{"id":"https://openalex.org/W7165017283","doi":"https://doi.org/10.1158/0008-5472.32704925","title":"Figure S6 from The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination\u2013Deficient Tumors","display_name":"Figure S6 from The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination\u2013Deficient Tumors","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7165017283","doi":"https://doi.org/10.1158/0008-5472.32704925"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.32704925","doi":"https://doi.org/10.1158/0008-5472.32704925","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32704925","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.32704925","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042693679","display_name":"Louise Cadzow","orcid":"https://orcid.org/0009-0004-5779-4232","observed_orcids":["https://orcid.org/0009-0004-5779-4232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louise Cadzow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-5779-4232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091424768","display_name":"Jehrod B. Brenneman","orcid":"https://orcid.org/0000-0001-6720-4508","observed_orcids":["https://orcid.org/0000-0001-6720-4508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jehrod Brenneman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6720-4508","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089107314","display_name":"Erica R. Tobin","orcid":"https://orcid.org/0009-0009-0056-5224","observed_orcids":["https://orcid.org/0009-0009-0056-5224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Tobin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-0056-5224","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086231024","display_name":"Pamela Sullivan","orcid":"https://orcid.org/0009-0006-7909-7803","observed_orcids":["https://orcid.org/0009-0006-7909-7803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela Sullivan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7909-7803","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028674363","display_name":"Sumeet U. Nayak","orcid":"https://orcid.org/0000-0002-3326-6484","observed_orcids":["https://orcid.org/0000-0002-3326-6484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumeet Nayak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3326-6484","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042602186","display_name":"Janid A. Ali","orcid":"https://orcid.org/0009-0002-6166-2182","observed_orcids":["https://orcid.org/0009-0002-6166-2182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janid A. Ali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-6166-2182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110720892","display_name":"Sol Shenker","orcid":"https://orcid.org/0000-0003-3010-9413","observed_orcids":["https://orcid.org/0000-0003-3010-9413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sol Shenker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3010-9413","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110051750","display_name":"Jim Griffith","orcid":"https://orcid.org/0009-0006-4504-7760","observed_orcids":["https://orcid.org/0009-0006-4504-7760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jim Griffith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-4504-7760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004182311","display_name":"Michael S. McGuire","orcid":"https://orcid.org/0009-0009-2492-1625","observed_orcids":["https://orcid.org/0009-0009-2492-1625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael McGuire","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-2492-1625","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020357564","display_name":"Paula E. Grasberger","orcid":"https://orcid.org/0000-0003-4241-081X","observed_orcids":["https://orcid.org/0000-0003-4241-081X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Grasberger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4241-081X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038601075","display_name":"Yuji Mishina","orcid":"https://orcid.org/0009-0001-3612-9207","observed_orcids":["https://orcid.org/0009-0001-3612-9207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Mishina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-3612-9207","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077947042","display_name":"Morgan Murray","orcid":"https://orcid.org/0009-0003-2942-8836","observed_orcids":["https://orcid.org/0009-0003-2942-8836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan Murray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-2942-8836","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070142933","display_name":"Anne E. Dodson","orcid":"https://orcid.org/0000-0001-7719-0496","observed_orcids":["https://orcid.org/0000-0001-7719-0496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne E. Dodson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7719-0496","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080199009","display_name":"Hugh Gannon","orcid":"https://orcid.org/0000-0003-0923-7330","observed_orcids":["https://orcid.org/0000-0003-0923-7330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugh Gannon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0923-7330","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103733399","display_name":"Elsa Beyer Krall","orcid":"https://orcid.org/0009-0001-6130-613X","observed_orcids":["https://orcid.org/0009-0001-6130-613X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elsa Krall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-6130-613X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045621908","display_name":"Jeff Hixon","orcid":"https://orcid.org/0009-0001-4460-2041","observed_orcids":["https://orcid.org/0009-0001-4460-2041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Hixon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4460-2041","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014982944","display_name":"Edmond Chipumuro","orcid":"https://orcid.org/0009-0009-1640-1718","observed_orcids":["https://orcid.org/0009-0009-1640-1718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmond Chipumuro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1640-1718","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072818782","display_name":"Kerstin W. Sinkevicius","orcid":"https://orcid.org/0000-0002-4000-6277","observed_orcids":["https://orcid.org/0000-0002-4000-6277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerstin Sinkevicius","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4000-6277","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080775024","display_name":"Prafulla C. Gokhale","orcid":"https://orcid.org/0000-0002-1974-5921","observed_orcids":["https://orcid.org/0000-0002-1974-5921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prafulla C. Gokhale","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1974-5921","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109745888","display_name":"Suthakar Ganapathy","orcid":"https://orcid.org/0000-0003-3828-5382","observed_orcids":["https://orcid.org/0000-0003-3828-5382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suthakar Ganapathy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3828-5382","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ursula A. Matulonis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3103-6992","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060953135","display_name":"Joyce F. Liu","orcid":"https://orcid.org/0000-0003-3888-3972","observed_orcids":["https://orcid.org/0000-0003-3888-3972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce F. Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3888-3972","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085749352","display_name":"Andrew J. Olaharski","orcid":"https://orcid.org/0009-0008-2077-2960","observed_orcids":["https://orcid.org/0009-0008-2077-2960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Olaharski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2077-2960","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034299556","display_name":"Dipen P. Sangurdekar","orcid":"https://orcid.org/0000-0001-9474-0808","observed_orcids":["https://orcid.org/0000-0001-9474-0808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dipen Sangurdekar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9474-0808","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061268748","display_name":"Hanlan Liu","orcid":"https://orcid.org/0009-0003-7724-9103","observed_orcids":["https://orcid.org/0009-0003-7724-9103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanlan Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7724-9103","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062794895","display_name":"Jeremy Wilt","orcid":"https://orcid.org/0009-0007-6078-3587","observed_orcids":["https://orcid.org/0009-0007-6078-3587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Wilt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-6078-3587","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113729298","display_name":"Michael R. Schlabach","orcid":"https://orcid.org/0009-0004-2729-7614","observed_orcids":["https://orcid.org/0009-0004-2729-7614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schlabach","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-2729-7614","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026781698","display_name":"Frank P. Stegmeier","orcid":"https://orcid.org/0009-0005-3612-2418","observed_orcids":["https://orcid.org/0009-0005-3612-2418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Stegmeier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-3612-2418","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054650617","display_name":"Andrew A. Wylie","orcid":"https://orcid.org/0009-0000-2694-231X","observed_orcids":["https://orcid.org/0009-0000-2694-231X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew A. Wylie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2694-231X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp1-inhibitor","display_name":"USP1 inhibitor","score":0.871999979019165},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.4659999907016754},{"id":"https://openalex.org/keywords/cell-lines","display_name":"cell lines","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6930999755859375},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6887000203132629},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5978999733924866},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5012000203132629},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.4973999857902527},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4715999960899353},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.46810001134872437},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44769999384880066},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.43799999356269836},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.39500001072883606},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2741999924182892}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.32704925","doi":"https://doi.org/10.1158/0008-5472.32704925","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32704925","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.32704925","doi":"https://doi.org/10.1158/0008-5472.32704925","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32704925","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403436765","https://openalex.org/W7165048988","https://openalex.org/W4403436732","https://openalex.org/W7164986571","https://openalex.org/W4403436813","https://openalex.org/W7164992437","https://openalex.org/W4403437033","https://openalex.org/W7165020048","https://openalex.org/W4403436745","https://openalex.org/W4403436939"],"abstract_inverted_index":{"Western":[0],"blot":[1],"analysis":[2],"of":[3],"sensitive":[4],"and":[5],"insensitive":[6],"cell":[7],"lines":[8],"to":[9],"USP1":[10],"inhibition":[11]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-18T00:00:00"}