{"id":"https://openalex.org/W7164404696","doi":"https://doi.org/10.1016/j.stemcr.2026.102956","title":"Suppression of ATM kinase signaling accelerates cellular senescence","display_name":"Suppression of ATM kinase signaling accelerates cellular senescence","publication_year":2026,"publication_date":"2026-06-11","ids":{"openalex":"https://openalex.org/W7164404696","doi":"https://doi.org/10.1016/j.stemcr.2026.102956","pmid":"https://pubmed.ncbi.nlm.nih.gov/42276063"},"language":"en","primary_location":{"id":"doi:10.1016/j.stemcr.2026.102956","doi":"https://doi.org/10.1016/j.stemcr.2026.102956","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102956","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.stemcr.2026.102956","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036781307","display_name":"Kei\u2010ichi Ishikawa","orcid":"https://orcid.org/0000-0003-2305-301X","observed_orcids":["https://orcid.org/0000-0003-2305-301X"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kei-ichi Ishikawa","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: kishikaw@juntendo.ac.jp"],"raw_orcid":"https://orcid.org/0000-0003-2305-301X","affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: kishikaw@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102320564","display_name":"Takahiro Shiga","orcid":"https://orcid.org/0009-0006-0789-3819","observed_orcids":["https://orcid.org/0009-0006-0789-3819"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Shiga","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132702233","display_name":"Takumi Hirose","orcid":"https://orcid.org/0000-0003-2229-4954","observed_orcids":["https://orcid.org/0000-0003-2229-4954"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Hirose","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112317470","display_name":"Naoko Kuzumaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Kuzumaki","raw_affiliation_strings":["Department of Physiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138402884","display_name":"Sakura Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakura Miyoshi","raw_affiliation_strings":["Department of Physiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101773893","display_name":"Akihiro Yamaguchi","orcid":"https://orcid.org/0000-0003-2786-8566","observed_orcids":["https://orcid.org/0000-0003-2786-8566","https://orcid.org/0009-0004-0198-538X"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Yamaguchi","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052516544","display_name":"Hidetaka Tamune","orcid":"https://orcid.org/0000-0002-5581-5720","observed_orcids":["https://orcid.org/0000-0002-5581-5720"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetaka Tamune","raw_affiliation_strings":["Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027757654","display_name":"Avijite Kumer Sarkar","orcid":"https://orcid.org/0000-0002-7646-6566","observed_orcids":["https://orcid.org/0000-0002-7646-6566"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Avijite Kumer Sarkar","raw_affiliation_strings":["Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010292463","display_name":"Kento Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kento Nakai","raw_affiliation_strings":["Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032150536","display_name":"Kazuyoshi Baba","orcid":"https://orcid.org/0000-0001-8025-2168","observed_orcids":["https://orcid.org/0000-0001-8025-2168"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Baba","raw_affiliation_strings":["Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, School of Dentistry, Showa University, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138445346","display_name":"Shigeo Okabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Okabe","raw_affiliation_strings":["Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138456281","display_name":"Nobutaka Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutaka Hattori","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Wako, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Wako, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124087606","display_name":"Hideyuki Okano","orcid":"https://orcid.org/0000-0001-7482-5935","observed_orcids":["https://orcid.org/0000-0001-7482-5935"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Okano","raw_affiliation_strings":["Department of Physiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088573439","display_name":"Wado Akamatsu","orcid":"https://orcid.org/0009-0003-4947-1428","observed_orcids":["https://orcid.org/0009-0003-4947-1428"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Wado Akamatsu","raw_affiliation_strings":["Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: awado@juntendo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: awado@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036781307","https://openalex.org/A5088573439"],"corresponding_institution_ids":["https://openalex.org/I34077901"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.9386,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87748978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"21","issue":"7","first_page":"102956","last_page":"102956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9509999752044678},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neuronal-maturation","display_name":"neuronal maturation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/age-related-neurodegenerative-diseases","display_name":"age-related neurodegenerative diseases","score":0.9679999947547913},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.8118000030517578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7943000197410583},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7089999914169312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6541000008583069},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.6322000026702881},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5631999969482422},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.5464000105857849},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5127999782562256},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42170000076293945},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3788999915122986},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3005000054836273},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2840999960899353},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.2736999988555908},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C2781011225","wikidata":"https://www.wikidata.org/wiki/Q7181400","display_name":"Phenotypic switching","level":4,"score":0.25699999928474426},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.25679999589920044}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.stemcr.2026.102956","doi":"https://doi.org/10.1016/j.stemcr.2026.102956","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102956","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},{"id":"pmid:42276063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42276063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13385434","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13385434/pdf/main.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Reports","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.stemcr.2026.102956","doi":"https://doi.org/10.1016/j.stemcr.2026.102956","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2026.102956","pdf_url":null,"source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2228554923","display_name":null,"funder_award_id":"17H05706","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4671105147","display_name":"\u5b64\u767a\u6027\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5iPS\u7d30\u80de\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u6d3b\u7528\u3057\u305f\u6cbb\u7642\u85ac\u63a2\u7d22","funder_award_id":"25bm1423015h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4814308535","display_name":"\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u306e\u75c5\u614b\u89e3\u660e\u3092\u76ee\u6307\u3057\u305f\u9769\u65b0\u7684\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0","funder_award_id":"24gm1310003h0006","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4919366169","display_name":"iPS \u7d30\u80de\u306e\u8001\u5316\u5236\u5fa1\u3068\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u8a98\u5c0e\u6280\u8853\u306b\u3088\u308b\u8133\u5185\u74b0\u5883\u518d\u73fe\u3092\u7528\u3044\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u5275\u85ac\u57fa\u76e4\u306e\u69cb\u7bc9","funder_award_id":"25ak0101236h0002","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6030472161","display_name":null,"funder_award_id":"S1411007","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6097327461","display_name":"Generation of an aged Parkinson's disease brain model and elucidation of its pathophysiology using iPS cells","funder_award_id":"20K07873","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6614378709","display_name":"Establishment of an aging brain environment model as a basis for iPS cell research on neurodegenerative diseases.","funder_award_id":"19K16930","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7028972502","display_name":null,"funder_award_id":"JP17ek0109244","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8733000822","display_name":"\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u304a\u3051\u308b\u75be\u60a3\u4fee\u98fe\u85ac\u5019\u88dc\u306e\u540c\u5b9a\u3068precision medicine\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u30a2\u30ab\u30c7\u30df\u30a2\u3068\u4f01\u696d\u306e\u6280\u8853\u878d\u5408\u306b\u3088\u308b\u65b0\u305f\u306a\u5275\u85ac\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a","funder_award_id":"22ak0101112h0004","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320327572","display_name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","ror":"https://ror.org/05h2t6865"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F8187730312","display_name":"Centre de Recherche en \u00c9conomie et Statistique","ror":"https://ror.org/0449khs19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1033197108","https://openalex.org/W1806909159","https://openalex.org/W1824210888","https://openalex.org/W2009129665","https://openalex.org/W2020595943","https://openalex.org/W2046589688","https://openalex.org/W2059370490","https://openalex.org/W2081914422","https://openalex.org/W2102278945","https://openalex.org/W2108234281","https://openalex.org/W2109838416","https://openalex.org/W2125632841","https://openalex.org/W2128807350","https://openalex.org/W2135564059","https://openalex.org/W2138207763","https://openalex.org/W2138977668","https://openalex.org/W2149364340","https://openalex.org/W2279004173","https://openalex.org/W2319232270","https://openalex.org/W2378580723","https://openalex.org/W2399161531","https://openalex.org/W2530753724","https://openalex.org/W2534142475","https://openalex.org/W2571764284","https://openalex.org/W2598437549","https://openalex.org/W2607084862","https://openalex.org/W2752676842","https://openalex.org/W2768698703","https://openalex.org/W2769606714","https://openalex.org/W2893617001","https://openalex.org/W2901293244","https://openalex.org/W2961542879","https://openalex.org/W2962291520","https://openalex.org/W2970454553","https://openalex.org/W2972368830","https://openalex.org/W2974029161","https://openalex.org/W2980110729","https://openalex.org/W2988310131","https://openalex.org/W3031142363","https://openalex.org/W3042790734","https://openalex.org/W3111207111","https://openalex.org/W3139305102","https://openalex.org/W3158627234","https://openalex.org/W3173577024","https://openalex.org/W3198101085","https://openalex.org/W4200040118","https://openalex.org/W4200380426","https://openalex.org/W4210773266","https://openalex.org/W4313531093","https://openalex.org/W4384008545","https://openalex.org/W4391344278","https://openalex.org/W4391483361","https://openalex.org/W4392356353","https://openalex.org/W4399605333","https://openalex.org/W4399970235","https://openalex.org/W4400496534"],"related_works":[],"abstract_inverted_index":{"Cells":[0],"derived":[1],"from":[2],"rejuvenated":[3],"human":[4],"induced":[5],"pluripotent":[6],"stem":[7],"cells":[8,28,110],"(hiPSCs)":[9],"require":[10],"extended":[11],"culture":[12],"periods":[13],"to":[14,22,46,51],"achieve":[15],"functional":[16],"maturation,":[17],"and":[18,36,55,80,86,126],"it":[19],"remains":[20],"difficult":[21],"recapitulate":[23],"cellular":[24],"senescence":[25],"in":[26,29,83,96,133],"these":[27],"vitro.":[30],"This":[31],"limitation":[32],"hinders":[33],"the":[34,57,91],"accurate":[35],"efficient":[37],"modeling":[38],"of":[39,59,93,99,136],"age-related":[40,100,137],"neurodegenerative":[41,101,138],"diseases.":[42,102,139],"Here,":[43],"we":[44,68],"aimed":[45],"establish":[47],"a":[48,64,124],"simple":[49,125],"approach":[50],"promote":[52],"neuronal":[53],"maturation":[54],"improve":[56],"efficiency":[58],"hiPSC-based":[60],"disease":[61],"modeling.":[62],"Using":[63],"small-molecule":[65],"inhibitor":[66],"library,":[67],"identified":[69],"an":[70],"ATM":[71],"kinase":[72],"inhibitor,":[73],"KU60019,":[74],"that":[75,107,121],"promotes":[76],"both":[77],"maturation-associated":[78],"features":[79],"senescence-associated":[81],"phenotypes":[82,95],"hiPSC-derived":[84],"neurons":[85],"fibroblasts.":[87],"KU60019":[88,122],"treatment":[89],"promoted":[90],"manifestation":[92],"disease-relevant":[94],"hiPSC":[97,134],"models":[98,135],"Furthermore,":[103],"senolytic":[104],"analyses":[105],"suggested":[106],"KU60019-induced":[108],"senescent":[109],"depend":[111],"on":[112],"pro-survival":[113],"pathways,":[114],"including":[115],"HSP90-associated":[116],"signaling.":[117],"These":[118],"findings":[119],"suggest":[120],"provides":[123],"useful":[127],"tool":[128],"for":[129],"accelerating":[130],"phenotypic":[131],"recapitulation":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2026-06-12T00:00:00"}