{"id":"https://openalex.org/W7165009237","doi":"https://doi.org/10.1158/2767-9764.32702391","title":"Figure 2 from Advanced CD276-Targeting Dual-Payload Antibody\u2013Drug Conjugates for Cancer Therapy","display_name":"Figure 2 from Advanced CD276-Targeting Dual-Payload Antibody\u2013Drug Conjugates for Cancer Therapy","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7165009237","doi":"https://doi.org/10.1158/2767-9764.32702391"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.32702391","doi":"https://doi.org/10.1158/2767-9764.32702391","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.32702391","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.32702391","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019392401","display_name":"Zhuoxin \u201cZora\u201d Zhou","orcid":"https://orcid.org/0009-0006-2669-9595","observed_orcids":["https://orcid.org/0009-0006-2669-9595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhuoxin Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-2669-9595","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107060971","display_name":"Davis Ballard","orcid":"https://orcid.org/0009-0009-4277-6468","observed_orcids":["https://orcid.org/0009-0009-4277-6468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Davis Ballard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4277-6468","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019408916","display_name":"Jiashuai Zhang","orcid":"https://orcid.org/0000-0001-8953-8963","observed_orcids":["https://orcid.org/0000-0001-8953-8963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiashuai Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8953-8963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121477320","display_name":"Zhantao Du","orcid":"https://orcid.org/0009-0006-3321-2634","observed_orcids":["https://orcid.org/0009-0006-3321-2634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhantao Du","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-3321-2634","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085114789","display_name":"Natsorn Watcharadulyarat","orcid":"https://orcid.org/0009-0001-3573-2223","observed_orcids":["https://orcid.org/0009-0001-3573-2223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natsorn Watcharadulyarat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-3573-2223","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092978984","display_name":"Tanvi Varadkar","orcid":"https://orcid.org/0009-0000-7235-1414","observed_orcids":["https://orcid.org/0009-0000-7235-1414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanvi Varadkar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7235-1414","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040367171","display_name":"Srijita Chowdhury","orcid":"https://orcid.org/0000-0001-7785-984X","observed_orcids":["https://orcid.org/0000-0001-7785-984X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srijita Chowdhury","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7785-984X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134108454","display_name":"Sathvik R. Kambam","orcid":"https://orcid.org/0009-0002-2123-2364","observed_orcids":["https://orcid.org/0009-0002-2123-2364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sathvik R. Kambam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2123-2364","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113349403","display_name":"Peiqun Hu","orcid":"https://orcid.org/0009-0008-1465-2217","observed_orcids":["https://orcid.org/0009-0008-1465-2217","https://orcid.org/0009-0005-8514-7611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phoebe Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1465-2217","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130500473","display_name":"Selena Khanal","orcid":"https://orcid.org/0009-0002-1054-4426","observed_orcids":["https://orcid.org/0009-0002-1054-4426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selena Khanal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-1054-4426","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022429262","display_name":"Lufang Zhou","orcid":"https://orcid.org/0000-0002-1321-8442","observed_orcids":["https://orcid.org/0000-0002-1321-8442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lufang Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1321-8442","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082669345","display_name":"Margaret Liu","orcid":"https://orcid.org/0000-0002-4617-9750","observed_orcids":["https://orcid.org/0000-0002-4617-9750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoguang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4617-9750","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.8669999837875366},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dual-payload-adc","display_name":"dual-payload ADC","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dm1","display_name":"DM1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/deruxtecan","display_name":"deruxtecan","score":0.8970000147819519},{"id":"https://openalex.org/keywords/monomethyl-auristatin-f","display_name":"monomethyl auristatin F","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tcep-reduction","display_name":"TCEP reduction","score":0.847000002861023},{"id":"https://openalex.org/keywords/conjugation-strategies","display_name":"conjugation strategies","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.8587999939918518},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6191999912261963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5677000284194946},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4496000111103058},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.4221000075340271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37059998512268066},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3522000014781952},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.24529999494552612}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.32702391","doi":"https://doi.org/10.1158/2767-9764.32702391","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.32702391","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.32702391","doi":"https://doi.org/10.1158/2767-9764.32702391","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.32702391","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165013239","https://openalex.org/W7165016802","https://openalex.org/W7155039643","https://openalex.org/W7165018302","https://openalex.org/W7148913056","https://openalex.org/W7164998223","https://openalex.org/W4385367779","https://openalex.org/W3163595140","https://openalex.org/W7165010790","https://openalex.org/W4410098055"],"abstract_inverted_index":{"Schematic":[0],"illustration":[1],"of":[2,12,24,41,46,59,71,76,89,105],"DualADC":[3],"conjugation":[4,11,23,40,45,58,70,75,88,104],"strategies":[5],"and":[6],"HPLC":[7,36,66,100],"characterization.":[8],"A,":[9],"mAb-DM1/IMQ:":[10],"DM1":[13],"to":[14,26,48,78,91],"the":[15,27,39,49,69,79,92,103],"mAb":[16,51,81],"via":[17,31,52,61,82,95],"a":[18,32,53,62,83,96],"lysine-based":[19,63,97],"strategy,":[20,55,85],"followed":[21,56,86],"by":[22,57,87],"IMQ":[25,60,90],"TCEP-reduced":[28,50,80],"mAb-DM1":[29],"ADC":[30,94],"cysteine-based":[33,54,84],"strategy.":[34,64,98],"B,":[35],"characterization":[37,67,101],"confirming":[38,68,102],"mAb-DM1/IMQ.":[42],"C,":[43],"mAb-DXd/IMQ:":[44],"DXd":[47],"D,":[65],"mAb-DXd/IMQ.":[72],"E,":[73],"mAb-MMAF/IMQ:":[74],"MMAF":[77],"mAb-MMAF":[93],"F,":[99],"mAb-MMAF/IMQ.":[106]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-18T00:00:00"}