{"id":"https://openalex.org/W7165637191","doi":"https://doi.org/10.5281/zenodo.20817608","title":"Multi-Omics Characterization of Fish Responses to Emerging Environmental Contaminants: Implications for Aquatic Toxicology and Sustainable Fisheries Management","display_name":"Multi-Omics Characterization of Fish Responses to Emerging Environmental Contaminants: Implications for Aquatic Toxicology and Sustainable Fisheries Management","publication_year":2026,"publication_date":"2026-06-23","ids":{"openalex":"https://openalex.org/W7165637191","doi":"https://doi.org/10.5281/zenodo.20817608"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.pakjmcr.com:article/1321","doi":null,"is_oa":true,"landing_page_url":"https://pakjmcr.com/index.php/1/article/view/1321","pdf_url":"https://pakjmcr.com/index.php/1/article/download/1321/1287","source":{"id":"https://openalex.org/S5407043329","display_name":"Pakistan Journal of Medical & Cardiological Review","issn_l":"3007-2379","issn":["3007-2379","3007-2387"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3007-2379","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pakjmcr.com/index.php/1/article/download/1321/1287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139190209","display_name":"Pakistan Journal of Medical & Cardiological Review","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pakistan Journal of Medical & Cardiological Review","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5139190209"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.6304,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.98771319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emerging-contaminants","display_name":"emerging contaminants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fish-toxicity","display_name":"fish toxicity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/contaminant-mixtures","display_name":"contaminant mixtures","score":0.8519999980926514},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.800000011920929},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/reproductive-impairment","display_name":"reproductive impairment","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.593999981880188},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4560000002384186},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7039999961853027},{"id":"https://openalex.org/keywords/toxicity-assessment","display_name":"toxicity prediction","score":0.5429999828338623},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6880000233650208},{"id":"https://openalex.org/keywords/sustainable-fisheries-management","display_name":"sustainable fisheries management","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pfas","display_name":"PFAS","score":0.6579999923706055},{"id":"https://openalex.org/keywords/microplastics","display_name":"microplastics","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pharmaceutical-pollutants","display_name":"pharmaceutical pollutants","score":0.8299999833106995},{"id":"https://openalex.org/keywords/personal-care-products","display_name":"personal care products","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nanomaterials","display_name":"nanomaterials","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.5465999841690063},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.5339000225067139},{"id":"https://openalex.org/C158278297","wikidata":"https://www.wikidata.org/wiki/Q1756633","display_name":"Aquatic animal","level":3,"score":0.399399995803833},{"id":"https://openalex.org/C91375879","wikidata":"https://www.wikidata.org/wiki/Q15473274","display_name":"Environmental planning","level":1,"score":0.37779998779296875},{"id":"https://openalex.org/C66204764","wikidata":"https://www.wikidata.org/wiki/Q219416","display_name":"Sustainability","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C202041845","wikidata":"https://www.wikidata.org/wiki/Q5454893","display_name":"Fisheries management","level":3,"score":0.3630000054836273},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.352400004863739},{"id":"https://openalex.org/C8381438","wikidata":"https://www.wikidata.org/wiki/Q4117900","display_name":"Aquatic toxicology","level":3,"score":0.35019999742507935},{"id":"https://openalex.org/C514101110","wikidata":"https://www.wikidata.org/wiki/Q14373","display_name":"Fishing","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C175327387","wikidata":"https://www.wikidata.org/wiki/Q3289906","display_name":"Aquatic ecosystem","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C2991714712","wikidata":"https://www.wikidata.org/wiki/Q3289906","display_name":"Aquatic environment","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C107826830","wikidata":"https://www.wikidata.org/wiki/Q929380","display_name":"Environmental resource management","level":1,"score":0.3246999979019165},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.31040000915527344},{"id":"https://openalex.org/C86909935","wikidata":"https://www.wikidata.org/wiki/Q188989","display_name":"Aquaculture","level":3,"score":0.2913999855518341},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C2780748813","wikidata":"https://www.wikidata.org/wiki/Q7649683","display_name":"Sustainable management","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25760000944137573},{"id":"https://openalex.org/C552854447","wikidata":"https://www.wikidata.org/wiki/Q131201","display_name":"Sustainable development","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C87709641","wikidata":"https://www.wikidata.org/wiki/Q4782809","display_name":"Aquatic science","level":3,"score":0.25119999051094055},{"id":"https://openalex.org/C135895429","wikidata":"https://www.wikidata.org/wiki/Q1420050","display_name":"Fisheries science","level":4,"score":0.2508000135421753}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ojs2.pakjmcr.com:article/1321","doi":null,"is_oa":true,"landing_page_url":"https://pakjmcr.com/index.php/1/article/view/1321","pdf_url":"https://pakjmcr.com/index.php/1/article/download/1321/1287","source":{"id":"https://openalex.org/S5407043329","display_name":"Pakistan Journal of Medical & Cardiological Review","issn_l":"3007-2379","issn":["3007-2379","3007-2387"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3007-2379","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.20817608","doi":"https://doi.org/10.5281/zenodo.20817608","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.20817608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.20817609","doi":"https://doi.org/10.5281/zenodo.20817609","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.20817609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:ojs2.pakjmcr.com:article/1321","doi":null,"is_oa":true,"landing_page_url":"https://pakjmcr.com/index.php/1/article/view/1321","pdf_url":"https://pakjmcr.com/index.php/1/article/download/1321/1287","source":{"id":"https://openalex.org/S5407043329","display_name":"Pakistan Journal of Medical & Cardiological Review","issn_l":"3007-2379","issn":["3007-2379","3007-2387"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3007-2379","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7165637191.pdf","grobid_xml":"https://content.openalex.org/works/W7165637191.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W7139929706","https://openalex.org/W7151034310","https://openalex.org/W7151093715","https://openalex.org/W7160264926"],"related_works":["https://openalex.org/W4413165405","https://openalex.org/W7155529820","https://openalex.org/W4280640972","https://openalex.org/W4416565497","https://openalex.org/W4404704823","https://openalex.org/W4408997127","https://openalex.org/W7123338252","https://openalex.org/W4382023216","https://openalex.org/W7165737223","https://openalex.org/W7204486728"],"abstract_inverted_index":{"Emerging":[0],"environmental":[1,245],"contaminants":[2,29],"(EECs),":[3],"including":[4],"microplastics,":[5],"pharmaceutical":[6],"residues,":[7],"personal":[8],"care":[9],"products,":[10],"endocrine-disrupting":[11],"chemicals,":[12],"nanomaterials,":[13],"and":[14,16,39,49,71,123,133,153,177,189,211,228,244],"per-":[15],"polyfluoroalkyl":[17],"substances":[18],"(PFAS),":[19],"have":[20],"become":[21],"major":[22],"threats":[23],"to":[24,60,64,84,89,127,162,239],"aquatic":[25,225],"ecosystems":[26],"worldwide.":[27],"These":[28],"may":[30,165],"induce":[31],"oxidative":[32,168],"stress,":[33],"metabolic":[34],"dysfunction,":[35],"endocrine":[36,175],"disruption,":[37],"immunotoxicity,":[38],"reproductive":[40],"impairment":[41],"in":[42,54],"fish":[43,87,97],"populations,":[44],"thereby":[45],"threatening":[46],"fisheries":[47,242],"sustainability":[48],"ecosystem":[50],"resilience.":[51],"Recent":[52],"advances":[53],"multi-omics":[55,82,234],"technologies":[56],"provide":[57],"unprecedented":[58],"opportunities":[59],"investigate":[61],"biological":[62,105],"responses":[63,88,213],"contaminant":[65,92,99,163],"exposure":[66,100,161],"at":[67],"molecular,":[68],"cellular,":[69],"physiological,":[70],"ecological":[72,209],"levels.":[73],"The":[74,140],"present":[75],"study":[76,112],"was":[77],"designed":[78],"as":[79,193],"a":[80,220],"predictive":[81,237],"framework":[83,142,218],"characterize":[85],"anticipated":[86],"environmentally":[90],"relevant":[91],"mixtures.":[93],"Importantly,":[94],"no":[95],"live":[96],"experiments,":[98],"trials,":[101],"laboratory":[102],"analyses,":[103],"or":[104],"sample":[106],"collections":[107],"were":[108],"performed.":[109],"Instead,":[110],"the":[111,205,230],"integrates":[113,143],"current":[114],"scientific":[115],"knowledge,":[116],"published":[117],"toxicological":[118],"evidence,":[119],"systems":[120],"biology":[121],"principles,":[122],"artificial":[124],"intelligence-assisted":[125],"modeling":[126],"generate":[128],"biologically":[129],"plausible":[130],"response":[131],"scenarios":[132],"methodological":[134],"templates":[135],"for":[136,207,223],"future":[137,224],"experimental":[138],"validation.":[139],"proposed":[141],"transcriptomics,":[144],"proteomics,":[145],"metabolomics,":[146],"epigenomics,":[147],"gut":[148],"microbiome":[149],"profiling,":[150],"histopathological":[151],"assessment,":[152],"machine-learning-based":[154],"toxicity":[155],"prediction.":[156],"Simulated":[157],"outcomes":[158],"suggest":[159],"that":[160],"mixtures":[164],"significantly":[166],"alter":[167],"stress":[169],"pathways,":[170],"inflammatory":[171],"responses,":[172],"energy":[173],"metabolism,":[174],"signaling,":[176],"microbial":[178],"community":[179],"composition.":[180],"Multi-omics":[181],"integration":[182],"identifies":[183],"NRF2,":[184],"CYP1A,":[185],"HSP70,":[186],"TNF-\u03b1,":[187],"IL-1\u03b2,":[188],"mitochondrial":[190],"dysfunction":[191],"pathways":[192],"central":[194],"hubs":[195],"associated":[196],"with":[197,214,236],"contaminant-induced":[198],"toxicity.":[199],"Artificial":[200],"intelligence":[201],"models":[202],"further":[203],"demonstrate":[204],"potential":[206],"predicting":[208],"risk":[210],"biomarker":[212],"high":[215],"accuracy.":[216],"This":[217],"provides":[219],"comprehensive":[221],"template":[222],"toxicology":[226],"investigations":[227],"highlights":[229],"importance":[231],"of":[232],"integrating":[233],"approaches":[235],"analytics":[238],"support":[240],"sustainable":[241],"management":[243],"monitoring":[246],"programs.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-06-24T00:00:00"}
