{"id":"https://openalex.org/W7165652003","doi":"https://doi.org/10.1088/2053-1591/ae814d","title":"A pH-responsive metal-phenolic nanoplatform for integrated chemosensitization and cardioprotection via dual AKR1C3/survivin inhibition","display_name":"A pH-responsive metal-phenolic nanoplatform for integrated chemosensitization and cardioprotection via dual AKR1C3/survivin inhibition","publication_year":2026,"publication_date":"2026-06-23","ids":{"openalex":"https://openalex.org/W7165652003","doi":"https://doi.org/10.1088/2053-1591/ae814d"},"language":"en","primary_location":{"id":"doi:10.1088/2053-1591/ae814d","doi":"https://doi.org/10.1088/2053-1591/ae814d","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2053-1591/ae814d","pdf_url":null,"source":{"id":"https://openalex.org/S4210216311","display_name":"Materials Research Express","issn_l":"2053-1591","issn":["2053-1591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Research Express","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1088/2053-1591/ae814d","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022566213","display_name":"Fang Zhao","orcid":"https://orcid.org/0000-0002-5035-5753","observed_orcids":["https://orcid.org/0000-0002-5035-5753"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Zhao","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":"https://orcid.org/0000-0002-5035-5753","affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017121768","display_name":"Yumei Qian","orcid":"https://orcid.org/0000-0002-1692-6241","observed_orcids":["https://orcid.org/0000-0002-1692-6241"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumei Qian","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000074603","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0002-4091-8532","observed_orcids":["https://orcid.org/0000-0002-4091-8532","https://orcid.org/0000-0003-3703-2527","https://orcid.org/0000-0002-4225-5226","https://orcid.org/0000-0001-9467-0942","https://orcid.org/0000-0002-1438-9307","https://orcid.org/0000-0002-4310-1966","https://orcid.org/0000-0001-6180-676X","https://orcid.org/0000-0002-1364-8653","https://orcid.org/0000-0002-4040-2448","https://orcid.org/0000-0002-5662-4600","https://orcid.org/0000-0002-6134-6094","https://orcid.org/0000-0002-6287-1640","https://orcid.org/0000-0002-6636-8831","https://orcid.org/0000-0002-7825-0494","https://orcid.org/0000-0003-1015-8998","https://orcid.org/0000-0003-1048-7994","https://orcid.org/0000-0003-2089-186X","https://orcid.org/0000-0001-6051-4992","https://orcid.org/0000-0001-9386-5027","https://orcid.org/0000-0002-0754-935X","https://orcid.org/0000-0002-0947-3475","https://orcid.org/0000-0002-3144-8604","https://orcid.org/0000-0002-5276-4518","https://orcid.org/0000-0002-5598-6925","https://orcid.org/0000-0002-6972-8708","https://orcid.org/0000-0002-8209-2898","https://orcid.org/0000-0003-3964-2433","https://orcid.org/0000-0003-4431-2279","https://orcid.org/0000-0003-4674-4059","https://orcid.org/0009-0000-6572-6898","https://orcid.org/0009-0000-7907-9388","https://orcid.org/0009-0001-5752-0264","https://orcid.org/0009-0006-0540-4938","https://orcid.org/0009-0006-3953-305X","https://orcid.org/0009-0008-1843-5519","https://orcid.org/0000-0001-5065-2769","https://orcid.org/0000-0001-5604-5505","https://orcid.org/0000-0001-5988-1998","https://orcid.org/0000-0001-6489-286X","https://orcid.org/0000-0001-6682-6006","https://orcid.org/0000-0001-6772-5776","https://orcid.org/0000-0001-6868-5438","https://orcid.org/0000-0001-8495-6103","https://orcid.org/0000-0001-8623-0453","https://orcid.org/0000-0001-8687-4427","https://orcid.org/0000-0001-8785-2692","https://orcid.org/0000-0001-9807-6844","https://orcid.org/0000-0002-0005-7619","https://orcid.org/0000-0002-0130-9785","https://orcid.org/0000-0002-0491-8295","https://orcid.org/0000-0002-0815-2776","https://orcid.org/0000-0002-0864-9029","https://orcid.org/0000-0002-1488-4762","https://orcid.org/0000-0002-1490-6802","https://orcid.org/0000-0002-2135-5076","https://orcid.org/0000-0002-2971-7828","https://orcid.org/0000-0002-3362-7155","https://orcid.org/0000-0002-3530-3525","https://orcid.org/0000-0002-3537-1253","https://orcid.org/0000-0002-3860-8463","https://orcid.org/0000-0002-3872-5336","https://orcid.org/0000-0002-3931-4096","https://orcid.org/0000-0002-3968-7992","https://orcid.org/0000-0002-4186-3799","https://orcid.org/0000-0002-4495-0636","https://orcid.org/0000-0002-5070-4511","https://orcid.org/0000-0002-5241-5203","https://orcid.org/0000-0002-6278-4061","https://orcid.org/0000-0002-6489-4459","https://orcid.org/0000-0002-6561-9109","https://orcid.org/0000-0002-7132-5860","https://orcid.org/0000-0002-7378-8260","https://orcid.org/0000-0002-7540-892X","https://orcid.org/0000-0002-7669-768X","https://orcid.org/0000-0002-7680-1731","https://orcid.org/0000-0002-8071-629X","https://orcid.org/0000-0002-9266-8600","https://orcid.org/0000-0002-9477-2313","https://orcid.org/0000-0002-9609-6865","https://orcid.org/0000-0002-9799-3293","https://orcid.org/0000-0002-9831-8783","https://orcid.org/0000-0003-0566-4802","https://orcid.org/0000-0003-0633-8355","https://orcid.org/0000-0003-1033-8737","https://orcid.org/0000-0003-1995-7219","https://orcid.org/0000-0003-2266-6682","https://orcid.org/0000-0003-3526-560X","https://orcid.org/0000-0003-3689-6964","https://orcid.org/0000-0003-4250-3805","https://orcid.org/0000-0003-4271-3554","https://orcid.org/0009-0000-0235-1371","https://orcid.org/0009-0000-2097-9373","https://orcid.org/0009-0000-2610-7680","https://orcid.org/0009-0000-3730-6861","https://orcid.org/0009-0000-4637-4639","https://orcid.org/0009-0000-5296-5523","https://orcid.org/0009-0000-6509-5694","https://orcid.org/0009-0000-7131-1832","https://orcid.org/0009-0000-8564-9228","https://orcid.org/0009-0001-0338-8528","https://orcid.org/0009-0001-0383-126X","https://orcid.org/0009-0001-0703-8445","https://orcid.org/0009-0001-1212-3660","https://orcid.org/0009-0001-2852-6608","https://orcid.org/0009-0001-3206-6667","https://orcid.org/0009-0001-4443-0243","https://orcid.org/0009-0001-6723-4456","https://orcid.org/0009-0001-7156-743X","https://orcid.org/0009-0001-8004-8703","https://orcid.org/0009-0002-0806-4087","https://orcid.org/0009-0002-1771-3763","https://orcid.org/0009-0002-2959-4095","https://orcid.org/0009-0002-3110-8594","https://orcid.org/0009-0002-3999-0569","https://orcid.org/0009-0002-4946-5813","https://orcid.org/0009-0002-5125-5014","https://orcid.org/0009-0002-6785-8485","https://orcid.org/0009-0002-7667-6632","https://orcid.org/0009-0002-7856-1804","https://orcid.org/0009-0002-9567-1263","https://orcid.org/0009-0003-0192-6112","https://orcid.org/0009-0003-1350-7767","https://orcid.org/0009-0003-2133-4691","https://orcid.org/0009-0003-3358-4495","https://orcid.org/0009-0003-3395-2059","https://orcid.org/0009-0003-4252-2288","https://orcid.org/0009-0003-5606-5954","https://orcid.org/0009-0003-6026-0226","https://orcid.org/0009-0003-6306-9611","https://orcid.org/0009-0003-7714-0060","https://orcid.org/0009-0003-9738-4484","https://orcid.org/0009-0004-0953-5631","https://orcid.org/0009-0004-2597-460X","https://orcid.org/0009-0004-3989-5507","https://orcid.org/0009-0004-4464-6396","https://orcid.org/0009-0004-6178-6294","https://orcid.org/0009-0004-6249-7152","https://orcid.org/0009-0004-6732-8104","https://orcid.org/0009-0004-7233-8227","https://orcid.org/0009-0005-1496-9183","https://orcid.org/0009-0005-2539-6851","https://orcid.org/0009-0005-3453-9842","https://orcid.org/0009-0005-4380-9808","https://orcid.org/0009-0005-4913-5904","https://orcid.org/0009-0005-4922-8502","https://orcid.org/0009-0005-6609-3371","https://orcid.org/0009-0005-7123-9056","https://orcid.org/0009-0006-1342-3020","https://orcid.org/0009-0006-1836-0823","https://orcid.org/0009-0006-5733-8258","https://orcid.org/0009-0006-7931-8661","https://orcid.org/0009-0006-9458-9267","https://orcid.org/0009-0006-9629-7639","https://orcid.org/0009-0007-0195-0816","https://orcid.org/0009-0007-1120-2045","https://orcid.org/0009-0007-1342-272X","https://orcid.org/0009-0007-3011-530X","https://orcid.org/0009-0007-3259-798X","https://orcid.org/0009-0007-5621-8219","https://orcid.org/0009-0007-5894-4724","https://orcid.org/0009-0007-6119-6034","https://orcid.org/0009-0007-6270-7086","https://orcid.org/0009-0007-9873-799X","https://orcid.org/0009-0008-1257-9933","https://orcid.org/0009-0008-2210-3664","https://orcid.org/0009-0008-2458-4932","https://orcid.org/0009-0008-3637-7922","https://orcid.org/0009-0008-3789-3136","https://orcid.org/0009-0008-4576-9477","https://orcid.org/0009-0008-4640-5333","https://orcid.org/0009-0008-9069-1162","https://orcid.org/0009-0008-9817-1612","https://orcid.org/0009-0009-0547-0873","https://orcid.org/0009-0009-0688-5966","https://orcid.org/0009-0009-1012-801X","https://orcid.org/0009-0009-1925-9518","https://orcid.org/0009-0009-2931-9246","https://orcid.org/0009-0009-3980-9564","https://orcid.org/0009-0009-4389-583X","https://orcid.org/0009-0009-6469-9053","https://orcid.org/0009-0009-6668-2554","https://orcid.org/0009-0009-6915-6912","https://orcid.org/0009-0009-8140-7710","https://orcid.org/0009-0009-9094-6046"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088982859","display_name":"Hongxia Li","orcid":"https://orcid.org/0000-0002-0196-4296","observed_orcids":["https://orcid.org/0000-0002-0196-4296"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongxia Li","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139132378","display_name":"Xing Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Shan","raw_affiliation_strings":["School of Continuing Education, Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Continuing Education, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101695825","display_name":"Peng Lei","orcid":"https://orcid.org/0000-0002-7198-5711","observed_orcids":["https://orcid.org/0000-0002-7198-5711","https://orcid.org/0000-0002-1969-0035"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Peng","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052732777","display_name":"Lingling Shan","orcid":"https://orcid.org/0000-0002-8985-0997","observed_orcids":["https://orcid.org/0000-0002-8985-0997"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingling Shan","raw_affiliation_strings":["School of Biology and Food Engineering, Suzhou University"],"raw_orcid":"https://orcid.org/0000-0002-8985-0997","affiliations":[{"raw_affiliation_string":"School of Biology and Food Engineering, Suzhou University","institution_ids":["https://openalex.org/I4405254887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088982859"],"corresponding_institution_ids":["https://openalex.org/I4405254887"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"13","first_page":"135002","last_page":"135002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ph-responsive-drug-delivery","display_name":"pH-responsive drug delivery","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dihydromyricetin","display_name":"dihydromyricetin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.7590000033378601},{"id":"https://openalex.org/keywords/doxorubicinol","display_name":"doxorubicinol","score":0.7459999918937683},{"id":"https://openalex.org/keywords/anthracycline-resistance","display_name":"anthracycline resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.871999979019165},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.792900025844574},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.7312999963760376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6859999895095825},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6504999995231628},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6233000159263611},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5185999870300293},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46619999408721924},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4643000066280365},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4489000141620636},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4442000091075897},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.38670000433921814},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C3019325349","wikidata":"https://www.wikidata.org/wiki/Q3874753","display_name":"Dual mode","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C3019440502","wikidata":"https://www.wikidata.org/wiki/Q500430","display_name":"Dual role","level":2,"score":0.2606000006198883}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1088/2053-1591/ae814d","doi":"https://doi.org/10.1088/2053-1591/ae814d","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2053-1591/ae814d","pdf_url":null,"source":{"id":"https://openalex.org/S4210216311","display_name":"Materials Research Express","issn_l":"2053-1591","issn":["2053-1591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Research Express","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:eb0bd8a5f1fb497e8e7b58849ee6c272","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/eb0bd8a5f1fb497e8e7b58849ee6c272","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Research Express, Vol 13, Iss 13, p 135002 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1088/2053-1591/ae814d","doi":"https://doi.org/10.1088/2053-1591/ae814d","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2053-1591/ae814d","pdf_url":null,"source":{"id":"https://openalex.org/S4210216311","display_name":"Materials Research Express","issn_l":"2053-1591","issn":["2053-1591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Research Express","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320336618","display_name":"Science and Technology Program of Suzhou","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1973461890","https://openalex.org/W1983461177","https://openalex.org/W1985892485","https://openalex.org/W1990197810","https://openalex.org/W2009190051","https://openalex.org/W2076115473","https://openalex.org/W2077680152","https://openalex.org/W2462022051","https://openalex.org/W2557143494","https://openalex.org/W2565481405","https://openalex.org/W2565830107","https://openalex.org/W2608742026","https://openalex.org/W2732780281","https://openalex.org/W2754675042","https://openalex.org/W2889362289","https://openalex.org/W2902267205","https://openalex.org/W2921102985","https://openalex.org/W2939798497","https://openalex.org/W2942527068","https://openalex.org/W2947130426","https://openalex.org/W2954312145","https://openalex.org/W2962839931","https://openalex.org/W3000437332","https://openalex.org/W3003440392","https://openalex.org/W3007492121","https://openalex.org/W3007915375","https://openalex.org/W3012019026","https://openalex.org/W3015651035","https://openalex.org/W3034149341","https://openalex.org/W3038332328","https://openalex.org/W3114384318","https://openalex.org/W3117852386","https://openalex.org/W3155865225","https://openalex.org/W3157067843","https://openalex.org/W3179383087","https://openalex.org/W3205499635","https://openalex.org/W4200296838","https://openalex.org/W4206039157","https://openalex.org/W4206273666","https://openalex.org/W4211149894","https://openalex.org/W4282840856","https://openalex.org/W4282974577","https://openalex.org/W4327732491","https://openalex.org/W4396536484","https://openalex.org/W4403412903","https://openalex.org/W4403965455","https://openalex.org/W4404153170","https://openalex.org/W4408592805","https://openalex.org/W4416272396","https://openalex.org/W4417114895"],"related_works":["https://openalex.org/W7160331082","https://openalex.org/W4385900130","https://openalex.org/W4388423704","https://openalex.org/W4412594497","https://openalex.org/W3096995764","https://openalex.org/W4408246202","https://openalex.org/W7128395856","https://openalex.org/W4385564815","https://openalex.org/W4415113768","https://openalex.org/W7221459413"],"abstract_inverted_index":{"Abstract":[0],"The":[1,50],"clinical":[2,195],"utility":[3],"of":[4,16,114,141,182],"doxorubicin":[5],"(DOX)":[6],"is":[7],"significantly":[8,72],"hindered":[9],"by":[10,35],"potent":[11],"cardiotoxicity":[12,184],"and":[13,46,61,88,108,122,180],"the":[14,36,68,81,85,105,112,139],"emergence":[15],"drug":[17],"resistance.":[18],"To":[19],"circumvent":[20],"these":[21],"limitations,":[22],"we":[23],"engineered":[24],"a":[25,62,71,174,186],"multifunctional,":[26],"self-assembled":[27],"coordination":[28,38,189],"nanoplatform-DOX/DMY-Fe":[29],"3+":[30,41],"@PEG":[31],"nanoparticles":[32],"(DDFP":[33],"NPs)-driven":[34],"metal-phenolic":[37],"between":[39],"Fe":[40],",":[42],"DOX,":[43],"dihydromyricetin":[44],"(DMY),":[45],"polyethylene":[47],"glycol":[48],"(PEG)-polyphenols.":[49],"resulting":[51],"DDFP":[52,96,158],"NPs":[53,97,159],"exhibited":[54],"high":[55],"drug-loading":[56],"capacity,":[57],"robust":[58,175],"colloidal":[59],"stability,":[60],"distinct":[63],"pH-responsive":[64],"release":[65],"profile.":[66],"Furthermore,":[67],"nanoplatform":[69],"demonstrated":[70],"prolonged":[73],"systemic":[74],"half-life,":[75],"which":[76],"facilitated":[77],"preferential":[78],"accumulation":[79],"within":[80],"tumor":[82,130],"microenvironment":[83],"via":[84],"enhanced":[86],"permeability":[87],"retention":[89],"effect.":[90],"In":[91,149],"vitro":[92],"investigations":[93],"revealed":[94],"that":[95,157,177],"efficiently":[98],"internalized":[99],"into":[100,143],"U87MG":[101,153],"glioma":[102],"cells,":[103],"where":[104],"co-delivered":[106],"DMY":[107],"DOX":[109,142],"synergistically":[110],"downregulated":[111],"expression":[113],"aldo-keto":[115],"reductase":[116],"family":[117],"1":[118],"member":[119],"C3":[120],"(AKR1C3)":[121],"Survivin.":[123],"This":[124],"dual-target":[125],"reduction":[126],"not":[127],"only":[128],"sensitized":[129],"cells":[131],"to":[132],"DOX-induced":[133],"apoptosis":[134],"but":[135],"also":[136],"potentially":[137],"suppressed":[138],"bioreduction":[140],"its":[144],"cardiotoxic":[145],"metabolite,":[146],"doxorubicinol":[147],"(DOXOL).":[148],"vivo":[150],"evaluations":[151],"in":[152,197],"xenograft":[154],"models":[155],"confirmed":[156],"achieved":[160],"superior":[161],"antitumor":[162],"efficacy":[163],"while":[164],"markedly":[165],"alleviating":[166],"DOX-associated":[167],"myocardial":[168],"damage.":[169],"Collectively,":[170],"this":[171],"study":[172],"establishes":[173],"nano-strategy":[176],"integrates":[178],"chemosensitization":[179],"attenuation":[181],"acute":[183],"through":[185],"rationally":[187],"designed":[188],"system,":[190],"offering":[191],"significant":[192],"potential":[193],"for":[194],"translation":[196],"anthracycline-based":[198],"cancer":[199],"therapy.":[200]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-06-24T00:00:00"}