{"id":"https://openalex.org/W7164846292","doi":"https://doi.org/10.3390/metabo16060411","title":"Multi-Targeted Intervention of Eucommia ulmoides and Its Bioactive Constituents Against Metabolic Syndrome: From Molecular Mechanisms and Gut Microbiota Modulation to Clinical Translation","display_name":"Multi-Targeted Intervention of Eucommia ulmoides and Its Bioactive Constituents Against Metabolic Syndrome: From Molecular Mechanisms and Gut Microbiota Modulation to Clinical Translation","publication_year":2026,"publication_date":"2026-06-12","ids":{"openalex":"https://openalex.org/W7164846292","doi":"https://doi.org/10.3390/metabo16060411","pmid":"https://pubmed.ncbi.nlm.nih.gov/42346391"},"language":"en","primary_location":{"id":"doi:10.3390/metabo16060411","doi":"https://doi.org/10.3390/metabo16060411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16060411","pdf_url":"https://www.mdpi.com/2218-1989/16/6/411/pdf?version=1781271580","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-1989/16/6/411/pdf?version=1781271580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138672307","display_name":"Fanjia Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanjia Cheng","raw_affiliation_strings":["Laboratory of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089091472","display_name":"Chenghao Lv","orcid":"https://orcid.org/0000-0002-1165-2720","observed_orcids":["https://orcid.org/0000-0002-1165-2720"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenghao Lv","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0002-1165-2720","affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083342725","display_name":"Yuhang Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Yi","raw_affiliation_strings":["College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037781729","display_name":"D Wang","orcid":"https://orcid.org/0000-0001-5612-6313","observed_orcids":["https://orcid.org/0000-0001-5612-6313","https://orcid.org/0000-0001-8463-4104","https://orcid.org/0000-0002-9285-3750","https://orcid.org/0000-0003-0428-5982","https://orcid.org/0000-0003-3583-9933","https://orcid.org/0000-0003-3796-6290","https://orcid.org/0009-0004-6081-5823","https://orcid.org/0009-0005-8390-9192","https://orcid.org/0009-0008-1547-0052"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Wang","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064641541","display_name":"W Q Wang","orcid":"https://orcid.org/0000-0002-8066-1380","observed_orcids":["https://orcid.org/0000-0002-8066-1380","https://orcid.org/0000-0003-2834-203X","https://orcid.org/0009-0005-4048-0795"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Wang","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110723","display_name":"Hunan Academy of Agricultural Sciences","ror":"https://ror.org/01fj5gf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210110723"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Li","raw_affiliation_strings":["Hunan Institute of Agricultural Product Processing and Quality Safety, Hunan Academy of Agricultural Sciences, Changsha 410125, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Institute of Agricultural Product Processing and Quality Safety, Hunan Academy of Agricultural Sciences, Changsha 410125, China","institution_ids":["https://openalex.org/I4210110723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078950228","display_name":"Runze Zhou","orcid":"https://orcid.org/0009-0009-9370-3592","observed_orcids":["https://orcid.org/0009-0009-9370-3592","https://orcid.org/0000-0002-8060-5717"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runze Zhou","raw_affiliation_strings":["College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"],"raw_orcid":"https://orcid.org/0009-0009-9370-3592","affiliations":[{"raw_affiliation_string":"College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071462296","display_name":"Qili Li","orcid":"https://orcid.org/0000-0001-5775-8910","observed_orcids":["https://orcid.org/0000-0001-5775-8910"]},"institutions":[{"id":"https://openalex.org/I4210110723","display_name":"Hunan Academy of Agricultural Sciences","ror":"https://ror.org/01fj5gf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210110723"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qili Li","raw_affiliation_strings":["Hunan Institute of Agricultural Product Processing and Quality Safety, Hunan Academy of Agricultural Sciences, Changsha 410125, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Institute of Agricultural Product Processing and Quality Safety, Hunan Academy of Agricultural Sciences, Changsha 410125, China","institution_ids":["https://openalex.org/I4210110723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073512617","display_name":"Si Qin","orcid":"https://orcid.org/0000-0002-0788-2099","observed_orcids":["https://orcid.org/0000-0002-0788-2099"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Si Qin","raw_affiliation_strings":["Laboratory of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China"],"raw_orcid":"https://orcid.org/0000-0002-0788-2099","affiliations":[{"raw_affiliation_string":"Laboratory of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China","institution_ids":["https://openalex.org/I52180223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071462296","https://openalex.org/A5073512617"],"corresponding_institution_ids":["https://openalex.org/I4210110723","https://openalex.org/I52180223"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44525759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"6","first_page":"411","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eucommia-ulmoides","display_name":"Eucommia ulmoides","score":1.0},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/asperuloside","display_name":"asperuloside","score":0.859000027179718},{"id":"https://openalex.org/keywords/iridoids","display_name":"iridoids","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7730000019073486},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/akkermansia","display_name":"Akkermansia","score":0.8019999861717224},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.5809999704360962},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ace2-ang-1-7-mas-axis","display_name":"ACE2/Ang-(1-7)/Mas axis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7360000014305115},{"id":"https://openalex.org/keywords/glycoside-hydrolysis","display_name":"glycosidic bond cleavage","score":0.6439999938011169},{"id":"https://openalex.org/keywords/traditional-medicinal-plants","display_name":"traditional medicinal plants","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2780409773","wikidata":"https://www.wikidata.org/wiki/Q131528","display_name":"Eucommia ulmoides","level":4,"score":0.8828999996185303},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6539999842643738},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5408999919891357},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4359000027179718},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.40470001101493835},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.39169999957084656},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.3718000054359436},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3650999963283539},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.36239999532699585},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.36000001430511475},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31940001249313354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314300000667572},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.27459999918937683},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25200000405311584}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/metabo16060411","doi":"https://doi.org/10.3390/metabo16060411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16060411","pdf_url":"https://www.mdpi.com/2218-1989/16/6/411/pdf?version=1781271580","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"pmid:42346391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42346391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ec0d83761f8740d6b0bb440834283239","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ec0d83761f8740d6b0bb440834283239","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 16, Iss 6, p 411 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13302839","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42346391/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/metabo16060411","doi":"https://doi.org/10.3390/metabo16060411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16060411","pdf_url":"https://www.mdpi.com/2218-1989/16/6/411/pdf?version=1781271580","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5803526299","display_name":null,"funder_award_id":"82305009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7069912303","display_name":null,"funder_award_id":"2024JJ5225","funder_id":"https://openalex.org/F4320321471","funder_display_name":"Hunan Provincial Science and Technology Department"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321471","display_name":"Hunan Provincial Science and Technology Department","ror":"https://ror.org/04qgr7x96"},{"id":"https://openalex.org/F4320331088","display_name":"Natural Science Foundation for Young Scientists of Shanxi Province","ror":null},{"id":"https://openalex.org/F4320335581","display_name":"Young Scientists Fund","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7164846292.pdf","grobid_xml":"https://content.openalex.org/works/W7164846292.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background/Objectives:":[0],"Metabolic":[1],"syndrome":[2],"(MetS)":[3],"is":[4],"a":[5,29,45,119,215],"pressing":[6],"global":[7],"health":[8],"challenge":[9],"comprising":[10],"obesity,":[11,128],"hyperglycemia,":[12],"hypertension,":[13],"and":[14,23,32,40,57,64,79,91,100,122,127,136,154,179,185,237],"hyperlipidemia.":[15],"Conventional":[16],"polypharmacy":[17],"often":[18],"presents":[19],"long-term":[20],"compliance":[21],"issues":[22],"side":[24],"effects.":[25],"Eucommia":[26],"ulmoides":[27,63,98,116,209],"Oliv.,":[28],"traditional":[30],"medicinal":[31],"edible":[33],"plant":[34],"rich":[35],"in":[36,68,77,80,204],"iridoids,":[37],"lignans,":[38],"flavonoids,":[39],"polysaccharides,":[41],"has":[42],"emerged":[43],"as":[44,214],"promising":[46],"natural":[47,217],"intervention.":[48],"This":[49],"review":[50],"aims":[51],"to":[52,83,232,243],"systematically":[53],"summarize":[54],"the":[55,75,85,145,169,176,189,197,238],"bioavailability":[56,192],"multifaceted":[58],"pharmacological":[59],"mechanisms":[60],"of":[61,193,200,240],"E.":[62,97,115,208],"its":[65,101,194,205],"bioactive":[66],"components":[67],"alleviating":[69],"MetS.":[70,220],"Methods:":[71],"We":[72],"comprehensively":[73],"reviewed":[74],"recent":[76],"vitro":[78],"vivo":[81],"literature":[82],"map":[84],"functional":[86],"evidence,":[87],"specific":[88],"signaling":[89],"pathways,":[90],"gut":[92,146,201],"microbiota\u2013host":[93],"interactions":[94],"associated":[95],"with":[96],"extracts":[99],"key":[102],"phytochemicals":[103],"(e.g.,":[104],"asperuloside)":[105],"against":[106],"various":[107],"metabolic":[108],"dysfunctions.":[109],"Results:":[110],"Current":[111],"evidence":[112],"indicates":[113],"that":[114],"operates":[117],"through":[118],"\u201cmulti-component,":[120],"multi-target,":[121],"multi-pathway\u201d":[123],"paradigm.":[124],"For":[125],"hyperlipidemia":[126],"it":[129,142],"activates":[130],"hepatic":[131],"lipid":[132],"metabolism":[133],"(PPAR\u03b1/CPT1A,":[134],"FXR/CYP7A1)":[135],"mitigates":[137],"oxidative":[138],"stress":[139],"(Nrf2/ARE).":[140],"Furthermore,":[141],"dose-dependently":[143],"reshapes":[144],"microbiota":[147],"by":[148,167,182],"enriching":[149],"beneficial":[150],"bacteria":[151],"like":[152],"Akkermansia":[153],"increasing":[155],"butyrate":[156],"production,":[157],"exerting":[158],"profound":[159],"gut\u2013liver":[160],"axis":[161],"regulation.":[162],"It":[163],"also":[164],"ameliorates":[165],"hypertension":[166],"activating":[168],"ACE2-Ang-(1\u20137)-Mas":[170],"axis,":[171],"improves":[172],"insulin":[173],"resistance":[174],"via":[175],"AMPK/PI3K/Akt":[177],"cascade,":[178],"manages":[180],"hyperuricemia":[181],"modulating":[183],"XOD":[184],"renal":[186],"transporters.":[187],"Notably,":[188],"low":[190],"oral":[191],"glycosides":[195],"highlights":[196],"crucial":[198],"role":[199],"microbial":[202],"hydrolysis":[203],"efficacy.":[206,246],"Conclusions:":[207],"holds":[210],"substantial":[211],"therapeutic":[212],"potential":[213],"multi-target":[216],"supplement":[218],"for":[219],"However,":[221],"future":[222],"translational":[223],"applications":[224],"necessitate":[225],"large-scale":[226],"randomized":[227],"clinical":[228,245],"trials,":[229],"multi-omics":[230],"studies":[231],"further":[233],"clarify":[234],"host\u2013microbiome":[235],"interactions,":[236],"development":[239],"standardized":[241],"formulations":[242],"ensure":[244]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-06-16T00:00:00"}