{"id":"https://openalex.org/W7165882810","doi":"https://doi.org/10.1007/s10237-026-02090-6","title":"Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis","display_name":"Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7165882810","doi":"https://doi.org/10.1007/s10237-026-02090-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42350797"},"language":"en","primary_location":{"id":"doi:10.1007/s10237-026-02090-6","doi":"https://doi.org/10.1007/s10237-026-02090-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10237-026-02090-6","pdf_url":null,"source":{"id":"https://openalex.org/S11710983","display_name":"Biomechanics and Modeling in Mechanobiology","issn_l":"1617-7940","issn":["1617-7940","1617-7959"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomechanics and Modeling in Mechanobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10237-026-02090-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063409629","display_name":"J. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["National Centre for Advanced Tribology at Southampton, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Advanced Tribology at Southampton, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082613480","display_name":"Orestis L. Katsamenis","orcid":"https://orcid.org/0000-0003-4367-4147","observed_orcids":["https://orcid.org/0000-0003-4367-4147"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Orestis L. Katsamenis","raw_affiliation_strings":["Bioengineering Science Research Group, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK","\u03bc-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Science Research Group, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"\u03bc-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040913624","display_name":"Georges Limbert","orcid":"https://orcid.org/0000-0002-4268-6106","observed_orcids":["https://orcid.org/0000-0002-4268-6106"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["CN","GB","ZA"],"is_corresponding":true,"raw_author_name":"Georges Limbert","raw_affiliation_strings":["Bioengineering Science Research Group, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK. g.limbert@soton.ac.uk","Laboratory of Biomechanics and Mechanobiology, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, 7935, Observatory, South Africa. g.limbert@soton.ac.uk","National Centre for Advanced Tribology at Southampton, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK. g.limbert@soton.ac.uk","School of Mechanics and Aerospace Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, People's Republic of China. g.limbert@soton.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Science Research Group, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK. g.limbert@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Laboratory of Biomechanics and Mechanobiology, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, 7935, Observatory, South Africa. g.limbert@soton.ac.uk","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"National Centre for Advanced Tribology at Southampton, Department of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK. g.limbert@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"School of Mechanics and Aerospace Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, People's Republic of China. g.limbert@soton.ac.uk","institution_ids":["https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040913624"],"corresponding_institution_ids":["https://openalex.org/I157614274","https://openalex.org/I27357992","https://openalex.org/I43439940"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37738958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11558","display_name":"Composite Material Mechanics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-dermis","display_name":"human dermis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/collagen-fiber-orientation","display_name":"collagen fiber orientation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/micromechanical-modeling","display_name":"micromechanical modeling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/structure-tensor-analysis","display_name":"structure tensor analysis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/transversely-isotropic-hyperelasticity","display_name":"transversely isotropic hyperelasticity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fiber-dispersion","display_name":"fiber dispersion","score":0.5370000004768372},{"id":"https://openalex.org/keywords/collagen-structure","display_name":"collagen structure","score":0.4819999933242798},{"id":"https://openalex.org/keywords/skin-mechanics","display_name":"skin biomechanics","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C37167619","wikidata":"https://www.wikidata.org/wiki/Q3312239","display_name":"Micromechanics","level":3,"score":0.7803000211715698},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7455999851226807},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.654699981212616},{"id":"https://openalex.org/C108729823","wikidata":"https://www.wikidata.org/wiki/Q3716064","display_name":"Stiffening","level":2,"score":0.5343000292778015},{"id":"https://openalex.org/C85725439","wikidata":"https://www.wikidata.org/wiki/Q466686","display_name":"Anisotropy","level":2,"score":0.5246000289916992},{"id":"https://openalex.org/C101842124","wikidata":"https://www.wikidata.org/wiki/Q2449817","display_name":"Transverse isotropy","level":3,"score":0.4848000109195709},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.4343999922275543},{"id":"https://openalex.org/C184050105","wikidata":"https://www.wikidata.org/wiki/Q273163","display_name":"Isotropy","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C22411076","wikidata":"https://www.wikidata.org/wiki/Q668113","display_name":"Hexahedron","level":3,"score":0.4196999967098236},{"id":"https://openalex.org/C131336679","wikidata":"https://www.wikidata.org/wiki/Q901006","display_name":"Orthotropic material","level":3,"score":0.38190001249313354},{"id":"https://openalex.org/C2780757906","wikidata":"https://www.wikidata.org/wiki/Q5276676","display_name":"Dilation (metric space)","level":2,"score":0.38119998574256897},{"id":"https://openalex.org/C193867417","wikidata":"https://www.wikidata.org/wiki/Q6889814","display_name":"Modulus","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C155281189","wikidata":"https://www.wikidata.org/wiki/Q3518150","display_name":"Tensor (intrinsic definition)","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C29320194","wikidata":"https://www.wikidata.org/wiki/Q7201019","display_name":"Plane stress","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C121854251","wikidata":"https://www.wikidata.org/wiki/Q62932","display_name":"Elasticity (physics)","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C31555180","wikidata":"https://www.wikidata.org/wiki/Q3523867","display_name":"Material properties","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C202973686","wikidata":"https://www.wikidata.org/wiki/Q1937401","display_name":"Constitutive equation","level":3,"score":0.3255000114440918},{"id":"https://openalex.org/C147370603","wikidata":"https://www.wikidata.org/wiki/Q3801506","display_name":"Hyperelastic material","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C31487907","wikidata":"https://www.wikidata.org/wiki/Q1154597","display_name":"Polygon mesh","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.27950000762939453},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C163892269","wikidata":"https://www.wikidata.org/wiki/Q15300737","display_name":"Finite strain theory","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.27079999446868896},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C196029304","wikidata":"https://www.wikidata.org/wiki/Q2091584","display_name":"Young's modulus","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.25839999318122864},{"id":"https://openalex.org/C32833848","wikidata":"https://www.wikidata.org/wiki/Q4115054","display_name":"Extensibility","level":2,"score":0.2556999921798706}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10237-026-02090-6","doi":"https://doi.org/10.1007/s10237-026-02090-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10237-026-02090-6","pdf_url":null,"source":{"id":"https://openalex.org/S11710983","display_name":"Biomechanics and Modeling in Mechanobiology","issn_l":"1617-7940","issn":["1617-7940","1617-7959"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomechanics and Modeling in Mechanobiology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-8789068/v1","doi":"https://doi.org/10.21203/rs.3.rs-8789068/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8789068/v1","pdf_url":"https://www.researchsquare.com/article/rs-8789068/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:42350797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42350797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomechanics and modeling in mechanobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13303350","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42350797/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomech Model Mechanobiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10237-026-02090-6","doi":"https://doi.org/10.1007/s10237-026-02090-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10237-026-02090-6","pdf_url":null,"source":{"id":"https://openalex.org/S11710983","display_name":"Biomechanics and Modeling in Mechanobiology","issn_l":"1617-7940","issn":["1617-7940","1617-7959"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomechanics and Modeling in Mechanobiology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4820257642","display_name":"National Research Facility for Lab X-ray CT","funder_award_id":"EP/T02593X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320277","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543"},{"id":"https://openalex.org/F4320329624","display_name":"Roche Diabetes Care","ror":null},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W151104881","https://openalex.org/W180841315","https://openalex.org/W633407952","https://openalex.org/W889100393","https://openalex.org/W1836289879","https://openalex.org/W1948231917","https://openalex.org/W1976933585","https://openalex.org/W1981397830","https://openalex.org/W1984824517","https://openalex.org/W1985233782","https://openalex.org/W1987854799","https://openalex.org/W1993294353","https://openalex.org/W1994570526","https://openalex.org/W1998537763","https://openalex.org/W2003092644","https://openalex.org/W2012736920","https://openalex.org/W2016193552","https://openalex.org/W2016266030","https://openalex.org/W2023108847","https://openalex.org/W2033367967","https://openalex.org/W2038665424","https://openalex.org/W2039797495","https://openalex.org/W2044148298","https://openalex.org/W2053068826","https://openalex.org/W2056298986","https://openalex.org/W2056438456","https://openalex.org/W2059010914","https://openalex.org/W2059224163","https://openalex.org/W2063069344","https://openalex.org/W2073160989","https://openalex.org/W2073163692","https://openalex.org/W2085694776","https://openalex.org/W2099885273","https://openalex.org/W2100523924","https://openalex.org/W2109062539","https://openalex.org/W2115352852","https://openalex.org/W2120910876","https://openalex.org/W2121329108","https://openalex.org/W2127722806","https://openalex.org/W2128569032","https://openalex.org/W2129053762","https://openalex.org/W2146112273","https://openalex.org/W2148646485","https://openalex.org/W2154577866","https://openalex.org/W2159227957","https://openalex.org/W2160075959","https://openalex.org/W2166739553","https://openalex.org/W2167279371","https://openalex.org/W2195928948","https://openalex.org/W2232241375","https://openalex.org/W2318163251","https://openalex.org/W2338382002","https://openalex.org/W2397071937","https://openalex.org/W2413852627","https://openalex.org/W2469683796","https://openalex.org/W2471882967","https://openalex.org/W2520314182","https://openalex.org/W2548247411","https://openalex.org/W2554346696","https://openalex.org/W2555014301","https://openalex.org/W2559385252","https://openalex.org/W2602753961","https://openalex.org/W2612321476","https://openalex.org/W2614518491","https://openalex.org/W2620855806","https://openalex.org/W2736556908","https://openalex.org/W2793588385","https://openalex.org/W2801018675","https://openalex.org/W2885344721","https://openalex.org/W2910744418","https://openalex.org/W2920508044","https://openalex.org/W2939835156","https://openalex.org/W2944987242","https://openalex.org/W2947497498","https://openalex.org/W2947824415","https://openalex.org/W2947970624","https://openalex.org/W2947996685","https://openalex.org/W2974311424","https://openalex.org/W2982269720","https://openalex.org/W2996055831","https://openalex.org/W2997857110","https://openalex.org/W3081157633","https://openalex.org/W3093668091","https://openalex.org/W3132820744","https://openalex.org/W3158905681","https://openalex.org/W3180612993","https://openalex.org/W3195343650","https://openalex.org/W3196977363","https://openalex.org/W3207021014","https://openalex.org/W4220832365","https://openalex.org/W4224074227","https://openalex.org/W4240622873","https://openalex.org/W4246580579","https://openalex.org/W4248352086","https://openalex.org/W4280522634","https://openalex.org/W4287252554","https://openalex.org/W4306755968","https://openalex.org/W4321460281","https://openalex.org/W4384828996","https://openalex.org/W4385396537","https://openalex.org/W4386002664","https://openalex.org/W4386002840","https://openalex.org/W4388037109","https://openalex.org/W4390044229","https://openalex.org/W4392086155","https://openalex.org/W4392847554","https://openalex.org/W4392980419","https://openalex.org/W4400871227","https://openalex.org/W4403237251","https://openalex.org/W4403457594","https://openalex.org/W4406567381","https://openalex.org/W4406933483"],"related_works":[],"abstract_inverted_index":{"While":[0],"continuum":[1],"fibre-reinforced":[2],"constitutive":[3],"models":[4,100],"of":[5,17,153,200,231],"collagen-rich":[6],"soft":[7,232],"tissues":[8,233],"incorporate":[9],"microstructural":[10,208],"information":[11],"via":[12,72],"structure":[13,73],"tensor":[14,74],"invariants,":[15],"most":[16],"their":[18],"numerical":[19],"implementations":[20],"assume":[21],"spatially":[22,30,102],"uniform":[23,103],"fibre":[24,68,104,124,189,198,213],"orientations.":[25],"This":[26],"study":[27],"examined":[28],"how":[29],"heterogeneous":[31,140],"orientations,":[32],"captured":[33,58],"by":[34,150],"high-resolution":[35],"imaging":[36],"and":[37,96,137,157,225,236,240],"embedded":[38],"in":[39,84],"image-based":[40],"finite":[41],"element":[42],"models,":[43],"could":[44],"provide":[45],"novel":[46],"mechanistic":[47,220],"insights":[48,221],"into":[49,222],"tissue":[50],"micromechanics.":[51],"Serial":[52],"block-face":[53],"scanning":[54],"electron":[55],"microscopy":[56],"(SBF-SEM)":[57],"collagen":[59],"architecture":[60],"from":[61,207,234],"fresh":[62],"human":[63],"skin":[64],"dermis.":[65],"Voxel-level":[66],"3D":[67],"orientations":[69,81],"were":[70,82],"extracted":[71],"analysis.":[75],"Voxel-based":[76],"hexahedral":[77],"meshes":[78],"with":[79,86,101,121,135,171],"element-level":[80],"implemented":[83],"Abaqus/Standard":[85],"custom":[87],"UMATs\u00ae":[88],"user":[89],"subroutines":[90],"for":[91,182,197],"invariant-based":[92],"transversely":[93],"isotropic":[94],"hyperelasticity,":[95],"compared":[97],"to":[98,227,238],"classical":[99],"distributions":[105],"under":[106],"various":[107],"loading":[108],"conditions.":[109],"Spatial":[110],"heterogeneity":[111],"significantly":[112],"altered":[113],"micromechanical":[114],"responses.":[115],"Under":[116],"pseudo-homogeneous":[117],"uniaxial":[118],"extension":[119],"aligned":[120],"the":[122,204],"mean":[123],"orientation,":[125,129],"Models":[126,183],"1A":[127],"(uniform":[128,133],"no":[130],"dispersion),":[131,136],"1B":[132],"orientation":[134],"1C":[138,192],"(spatially":[139],"orientations)":[141],"yielded":[142],"nominal":[143],"stresses":[144],"at":[145,175,180],"44.6%":[146],"Green-Lagrange":[147],"strain":[148,166],"differing":[149],"a":[151,168,172,186,228],"factor":[152],"four":[154],"(0.5,":[155],"0.8":[156],"2.1":[158],"MPa,":[159,202],"respectively).":[160],"Model":[161,191],"1C's":[162],"maximum":[163],"principal":[164],"logarithmic":[165],"showed":[167],"broader":[169],"range":[170,230],"secondary":[173],"peak":[174],"0.5":[176],"versus":[177],"unimodal":[178],"peaks":[179],"0.3":[181],"1A/B.":[184],"With":[185],"purely":[187],"quadratic":[188],"energy,":[190],"recovered":[193],"exponential-like":[194],"macroscopic":[195],"stiffening":[196],"moduli":[199],"25-500":[201],"confirming":[203],"J-shape":[205],"arises":[206],"mechanism":[209],"rather":[210],"than":[211],"through":[212],"material":[214],"nonlinearity.":[215],"The":[216],"methodology":[217],"delivers":[218],"quantitative":[219],"dermal":[223],"micromechanics":[224],"generalises":[226],"wide":[229],"cornea":[235],"cartilage":[237],"arteries":[239],"lungs.":[241]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-06-26T00:00:00"}
