{"id":"https://openalex.org/W7164537367","doi":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6","title":"New treatments for systemic lupus erythematosus","display_name":"New treatments for systemic lupus erythematosus","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7164537367","doi":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-443-33957-8.00067-6","doi":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systemic Lupus Erythematosus","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7164580129","display_name":"Systemic Lupus Erythematosus"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093655786","display_name":"Milena Delai","orcid":"https://orcid.org/0009-0003-9180-9170","observed_orcids":["https://orcid.org/0009-0003-9180-9170"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milena Delai","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Division of Rheumatology, Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Division of Rheumatology, Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048559252","display_name":"Vasileios C. Kyttaris","orcid":"https://orcid.org/0000-0001-7652-3826","observed_orcids":["https://orcid.org/0000-0001-7652-3826"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasileios C. Kyttaris","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Division of Rheumatology, Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Division of Rheumatology, Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49450549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"933","last_page":"946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.628000020980835},{"id":"https://openalex.org/keywords/belimumab","display_name":"belimumab","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd22","display_name":"CD22","score":0.6769999861717224},{"id":"https://openalex.org/keywords/interferon-signaling-pathway","display_name":"interferon pathway","score":0.8870000243186951},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.7799999713897705},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/voclosporin","display_name":"voclosporin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":1.0},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7770000100135803},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.9120000004768372},{"id":"https://openalex.org/keywords/renal-lupus","display_name":"renal lupus","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8263999819755554},{"id":"https://openalex.org/C2781205201","wikidata":"https://www.wikidata.org/wiki/Q1996249","display_name":"Belimumab","level":5,"score":0.8032000064849854},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.6700999736785889},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5350000262260437},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3901999890804291},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.38269999623298645},{"id":"https://openalex.org/C2909935303","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolate","level":3,"score":0.37560001015663147},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.3249000012874603},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.3050000071525574},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.29660001397132874},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.27570000290870667},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26989999413490295},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-443-33957-8.00067-6","doi":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-443-33957-8.00067-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systemic Lupus Erythematosus","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1920228500","https://openalex.org/W1982924102","https://openalex.org/W1989273660","https://openalex.org/W2046330020","https://openalex.org/W2097165105","https://openalex.org/W2131457901","https://openalex.org/W2131469748","https://openalex.org/W2136149088","https://openalex.org/W2146853551","https://openalex.org/W2199189793","https://openalex.org/W2297622352","https://openalex.org/W2551404503","https://openalex.org/W2556359407","https://openalex.org/W2564284206","https://openalex.org/W2588655590","https://openalex.org/W2600952481","https://openalex.org/W2793218229","https://openalex.org/W2891364583","https://openalex.org/W2900364017","https://openalex.org/W2914307879","https://openalex.org/W2975225206","https://openalex.org/W2983004004","https://openalex.org/W2995521654","https://openalex.org/W2999362895","https://openalex.org/W3007483088","https://openalex.org/W3023267770","https://openalex.org/W3043594385","https://openalex.org/W3047551100","https://openalex.org/W3085025551","https://openalex.org/W3086471819","https://openalex.org/W3122338628","https://openalex.org/W3127873159","https://openalex.org/W3159830316","https://openalex.org/W3164417236","https://openalex.org/W3164853149","https://openalex.org/W3168298091","https://openalex.org/W3199432015","https://openalex.org/W3199695429","https://openalex.org/W3204486592","https://openalex.org/W3207193145","https://openalex.org/W3215126343","https://openalex.org/W3215794307","https://openalex.org/W4213290980","https://openalex.org/W4220657516","https://openalex.org/W4221096368","https://openalex.org/W4225295142","https://openalex.org/W4229019148","https://openalex.org/W4284672782","https://openalex.org/W4285260832","https://openalex.org/W4288050416","https://openalex.org/W4294908091","https://openalex.org/W4307974896","https://openalex.org/W4308834504","https://openalex.org/W4309045980","https://openalex.org/W4310580569","https://openalex.org/W4319264346","https://openalex.org/W4321452485","https://openalex.org/W4321764166","https://openalex.org/W4321766489","https://openalex.org/W4323856799","https://openalex.org/W4376872138","https://openalex.org/W4384522068","https://openalex.org/W4384627186","https://openalex.org/W4384665232","https://openalex.org/W4385737512","https://openalex.org/W4387569385","https://openalex.org/W4387694638","https://openalex.org/W4390047658","https://openalex.org/W4390116636","https://openalex.org/W4392630513","https://openalex.org/W4393951357","https://openalex.org/W4399482322","https://openalex.org/W4400017124","https://openalex.org/W4400657420","https://openalex.org/W4401695143","https://openalex.org/W4402055550","https://openalex.org/W4402093176","https://openalex.org/W4402923138","https://openalex.org/W4403143688","https://openalex.org/W4403275123","https://openalex.org/W4403394225","https://openalex.org/W4404632242","https://openalex.org/W4405388519","https://openalex.org/W4406762220","https://openalex.org/W4407259591","https://openalex.org/W4408498473","https://openalex.org/W4408629225","https://openalex.org/W4409488205"],"related_works":["https://openalex.org/W3037538945","https://openalex.org/W3144563647","https://openalex.org/W3012583953","https://openalex.org/W4210902943","https://openalex.org/W2057532699","https://openalex.org/W2594733496","https://openalex.org/W4393951357","https://openalex.org/W4225814441","https://openalex.org/W4200103527","https://openalex.org/W2135452423"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2026-06-13T00:00:00"}