{"id":"https://openalex.org/W7164933945","doi":"https://doi.org/10.1093/jac/dkag180","title":"A randomized controlled Phase I de-escalation trial of molnupiravir and nirmatrelvir/ritonavir combination for mild-moderate SARS-CoV-2 infection","display_name":"A randomized controlled Phase I de-escalation trial of molnupiravir and nirmatrelvir/ritonavir combination for mild-moderate SARS-CoV-2 infection","publication_year":2026,"publication_date":"2026-05-07","ids":{"openalex":"https://openalex.org/W7164933945","doi":"https://doi.org/10.1093/jac/dkag180","pmid":"https://pubmed.ncbi.nlm.nih.gov/42301199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13270479"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkag180","doi":"https://doi.org/10.1093/jac/dkag180","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkag180","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/jac/dkag180","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041365930","display_name":"Saye Khoo","orcid":"https://orcid.org/0000-0002-2769-0967","observed_orcids":["https://orcid.org/0000-0002-2769-0967"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Saye H Khoo","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-2769-0967","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129793273","display_name":"Richard FitzGerald","orcid":"https://orcid.org/0000-0003-0227-4200","observed_orcids":["https://orcid.org/0000-0003-0227-4200"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard FitzGerald","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0003-0227-4200","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080267247","display_name":"Christopher John Edwards","orcid":"https://orcid.org/0000-0002-8233-6602","observed_orcids":["https://orcid.org/0000-0002-8233-6602"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher J Edwards","raw_affiliation_strings":["NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":"https://orcid.org/0000-0002-8233-6602","affiliations":[{"raw_affiliation_string":"NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062726427","display_name":"Shazaad S. Y. Ahmad","orcid":"https://orcid.org/0000-0002-0400-8937","observed_orcids":["https://orcid.org/0000-0002-0400-8937"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4405271435","display_name":"NIHR Manchester Clinical Research Facility","ror":"https://ror.org/02e706q76","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4405271435"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shazaad Ahmad","raw_affiliation_strings":["NIHR Manchester Clinical Research Facility, University of Manchester , Manchester ,"],"raw_orcid":"https://orcid.org/0000-0002-0400-8937","affiliations":[{"raw_affiliation_string":"NIHR Manchester Clinical Research Facility, University of Manchester , Manchester ,","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4405271435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109966174","display_name":"Geoffrey Saunders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geoffrey Saunders","raw_affiliation_strings":["Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089793108","display_name":"Laura Else","orcid":"https://orcid.org/0009-0007-0078-3294","observed_orcids":["https://orcid.org/0009-0007-0078-3294"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura J Else","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0009-0007-0078-3294","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059419654","display_name":"Victoria E. Shaw","orcid":"https://orcid.org/0000-0002-0429-0186","observed_orcids":["https://orcid.org/0000-0002-0429-0186"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Shaw","raw_affiliation_strings":["Clinical Directorate, University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-0429-0186","affiliations":[{"raw_affiliation_string":"Clinical Directorate, University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077581045","display_name":"Pavel Mozgunov","orcid":"https://orcid.org/0000-0001-6810-0284","observed_orcids":["https://orcid.org/0000-0001-6810-0284"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pavel Mozgunov","raw_affiliation_strings":["MRC Biostatistics Unit, University of Cambridge , Cambridge ,"],"raw_orcid":"https://orcid.org/0000-0001-6810-0284","affiliations":[{"raw_affiliation_string":"MRC Biostatistics Unit, University of Cambridge , Cambridge ,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050723763","display_name":"Josh Northey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joshua Northey","raw_affiliation_strings":["Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067575028","display_name":"Laura Dickinson","orcid":"https://orcid.org/0000-0001-5557-9396","observed_orcids":["https://orcid.org/0000-0001-5557-9396"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Dickinson","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073387972","display_name":"Emma Knox","orcid":"https://orcid.org/0009-0004-3221-5820","observed_orcids":["https://orcid.org/0009-0004-3221-5820"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma Knox","raw_affiliation_strings":["Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":"https://orcid.org/0009-0004-3221-5820","affiliations":[{"raw_affiliation_string":"Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030766359","display_name":"Amanda Buadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda Buadi","raw_affiliation_strings":["NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Colin Hale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin Hale","raw_affiliation_strings":["NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063085944","display_name":"Helen E. Reynolds","orcid":"https://orcid.org/0000-0001-7443-4520","observed_orcids":["https://orcid.org/0000-0001-7443-4520"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen E Reynolds","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0001-7443-4520","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114025934","display_name":"Calley Middleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Calley Middleton","raw_affiliation_strings":["Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082444206","display_name":"Katie Bullock","orcid":"https://orcid.org/0000-0002-5758-0179","observed_orcids":["https://orcid.org/0000-0002-5758-0179"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katie Bullock","raw_affiliation_strings":["Molecular & Clinical Cancer Medicine, University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-5758-0179","affiliations":[{"raw_affiliation_string":"Molecular & Clinical Cancer Medicine, University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076306365","display_name":"Lauren E. Walker","orcid":"https://orcid.org/0000-0003-1354-0826","observed_orcids":["https://orcid.org/0000-0003-1354-0826"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lauren Walker","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0003-1354-0826","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007068865","display_name":"Michelle Tetlow","orcid":"https://orcid.org/0000-0002-1064-3187","observed_orcids":["https://orcid.org/0000-0002-1064-3187"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michelle Tetlow","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108244011","display_name":"Rebecca Lyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Lyon","raw_affiliation_strings":["NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079733302","display_name":"Jennifer Gibney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270996","display_name":"Liverpool University Hospitals NHS Foundation Trust","ror":"https://ror.org/01pd4a160","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405270996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Gibney","raw_affiliation_strings":["NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Liverpool Clinical Research Facility, NHS University Hospitals of Liverpool Group , Liverpool ,","institution_ids":["https://openalex.org/I4405270996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022857046","display_name":"Alieu Amara","orcid":"https://orcid.org/0000-0002-1137-2948","observed_orcids":["https://orcid.org/0000-0002-1137-2948"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alieu Amara","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-1137-2948","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030627781","display_name":"William Greenhalf","orcid":"https://orcid.org/0000-0002-1865-3195","observed_orcids":["https://orcid.org/0000-0002-1865-3195"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Greenhalf","raw_affiliation_strings":["Molecular & Clinical Cancer Medicine, University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-1865-3195","affiliations":[{"raw_affiliation_string":"Molecular & Clinical Cancer Medicine, University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057471748","display_name":"Abigail Burdon","orcid":"https://orcid.org/0000-0002-0883-4160","observed_orcids":["https://orcid.org/0000-0002-0883-4160"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abigail Burdon","raw_affiliation_strings":["MRC Biostatistics Unit, University of Cambridge , Cambridge ,"],"raw_orcid":"https://orcid.org/0000-0002-0883-4160","affiliations":[{"raw_affiliation_string":"MRC Biostatistics Unit, University of Cambridge , Cambridge ,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030226133","display_name":"Jan Dixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jan Dixon","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053252382","display_name":"Thomas Jaki","orcid":"https://orcid.org/0000-0002-1096-188X","observed_orcids":["https://orcid.org/0000-0002-1096-188X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Thomas Jaki","raw_affiliation_strings":["Computational Statistics, University of Regensburg , Regensburg ,","MRC Biostatistics Unit, University of Cambridge , Cambridge ,"],"raw_orcid":"https://orcid.org/0000-0002-1096-188X","affiliations":[{"raw_affiliation_string":"Computational Statistics, University of Regensburg , Regensburg ,","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"MRC Biostatistics Unit, University of Cambridge , Cambridge ,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113942773","display_name":"Justin Chiong","orcid":"https://orcid.org/0000-0001-8063-6399","observed_orcids":["https://orcid.org/0000-0001-8063-6399"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Justin Chiong","raw_affiliation_strings":["Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0001-8063-6399","affiliations":[{"raw_affiliation_string":"Centre for Experimental Therapeutics (TherEx), University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069610196","display_name":"David Griffith Lalloo","orcid":"https://orcid.org/0000-0001-7680-2200","observed_orcids":["https://orcid.org/0000-0001-7680-2200"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David G Lalloo","raw_affiliation_strings":["Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0001-7680-2200","affiliations":[{"raw_affiliation_string":"Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066429649","display_name":"Andrew Owen","orcid":"https://orcid.org/0000-0002-9819-7651","observed_orcids":["https://orcid.org/0000-0002-9819-7651"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4405260362","display_name":"Centre of Excellence for Long-acting Therapeutics","ror":"https://ror.org/03mmsx307","country_code":"GB","type":"facility","lineage":["https://openalex.org/I146655781","https://openalex.org/I4405260362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andew Owen","raw_affiliation_strings":["Centre of Excellence for Long-Acting Therapeutics, University of Liverpool , Liverpool ,"],"raw_orcid":"https://orcid.org/0000-0002-9819-7651","affiliations":[{"raw_affiliation_string":"Centre of Excellence for Long-Acting Therapeutics, University of Liverpool , Liverpool ,","institution_ids":["https://openalex.org/I146655781","https://openalex.org/I4405260362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073271682","display_name":"Michael Jacobs","orcid":"https://orcid.org/0000-0001-5440-7381","observed_orcids":["https://orcid.org/0000-0001-5440-7381"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Jacobs","raw_affiliation_strings":["Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","Keble College, University of Oxford , Oxford ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","institution_ids":["https://openalex.org/I194839184"]},{"raw_affiliation_string":"Keble College, University of Oxford , Oxford ,","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023940756","display_name":"Tom E. Fletcher","orcid":"https://orcid.org/0000-0002-3712-415X","observed_orcids":["https://orcid.org/0000-0002-3712-415X"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Fletcher","raw_affiliation_strings":["Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084659683","display_name":"Gareth Owen Griffiths","orcid":"https://orcid.org/0000-0002-9579-8021","observed_orcids":["https://orcid.org/0000-0002-9579-8021"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Griffiths","raw_affiliation_strings":["Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,"],"raw_orcid":"https://orcid.org/0000-0002-9579-8021","affiliations":[{"raw_affiliation_string":"Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton ,","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138698216","display_name":"the AGILE CST-8 study group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the AGILE CST-8 study group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060349311","display_name":"Nicholas Iain Paton","orcid":"https://orcid.org/0000-0002-7003-9838","observed_orcids":["https://orcid.org/0000-0002-7003-9838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas Paton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019822248","display_name":"Fred Hayden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred Hayden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113936084","display_name":"Janet H Darbyshire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Darbyshire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138747625","display_name":"Amy Lucas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090439614","display_name":"Ulrika Lorch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrika Lorch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047893376","display_name":"Andrew Freedman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Freedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138729027","display_name":"Richard Knight","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Knight","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138707806","display_name":"Steven Julious","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Julious","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138700786","display_name":"Thomas Edwards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Edwards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005536591","display_name":"Christopher Myerscough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Myerscough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138709518","display_name":"Nuala Tainton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nuala Tainton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048953282","display_name":"Oliver Edwards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Edwards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061529989","display_name":"K L Thorne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerensa Thorne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029407907","display_name":"Sujan Dilly Penchala","orcid":"https://orcid.org/0000-0002-0504-1579","observed_orcids":["https://orcid.org/0000-0002-0504-1579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujan Dily Penchala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138713790","display_name":"Rachel Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129805956","display_name":"Callum Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Callum Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091594381","display_name":"Kate Dodd","orcid":"https://orcid.org/0000-0001-5829-3086","observed_orcids":["https://orcid.org/0000-0001-5829-3086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Dodd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015364331","display_name":"Callum AH Docherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Callum Docherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082817419","display_name":"C Boe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte Boe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069601905","display_name":"Alasdair Munro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alasdair Munro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Owens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Owens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055524274","display_name":"Mihaela Pacurar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mihaela Pacurar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018537669","display_name":"Gavin Babbage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gavin Babbage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5138711918","display_name":"Liza Shiner-Clark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liza Shiner-Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5041365930"],"corresponding_institution_ids":["https://openalex.org/I146655781","https://openalex.org/I4405270996"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":{"value":2869,"currency":"GBP","value_usd":3784},"fwci":4.1899,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.93421076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"81","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molnupiravir","display_name":"molnupiravir","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nirmatrelvir-ritonavir","display_name":"nirmatrelvir/ritonavir","score":0.9869999885559082},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dose-de-escalation","display_name":"dose de-escalation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8610000014305115},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8723999857902527},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8292999863624573},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6851000189781189},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.519599974155426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4927999973297119},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47589999437332153},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4693000018596649},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.38530001044273376},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3831999897956848},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.373199999332428},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.37229999899864197},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2660999894142151},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C2776768635","wikidata":"https://www.wikidata.org/wiki/Q3427301","display_name":"Volunteer","level":2,"score":0.26260000467300415}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003562","descriptor_name":"Cytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/jac/dkag180","doi":"https://doi.org/10.1093/jac/dkag180","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkag180","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.01.25326797","doi":"https://doi.org/10.1101/2025.05.01.25326797","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.01.25326797","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/05/02/2025.05.01.25326797.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42301199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42301199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:pubmedcentral.nih.gov:13270479","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42301199/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:243120","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-2769-0967>,","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/243120/1/A%20randomized%20controlled%20Phase%20I%20de-escalation%20trial%20of%20molnupiravir%20and%20nirmatrelvirritonavir%20combination%20for%20mild-moderate%20.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/405636","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/405636","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/51b3d5fe-0920-46f2-b791-7ab28bbefb6f/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/jac/dkag180","doi":"https://doi.org/10.1093/jac/dkag180","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkag180","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1380107558","display_name":"Bringing Innovative Methods for Early Phase Precision Medicine Trials Into Practice","funder_award_id":"NIHR300576","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G1590801500","display_name":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment","funder_award_id":"221590","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7648148677","display_name":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment","funder_award_id":"MR/V028391/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8304670825","display_name":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment","funder_award_id":"221590/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G866144867","display_name":null,"funder_award_id":"NIHR300576","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G915645594","display_name":null,"funder_award_id":"MC UU 00040/03","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312382","display_name":"ViiV Healthcare","ror":"https://ror.org/01cc9yk21"},{"id":"https://openalex.org/F4320313529","display_name":"Celldex Therapeutics","ror":"https://ror.org/055923009"},{"id":"https://openalex.org/F4320314605","display_name":"Astex Pharmaceuticals","ror":"https://ror.org/05fx1fs38"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320066","display_name":"Asthma and Lung UK","ror":"https://ror.org/03z7xev21"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320331688","display_name":"National Institute for Health Research Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":"https://ror.org/02fe4h741"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7164933945.pdf","grobid_xml":"https://content.openalex.org/works/W7164933945.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1977685796","https://openalex.org/W3036176716","https://openalex.org/W3189646261","https://openalex.org/W3196761554","https://openalex.org/W3198019853","https://openalex.org/W4200206478","https://openalex.org/W4205982475","https://openalex.org/W4220915936","https://openalex.org/W4226163566","https://openalex.org/W4283323022","https://openalex.org/W4286434216","https://openalex.org/W4297255628","https://openalex.org/W4306828790","https://openalex.org/W4312134853","https://openalex.org/W4312211133","https://openalex.org/W4361190367","https://openalex.org/W4365519893","https://openalex.org/W4372219003","https://openalex.org/W4385997556","https://openalex.org/W4391136081","https://openalex.org/W4391163923","https://openalex.org/W4394582335","https://openalex.org/W4396581928","https://openalex.org/W4400433102","https://openalex.org/W4402634374","https://openalex.org/W4408831444"],"related_works":["https://openalex.org/W4410023661","https://openalex.org/W4394879458","https://openalex.org/W3196761554","https://openalex.org/W4306673647","https://openalex.org/W4308496110","https://openalex.org/W4400433048","https://openalex.org/W4414802302","https://openalex.org/W7203596740","https://openalex.org/W4410383600","https://openalex.org/W4387124178"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"The":[2],"AGILE":[3],"CST-8":[4],"(NCT04746183)":[5],"Phase":[6,79],"I":[7,80],"de-escalation":[8,171],"trial":[9],"evaluated":[10],"the":[11,89,140],"safety":[12],"and":[13,18,51,116,136,192,214,219,232],"tolerability":[14],"of":[15,32,70,91,103,131,185,208,222],"combination":[16,57,83,155,227,239],"molnupiravir":[17,40,149],"nirmatrelvir/ritonavir":[19,157,229],"for":[20,65,245],"mild-moderate":[21],"COVID-19.":[22],"Methods":[23],"Adult":[24],"outpatients":[25],"with":[26,58,156,205,228],"SARS-CoV-2":[27],"infection":[28],"within":[29],"5":[30,66,191],"days":[31,67],"symptoms":[33],"were":[34,125,195],"randomly":[35],"assigned":[36],"2:1":[37],"to":[38,49,143],"receive":[39],"[starting":[41],"at":[42,150,189,241],"800":[43,151],"mg":[44,53,152],"twice":[45],"daily":[46],"(BD)":[47],"reducing":[48],"600":[50],"400":[52],"if":[54,88],"necessary]":[55],"in":[56,154,226],"nirmatrelvir":[59,209],"(300":[60],"mg)/ritonavir":[61],"(100":[62],"mg)":[63],"BD":[64,153],"versus":[68],"standard":[69,102,130],"care.":[71],"Using":[72],"a":[73,82,159],"dose":[74,84,170],"de-escalation,":[75],"open-label,":[76],"Bayesian":[77],"adaptive":[78],"trial,":[81],"was":[85,105,172,203,216,230],"considered":[86],"unsafe":[87],"probability":[90],"30%":[92],"or":[93,107,166],"greater":[94],"dose-limiting":[95],"toxicity":[96],"risk":[97],"(DLT\u2014the":[98],"primary":[99,141],"outcome)":[100],"over":[101],"care":[104],"25%":[106],"higher.":[108],"Secondary":[109],"endpoints":[110],"included":[111],"tolerability,":[112],"clinical":[113],"progression,":[114],"pharmacokinetics":[115],"virological":[117],"responses.":[118],"Results":[119],"Of":[120],"49":[121],"participants":[122,176],"screened,":[123],"24":[124],"enrolled":[126],"(16":[127],"combination,":[128],"8":[129],"care)":[132],"between":[133],"January":[134],"2023":[135],"September":[137],"2023.":[138],"For":[139],"endpoint,":[142],"Day":[144,162,168,190,193],"11,":[145],"no":[146],"participant":[147],"starting":[148],"reported":[158,177],"DLT":[160],"by":[161,167],"11":[163,194],"(primary":[164],"endpoint)":[165],"29;":[169],"not":[173,196],"required.":[174],"No":[175],"severe":[178],"adverse":[179],"events":[180],"(grade":[181],"\u22653).":[182],"Although":[183],"proportions":[184],"swab":[186],"PCR":[187],"negativity":[188],"statistically":[197],"different,":[198],"faster":[199],"initial":[200],"viral":[201],"clearance":[202],"observed":[204],"treatment.":[206],"Penetration":[207],"into":[210],"saliva,":[211],"nasal":[212],"secretions":[213],"tears":[215],"19%,":[217],"65%":[218],"91%":[220],"that":[221],"plasma.":[223],"Conclusions":[224],"Molnupiravir":[225],"safe":[231],"well-tolerated;":[233],"later":[234],"phase":[235],"trials":[236],"should":[237],"evaluate":[238],"therapy":[240],"currently":[242],"recommended":[243],"doses":[244],"each":[246],"drug.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-06-17T00:00:00"}