{"id":"https://openalex.org/W7164998484","doi":"https://doi.org/10.1158/0008-5472.32705321","title":"Supplementary Table 5 from Spatiotemporal Profiling Defines Persistence and Resistance Dynamics during Targeted Treatment of Melanoma","display_name":"Supplementary Table 5 from Spatiotemporal Profiling Defines Persistence and Resistance Dynamics during Targeted Treatment of Melanoma","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7164998484","doi":"https://doi.org/10.1158/0008-5472.32705321"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.32705321","doi":"https://doi.org/10.1158/0008-5472.32705321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32705321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.32705321","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049903801","display_name":"Jill Carol Rubinstein","orcid":"https://orcid.org/0000-0002-1222-8657","observed_orcids":["https://orcid.org/0000-0002-1222-8657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill C. Rubinstein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1222-8657","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050246743","display_name":"Sergii Domanskyi","orcid":"https://orcid.org/0000-0002-6847-6019","observed_orcids":["https://orcid.org/0000-0002-6847-6019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergii Domanskyi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6847-6019","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088803747","display_name":"Todd Sheridan","orcid":"https://orcid.org/0000-0001-8968-9315","observed_orcids":["https://orcid.org/0000-0001-8968-9315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd B. Sheridan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8968-9315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013763988","display_name":"Brian J. Sanderson","orcid":"https://orcid.org/0000-0002-0310-0440","observed_orcids":["https://orcid.org/0000-0002-0310-0440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Sanderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0310-0440","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034172129","display_name":"SungHee Park","orcid":"https://orcid.org/0000-0002-3453-9501","observed_orcids":["https://orcid.org/0000-0002-3453-9501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SungHee Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3453-9501","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032574056","display_name":"Jessica Kaster","orcid":"https://orcid.org/0000-0001-9622-8795","observed_orcids":["https://orcid.org/0000-0001-9622-8795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Kaster","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9622-8795","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835566","display_name":"Haiyin Li","orcid":"https://orcid.org/0000-0001-6205-7588","observed_orcids":["https://orcid.org/0000-0001-6205-7588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haiyin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6205-7588","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036556841","display_name":"Olga Anczuk\u00f3w","orcid":"https://orcid.org/0000-0003-0516-2677","observed_orcids":["https://orcid.org/0000-0003-0516-2677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Anczukow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0516-2677","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0839-0739","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078627287","display_name":"Jeffrey H. Chuang","orcid":"https://orcid.org/0000-0002-3298-2358","observed_orcids":["https://orcid.org/0000-0002-3298-2358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey H. Chuang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3298-2358","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tumor-persistence","display_name":"tumor persistence","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.6875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6115000247955322},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5929999947547913},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5702999830245972},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5631999969482422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4839000105857849},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.4729999899864197},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.4724000096321106},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.3797000050544739},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3361000120639801},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26969999074935913},{"id":"https://openalex.org/C2779466056","wikidata":"https://www.wikidata.org/wiki/Q107630651","display_name":"Time point","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.32705321","doi":"https://doi.org/10.1158/0008-5472.32705321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32705321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/32705321","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Table_5_from_Spatiotemporal_Profiling_Defines_Persistence_and_Resistance_Dynamics_during_Targeted_Treatment_of_Melanoma/32705321","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.32705321","doi":"https://doi.org/10.1158/0008-5472.32705321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.32705321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405596370","https://openalex.org/W4362597307","https://openalex.org/W4408122084","https://openalex.org/W4361920573","https://openalex.org/W4362401232","https://openalex.org/W2415801554","https://openalex.org/W1984466062","https://openalex.org/W4391446672","https://openalex.org/W7127165822"],"abstract_inverted_index":{"Differentially":[0],"expressed":[1],"genes":[2],"between":[3],"time":[4,8],"point":[5,9],"1":[6],"and":[7,37,41],"0":[10],"with":[11],"significant":[12],"corrected":[13],"p-values":[14],"in":[15,23,31,38],"the":[16,24,32],"resistant":[17,42],"lineages":[18,26],"(1,":[19],"2)":[20],"but":[21,34],"not":[22,35],"sensitive":[25,33,40],"(0,":[27],"5,":[28],"8)":[29],",":[30],"resistant,":[36],"both":[39],"(WM4007).":[43]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-18T00:00:00"}