{"id":"https://openalex.org/W7164530235","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107883","title":"Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patients","display_name":"Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patients","publication_year":2026,"publication_date":"2026-06-12","ids":{"openalex":"https://openalex.org/W7164530235","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107883","pmid":"https://pubmed.ncbi.nlm.nih.gov/42285311"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijantimicag.2026.107883","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107883","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107883","pdf_url":null,"source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ijantimicag.2026.107883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019350618","display_name":"Paul G. Williams","orcid":"https://orcid.org/0000-0002-4867-4456","observed_orcids":["https://orcid.org/0000-0002-4867-4456"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210101259","display_name":"Sunshine Coast University Hospital","ror":"https://ror.org/017ay4a94","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210101259"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Paul Williams","raw_affiliation_strings":["University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Pharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia. Electronic address: p.g.williams@uq.edu.au"],"raw_orcid":"https://orcid.org/0000-0002-4867-4456","affiliations":[{"raw_affiliation_string":"University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Pharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia. Electronic address: p.g.williams@uq.edu.au","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210101259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023993805","display_name":"Menino Osbert Cotta","orcid":"https://orcid.org/0000-0002-2058-2314","observed_orcids":["https://orcid.org/0000-0002-2058-2314"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Menino Osbert Cotta","raw_affiliation_strings":["University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043218702","display_name":"Mohd Hafiz Abdul-Aziz","orcid":"https://orcid.org/0000-0002-8889-5579","observed_orcids":["https://orcid.org/0000-0002-8889-5579"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mohd H. Abdul-Aziz","raw_affiliation_strings":["University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091615543","display_name":"Kathryn Michelle Wilks","orcid":"https://orcid.org/0000-0001-9670-4050","observed_orcids":["https://orcid.org/0000-0001-9670-4050"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210101259","display_name":"Sunshine Coast University Hospital","ror":"https://ror.org/017ay4a94","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210101259"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Wilks","raw_affiliation_strings":["Infectious Diseases Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia; School of Public Health, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia; School of Public Health, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210101259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090507465","display_name":"Lauren Murray","orcid":"https://orcid.org/0000-0002-7567-1525","observed_orcids":["https://orcid.org/0000-0002-7567-1525"]},"institutions":[{"id":"https://openalex.org/I4210101259","display_name":"Sunshine Coast University Hospital","ror":"https://ror.org/017ay4a94","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210101259"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lauren Murray","raw_affiliation_strings":["Intensive Care Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia","institution_ids":["https://openalex.org/I4210101259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046635592","display_name":"Steven C. Wallis","orcid":"https://orcid.org/0000-0002-2392-9854","observed_orcids":["https://orcid.org/0000-0002-2392-9854"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steven C. Wallis","raw_affiliation_strings":["University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073244206","display_name":"Gareth Beall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101259","display_name":"Sunshine Coast University Hospital","ror":"https://ror.org/017ay4a94","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210101259"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gareth Beall","raw_affiliation_strings":["Pharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia","institution_ids":["https://openalex.org/I4210101259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037468542","display_name":"Jason Alexander Roberts","orcid":"https://orcid.org/0000-0001-6218-435X","observed_orcids":["https://orcid.org/0000-0001-6218-435X","https://orcid.org/0000-0003-0268-6723"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I4405269172","display_name":"Metro North Hospital and Health Service","ror":"https://ror.org/03a0hqz22","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4405269172"]}],"countries":["AU","FR"],"is_corresponding":false,"raw_author_name":"Jason A. Roberts","raw_affiliation_strings":["University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; UR UM 103, University of Montpellier, Division of Anesthesia Critical Care and Emergency and Pain Medicine, Nimes University Hospital, Nimes, France; Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; UR UM 103, University of Montpellier, Division of Anesthesia Critical Care and Emergency and Pain Medicine, Nimes University Hospital, Nimes, France; Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I4405269172"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019350618"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210101259"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":{"value":3280,"currency":"USD","value_usd":3280},"fwci":8.19,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.9790457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"67","issue":"9","first_page":"107883","last_page":"107883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dosing-nomogram","display_name":"dosing nomogram","score":0.8080000281333923},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9100000262260437},{"id":"https://openalex.org/keywords/critically-ill-adults","display_name":"critically ill adults","score":0.875},{"id":"https://openalex.org/keywords/piperacillin","display_name":"piperacillin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tazobactam","display_name":"tazobactam","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antibiotic-dosing","display_name":"antibiotic dosing","score":0.7400000095367432},{"id":"https://openalex.org/keywords/antibiotic-toxicity","display_name":"antibiotic toxicity","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.8848000168800354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8756999969482422},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.855400025844574},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8300999999046326},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7095999717712402},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3953000009059906},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.37940001487731934},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3474999964237213},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2806999981403351}],"mesh":[{"descriptor_ui":"D000097902","descriptor_name":"beta Lactam Antibiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijantimicag.2026.107883","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107883","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107883","pdf_url":null,"source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},{"id":"pmid:42285311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42285311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of antimicrobial agents","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05826193v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05826193","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Antimicrobial Agents, 2026, 67 (9), pp.107883. ⟨10.1016/j.ijantimicag.2026.107883⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ijantimicag.2026.107883","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107883","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107883","pdf_url":null,"source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1124935586","display_name":"Translating precision antibiotic dosing into better outcomes for severe infections","funder_award_id":"2009736","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G368407344","display_name":"Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)","funder_award_id":"2007007","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311492","display_name":"Wishlist","ror":"https://ror.org/00mfshe62"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1971624521","https://openalex.org/W1993542492","https://openalex.org/W1998853564","https://openalex.org/W2101416655","https://openalex.org/W2149974939","https://openalex.org/W2153997139","https://openalex.org/W2239960209","https://openalex.org/W2810311913","https://openalex.org/W2987307066","https://openalex.org/W3012868903","https://openalex.org/W3022327571","https://openalex.org/W4210402439","https://openalex.org/W4308766976","https://openalex.org/W4392619714","https://openalex.org/W4392748872","https://openalex.org/W4396813863","https://openalex.org/W4399585721"],"related_works":["https://openalex.org/W2085150747","https://openalex.org/W3028728112","https://openalex.org/W2991629817","https://openalex.org/W4378515160","https://openalex.org/W4205193664","https://openalex.org/W4389030480","https://openalex.org/W6997041868","https://openalex.org/W1899209738","https://openalex.org/W2055787274","https://openalex.org/W4384662952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Therapeutic":[1,174],"drug":[2],"monitoring":[3],"(TDM)":[4],"individualises":[5],"antibiotic":[6,53],"dosing,":[7],"aiming":[8],"for":[9,218],"therapeutic":[10,40,81,114,142,228],"exposures":[11,41,98],"and":[12,25,102,107,122,132,147,155,161,170,183,193],"minimising":[13],"toxicity.":[14],"However,":[15],"TDM":[16],"cannot":[17],"always":[18],"be":[19],"performed":[20],"due":[21],"to":[22,30,35,130,135,153,158,191,196],"resource":[23],"requirements,":[24],"clinicians":[26],"often":[27],"dose":[28],"according":[29],"guidelines.":[31],"This":[32,56],"study":[33,62],"aimed":[34],"quantify":[36],"the":[37,76,87,92,103,140,162],"achievement":[38],"of":[39,47,63,66,78,125,165,186,205,225],"(concentrations)":[42],"in":[43,68,119,180,221],"a":[44,58,201,215,222],"heterogeneous":[45,203],"cohort":[46,61],"critically":[48,69,206],"ill":[49,70,207],"adults":[50,208],"using":[51],"nomogram-based":[52,64],"dosing.":[54],"METHODS:":[55],"was":[57,75,117],"prospective,":[59],"single-centre,":[60],"dosing":[65,212,216],"beta-lactams":[67,219],"adults.":[71],"The":[72],"primary":[73],"outcome":[74],"proportion":[77,164,224],"patients":[79,126,187,226],"with":[80,100,144,209],"exposures,":[82],"that":[83],"is":[84],"those":[85],"above":[86],"efficacy":[88],"threshold":[89],"but":[90],"below":[91],"toxic":[93],"threshold.":[94],"Secondary":[95],"endpoints":[96],"were":[97,178],"associated":[99],"toxicity,":[101],"relationship":[104],"between":[105],"exposure":[106,116],"clinical":[108],"outcomes.":[109],"RESULTS:":[110],"In":[111,200],"79":[112],"patients,":[113],"beta-lactam":[115],"achieved":[118,179],"82%":[120],"(63/77)":[121],"81%":[123],"(35/43)":[124],"at":[127,150,188],"days":[128,133,151,156,189,194],"1":[129,152,190],"3":[131,154,192],"4":[134,157,195],"6,":[136,159,197],"respectively.":[137,173,198],"Piperacillin":[138],"yielded":[139],"lowest":[141],"attainment,":[143],"75%":[145],"(24/32)":[146],"71%":[148],"(12/17)":[149],"respectively,":[160],"highest":[163],"sub-therapeutic":[166],"exposures:":[167],"25%":[168],"(8/32)":[169],"29%":[171],"(5/17),":[172],"tazobactam":[175],"trough":[176],"concentrations":[177],"66%":[181],"(21/32)":[182],"65%":[184],"(11/17)":[185],"CONCLUSIONS:":[199],"single-centre":[202],"population":[204],"infection,":[210],"initial":[211],"informed":[213],"by":[214],"nomogram":[217],"resulted":[220],"high":[223],"achieving":[227],"exposures.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-06-13T00:00:00"}