{"id":"https://openalex.org/W7164531007","doi":"https://doi.org/10.2337/dc26-0632","title":"Extended Follow-up of Type 1 Diabetes Immunotherapy Trial Participants Suggests Benign Side Effect Profile","display_name":"Extended Follow-up of Type 1 Diabetes Immunotherapy Trial Participants Suggests Benign Side Effect Profile","publication_year":2026,"publication_date":"2026-06-12","ids":{"openalex":"https://openalex.org/W7164531007","doi":"https://doi.org/10.2337/dc26-0632","pmid":"https://pubmed.ncbi.nlm.nih.gov/42283716","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13385935"},"language":"en","primary_location":{"id":"doi:10.2337/dc26-0632","doi":"https://doi.org/10.2337/dc26-0632","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc26-0632","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42283716/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091167706","display_name":"Laura M. Jacobsen","orcid":"https://orcid.org/0000-0002-5144-7836","observed_orcids":["https://orcid.org/0000-0002-5144-7836"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura M. Jacobsen","raw_affiliation_strings":["Departments of Pediatrics and Pathology, Diabetes Institute, College of Medicine, University of Florida, Gainesville 1 , FL"],"raw_orcid":"https://orcid.org/0000-0002-5144-7836","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pathology, Diabetes Institute, College of Medicine, University of Florida, Gainesville 1 , FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138550299","display_name":"Dave Cuthbertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dave Cuthbertson","raw_affiliation_strings":["Health Informatics Institute, University of South Florida 2 , Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Informatics Institute, University of South Florida 2 , Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005390831","display_name":"Jamie Lynn Felton","orcid":"https://orcid.org/0000-0002-6170-1156","observed_orcids":["https://orcid.org/0000-0002-6170-1156"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Felton","raw_affiliation_strings":["Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076715530","display_name":"Jennifer L. Sherr","orcid":"https://orcid.org/0000-0001-9301-3043","observed_orcids":["https://orcid.org/0000-0001-9301-3043"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Sherr","raw_affiliation_strings":["Department of Pediatrics, Yale School of Medicine 4 , New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yale School of Medicine 4 , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007930011","display_name":"Kimber M. Simmons","orcid":"https://orcid.org/0000-0003-0560-5773","observed_orcids":["https://orcid.org/0000-0003-0560-5773"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimber M. Simmons","raw_affiliation_strings":["Barbara Davis Center, University of Colorado School of Medicine 5 , Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Davis Center, University of Colorado School of Medicine 5 , Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044222685","display_name":"Jennifer Hosford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Hosford","raw_affiliation_strings":["Departments of Pediatrics and Pathology, Diabetes Institute, College of Medicine, University of Florida, Gainesville 1 , FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pathology, Diabetes Institute, College of Medicine, University of Florida, Gainesville 1 , FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040254155","display_name":"Heba M. Ismail","orcid":"https://orcid.org/0000-0003-0102-0030","observed_orcids":["https://orcid.org/0000-0003-0102-0030"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heba M. Ismail","raw_affiliation_strings":["Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020555978","display_name":"Carla J. Greenbaum","orcid":"https://orcid.org/0000-0003-4451-9800","observed_orcids":["https://orcid.org/0000-0003-4451-9800"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla J. Greenbaum","raw_affiliation_strings":["Benaroya Research Institute 6 , Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute 6 , Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068398869","display_name":"Diane K. Wherrett","orcid":"https://orcid.org/0000-0003-0629-5316","observed_orcids":["https://orcid.org/0000-0003-0629-5316"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Diane K. Wherrett","raw_affiliation_strings":["Department of Pediatrics, Hospital for Sick Children and University of Toronto 7 , Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hospital for Sick Children and University of Toronto 7 , Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012252752","display_name":"Ashley Pinckney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153694","display_name":"Rho (United States)","ror":"https://ror.org/049ba1e57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Pinckney","raw_affiliation_strings":["Rho 8 , Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rho 8 , Durham, NC","institution_ids":["https://openalex.org/I4210153694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015647447","display_name":"Srinath Sanda","orcid":"https://orcid.org/0000-0002-6983-6864","observed_orcids":["https://orcid.org/0000-0002-6983-6864"]},"institutions":[{"id":"https://openalex.org/I4210094308","display_name":"Immune Tolerance Network","ror":"https://ror.org/00pjnm784","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210094308","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinath Sanda","raw_affiliation_strings":["Immune Tolerance Network 9 , San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Network 9 , San Francisco, CA","institution_ids":["https://openalex.org/I4210094308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045595295","display_name":"Linda Anne DiMeglio","orcid":"https://orcid.org/0000-0002-8033-6078","observed_orcids":["https://orcid.org/0000-0002-8033-6078"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda A. DiMeglio","raw_affiliation_strings":["Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091585953","display_name":"Lauren E. Higdon","orcid":"https://orcid.org/0000-0002-6470-6155","observed_orcids":["https://orcid.org/0000-0002-6470-6155"]},"institutions":[{"id":"https://openalex.org/I4210094308","display_name":"Immune Tolerance Network","ror":"https://ror.org/00pjnm784","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210094308","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Higdon","raw_affiliation_strings":["Immune Tolerance Network 9 , San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Network 9 , San Francisco, CA","institution_ids":["https://openalex.org/I4210094308"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063131669","display_name":"Carmella Evans\u2010Molina","orcid":"https://orcid.org/0000-0001-7764-8663","observed_orcids":["https://orcid.org/0000-0001-7764-8663"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmella Evans-Molina","raw_affiliation_strings":["Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN","Roudebush VA Medical Center 10 , Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and the IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine 3 , Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Roudebush VA Medical Center 10 , Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5091167706"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38999884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"8","first_page":"1428","last_page":"1433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7540000081062317},{"id":"https://openalex.org/keywords/trial-participants","display_name":"trial participants","score":0.531000018119812},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5669999718666077},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.921999990940094},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.8299999833106995},{"id":"https://openalex.org/keywords/severe-infection","display_name":"serious infections","score":0.7889999747276306},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9139999747276306},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.9419999718666077},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.972000002861023},{"id":"https://openalex.org/keywords/trialnet","display_name":"TrialNet","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9645000100135803},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6764000058174133},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6326000094413757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6089000105857849},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6032999753952026},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5879999995231628},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5127000212669373},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.510200023651123},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49149999022483826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35339999198913574},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3343000113964081},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29899999499320984},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2849000096321106},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2779616870","wikidata":"https://www.wikidata.org/wiki/Q4677560","display_name":"Active immunotherapy","level":4,"score":0.2703999876976013},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2653999924659729},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/dc26-0632","doi":"https://doi.org/10.2337/dc26-0632","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc26-0632","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:42283716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42283716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13385935","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42283716/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13385935","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42283716/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1803235707","display_name":"TrialNet: University of Florida Clinical Center and Network","funder_award_id":"U01DK085461","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1980108060","display_name":"Type 1 Diabetes-A Proposal for Prevention & Intervention","funder_award_id":"U01DK085476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1980346786","display_name":"CLINICAL AFFILIATE OF THE TYPE 1 DIABETES TRIALNET","funder_award_id":"U01DK085499","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2154557950","display_name":"Chicagoland Diabetes TrialNet Clinical Center","funder_award_id":"U01DK103153","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2942876743","display_name":null,"funder_award_id":"U01 DK061010, U01 DK061034, U01 DK061042, U01 DK06","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3707381941","display_name":"Continuation of UCSF as a Clinical Center for TrialNet","funder_award_id":"U01DK061010","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3995607734","display_name":"Type 1 Diabetes TrialNet Clinical Centers - Kansas City","funder_award_id":"U01DK106984","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G40899694","display_name":"Prediction and Prevention of Type 1 Diabetes (TrialNet)","funder_award_id":"U01DK061058","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4244245306","display_name":"Northwest Clinical Center for Type 1 Diabetes - TrialNet","funder_award_id":"U01DK061034","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5164839806","display_name":"Type 1 Diabetes TrialNet: Toronto Clinical Center","funder_award_id":"U01DK107013","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G579390700","display_name":"NIDDK Type 1 Diabetes TrialNet Data Coordinating Center","funder_award_id":"UC4DK106993","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G584698736","display_name":"TrialNet at Stanford University","funder_award_id":"U01DK061042","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G599242060","display_name":"Vanderbilt University:  Clinical Center Application, Type 1 Diabetes TrialNet","funder_award_id":"U01DK085465","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7216956197","display_name":"USF TrialNet Clinical Center","funder_award_id":"U01DK103266","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7529499147","display_name":"Data Coordinating Center for Type 1 Diabetes TrialNet (UC4)USF: TrialNet UC4-3","funder_award_id":"UC4DK117009","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7559843093","display_name":"Type 1 diabetes TrialNet Center at Yale University","funder_award_id":"U01DK085466","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8090474474","display_name":"TrialNet: Diabetes Type 1 Prevention","funder_award_id":"U01DK085509","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8104800703","display_name":"Type 1 Diabetes TrialNet at Indiana University Clinical Center","funder_award_id":"U01DK107014","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8135711613","display_name":"An Atlanta TrialNet Center: Building a Pathway to 70 Clinical Trial Subjects per Year","funder_award_id":"U01DK106994","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8482177663","display_name":"Texas Children's Hospital and Baylor College of Medicine TrialNet Clinical Center","funder_award_id":"U01DK103180","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000867929","display_name":"Data Coordinating Center for Type 1 Diabetes TrialNet","funder_award_id":"U01DK106993","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000871931","display_name":"Immune Tolerance Network","funder_award_id":"UM1AI109565","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000872416","display_name":"Type 1 Diabetes TrialNet Clinical Network Hub","funder_award_id":"U01DK103282","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2009720809","https://openalex.org/W2064431167","https://openalex.org/W2096862996","https://openalex.org/W2098954537","https://openalex.org/W2099862791","https://openalex.org/W2106218189","https://openalex.org/W2109121747","https://openalex.org/W2109886432","https://openalex.org/W2135484010","https://openalex.org/W2154694193","https://openalex.org/W2333217165","https://openalex.org/W2769332703","https://openalex.org/W2883621086","https://openalex.org/W2935961302","https://openalex.org/W2948104235","https://openalex.org/W2989841956","https://openalex.org/W3212575051","https://openalex.org/W4324305894","https://openalex.org/W4386734102","https://openalex.org/W7125400932"],"related_works":["https://openalex.org/W2142928893","https://openalex.org/W6992568175","https://openalex.org/W4253402126","https://openalex.org/W2904763939","https://openalex.org/W2527715815","https://openalex.org/W2173141813","https://openalex.org/W2130004850","https://openalex.org/W4393132395","https://openalex.org/W2062187990","https://openalex.org/W2132051812"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Long-term":[1,35],"side":[2],"effect":[3],"surveillance":[4],"after":[5,74],"immunotherapy":[6,148,155],"clinical":[7],"trial":[8,76,156],"participation":[9],"in":[10,38,79,89,139],"individuals":[11],"with":[12],"or":[13,43],"at":[14,55],"risk":[15],"of":[16,68,92,154],"type":[17],"1":[18,40,48],"diabetes":[19],"is":[20,158],"needed.":[21],"RESEARCH":[22],"DESIGN":[23],"AND":[24],"METHODS:":[25],"Participants":[26,62],"from":[27],"14":[28],"randomized":[29],"controlled":[30],"trials":[31],"(47%)":[32],"joined":[33],"the":[34,90],"Investigative":[36],"Follow-up":[37],"Type":[39,47],"Diabetes":[41,49],"TrialNet":[42],"Immune":[44],"Tolerance":[45],"Network":[46],"Extension":[50],"Study,":[51],"and":[52,113,120],"98%":[53],"answered":[54],"least":[56],"one":[57],"health-related":[58],"outcomes":[59,142],"question.":[60],"RESULTS:":[61],"were":[63,86],"observed":[64,136],"for":[65,132],"a":[66],"median":[67],"1.78":[69],"(interquartile":[70],"range":[71],"0.89-4.04)":[72],"years":[73],"original":[75],"completion":[77],"and,":[78],"some,":[80],"up":[81],"to":[82,98],"18":[83],"years.":[84],"There":[85],"no":[87,137],"differences":[88,138],"frequency":[91],"self-reported":[93,140],"health":[94,141],"outcomes,":[95],"including":[96],"moderate":[97],"severe":[99],"hypoglycemia":[100],"events,":[101],"hospitalizations,":[102],"serious":[103],"infections":[104],"(including":[105],"COVID-19":[106],"infection),":[107],"new":[108],"allergic":[109],"reactions,":[110],"autoimmune":[111],"disease,":[112],"cancer":[114],"incidence,":[115],"between":[116,143],"those":[117,144],"receiving":[118],"active":[119,147],"placebo":[121],"therapy":[122],"(n":[123],"=":[124],"209-473":[125],"responses":[126],"per":[127],"question;":[128],"P":[129],">":[130],"0.05":[131],"all).":[133],"CONCLUSIONS:":[134],"We":[135],"who":[145],"received":[146],"versus":[149],"placebo.":[150],"Continued":[151],"long-term":[152],"follow-up":[153],"participants":[157],"essential.":[159]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-06-13T00:00:00"}
