{"id":"https://openalex.org/W7165115688","doi":"https://doi.org/10.1002/ejoc.70628","title":"Dormant Grignard Reagents in One\u2010Pot Double Additions: Sequential Reactivity with Imidates","display_name":"Dormant Grignard Reagents in One\u2010Pot Double Additions: Sequential Reactivity with Imidates","publication_year":2026,"publication_date":"2026-06-19","ids":{"openalex":"https://openalex.org/W7165115688","doi":"https://doi.org/10.1002/ejoc.70628"},"language":"en","primary_location":{"id":"doi:10.1002/ejoc.70628","doi":"https://doi.org/10.1002/ejoc.70628","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.70628","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122749304","display_name":"Huong Giang Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132387","display_name":"Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans","ror":"https://ror.org/03a9gd656","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210108471","https://openalex.org/I4210128300","https://openalex.org/I4210132387"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Huong Giang Nguyen","raw_affiliation_strings":["IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France","institution_ids":["https://openalex.org/I4210132387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044638915","display_name":"Fabien Boeda","orcid":"https://orcid.org/0000-0003-2569-4566","observed_orcids":["https://orcid.org/0000-0003-2569-4566"]},"institutions":[{"id":"https://openalex.org/I4210132387","display_name":"Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans","ror":"https://ror.org/03a9gd656","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210108471","https://openalex.org/I4210128300","https://openalex.org/I4210132387"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Boeda","raw_affiliation_strings":["IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France","institution_ids":["https://openalex.org/I4210132387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106744158","display_name":"Morwenna S. M. Pearson-Long","orcid":"https://orcid.org/0000-0002-3101-4857","observed_orcids":["https://orcid.org/0000-0002-3101-4857"]},"institutions":[{"id":"https://openalex.org/I4210132387","display_name":"Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans","ror":"https://ror.org/03a9gd656","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210108471","https://openalex.org/I4210128300","https://openalex.org/I4210132387"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Morwenna S. M. Pearson\u2010Long","raw_affiliation_strings":["IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France"],"raw_orcid":"https://orcid.org/0000-0002-3101-4857","affiliations":[{"raw_affiliation_string":"IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France","institution_ids":["https://openalex.org/I4210132387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108684614","display_name":"Philippe Bertus","orcid":"https://orcid.org/0000-0002-1174-5097","observed_orcids":["https://orcid.org/0000-0002-1174-5097"]},"institutions":[{"id":"https://openalex.org/I4210132387","display_name":"Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans","ror":"https://ror.org/03a9gd656","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210108471","https://openalex.org/I4210128300","https://openalex.org/I4210132387"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Bertus","raw_affiliation_strings":["IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France"],"raw_orcid":"https://orcid.org/0000-0002-1174-5097","affiliations":[{"raw_affiliation_string":"IMMM \u2010 Institut des Mol\u00e9cules et Mat\u00e9riaux du Mans  Le Mans France","institution_ids":["https://openalex.org/I4210132387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210132387"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36221243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"28","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12228","display_name":"Coordination Chemistry and Organometallics","score":0.34940001368522644,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12228","display_name":"Coordination Chemistry and Organometallics","score":0.34940001368522644,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.34060001373291016,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.13019999861717224,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grignard-reagents","display_name":"Grignard reagents","score":0.9390000104904175},{"id":"https://openalex.org/keywords/imidates","display_name":"imidates","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sequential-addition","display_name":"sequential addition","score":0.6740000247955322},{"id":"https://openalex.org/keywords/sulfonamides","display_name":"sulfonamides","score":0.8659999966621399},{"id":"https://openalex.org/keywords/diastereoselective-synthesis","display_name":"diastereoselective synthesis","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9758999943733215},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.8339999914169312},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.7059000134468079},{"id":"https://openalex.org/C2993098599","wikidata":"https://www.wikidata.org/wiki/Q1238028","display_name":"Grignard reagent","level":3,"score":0.6740999817848206},{"id":"https://openalex.org/C2780616238","wikidata":"https://www.wikidata.org/wiki/Q337748","display_name":"Grignard reaction","level":3,"score":0.5627999901771545},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5303999781608582},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.5284000039100647},{"id":"https://openalex.org/C2780129066","wikidata":"https://www.wikidata.org/wiki/Q192596","display_name":"Aliphatic compound","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C91967747","wikidata":"https://www.wikidata.org/wiki/Q2770033","display_name":"Group 2 organometallic chemistry","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.26460000872612}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ejoc.70628","doi":"https://doi.org/10.1002/ejoc.70628","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.70628","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-05663185v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05663185","pdf_url":null,"source":{"id":"https://openalex.org/S4406922276","display_name":"INRIA a CCSD electronic archive server","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Organic Chemistry, 2026, ⟨10.1002/ejoc.70628⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1967328199","https://openalex.org/W1969968495","https://openalex.org/W1975150196","https://openalex.org/W1977918492","https://openalex.org/W1983217729","https://openalex.org/W1987652772","https://openalex.org/W1997595536","https://openalex.org/W2001583513","https://openalex.org/W2002778997","https://openalex.org/W2007366299","https://openalex.org/W2009034595","https://openalex.org/W2035358042","https://openalex.org/W2039134104","https://openalex.org/W2040723714","https://openalex.org/W2046757918","https://openalex.org/W2063787740","https://openalex.org/W2068351994","https://openalex.org/W2068355702","https://openalex.org/W2074880623","https://openalex.org/W2075813623","https://openalex.org/W2089098155","https://openalex.org/W2097066828","https://openalex.org/W2131146694","https://openalex.org/W2133493088","https://openalex.org/W2150294150","https://openalex.org/W2159851699","https://openalex.org/W2163795342","https://openalex.org/W2183017628","https://openalex.org/W2286730719","https://openalex.org/W2325683537","https://openalex.org/W2417265524","https://openalex.org/W2514346245","https://openalex.org/W2551874852","https://openalex.org/W2739964108","https://openalex.org/W2770700131","https://openalex.org/W2786461532","https://openalex.org/W2803247320","https://openalex.org/W2941978805","https://openalex.org/W2950548654","https://openalex.org/W2950615396","https://openalex.org/W2950839648","https://openalex.org/W2951478616","https://openalex.org/W2952303778","https://openalex.org/W2953314004","https://openalex.org/W3206637869","https://openalex.org/W4320710329","https://openalex.org/W4323527449","https://openalex.org/W4378782560"],"related_works":[],"abstract_inverted_index":{"A":[0],"new":[1],"method":[2],"for":[3],"the":[4,21,36,41,47],"successive":[5],"addition":[6,48],"of":[7,23,49],"two":[8],"different":[9],"Grignard":[10,53],"reagents":[11],"onto":[12,40],"imidate":[13],"derivatives":[14],"is":[15,29,71],"presented.":[16],"The":[17,65],"originality":[18],"lies":[19],"in":[20,44,62],"use":[22],"a":[24,68],"specific":[25],"organomagnesium":[26],"reagent,":[27],"which":[28],"not":[30],"able":[31],"to":[32,67],"directly":[33],"react":[34],"with":[35],"imidate,":[37],"but":[38],"reacts":[39],"species":[42],"generated":[43],"situ":[45],"after":[46],"another":[50],"more":[51],"reactive":[52],"reagent.":[54],"By":[55],"this":[56],"route,":[57],"several":[58],"sulfonamides":[59],"are":[60],"prepared":[61],"good":[63],"yields.":[64],"extension":[66],"diastereoselective":[69],"version":[70],"successfully":[72],"described":[73],"using":[74],"chiral":[75],"N":[76],"\u2010sulfinyl":[77],"imidates.":[78]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-06-19T00:00:00"}