org/W4318043110","https://openalex.org/W7222997156","https://openalex.org/W7147484821","https://openalex.org/W7117360307","https://openalex.org/W4321349977"],"abstract_inverted_index":{"Background":[0],"Non-small":[1],"cell":[2],"lung":[3],"cancer":[4],"(NSCLC)":[5],"is":[6,24,261],"one":[7],"of":[8,18,115,168,205,219,251,276],"the":[9,15,25,50,101,166,217,246,272],"most":[10],"common":[11],"malignancies":[12],"and":[13,52,66,84,103,118,139,162,178,209,221,253,269],"remains":[14],"leading":[16],"cause":[17],"cancer-related":[19],"mortality":[20],"worldwide.":[21],"Although":[22],"surgery":[23],"main":[26],"treatment":[27,78,248],"modality":[28],"for":[29,86],"resectable":[30,70,149,185,228],"disease,":[31],"recurrence":[32],"rates":[33,177],"after":[34],"curative-intent":[35],"resection":[36],"remain":[37,257],"high.":[38],"In":[39],"recent":[40],"years,":[41],"immune":[42,169],"checkpoint":[43,170],"inhibitors":[44,171],"have":[45],"been":[46],"increasingly":[47],"investigated":[48],"in":[49,69,148,182,224],"neoadjuvant":[51,67,146,220],"perioperative":[53,65,144,222,277],"settings.":[54],"Aims":[55],"This":[56,90],"narrative":[57,91],"review":[58,92],"aimed":[59],"to":[60,127,143,172,263,270],"summarise":[61],"current":[62],"evidence":[63,215,232],"on":[64,75,95],"immunotherapy":[68,147,223],"NSCLC,":[71],"with":[72,184,202,227],"particular":[73],"emphasis":[74],"differences":[76],"between":[77],"strategies,":[79],"clinical":[80,87,119,137,274],"outcomes,":[81],"safety,":[82],"biomarkers":[83],"implications":[85],"practice.":[88],"Methods":[89],"was":[93,109,130],"based":[94],"a":[96],"literature":[97],"search":[98,108],"performed":[99],"using":[100],"PubMed":[102],"Google":[104],"Scholar":[105],"databases.":[106],"The":[107,230],"supplemented":[110],"by":[111],"screening":[112],"reference":[113],"lists":[114],"relevant":[116,142],"articles":[117],"trial":[120],"registries.":[121],"Literature":[122],"published":[123],"from":[124,234],"database":[125],"inception":[126],"March":[128],"2026":[129],"considered.":[131],"Clinical":[132],"trials,":[133,157,237],"meta-analyses,":[134],"systematic":[135],"reviews,":[136],"guidelines":[138],"translational":[140],"studies":[141,241],"or":[145],"NSCLC":[150],"were":[151],"included.":[152],"Results":[153],"Landmark":[154],"phase":[155,235,239],"III":[156,236],"including":[158,190],"CheckMate":[159],"816,":[160],"KEYNOTE-671":[161],"AEGEAN,":[163],"demonstrated":[164],"that":[165],"addition":[167],"chemotherapy":[173],"improved":[174],"pathological":[175],"response":[176],"prolonged":[179],"event-free":[180],"survival":[181,267],"patients":[183,226],"NSCLC.":[186,229],"Phase":[187],"II":[188,240],"studies,":[189],"NADIM,":[191],"provided":[192],"further":[193],"supportive":[194,243],"evidence,":[195],"although":[196],"their":[197],"findings":[198],"should":[199],"be":[200],"interpreted":[201],"caution":[203],"because":[204],"smaller":[206],"sample":[207],"sizes":[208],"study":[210],"design":[211],"limitations.":[212],"Conclusions":[213],"Current":[214],"supports":[216],"use":[218],"selected":[225],"strongest":[231],"comes":[233],"while":[238],"provide":[242],"data.":[244],"However,":[245],"optimal":[247],"strategy,":[249],"duration":[250],"therapy":[252],"biomarker-based":[254],"patient":[255],"selection":[256],"unresolved.":[258],"Longer":[259],"follow-up":[260],"required":[262],"confirm":[264],"mature":[265],"overall":[266],"outcomes":[268],"define":[271],"long-term":[273],"benefit":[275],"immunotherapy.":[278]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-26T00:00:00"}