{"id":"https://openalex.org/W7164986543","doi":"https://doi.org/10.1158/1078-0432.32710249","title":"Supplementary Table S2 from ESR1 Y537S and D538G Mutations Drive Resistance to CDK4/6 Inhibitors in Estrogen Receptor\u2013Positive Breast Cancer","display_name":"Supplementary Table S2 from ESR1 Y537S and D538G Mutations Drive Resistance to CDK4/6 Inhibitors in Estrogen Receptor\u2013Positive Breast Cancer","publication_year":2026,"publication_date":"2026-06-17","ids":{"openalex":"https://openalex.org/W7164986543","doi":"https://doi.org/10.1158/1078-0432.32710249"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.32710249","doi":"https://doi.org/10.1158/1078-0432.32710249","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.32710249","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.32710249","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100744090","display_name":"Chang-Ching A. Lin","orcid":"https://orcid.org/0000-0001-6659-5543","observed_orcids":["https://orcid.org/0000-0001-6659-5543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang-Ching A. Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6659-5543","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092122840","display_name":"Mar\u00eda del Rosario Chica-Parrado","orcid":"https://orcid.org/0000-0001-5007-7063","observed_orcids":["https://orcid.org/0000-0001-5007-7063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Rosario Chica-Parrado","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5007-7063","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061962242","display_name":"Nisha G Unni","orcid":"https://orcid.org/0000-0003-1549-4720","observed_orcids":["https://orcid.org/0000-0003-1549-4720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nisha Unni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1549-4720","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060092579","display_name":"Ellen Jaeger","orcid":"https://orcid.org/0009-0005-1386-614X","observed_orcids":["https://orcid.org/0009-0005-1386-614X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen Jaeger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-1386-614X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113155689","display_name":"Yisheng V. Fang","orcid":"https://orcid.org/0000-0002-5002-8162","observed_orcids":["https://orcid.org/0000-0002-5002-8162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yisheng V. Fang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5002-8162","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050753536","display_name":"Lei Ming Guo","orcid":"https://orcid.org/0000-0002-6072-2377","observed_orcids":["https://orcid.org/0000-0002-6072-2377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6072-2377","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086774807","display_name":"Fabiana Napolitano","orcid":"https://orcid.org/0000-0002-2463-8952","observed_orcids":["https://orcid.org/0000-0002-2463-8952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiana Napolitano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2463-8952","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002131353","display_name":"Pamela Luna","orcid":"https://orcid.org/0009-0007-9127-1541","observed_orcids":["https://orcid.org/0009-0007-9127-1541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela Luna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9127-1541","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108737551","display_name":"Michelle Harris","orcid":"https://orcid.org/0009-0002-8702-4189","observed_orcids":["https://orcid.org/0009-0002-8702-4189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Harris","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-8702-4189","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038841214","display_name":"Calvin Y. Chao","orcid":"https://orcid.org/0000-0002-9704-9227","observed_orcids":["https://orcid.org/0000-0002-9704-9227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Calvin Chao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9704-9227","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079210379","display_name":"Lin Xu","orcid":"https://orcid.org/0000-0001-5815-4457","observed_orcids":["https://orcid.org/0000-0001-5815-4457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5815-4457","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043946489","display_name":"Carlos L. Arteaga","orcid":"https://orcid.org/0000-0003-0870-9586","observed_orcids":["https://orcid.org/0000-0003-0870-9586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos L. Arteaga","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0870-9586","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020373259","display_name":"Ariella B. Hanker","orcid":"https://orcid.org/0000-0002-8655-8341","observed_orcids":["https://orcid.org/0000-0002-8655-8341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariella B. Hanker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8655-8341","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.824999988079071},{"id":"https://openalex.org/keywords/y537s-mutation","display_name":"Y537S mutation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/d538g-mutation","display_name":"D538G mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.7910000085830688},{"id":"https://openalex.org/keywords/previously-treated-patients","display_name":"previously treated patients","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6470999717712402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6011000275611877},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5335999727249146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4659000039100647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.460099995136261},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.44119998812675476},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.439300000667572},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4343000054359436},{"id":"https://openalex.org/C2776162770","wikidata":"https://www.wikidata.org/wiki/Q4653351","display_name":"APOBEC","level":4,"score":0.4336000084877014},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.27649998664855957},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703000009059906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.32710249","doi":"https://doi.org/10.1158/1078-0432.32710249","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.32710249","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.32710249","doi":"https://doi.org/10.1158/1078-0432.32710249","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.32710249","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407902344","https://openalex.org/W7165019625","https://openalex.org/W4396587803","https://openalex.org/W2396900282","https://openalex.org/W7166309331","https://openalex.org/W3123311824","https://openalex.org/W4321375744","https://openalex.org/W4322773982","https://openalex.org/W6920376556","https://openalex.org/W3212605524"],"abstract_inverted_index":{"Prevalence":[0],"of":[1],"gene":[2],"alterations":[3],"in":[4,10],"patients":[5],"treated":[6],"with":[7],"different":[8],"CDK4/6i":[9],"xF":[11]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-18T00:00:00"}