{"id":"https://openalex.org/W7165572987","doi":"https://doi.org/10.64898/2026.06.17.26355783","title":"Maternal-Fetal immune networks and viral signatures in the healthy amniotic cavity","display_name":"Maternal-Fetal immune networks and viral signatures in the healthy amniotic cavity","publication_year":2026,"publication_date":"2026-06-22","ids":{"openalex":"https://openalex.org/W7165572987","doi":"https://doi.org/10.64898/2026.06.17.26355783"},"language":"en","primary_location":{"id":"doi:10.64898/2026.06.17.26355783","doi":"https://doi.org/10.64898/2026.06.17.26355783","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.17.26355783","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/06/22/2026.06.17.26355783.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/06/22/2026.06.17.26355783.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007682014","display_name":"Mar\u00eda Gonz\u00e1lez-Rovira","orcid":"https://orcid.org/0000-0001-8166-7621","observed_orcids":["https://orcid.org/0000-0001-8166-7621"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Gonz\u00e1lez-Rovira","raw_affiliation_strings":["Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8166-7621","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064468953","display_name":"Lutgardo Garc\u00eda\u2010D\u00edaz","orcid":"https://orcid.org/0000-0001-5040-4896","observed_orcids":["https://orcid.org/0000-0001-5040-4896"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L Garc\u00eda-D\u00edaz","raw_affiliation_strings":["Department of Materno-Fetal Medicine, Genetics, and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, Seville, Spain","Department of Surgery, Faculty of Medicine, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5040-4896","affiliations":[{"raw_affiliation_string":"Department of Materno-Fetal Medicine, Genetics, and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]},{"raw_affiliation_string":"Department of Surgery, Faculty of Medicine, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094088536","display_name":"Cristina Mart\u00ednez-Pancorbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095067","display_name":"Hospital Quir\u00f3nsalud Sagrado Coraz\u00f3n","ror":"https://ror.org/00p8vgm81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210095067"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C Mart\u00ednez-Pancorbo","raw_affiliation_strings":["Obstetrics and Gynecology Department, Sagrado Coraz\u00f3n Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department, Sagrado Coraz\u00f3n Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210095067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031120481","display_name":"Alfonso Rodr\u00edguez\u2010Herrera","orcid":"https://orcid.org/0000-0002-1155-280X","observed_orcids":["https://orcid.org/0000-0002-1155-280X","https://orcid.org/0000-0003-3683-5694"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210159346","display_name":"St. Luke's General Hospital","ror":"https://ror.org/05p668j08","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210136517","https://openalex.org/I4210159346"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A Rodr\u00edguez-Herrera","raw_affiliation_strings":["St. Luke\u2019s General Hospital, UCD School of Medicine, University College Dublin, Kilkenny &, Kilkenny, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-3683-5694","affiliations":[{"raw_affiliation_string":"St. Luke\u2019s General Hospital, UCD School of Medicine, University College Dublin, Kilkenny &, Kilkenny, Ireland","institution_ids":["https://openalex.org/I100930933","https://openalex.org/I4210159346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045288476","display_name":"Javier S\u00e1nchez","orcid":"https://orcid.org/0000-0001-7315-9790","observed_orcids":["https://orcid.org/0000-0001-7315-9790"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J S\u00e1nchez","raw_affiliation_strings":["Department of Materno-Fetal Medicine, Genetics, and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materno-Fetal Medicine, Genetics, and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086629019","display_name":"David Bernardo","orcid":"https://orcid.org/0000-0002-2843-6696","observed_orcids":["https://orcid.org/0000-0002-2843-6696"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210141160","display_name":"Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid","ror":"https://ror.org/03kjyy960","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I134820265","https://openalex.org/I4210141160"]},{"id":"https://openalex.org/I4405268343","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Infecciosas","ror":"https://ror.org/00nd8zg79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268343"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Bernardo","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERinfec), Madrid, Spain","Mucosal Immunology Lab, Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM, Universidad de Valladolid-CISC), Valladolid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2843-6696","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERinfec), Madrid, Spain","institution_ids":["https://openalex.org/I4210115082","https://openalex.org/I4405268343"]},{"raw_affiliation_string":"Mucosal Immunology Lab, Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM, Universidad de Valladolid-CISC), Valladolid, Spain","institution_ids":["https://openalex.org/I108103353","https://openalex.org/I4210141160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102897864","display_name":"Mustafa Karata\u015f","orcid":"https://orcid.org/0000-0002-2464-0593","observed_orcids":["https://orcid.org/0000-0002-2464-0593"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Karatas","raw_affiliation_strings":["Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2464-0593","affiliations":[{"raw_affiliation_string":"Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042938566","display_name":"Jos\u00e9 Antonio Garc\u00eda\u2010Mejido","orcid":"https://orcid.org/0000-0002-3079-5583","observed_orcids":["https://orcid.org/0000-0002-3079-5583"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JA Garc\u00eda-Mejido","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, University of Seville, Seville, Spain","Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen de Valme/CSIC/University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3079-5583","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen de Valme/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114375266","display_name":"Carolina Sousa","orcid":"https://orcid.org/0000-0002-9235-9496","observed_orcids":["https://orcid.org/0000-0002-9235-9496"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C Sousa","raw_affiliation_strings":["Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9235-9496","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077886382","display_name":"Encarnaci\u00f3n Mellado","orcid":"https://orcid.org/0000-0002-7135-1428","observed_orcids":["https://orcid.org/0000-0002-7135-1428"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E Mellado","raw_affiliation_strings":["Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7135-1428","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101881471","display_name":"Jos\u00e9 Antonio Sainz\u2010Bueno","orcid":"https://orcid.org/0000-0002-9571-3219","observed_orcids":["https://orcid.org/0000-0002-9571-3219"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JA Sainz-Bueno","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, University of Seville, Seville, Spain","Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen de Valme/CSIC/University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9571-3219","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen de Valme/CSIC/University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042890617","display_name":"Jelle Matthijnssens","orcid":"https://orcid.org/0000-0003-1188-9733","observed_orcids":["https://orcid.org/0000-0003-1188-9733"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Matthijnssens","raw_affiliation_strings":["Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1188-9733","affiliations":[{"raw_affiliation_string":"Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103076745","display_name":"Mar\u00eda de Lourdes Moreno","orcid":"https://orcid.org/0000-0002-7490-2037","observed_orcids":["https://orcid.org/0000-0002-7490-2037"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"ML Moreno","raw_affiliation_strings":["Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7490-2037","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amniotic-cavity","display_name":"amniotic cavity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fetal-immune-development","display_name":"fetal immune development","score":0.800000011920929},{"id":"https://openalex.org/keywords/herpesviruses","display_name":"herpesvirus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/polyomaviridae","display_name":"Polyomaviridae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/picornavirus","display_name":"picornavirus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fetal-malformations","display_name":"fetal malformations","score":0.5270000100135803},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.753000020980835},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8690000176429749},{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/human-beta-defensin-3","display_name":"human beta-defensin 3","score":0.996999979019165},{"id":"https://openalex.org/keywords/regulatory-cytokines","display_name":"regulatory cytokines","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/placental-barrier","display_name":"placental barrier","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.817799985408783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6891999840736389},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6449000239372253},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5947999954223633},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.5860999822616577},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.36410000920295715},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.36250001192092896},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.30720001459121704},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27559998631477356},{"id":"https://openalex.org/C3018558359","wikidata":"https://www.wikidata.org/wiki/Q1660157","display_name":"Immune escape","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.06.17.26355783","doi":"https://doi.org/10.64898/2026.06.17.26355783","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.17.26355783","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/06/22/2026.06.17.26355783.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.06.17.26355783","doi":"https://doi.org/10.64898/2026.06.17.26355783","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.17.26355783","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/06/22/2026.06.17.26355783.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5619151805","display_name":"The impact of the COVID pandemic on rotavirus epidemiology & environmental sampling as a tool to monitor enteric virus circulation","funder_award_id":"11P7I24N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5635532810","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5699655065","display_name":null,"funder_award_id":"PID2024-157768OB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G6033112984","display_name":null,"funder_award_id":"MICIU/AEI/10","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7084143925","display_name":null,"funder_award_id":"AEI/10","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G717256432","display_name":null,"funder_award_id":"PID2024","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8667377315","display_name":null,"funder_award_id":"MICIU/AEI/10","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"}],"funders":[{"id":"https://openalex.org/F4320310967","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7165572987.pdf","grobid_xml":"https://content.openalex.org/works/W7165572987.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W49611453","https://openalex.org/W1008189539","https://openalex.org/W1498159349","https://openalex.org/W1992022606","https://openalex.org/W1992856216","https://openalex.org/W2016676597","https://openalex.org/W2018534614","https://openalex.org/W2031665927","https://openalex.org/W2032739461","https://openalex.org/W2036736591","https://openalex.org/W2050471622","https://openalex.org/W2053687897","https://openalex.org/W2062687768","https://openalex.org/W2072066004","https://openalex.org/W2076398764","https://openalex.org/W2083096979","https://openalex.org/W2088938590","https://openalex.org/W2108813933","https://openalex.org/W2121017845","https://openalex.org/W2127763342","https://openalex.org/W2168095323","https://openalex.org/W2170486072","https://openalex.org/W2274216917","https://openalex.org/W2281227512","https://openalex.org/W2599501186","https://openalex.org/W2608535836","https://openalex.org/W2764098312","https://openalex.org/W2794083477","https://openalex.org/W2800111784","https://openalex.org/W2805138585","https://openalex.org/W2887886862","https://openalex.org/W2903174799","https://openalex.org/W2937135742","https://openalex.org/W2975352505","https://openalex.org/W2977715643","https://openalex.org/W2996337495","https://openalex.org/W3006721638","https://openalex.org/W3035400545","https://openalex.org/W3093066914","https://openalex.org/W3161869051","https://openalex.org/W3194569026","https://openalex.org/W3195549289","https://openalex.org/W3209273683","https://openalex.org/W4281252748","https://openalex.org/W4293724505","https://openalex.org/W4317951846","https://openalex.org/W4321596617","https://openalex.org/W4327621000","https://openalex.org/W4379793326","https://openalex.org/W4381799426","https://openalex.org/W4385791530","https://openalex.org/W4386304974","https://openalex.org/W4388033386","https://openalex.org/W4398761372","https://openalex.org/W4402582200","https://openalex.org/W4403893807","https://openalex.org/W4404242228","https://openalex.org/W4407057953","https://openalex.org/W4408499903","https://openalex.org/W4415667086","https://openalex.org/W4415950656","https://openalex.org/W4416214127","https://openalex.org/W7119484670","https://openalex.org/W7125940965"],"related_works":["https://openalex.org/W2805138585","https://openalex.org/W4313562171","https://openalex.org/W7135185225","https://openalex.org/W4388617502","https://openalex.org/W1969075452","https://openalex.org/W3165023010","https://openalex.org/W2755767520","https://openalex.org/W2483470850","https://openalex.org/W2967206044","https://openalex.org/W4412767613"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"intrauterine":[2],"environment":[3,146],"has":[4],"traditionally":[5],"been":[6],"viewed":[7],"as":[8],"a":[9,62,102,155,187],"privileged":[10],"site":[11],"protected":[12],"by":[13,150],"the":[14,29,43,108,143,173,198],"placental":[15],"barrier.":[16],"However,":[17],"emerging":[18],"evidence":[19],"suggests":[20],"that":[21,142,166],"early":[22],"in":[23,50,69],"utero":[24],"microbial":[25],"exposure":[26],"may":[27,176],"prime":[28],"developing":[30],"fetal":[31,90,179],"immune":[32,48,105,120,145,180],"system.":[33],"Here,":[34],"using":[35],"target-enriched":[36],"metagenomics":[37],"and":[38,47,57,80,118,129],"high-dimensional":[39],"proteomics,":[40],"we":[41],"characterized":[42],"intra-amniotic":[44],"viral":[45,67,84,92,112,169],"landscape":[46],"networks":[49],"114":[51],"healthy":[52],"pregnancies":[53],"including":[54,122],"both":[55],"normal":[56],"anomalous":[58],"fetuses.":[59],"We":[60],"identify":[61],"sparse":[63],"yet":[64],"heterogeneous":[65],"human":[66],"signature":[68],"26%":[70],"of":[71,75,104,135,168,201],"samples,":[72],"predominantly":[73],"composed":[74],"Herpesviridae":[76],",":[77,79],"Polyomaviridae":[78],"Picornaviridae":[81],".":[82],"Although":[83],"reads":[85],"abundance":[86],"was":[87,114],"associated":[88,115],"with":[89,116,132],"abnormalities,":[91],"detection":[93],"generally":[94],"did":[95],"not":[96],"induce":[97],"overt":[98,184],"inflammatory":[99],"activation,":[100],"supporting":[101],"state":[103],"homeostasis":[106],"within":[107,172],"amniotic":[109,144,174],"cavity.":[110],"Instead,":[111],"presence":[113],"subtle":[117],"selective":[119],"modulation,":[121],"altered":[123],"inducible":[124],"antimicrobial":[125],"peptide":[126],"expression":[127],"(HBD-2":[128],"HBD-3),":[130],"coupled":[131],"an":[133],"attenuation":[134],"regulatory":[136],"cytokines.":[137],"Our":[138],"results":[139],"further":[140],"reveal":[141],"is":[147],"primarily":[148],"governed":[149],"gestational":[151],"age,":[152],"transitioning":[153],"from":[154],"Th1-predominant":[156],"\u201calert\u201d":[157],"phase":[158],"to":[159,178],"innate-readiness":[160],"preceding":[161],"parturition.":[162],"These":[163],"findings":[164],"suggest":[165],"fragments":[167],"genetic":[170],"material":[171],"cavity":[175],"contribute":[177],"instruction":[181],"without":[182],"triggering":[183],"inflammation,":[185],"providing":[186],"foundational":[188],"framework":[189],"for":[190],"understanding":[191],"how":[192],"\u201csilent\u201d":[193],"viral-exposure":[194],"during":[195],"gestation":[196],"influences":[197],"developmental":[199],"origins":[200],"neonatal":[202],"immunity.":[203]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-23T00:00:00"}