{"id":"https://openalex.org/W7164986582","doi":"https://doi.org/10.1158/0008-5472.c.8541914","title":"Data from Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies","display_name":"Data from Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7164986582","doi":"https://doi.org/10.1158/0008-5472.c.8541914"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.8541914","doi":"https://doi.org/10.1158/0008-5472.c.8541914","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8541914","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.8541914","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138828456","display_name":"Mario F. Fraga","orcid":"https://orcid.org/0000-0001-5871-758X","observed_orcids":["https://orcid.org/0000-0001-5871-758X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario F. Fraga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057966876","display_name":"Mar\u00eda Berdasco","orcid":"https://orcid.org/0000-0002-6750-0400","observed_orcids":["https://orcid.org/0000-0002-6750-0400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Berdasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082124562","display_name":"Esteban Ballestar","orcid":"https://orcid.org/0000-0002-1400-2440","observed_orcids":["https://orcid.org/0000-0002-1400-2440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esteban Ballestar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068392384","display_name":"Santiago Ropero","orcid":"https://orcid.org/0000-0003-3522-8104","observed_orcids":["https://orcid.org/0000-0003-3522-8104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santiago Ropero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138761718","display_name":"Pilar Lopez-Nieva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pilar Lopez-Nieva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554652","display_name":"Lidia Lopez\u2010Serra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lidia Lopez-Serra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138759532","display_name":"Jose\u0301 I. Marti\u0301n-Subero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose\u0301 I. Marti\u0301n-Subero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138762473","display_name":"Maria J. Calasanz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria J. Calasanz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080955509","display_name":"Isabel L\u00f3pez de Silanes","orcid":"https://orcid.org/0000-0001-6762-9792","observed_orcids":["https://orcid.org/0000-0001-6762-9792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabel Lopez de Silanes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138817089","display_name":"Fernando Setien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Setien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066806053","display_name":"Sara Casado","orcid":"https://orcid.org/0000-0002-7018-9772","observed_orcids":["https://orcid.org/0000-0002-7018-9772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Casado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037828387","display_name":"Agust\u00edn F. Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3792-4085","observed_orcids":["https://orcid.org/0000-0002-3792-4085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agustin F. Fernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138777276","display_name":"Reiner Siebert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reiner Siebert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083828029","display_name":"Stefano Stifani","orcid":"https://orcid.org/0000-0002-2376-7701","observed_orcids":["https://orcid.org/0000-0002-2376-7701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Stifani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5121073222","display_name":"Manel Esteller","orcid":"https://orcid.org/0000-0003-4490-6093","observed_orcids":["https://orcid.org/0000-0003-4490-6093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manel Esteller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tle1","display_name":"TLE1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7429999709129333},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.902999997138977},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.859000027179718},{"id":"https://openalex.org/keywords/csf-1-receptor","display_name":"CSF-1 receptor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7283999919891357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7210000157356262},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6403999924659729},{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.613099992275238},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6055999994277954},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5806000232696533},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5722000002861023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4684999883174896},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.44749999046325684},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42829999327659607},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.42149999737739563},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3824000060558319},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3652999997138977},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3255000114440918},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2937999963760376},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2791999876499176},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.2703999876976013},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.26159998774528503}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.8541914","doi":"https://doi.org/10.1158/0008-5472.c.8541914","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8541914","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.8541914","doi":"https://doi.org/10.1158/0008-5472.c.8541914","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8541914","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016701073","https://openalex.org/W1215979266","https://openalex.org/W2979555629","https://openalex.org/W2550796377","https://openalex.org/W1966030278","https://openalex.org/W2979933303","https://openalex.org/W2059387816","https://openalex.org/W2512063741","https://openalex.org/W2006354293","https://openalex.org/W2530932278"],"abstract_inverted_index":{"Abstract":[0],"An":[1],"undifferentiated":[2],"status":[3],"and":[4,51,75,89,107,146,169],"the":[5,45,84,90,160],"epigenetic":[6,85,156],"inactivation":[7,65,157],"of":[8,13,20,33,83,87,93,148,162],"tumor-suppressor":[9],"genes":[10],"are":[11,127],"hallmarks":[12],"transformed":[14],"cells.":[15],"Promoter":[16],"CpG":[17,62],"island":[18,63],"hypermethylation":[19],"differentiating":[21],"genes,":[22,137],"however,":[23],"has":[24],"rarely":[25],"been":[26],"reported.":[27],"The":[28],"Groucho":[29],"homologue":[30],"Transducin-like":[31],"Enhancer":[32],"Split":[34,149],"1":[35,144],"(TLE1)":[36],"is":[37],"a":[38,80],"multitasked":[39],"transcriptional":[40,131],"corepressor":[41],"that":[42,58,124,154],"acts":[43],"through":[44],"acute":[46],"myelogenous":[47],"leukemia":[48],"1,":[49],"Wnt,":[50],"Notch":[52],"signaling":[53],"pathways.":[54,171],"We":[55,77,121],"have":[56],"found":[57],"TLE1":[59,88,95,130,155],"undergoes":[60],"promoter":[61],"hypermethylation\u2013associated":[64],"in":[66,97,104,115],"hematologic":[67,163],"malignancies,":[68],"such":[69,138],"as":[70,139],"diffuse":[71],"large":[72],"B-cell":[73],"lymphoma":[74],"AML.":[76],"also":[78,122],"observed":[79],"mutual":[81],"exclusivity":[82],"alteration":[86,92],"cytogenetic":[91],"AML1.":[94],"reintroduction":[96],"hypermethylated":[98],"leukemia/lymphoma":[99],"cells":[100,117],"causes":[101],"growth":[102],"inhibition":[103],"colony":[105],"assays":[106],"nude":[108],"mice,":[109],"whereas":[110],"TLE1-short":[111],"hairpin":[112],"RNA":[113],"depletion":[114],"unmethylated":[116],"enhances":[118],"tumor":[119],"growth.":[120],"show":[123],"these":[125],"effects":[126],"mediated":[128],"by":[129,165],"repressor":[132],"activity":[133],"on":[134],"its":[135],"target":[136],"Cyclin":[140],"D1,":[141],"Colony-Stimulating":[142],"Factor":[143],"receptor,":[145],"Hairy/Enhancer":[147],"1.":[150],"These":[151],"data":[152],"suggest":[153],"contributes":[158],"to":[159],"development":[161],"malignancies":[164],"disrupting":[166],"critical":[167],"differentiation":[168],"growth-suppressing":[170],"[Cancer":[172],"Res":[173],"2008;68(11):4116\u201322]":[174]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-06-18T00:00:00"}