{"id":"https://openalex.org/W7165035753","doi":"https://doi.org/10.64898/2026.06.14.730922","title":"Exposure to perfluorooctanoic acid accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism","display_name":"Exposure to perfluorooctanoic acid accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7165035753","doi":"https://doi.org/10.64898/2026.06.14.730922","pmid":"https://pubmed.ncbi.nlm.nih.gov/42367950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13307966"},"language":"en","primary_location":{"id":"doi:10.64898/2026.06.14.730922","doi":"https://doi.org/10.64898/2026.06.14.730922","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.14.730922","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/17/2026.06.14.730922.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/17/2026.06.14.730922.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116393330","display_name":"Eric A Kilbourn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Kilbourn","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125578911","display_name":"Matthew R Lowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Lowe","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081943740","display_name":"Kanishka Panda","orcid":"https://orcid.org/0000-0001-7043-3010","observed_orcids":["https://orcid.org/0000-0001-7043-3010"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanishka Panda","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116078391","display_name":"Akshay Manoj Bhaskaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshay M. Bhaskaran","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039966691","display_name":"Guomao Zheng","orcid":"https://orcid.org/0000-0002-5235-9950","observed_orcids":["https://orcid.org/0000-0002-5235-9950"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guomao Zheng","raw_affiliation_strings":["Paul H. O\u2019Neill School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405 Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul H. O\u2019Neill School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405 Unites States","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138765363","display_name":"Aditi R. Aalati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi R. Aalati","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138786247","display_name":"Adam Malave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Malave","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138772075","display_name":"Sophia White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia White","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138778229","display_name":"Anna Graber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Graber","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138790856","display_name":"Nika Zulkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nika Zulkowski","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086065002","display_name":"Robert H. Pepin","orcid":"https://orcid.org/0000-0002-1828-1598","observed_orcids":["https://orcid.org/0000-0002-1828-1598"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Pepin","raw_affiliation_strings":["Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029642474","display_name":"Amina Salamova","orcid":"https://orcid.org/0000-0003-2174-030X","observed_orcids":["https://orcid.org/0000-0003-2174-030X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amina Salamova","raw_affiliation_strings":["Gangarosa Department of Environmental Health, Emory, Atlanta, Georgia 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gangarosa Department of Environmental Health, Emory, Atlanta, Georgia 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043837910","display_name":"Travis G. Nemkov","orcid":"https://orcid.org/0000-0001-8566-7119","observed_orcids":["https://orcid.org/0000-0001-8566-7119"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Nemkov","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA"],"raw_orcid":"https://orcid.org/0000-0001-8566-7119","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045175167","display_name":"Angelo D\u2019Alessandro","orcid":"https://orcid.org/0000-0002-2258-6490","observed_orcids":["https://orcid.org/0000-0002-2258-6490"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo D\u2019Alessandro","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-2258-6490","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000723312","display_name":"Swathi Yadlapalli","orcid":"https://orcid.org/0000-0001-5870-341X","observed_orcids":["https://orcid.org/0000-0001-5870-341X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swathi Yadlapalli","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159959521","display_name":"Pramod Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pramod Reddy","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076746488","display_name":"Edgar Meyh\u00f6fer","orcid":"https://orcid.org/0000-0001-5719-6030","observed_orcids":["https://orcid.org/0000-0001-5719-6030"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgar Meyhofer","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044984902","display_name":"Jason M. Tennessen","orcid":"https://orcid.org/0000-0002-3527-5683","observed_orcids":["https://orcid.org/0000-0002-3527-5683"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason M. Tennessen","raw_affiliation_strings":["Bloomington Drosophila Stock Center, Indiana University, Bloomington, IN 47405, United States","Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","Member, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA"],"raw_orcid":"https://orcid.org/0000-0002-3527-5683","affiliations":[{"raw_affiliation_string":"Bloomington Drosophila Stock Center, Indiana University, Bloomington, IN 47405, United States","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Member, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA","institution_ids":["https://openalex.org/I4390039234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044984902"],"corresponding_institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I4390039234","https://openalex.org/I592451"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfluorooctanoic-acid","display_name":"perfluorooctanoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pfas","display_name":"PFAS","score":0.8759999871253967},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9309999942779541},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.8240000009536743},{"id":"https://openalex.org/keywords/juvenile-development","display_name":"juvenile development","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7639999985694885},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metabolic-heat-production","display_name":"metabolic heat production","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sublethal-effects","display_name":"sublethal effects","score":0.7390000224113464},{"id":"https://openalex.org/keywords/temperature-response","display_name":"temperature sensitivity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/insect-life-history","display_name":"insect life history","score":0.4970000088214874},{"id":"https://openalex.org/keywords/persistent-pollutants","display_name":"persistent pollutants","score":0.625}],"concepts":[{"id":"https://openalex.org/C2775979320","wikidata":"https://www.wikidata.org/wiki/Q418348","display_name":"Perfluorooctanoic acid","level":2,"score":0.9668999910354614},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6796000003814697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5583000183105469},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5497000217437744},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.5317000150680542},{"id":"https://openalex.org/C2780401329","wikidata":"https://www.wikidata.org/wiki/Q6839919","display_name":"Microplastics","level":2,"score":0.4334000051021576},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.42829999327659607},{"id":"https://openalex.org/C13376991","wikidata":"https://www.wikidata.org/wiki/Q587698","display_name":"Ectotherm","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C2777612826","wikidata":"https://www.wikidata.org/wiki/Q1390","display_name":"Insect","level":2,"score":0.38749998807907104},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.37070000171661377},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3700000047683716},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3643999993801117},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33799999952316284},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C15224491","wikidata":"https://www.wikidata.org/wiki/Q7169338","display_name":"Permissive","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3003999888896942},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C3019289112","wikidata":"https://www.wikidata.org/wiki/Q7596908","display_name":"Developmental stage","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2793999910354614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2761000096797943},{"id":"https://openalex.org/C157518188","wikidata":"https://www.wikidata.org/wiki/Q2832888","display_name":"Juvenile fish","level":3,"score":0.2628999948501587}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.06.14.730922","doi":"https://doi.org/10.64898/2026.06.14.730922","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.14.730922","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/17/2026.06.14.730922.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42367950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42367950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13307966","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13307966/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.06.14.730922","doi":"https://doi.org/10.64898/2026.06.14.730922","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.14.730922","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/17/2026.06.14.730922.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2063588749","display_name":"Toward Precision Toxicology: New Approach Methodologies for Chemical Safety","funder_award_id":"965406","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3754633476","display_name":null,"funder_award_id":"UL1TR002529","funder_id":"https://openalex.org/F4320309408","funder_display_name":"Indiana Clinical and Translational Sciences Institute"},{"id":"https://openalex.org/G693627054","display_name":"FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE","funder_award_id":"U41HG000739","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7766147931","display_name":"Indiana Clinical and Translational Sciences Institute","funder_award_id":"UL1TR002529","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000886316","display_name":"Investigating metabolic responses to high sugar diets and the onset of diabetic phenotypes","funder_award_id":"R01DK136945","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000906447","display_name":"A Drosophila Model for the Regulation of Aerobic Glycolysis","funder_award_id":"R35GM119557","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000920026","display_name":"Spatiotemporal mechanisms controlling circadian rhythms","funder_award_id":"R35GM133737","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7165035753.pdf","grobid_xml":"https://content.openalex.org/works/W7165035753.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W117302021","https://openalex.org/W1815722210","https://openalex.org/W1971311303","https://openalex.org/W2002403131","https://openalex.org/W2010154023","https://openalex.org/W2019865464","https://openalex.org/W2025718559","https://openalex.org/W2036056595","https://openalex.org/W2052607700","https://openalex.org/W2055242200","https://openalex.org/W2066634548","https://openalex.org/W2066979436","https://openalex.org/W2083850113","https://openalex.org/W2084191969","https://openalex.org/W2085876270","https://openalex.org/W2099373817","https://openalex.org/W2105039688","https://openalex.org/W2112558380","https://openalex.org/W2114713612","https://openalex.org/W2131271579","https://openalex.org/W2138207763","https://openalex.org/W2163064437","https://openalex.org/W2166208596","https://openalex.org/W2167364244","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2249201704","https://openalex.org/W2307154373","https://openalex.org/W2318997803","https://openalex.org/W2582878148","https://openalex.org/W2584998078","https://openalex.org/W2809882610","https://openalex.org/W2901377336","https://openalex.org/W2944209771","https://openalex.org/W2946052571","https://openalex.org/W3014857321","https://openalex.org/W3035230031","https://openalex.org/W3041939347","https://openalex.org/W3082927574","https://openalex.org/W3086671504","https://openalex.org/W3091745167","https://openalex.org/W3092482473","https://openalex.org/W3095750227","https://openalex.org/W3099210309","https://openalex.org/W3115302287","https://openalex.org/W3129365558","https://openalex.org/W3144579504","https://openalex.org/W3198684761","https://openalex.org/W4280501942","https://openalex.org/W4285680289","https://openalex.org/W4289337620","https://openalex.org/W4295290250","https://openalex.org/W4360820722","https://openalex.org/W4377088915","https://openalex.org/W4386213939","https://openalex.org/W4387540019","https://openalex.org/W4388705905","https://openalex.org/W4391424688","https://openalex.org/W4392499189","https://openalex.org/W4396677206","https://openalex.org/W4401798942","https://openalex.org/W4403718853","https://openalex.org/W4409787524","https://openalex.org/W4410232887","https://openalex.org/W4411448591","https://openalex.org/W4411922474","https://openalex.org/W4414300464","https://openalex.org/W4415447320","https://openalex.org/W4416602230","https://openalex.org/W4417093679","https://openalex.org/W7129090003","https://openalex.org/W7131395964","https://openalex.org/W7164833312","https://openalex.org/W7202075402"],"related_works":["https://openalex.org/W2055242200","https://openalex.org/W4389752873","https://openalex.org/W4386188486","https://openalex.org/W4417093679","https://openalex.org/W7203737667","https://openalex.org/W3028530921","https://openalex.org/W2906799899","https://openalex.org/W4404414823","https://openalex.org/W2159358641","https://openalex.org/W4387296506"],"abstract_inverted_index":{"ABSTRACT":[0],"Per-":[1],"and":[2,63,85,109,144,156,162,187],"polyfluoroalkyl":[3],"substances":[4],"(PFAS)":[5],"are":[6],"persistent":[7],"environmental":[8,139,174,212],"contaminants":[9],"with":[10,124],"poorly":[11],"understood":[12],"sublethal":[13,166],"effects":[14,167],"on":[15],"insects.":[16],"Perfluorooctanoic":[17],"acid":[18],"(PFOA),":[19],"one":[20],"of":[21,82,189,226],"the":[22,42,184,190,223],"most":[23],"widely":[24],"distributed":[25],"legacy":[26],"PFAS":[27],"is":[28],"increasingly":[29],"recognized":[30],"for":[31],"altering":[32],"organismal":[33],"physiology":[34],"beyond":[35],"traditional":[36],"toxicity":[37],"endpoints.":[38],"Here,":[39],"we":[40,179,197],"use":[41],"fruit":[43,191],"fly":[44,192],"Drosophila":[45,193,202],"melanogaster":[46,194],"as":[47],"a":[48,160],"model":[49],"to":[50,75,87,98,138,211],"examine":[51],"how":[52,181],"PFOA":[53,78,101,153,182,200,219],"exposure":[54],"during":[55],"larval":[56,103],"(juvenile)":[57],"development":[58],"reshapes":[59],"insect":[60,171,227],"life-history":[61],"progression":[62],"metabolic":[64,88,112,155],"homeostasis.":[65],"Our":[66],"studies":[67],"reveal":[68],"that":[69,90,117,129,152,168,199,217],"at":[70],"environmentally":[71],"relevant":[72],"concentrations":[73,96],"(nM":[74],"low":[76],"\u00b5M),":[77],"induces":[79],"precocious":[80],"expression":[81],"developmentally-regulated":[83],"genes":[84],"leads":[86],"changes":[89],"persist":[91],"into":[92],"adulthood.":[93],"At":[94],"higher":[95],"used":[97],"probe":[99],"mechanism,":[100],"accelerates":[102,201],"development,":[104,186],"disrupts":[105,154],"mitochondrial":[106,120],"membrane":[107],"potential,":[108],"increases":[110],"whole-organism":[111],"heat":[113],"production":[114],"\u2013":[115],"results":[116],"suggest":[118,216],"altered":[119],"energetic":[121],"efficiency.":[122],"Consistent":[123],"this":[125],"tradeoff,":[126],"PFOA-exposed":[127],"larvae":[128,209],"develop":[130],"faster":[131],"under":[132,173],"permissive":[133],"conditions":[134],"exhibit":[135],"heightened":[136],"sensitivity":[137],"stressors,":[140],"including":[141],"elevated":[142],"temperature":[143],"reduced":[145],"food":[146],"hydration.":[147],"Together,":[148],"these":[149],"findings":[150],"demonstrate":[151],"developmental":[157,224],"processes":[158],"in":[159],"dose-":[161],"context-dependent":[163],"manner,":[164],"highlighting":[165],"may":[169,221],"influence":[170],"resilience":[172],"stress.":[175,213],"SYNOPSIS":[176],"STATEMENT":[177],"Here":[178],"describe":[180],"alters":[183],"growth,":[185],"metabolism":[188],".":[195],"Specifically,":[196],"find":[198],"juvenile":[203],"growth":[204],"while":[205],"also":[206],"rendering":[207],"exposed":[208],"sensitive":[210],"These":[214],"observations":[215],"widespread":[218],"contamination":[220],"impair":[222],"fitness":[225],"populations.":[228]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-06-18T00:00:00"}
