{"id":"https://openalex.org/W7164479372","doi":"https://doi.org/10.1016/j.bbrep.2026.102671","title":"Inhibition of FGFR signaling attenuates phosphaturia and early kidney injury in sickle cell disease mice","display_name":"Inhibition of FGFR signaling attenuates phosphaturia and early kidney injury in sickle cell disease mice","publication_year":2026,"publication_date":"2026-06-13","ids":{"openalex":"https://openalex.org/W7164479372","doi":"https://doi.org/10.1016/j.bbrep.2026.102671","pmid":"https://pubmed.ncbi.nlm.nih.gov/42327487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13276783"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrep.2026.102671","doi":"https://doi.org/10.1016/j.bbrep.2026.102671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102671","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.bbrep.2026.102671","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090496116","display_name":"Marja M. Hurley","orcid":"https://orcid.org/0000-0002-2866-4242","observed_orcids":["https://orcid.org/0000-0002-2866-4242"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marja M. Hurley","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology and Metabolism, USA"],"raw_orcid":"https://orcid.org/0000-0002-2866-4242","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology and Metabolism, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350717","display_name":"Yanlin Wang","orcid":"https://orcid.org/0000-0002-6908-1529","observed_orcids":["https://orcid.org/0000-0002-6908-1529"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yanlin Wang","raw_affiliation_strings":["Division of Nephrology, UConn Health School of Medicine, Farmington, CT, 06030, USA"],"raw_orcid":"https://orcid.org/0000-0002-6908-1529","affiliations":[{"raw_affiliation_string":"Division of Nephrology, UConn Health School of Medicine, Farmington, CT, 06030, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076036469","display_name":"Liping Xiao","orcid":"https://orcid.org/0000-0002-9763-3001","observed_orcids":["https://orcid.org/0000-0002-9763-3001"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liping Xiao","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology and Metabolism, USA"],"raw_orcid":"https://orcid.org/0000-0002-9763-3001","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology and Metabolism, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076036469","https://openalex.org/A5090496116","https://openalex.org/A5100350717"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36298753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":null,"first_page":"102671","last_page":"102671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fgfr-signaling","display_name":"FGFR signaling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bgj398","display_name":"BGJ398","score":0.9079999923706055},{"id":"https://openalex.org/keywords/infigratinib","display_name":"infigratinib","score":0.968999981880188},{"id":"https://openalex.org/keywords/phosphaturia","display_name":"phosphaturia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9340000152587891},{"id":"https://openalex.org/keywords/phosphate-wasting","display_name":"phosphate wasting","score":0.6729999780654907},{"id":"https://openalex.org/keywords/npt2a","display_name":"Npt2a","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pit2","display_name":"PiT2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phosphate-transporters","display_name":"phosphate transporters","score":0.8119999766349792},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.640999972820282},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9359999895095825},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.824999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9309999942779541},{"id":"https://openalex.org/keywords/kim-1","display_name":"KIM-1","score":0.7250000238418579},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.683899998664856},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5709999799728394},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5605999827384949},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5509999990463257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.527899980545044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5163000226020813},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C2991844318","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"Renal injury","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.2953999936580658},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrep.2026.102671","doi":"https://doi.org/10.1016/j.bbrep.2026.102671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102671","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},{"id":"pmid:42327487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42327487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and biophysics reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13276783","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13276783/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem Biophys Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.bbrep.2026.102671","doi":"https://doi.org/10.1016/j.bbrep.2026.102671","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102671","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000278193","display_name":null,"funder_award_id":"R01DK129431-01A1 ( 2022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1963306946","https://openalex.org/W1964204750","https://openalex.org/W1972406498","https://openalex.org/W2039049441","https://openalex.org/W2044154722","https://openalex.org/W2047424940","https://openalex.org/W2059775409","https://openalex.org/W2086026048","https://openalex.org/W2091948921","https://openalex.org/W2094551185","https://openalex.org/W2095938777","https://openalex.org/W2129321769","https://openalex.org/W2133492406","https://openalex.org/W2139989191","https://openalex.org/W2148382170","https://openalex.org/W2155357669","https://openalex.org/W2164533721","https://openalex.org/W2368562936","https://openalex.org/W2437958072","https://openalex.org/W2521226842","https://openalex.org/W2789330893","https://openalex.org/W2792605613","https://openalex.org/W2898014977","https://openalex.org/W2901167248","https://openalex.org/W2944197605","https://openalex.org/W2973337048","https://openalex.org/W2992304821","https://openalex.org/W3082624513","https://openalex.org/W3082979654","https://openalex.org/W4200276534","https://openalex.org/W4306655509","https://openalex.org/W4307953000","https://openalex.org/W4311821306","https://openalex.org/W4378516143","https://openalex.org/W4388801208","https://openalex.org/W4392354682"],"related_works":["https://openalex.org/W4388801208","https://openalex.org/W7221599113","https://openalex.org/W4417399869","https://openalex.org/W4408932501","https://openalex.org/W2368562936","https://openalex.org/W1570418152","https://openalex.org/W2988168118","https://openalex.org/W2019397580","https://openalex.org/W2914864215","https://openalex.org/W2437958072"],"abstract_inverted_index":{"We":[0,215],"examined":[1],"whether":[2],"short":[3],"term":[4],"treatment":[5],"with":[6,41,63,197],"the":[7],"pan-FGF":[8],"Receptor":[9],"(FGFR)":[10],"inhibitor":[11],"BGJ398":[12,42,82,162,183],"(Infigratinib)":[13],"modulated":[14,212],"impaired":[15,201],"FGFR":[16,202],"downstream":[17,203],"signaling,":[18],"phosphate":[19,69,86,94],"wasting":[20],"and":[21,35,51,59,74,81,97,106,118,124,149,156,178,189,220],"markers":[22],"of":[23,90,131],"kidney":[24,133,187,226],"damage":[25],"in":[26,57,103,180,207],"sickle":[27],"cell":[28],"disease":[29],"(SCD)":[30],"mice.":[31],"Healthy":[32],"control":[33],"(Ctrl)":[34],"SCD":[36,58,66,104,132,181,208],"mice":[37],"were":[38,54,60,78,100,107,121,125,159],"subcutaneously":[39],"injected":[40],"for":[43],"24":[44],"h.":[45],"In":[46,65,199],"serum":[47,68],"both":[48],"FGF23":[49,53],"intact":[50],"carboxy-terminal-fragment":[52],"significantly":[55,72,79,83,101,108,122,126,160,171,185],"higher":[56,80],"not":[61,164],"decreased":[62,102,116,186],"BGJ398.":[64,111,129,214,234],"mice,":[67],"level":[70],"was":[71],"decreased,":[73],"urine":[75,85],"phosphate/creatinine":[76],"ratio":[77],"reduced":[84,127,172],"wasting.":[87],"Immunohistochemistry":[88],"analysis":[89],"kidneys":[91,105],"revealed":[92],"that":[93,114,194,209,218,228],"transporters":[95],"NPT2a":[96],"PIT-2":[98,119],"proteins":[99],"improved":[109],"by":[110,128,213,233],"Signaling":[112],"molecules":[113],"mediate":[115],"NPT2a,":[117],"expression":[120],"increased":[123],"Markers":[130],"injury":[134],"such":[135],"as":[136],"glomeruli":[137],"sclerosis,":[138],"tubular-damage-marker":[139],"NGAL,":[140,169],"early":[141],"kidney-damage-marker":[142],"KIM1,":[143],"inflammatory":[144],"M1":[145],"iNOS":[146,173],"+":[147,174],"macrophages,":[148,175],"cytokines":[150],"tumor":[151],"necrosis":[152],"factor":[153],"alpha":[154],"(TNFa)":[155],"interleukin-6":[157],"(IL-6)":[158],"increased.":[161],"did":[163],"reduce":[165],"glomerular":[166],"sclerosis":[167],"or":[168],"but":[170],"KIM-1,":[176],"TNFa,":[177],"IL-6":[179],"kidneys.":[182],"also":[184],"osteopontin":[188,219],"its":[190],"receptor":[191],"integrin":[192,222],"\u03b1V\u03b23,":[193],"are":[195],"associated":[196],"inflammation.":[198],"summary":[200],"signaling":[204,223],"mediated":[205],"phosphaturia":[206],"could":[210],"be":[211,230],"further":[216],"suggest":[217],"aberrant":[221],"contributes":[224],"to":[225],"inflammation":[227],"can":[229],"partially":[231],"rescued":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-06-13T00:00:00"}