{"id":"https://openalex.org/W7165366381","doi":"https://doi.org/10.1016/j.xcrm.2026.102874","title":"Safety and efficacy of GZR18, a long-acting GLP-1 analog, in Chinese patients with type 2 diabetes: A randomized, double-blind, phase 1b/2a trial","display_name":"Safety and efficacy of GZR18, a long-acting GLP-1 analog, in Chinese patients with type 2 diabetes: A randomized, double-blind, phase 1b/2a trial","publication_year":2026,"publication_date":"2026-06-19","ids":{"openalex":"https://openalex.org/W7165366381","doi":"https://doi.org/10.1016/j.xcrm.2026.102874","pmid":"https://pubmed.ncbi.nlm.nih.gov/42320483","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13400172"},"language":"en","primary_location":{"id":"doi:10.1016/j.xcrm.2026.102874","doi":"https://doi.org/10.1016/j.xcrm.2026.102874","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102874","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xcrm.2026.102874","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048431151","display_name":"M N Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Liu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: mingliu@tmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: mingliu@tmu.edu.cn","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113243148","display_name":"Xuhong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210114604","display_name":"Beijing Luhe Hospital Affiliated to Capital Medical University","ror":"https://ror.org/01zyn4z03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114604"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuhong Wang","raw_affiliation_strings":["Department of Endocrinology, Beijing Luhe Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Beijing Luhe Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210114604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036556655","display_name":"Meizi Li","orcid":"https://orcid.org/0000-0001-7000-5905","observed_orcids":["https://orcid.org/0000-0001-7000-5905","https://orcid.org/0000-0001-8813-1045"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]},{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meizi Li","raw_affiliation_strings":["Department of Endocrinology, The Affiliated Hospital of Yanbian University, Yanbian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Affiliated Hospital of Yanbian University, Yanbian, China","institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210131149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138975776","display_name":"Enyue Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]},{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Enyue Yang","raw_affiliation_strings":["Office of Clinical Trials, The Affiliated Hospital of Yanbian University, Yanbian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Clinical Trials, The Affiliated Hospital of Yanbian University, Yanbian, China","institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210131149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101114092","display_name":"Aige Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210157729","display_name":"First Affiliated Hospital of Hebei Medical University","ror":"https://ror.org/04z3aby64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157729"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aige Yang","raw_affiliation_strings":["Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210157729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109305445","display_name":"Mingxia Yuan","orcid":"https://orcid.org/0000-0001-8127-9709","observed_orcids":["https://orcid.org/0000-0001-8127-9709"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxia Yuan","raw_affiliation_strings":["Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031928455","display_name":"Ruihua Dong","orcid":"https://orcid.org/0000-0003-3463-5023","observed_orcids":["https://orcid.org/0000-0003-3463-5023"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruihua Dong","raw_affiliation_strings":["Research Ward, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Ward, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077624156","display_name":"Guijun Qin","orcid":"https://orcid.org/0000-0002-2503-7534","observed_orcids":["https://orcid.org/0000-0002-2503-7534","https://orcid.org/0000-0002-0533-9981","https://orcid.org/0000-0002-4924-0991","https://orcid.org/0000-0002-8612-6274"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guijun Qin","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139023327","display_name":"Ping Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Liu","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Ningxia Medical University, Yinchuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613430","display_name":"Chengqian Li","orcid":"https://orcid.org/0000-0001-7821-8462","observed_orcids":["https://orcid.org/0000-0001-7821-8462"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengqian Li","raw_affiliation_strings":["Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051342555","display_name":"Y Cao","orcid":"https://orcid.org/0009-0001-3357-6319","observed_orcids":["https://orcid.org/0009-0001-3357-6319","https://orcid.org/0000-0003-1493-7868","https://orcid.org/0000-0001-7157-6961","https://orcid.org/0000-0002-0811-4016","https://orcid.org/0000-0002-1390-4899","https://orcid.org/0000-0002-2891-4379","https://orcid.org/0000-0002-4251-3168","https://orcid.org/0000-0002-6126-3811","https://orcid.org/0000-0003-2716-6580","https://orcid.org/0000-0003-3594-4864","https://orcid.org/0009-0001-1044-1200","https://orcid.org/0009-0003-4663-6688","https://orcid.org/0009-0005-5277-8046","https://orcid.org/0009-0005-5625-336X","https://orcid.org/0009-0007-5924-7779","https://orcid.org/0009-0008-9429-1094","https://orcid.org/0009-0009-1021-0806"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Cao","raw_affiliation_strings":["Clinical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133197481","display_name":"Jing Zhao","orcid":"https://orcid.org/0009-0003-6674-4889","observed_orcids":["https://orcid.org/0009-0003-6674-4889"]},"institutions":[{"id":"https://openalex.org/I4210142553","display_name":"Lee's Pharmaceutical (China)","ror":"https://ror.org/04abccf14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhao","raw_affiliation_strings":["Gan & Lee Pharmaceuticals, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gan & Lee Pharmaceuticals, Beijing, China","institution_ids":["https://openalex.org/I4210142553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133236043","display_name":"Liyuan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142553","display_name":"Lee's Pharmaceutical (China)","ror":"https://ror.org/04abccf14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Zhao","raw_affiliation_strings":["Gan & Lee Pharmaceuticals, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gan & Lee Pharmaceuticals, Beijing, China","institution_ids":["https://openalex.org/I4210142553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133161622","display_name":"Wei Chen","orcid":"https://orcid.org/0009-0007-4543-7344","observed_orcids":["https://orcid.org/0009-0007-4543-7344"]},"institutions":[{"id":"https://openalex.org/I4210142553","display_name":"Lee's Pharmaceutical (China)","ror":"https://ror.org/04abccf14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Gan & Lee Pharmaceuticals, Beijing, China; Gan & Lee Pharmaceuticals Shandong Co., Ltd, Linyi, China. Electronic address: weichen45@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gan & Lee Pharmaceuticals, Beijing, China; Gan & Lee Pharmaceuticals Shandong Co., Ltd, Linyi, China. Electronic address: weichen45@126.com","institution_ids":["https://openalex.org/I4210142553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5048431151","https://openalex.org/A5133161622"],"corresponding_institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I4210142553"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":6.9944,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94752555,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"7","issue":"7","first_page":"102874","last_page":"102874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-acting-glp-1-receptor-agonists","display_name":"long-acting GLP-1 receptor agonists","score":0.9309999942779541},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7829999923706055},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.7829999923706055},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5220000147819519},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8317000269889832},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6898999810218811},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6351000070571899},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5839999914169312},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5561000108718872},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5268999934196472},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5181000232696533},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.5029000043869019},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4885999858379364},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45089998841285706},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.25769999623298645}],"mesh":[{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.xcrm.2026.102874","doi":"https://doi.org/10.1016/j.xcrm.2026.102874","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102874","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13400172","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13400172/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13400172/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep Med","raw_type":"Text"},{"id":"pmid:42320483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42320483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports. Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.xcrm.2026.102874","doi":"https://doi.org/10.1016/j.xcrm.2026.102874","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102874","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7165366381.pdf","grobid_xml":"https://content.openalex.org/works/W7165366381.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2104252114","https://openalex.org/W2117764934","https://openalex.org/W2137352234","https://openalex.org/W2163672679","https://openalex.org/W2258929611","https://openalex.org/W2425644022","https://openalex.org/W2519510391","https://openalex.org/W2572398654","https://openalex.org/W2799375839","https://openalex.org/W2943546226","https://openalex.org/W2951522032","https://openalex.org/W2972869264","https://openalex.org/W3081124857","https://openalex.org/W3081655479","https://openalex.org/W3093123473","https://openalex.org/W3119307884","https://openalex.org/W3185437491","https://openalex.org/W3195404919","https://openalex.org/W3210542663","https://openalex.org/W4200036848","https://openalex.org/W4283034671","https://openalex.org/W4321482636","https://openalex.org/W4402953901","https://openalex.org/W4405187712","https://openalex.org/W4408161595","https://openalex.org/W4414189723","https://openalex.org/W7152104387"],"related_works":["https://openalex.org/W7152104387","https://openalex.org/W4283034671","https://openalex.org/W4408161595","https://openalex.org/W4411292140","https://openalex.org/W4399878050","https://openalex.org/W4411293101","https://openalex.org/W7135403882","https://openalex.org/W7115902984","https://openalex.org/W7204082462","https://openalex.org/W4402953901"],"abstract_inverted_index":{"GZR18":[0,40,77,90,99,115,142],"is":[1,9,116,149],"a":[2],"long-acting":[3],"glucagon-like":[4],"peptide-1":[5],"receptor":[6],"agonist":[7],"that":[8],"under":[10],"development":[11,140],"for":[12,89,93,98,102],"the":[13,34,75],"treatment":[14],"of":[15,38,71,141],"type":[16],"2":[17],"diabetes":[18],"mellitus":[19],"(T2DM).":[20],"In":[21],"this":[22],"randomized,":[23],"double-blind,":[24],"placebo-controlled":[25],"phase":[26],"1b/2a":[27],"trial":[28,148],"in":[29,47,83,105,143],"Chinese":[30],"adults":[31],"with":[32,121],"T2DM,":[33],"safety":[35],"and":[36,58,108,118],"efficacy":[37],"once-weekly":[39],"are":[41,69,112],"evaluated":[42],"using":[43],"different":[44],"dose-titration":[45],"regimens":[46],"two":[48],"separate":[49],"parts:":[50],"Part":[51,59,95],"A":[52],"(0.5-4":[53],"mg":[54,62],"over":[55,63],"26":[56],"weeks)":[57],"B":[60],"(1.5-13":[61],"23":[64],"weeks).":[65],"Overall,":[66],"72":[67],"participants":[68],"enrolled,":[70],"whom":[72],"62":[73],"complete":[74],"trial.":[76],"significantly":[78],"reduces":[79],"glycated":[80],"hemoglobin":[81],"(HbA1c)":[82],"both":[84],"parts":[85],"(Part":[86],"A:":[87],"-1.32%":[88],"versus":[91,100],"0.86%":[92],"placebo;":[94],"B:":[96],"-1.81%":[97],"0.12%":[101],"placebo).":[103],"Improvements":[104],"body":[106],"weight":[107],"other":[109],"metabolic":[110],"parameters":[111],"also":[113],"observed.":[114],"safe":[117],"well":[119],"tolerated,":[120],"mostly":[122],"mild-to-moderate":[123],"gastrointestinal":[124],"adverse":[125,133],"events;":[126],"no":[127],"severe":[128],"hypoglycemia":[129],"or":[130],"treatment-related":[131],"serious":[132],"events":[134],"occurred.":[135],"These":[136],"findings":[137],"support":[138],"further":[139],"larger,":[144],"longer-term":[145],"trials.":[146],"The":[147],"registered":[150],"at":[151],"ClinicalTrials.gov":[152],"(NCT06256523).":[153]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-06-20T00:00:00"}
