{"id":"https://openalex.org/W7164201828","doi":"https://doi.org/10.1212/wnl.0000000000217343","title":"Post-hoc Analysis of Descartes-08, BCMA-directed mRNA CAR-T Therapy, in Biologic Non-responsive Versus Biologic Naive Generalized Myasthenia Gravis: Results from a Phase 2b Randomized Trial (P9-9.020)","display_name":"Post-hoc Analysis of Descartes-08, BCMA-directed mRNA CAR-T Therapy, in Biologic Non-responsive Versus Biologic Naive Generalized Myasthenia Gravis: Results from a Phase 2b Randomized Trial (P9-9.020)","publication_year":2026,"publication_date":"2026-06-09","ids":{"openalex":"https://openalex.org/W7164201828","doi":"https://doi.org/10.1212/wnl.0000000000217343"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000217343","doi":"https://doi.org/10.1212/wnl.0000000000217343","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000217343","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081119491","display_name":"Milo\u0161 D. Miljkovi\u0107","orcid":"https://orcid.org/0000-0001-5848-6320","observed_orcids":["https://orcid.org/0000-0001-5848-6320"]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milos Miljkovic","raw_affiliation_strings":["Cartesian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartesian","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015861848","display_name":"Tuan Vu","orcid":"https://orcid.org/0000-0003-0724-0210","observed_orcids":["https://orcid.org/0000-0003-0724-0210"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuan Vu","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032675624","display_name":"Hacer Durmu\u015f","orcid":"https://orcid.org/0000-0002-6426-676X","observed_orcids":["https://orcid.org/0000-0002-6426-676X"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hacer Durmus","raw_affiliation_strings":["Department of Neurology, Istanbul Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Istanbul Faculty of Medicine","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075621312","display_name":"Christopher M. Jewell","orcid":"https://orcid.org/0000-0002-6668-6928","observed_orcids":["https://orcid.org/0000-0002-6668-6928"]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Jewell","raw_affiliation_strings":["Cartesian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartesian","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070094631","display_name":"Hafsa Kamboh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hafsa Kamboh","raw_affiliation_strings":["Cartesian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartesian","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084580297","display_name":"Eva Rybak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Rybak","raw_affiliation_strings":["Cartesian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartesian","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014107810","display_name":"Renee Fedak","orcid":"https://orcid.org/0000-0003-4284-9283","observed_orcids":["https://orcid.org/0000-0003-4284-9283"]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Fedak","raw_affiliation_strings":["Cartesian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartesian","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089683798","display_name":"Tahseen Mozaffar","orcid":"https://orcid.org/0000-0002-1230-0188","observed_orcids":["https://orcid.org/0000-0002-1230-0188"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tahseen Mozaffar","raw_affiliation_strings":["University of California Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124443986","display_name":"James Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Howard","raw_affiliation_strings":["The University of North Carolina, Dept of Neurology, CB 7025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of North Carolina, Dept of Neurology, CB 7025","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11_Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalized-myasthenia-gravis","display_name":"generalized myasthenia gravis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.7440000176429749},{"id":"https://openalex.org/keywords/autologous-car-t","display_name":"autologous CAR-T","score":0.6110000014305115},{"id":"https://openalex.org/keywords/biologic-naive-patients","display_name":"biologic-naive patients","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fcrn-inhibitors","display_name":"FcRn inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/complement-inhibitors","display_name":"complement inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mg-adl","display_name":"MG-ADL","score":0.8529999852180481},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.953000009059906},{"id":"https://openalex.org/keywords/immune-markers","display_name":"immunological markers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7820000052452087},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6251999735832214},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5683000087738037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46630001068115234},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.4293000102043152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3061000108718872},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2614000141620636},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000217343","doi":"https://doi.org/10.1212/wnl.0000000000217343","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000217343","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409227653","https://openalex.org/W7119475395","https://openalex.org/W4413621725","https://openalex.org/W7134061406","https://openalex.org/W7119471393","https://openalex.org/W4244242195","https://openalex.org/W4381661028","https://openalex.org/W4415752635","https://openalex.org/W7155057220","https://openalex.org/W4405047662"],"abstract_inverted_index":{"Objective":[0],"To":[1],"compare":[2],"the":[3,63,143,158,237,243,261,283,293,307,326,344,362,381,405,429,454,480,504,528,547,567,586,607,626,795,813,831,849,918,937,949,963,1129,1148,1166,1184,1202,1220,1240,1258,1282,1400,1420,1445,1470,1495,1521,1545,1570,1594,1620,1645,1670,1696,1721,1746,1771,1791,1811,1832],"effects":[4],"of":[5,65,90,138,280,309,328,346,364,383,407,431,456,482,506,530,549,569,588,609,628,640,652,663,675,686,697,709,721,734,745,756,767,778,797,815,833,851,877,891,893,906,920,939,948,951,965,999,1010,1021,1084,1112,1131,1150,1168,1186,1204,1222,1242,1260,1284,1302,1313,1326,1337,1348,1360,1373,1384,1402,1422,1447,1472,1497,1523,1547,1572,1596,1622,1647,1672,1698,1723,1748,1773,1793,1813,1834,1868,1898,1910,1922,1934,1945,1961,1973,1985,1997,2026],"Descartes-08":[6,20,47,91,152,273],"in":[7,49,52,119,166,203,230,268,282,288,325,343,361,380,404,428,453,479,503,527,546,566,585,606,625,794,812,830,848,917,936,962,987,994,1069,1119,1128,1147,1165,1183,1201,1219,1239,1257,1281,1399,1419,1444,1469,1494,1520,1544,1569,1593,1619,1644,1669,1695,1720,1745,1770,1790,1810,1831,1851,1861,1875,1883,1893],"biologic":[8,11,67,159,196,258,262,284],"non-responsive":[9,197],"and":[10,77,121,153,168,175,180,184,192,205,212,217,220,225,260,303,2050],"naive":[12,160,263,285],"patients":[13,198],"with":[14,46,74,99,248,277,804,822,840,858,1411,2022,2046],"generalized":[15],"myasthenia":[16],"gravis":[17],"(gMG).":[18],"Background":[19],"is":[21,2029,2054],"an":[22,875,889,904,944,970,1082,1094,1110],"autologous,":[23],"BCMA-directed":[24],"mRNA":[25],"chimeric":[26],"antigen":[27],"receptor":[28],"(CAR)":[29],"T-cell":[30],"therapy":[31],"designed":[32],"for":[33,330,335,348,353,366,371,385,396,409,420,433,444,458,469,484,495,508,519,532,538,551,557,571,577,590,596,611,617,630,636,799,817,835,853,872,886,901,922,927,941,953,967,979,1079,1107,1133,1138,1152,1157,1170,1175,1188,1193,1206,1211,1224,1229,1244,1249,1262,1273,1286,1297,1404,1424,1435,1449,1460,1474,1485,1499,1510,1525,1536,1549,1560,1574,1585,1598,1609,1624,1635,1649,1660,1674,1685,1700,1711,1725,1736,1750,1761,1775,1781,1795,1801,1815,1821,1836,1842,1954],"outpatient":[34],"administration":[35],"without":[36],"lymphodepleting":[37],"chemotherapy.":[38],"In":[39,142,157,195],"a":[40,333,351,369,388,412,436,461,487,511,535,554,574,593,614,633,802,820,838,856,925,1041,1057,1136,1155,1173,1191,1209,1227,1247,1265,1289,1407,1427,1452,1477,1502,1528,1552,1577,1601,1627,1652,1677,1703,1728,1753,1778,1798,1818,1839,2011,2015,2039,2043],"Phase":[41],"2b":[42],"randomized":[43,83,150],"study,":[44],"treatment":[45,139],"resulted":[48],"significant":[50],"improvements":[51],"MG":[53,269],"severity":[54],"scores":[55,123],"compared":[56,274],"to":[57,85,101,151,155,275,318,864,1046,1062,2031,2056],"placebo.":[58,93,156],"This":[59],"post-hoc":[60,96],"analysis":[61],"examined":[62],"impact":[64],"prior":[66],"drug":[68],"exposure":[69,100],"on":[70,387,411,435,460,486,510,534,553,573,592,613,632,1264,1288,1426,1451,1476,1501,1527,1551,1576,1600,1626,1651,1676,1702,1727,1752,1777,1797,1817,1838],"outcomes.":[71],"Design/Methods":[72],"Adults":[73],"non-MuSK+":[75],"gMG":[76],"MG-ADL":[78,120,167,204],"\u22656":[79],"requiring":[80],"immunosuppression":[81],"were":[82,108,149,234,242,298],"1:1":[84],"receive":[86],"six":[87],"once-weekly":[88],"infusions":[89],"or":[92,105,254,312,391,415,439,464,490,514,946,974,1043,1059,1093,1268,1292,1430,1455,1480,1505,1531,1555,1580,1604,1630,1655,1680,1706,1731,1756,1848,1858,1872,1880,1890,2034,2059],"For":[94],"this":[95],"analysis,":[97],"participants":[98,148,264],"CD20-targeting":[102],"drugs,":[103],"FcRn":[104],"complement":[106],"inhibitors":[107],"deemed":[109],"\u201cbiologic":[110],"non-responders.\"":[111],"Efficacy":[112],"endpoints":[113],"included":[114],"mean":[115,163,200],"change":[116],"from":[117,647,659,670,682,693,704,716,728,741,752,763,774,785,1006,1017,1028,1040,1056,1097,1309,1320,1333,1344,1355,1367,1380,1391,1905,1917,1929,1941,1952,1968,1980,1992,2004],"baseline":[118],"QMG":[122,169,193,206],"at":[124,170,187,207,221],"Month":[125,128,171,188,208,222],"3":[126,172,209],"through":[127],"12.":[129],"Additional":[130],"analyses":[131],"explored":[132],"serum":[133],"cytokines":[134,233,290],"as":[135,332,350,368,801,819,837,855,874,888,903,924,943,969,1081,1109,1135,1154,1172,1190,1208,1226,1246,1406,2014,2042],"immune":[136],"biomarkers":[137],"response.":[140,295],"Results":[141],"modified":[144],"intent-to-treat":[145],"population,":[146],"15":[147],"11":[154],"population":[161],"(n=14),":[162],"(SD)":[164,201],"reduction":[165,202],"was":[173,210],"\u22125.2(1.1)":[174],"\u22125.0(1.3)":[176],"(Descrartes-08)":[177],"versus":[178,215],"\u22123.0(2.1)":[179],"\u22124.0(1.8)":[181],"(placebo),":[182],"respectively,":[183],"improved":[185],"further":[186],"12":[189],"(MG-ADL":[190],"\u22127.1[1.9]":[191],"\u22129.4[2.6]).":[194],"(n=12),":[199],"\u22122.5(1.3)":[211],"\u22122.2(2.0)":[213],"(Descartes-08)":[214],"\u22120.5(1.4)":[216],"0.5(1.4)":[218],"(placebo)":[219],"12,":[223],"\u22122.0(0.7)":[224],"\u22123.0(1.9),":[226],"respectively.":[227],"Post-infusion":[228],"differences":[229],"several":[231],"key":[232,289],"noted":[235],"between":[236],"two":[238],"groups.":[239],"Infusion-related":[240],"reactions":[241],"most":[244],"common":[245],"adverse":[246],"events,":[247],"no":[249],"cytopenia,":[250],"infections,":[251],"hypogammaglobulinemia,":[252],"CRS":[253],"ICANS.":[255],"Conclusions":[256],"Both":[257],"non-responders":[259],"had":[265,1849,1859,1873,1881,1891],"greater":[266,278],"improvement":[267],"efficacy":[270],"measures":[271],"after":[272],"placebo,":[276],"depth":[279],"response":[281],"group.":[286],"Changes":[287],"may":[291],"underpin":[292],"differential":[294],"Disclaimer:":[296],"Abstracts":[297],"not":[299,305],"reviewed":[300],"by":[301],"Neurology\u00ae":[302,310],"do":[304],"reflect":[306],"views":[308],"editors":[311],"staff.":[313],"Disclosure:":[314],"Author":[315],"has":[316,321,339,357,376,400,424,449,475,499,523,542,562,581,602,621,643,655,666,678,689,700,712,724,737,748,759,770,781,790,808,826,844,862,868,882,897,913,932,958,985,992,1002,1013,1024,1035,1051,1067,1075,1090,1103,1117,1124,1143,1161,1179,1197,1215,1235,1253,1277,1305,1316,1329,1340,1351,1363,1376,1387,1395,1415,1440,1465,1490,1516,1540,1565,1589,1615,1640,1665,1691,1716,1741,1766,1786,1806,1827,1847,1857,1871,1879,1889,1901,1913,1925,1937,1948,1964,1976,1988,2000,2010,2038],"nothing":[317,863],"discloseDr.":[319],"Vu":[320,338,356,375,399,423,448,474,498,522,541,561,580,601,620,642,654,665,677,688,699,711,723,736,747,758,769,780,789,807,825,843],"received":[322,340,358,377,401,425,450,476,500,524,543,563,582,603,622,644,656,667,679,690,701,713,725,738,749,760,771,782,791,809,827,845,869,883,898,914,933,959,1003,1014,1025,1036,1052,1076,1091,1104,1125,1144,1162,1180,1198,1216,1236,1254,1278,1306,1317,1330,1341,1352,1364,1377,1388,1396,1416,1441,1466,1491,1517,1541,1566,1590,1616,1641,1666,1692,1717,1742,1767,1787,1807,1828,1902,1914,1926,1938,1949,1965,1977,1989,2001],"personal":[323,341,359,378,402,426,451,477,501,525,544,564,583,604,623,792,810,828,846,870,884,899,915,934,960,1077,1105,1126,1145,1163,1181,1199,1217,1237,1255,1279,1397,1417,1442,1467,1492,1518,1542,1567,1591,1617,1642,1667,1693,1718,1743,1768,1788,1808,1829],"compensation":[324,342,360,379,403,427,452,478,502,526,545,565,584,605,624,793,811,829,847,871,885,900,916,935,961,1078,1106,1127,1146,1164,1182,1200,1218,1238,1256,1280,1398,1418,1443,1468,1493,1519,1543,1568,1592,1618,1643,1668,1694,1719,1744,1769,1789,1809,1830],"range":[327,345,363,382,406,430,455,481,505,529,548,568,587,608,627,796,814,832,850,919,938,964,1130,1149,1167,1185,1203,1221,1241,1259,1283,1401,1421,1446,1471,1496,1522,1546,1571,1595,1621,1646,1671,1697,1722,1747,1772,1792,1812,1833],"$5,000-$9,999":[329,347,384,457,507,550,610,921,1132,1151,1205,1223,1243,1448,1498],"serving":[331,349,367,386,410,434,459,485,509,533,552,572,591,612,631,800,818,836,854,873,887,902,923,942,968,1080,1108,1134,1153,1171,1189,1207,1225,1245,1263,1287,1405,1425,1450,1475,1500,1526,1550,1575,1599,1625,1650,1675,1701,1726,1751,1776,1796,1816,1837],"Consultant":[334,352,370,926,1137,1156,1174,1192,1210,1228,1248],"Dianthus.":[336,764],"Dr.":[337,355,374,398,422,447,473,497,521,540,560,579,600,619,641,653,664,676,687,698,710,722,735,746,757,768,779,788,806,824,842,860,866,880,895,911,930,956,983,990,1000,1011,1022,1033,1049,1073,1088,1101,1115,1122,1141,1159,1177,1195,1213,1233,1251,1275,1303,1314,1327,1338,1349,1361,1374,1385,1393,1413,1438,1463,1488,1514,1538,1563,1587,1613,1638,1663,1689,1714,1739,1764,1784,1804,1825,1845,1869,1899,1911,1923,1935,1946,1962,1974,1986,1998,2008,2036],"Amgen.":[354,618],"$500-$4,999":[365,432,483,629,798,816,834,852,966,1285,1403,1524,1548,1597,1623,1648,1673,1699,1749],"NMD":[372,786,1661,1981],"Pharma.":[373,787,1662,1738,1982],"Scientific":[389,413,437,462,488,512,1266,1290,1428,1453,1478,1503,1529,1553,1578,1602,1628,1653,1678,1704,1729,1754,2016],"Advisory":[390,414,438,463,489,513,976,1267,1291,1429,1454,1479,1504,1530,1554,1579,1603,1629,1654,1679,1705,1730,1755],"Data":[392,416,440,465,491,515,1269,1293,1431,1456,1481,1506,1532,1556,1581,1605,1631,1656,1681,1707,1732,1757],"Safety":[393,417,441,466,492,516,1270,1294,1432,1457,1482,1507,1533,1557,1582,1606,1632,1657,1682,1708,1733,1758],"Monitoring":[394,418,442,467,493,517,1271,1295,1433,1458,1483,1508,1534,1558,1583,1607,1633,1658,1683,1709,1734,1759],"board":[395,419,443,468,494,518,1272,1296,1434,1459,1484,1509,1535,1559,1584,1608,1634,1659,1684,1710,1735,1760],"ARGENX.":[397,683],"$10,000-$49,999":[408,570,589,1169,1187,1261,1423,1473,1573,1724,1774,1794,1814,1835],"Alexion.":[421,539,660],"Amgen":[445],"(Horizon).":[446],"Johnson":[470,597,1852,1854],"&":[471,598,730,1853],"Johnson.":[472,599,731],"Takeda.":[496],"VOR.":[520],"$50,000-$99,999":[531],"Speakers":[536,555,575,594,615,634,1779,1799,1819,1840],"Bureau":[537,556,576,595,616,635,1780,1800,1820,1841],"CSL":[558,648,705],"Behring.":[559,649,706],"Argenx.":[578,1158,1345],"Novartis.":[637,1537],"The":[638,650,661,673,684,695,707,719,732,743,754,765,776,997,1008,1019,1300,1311,1324,1335,1346,1358,1371,1382,1896,1908,1920,1932,1943,1959,1971,1983,1995],"institution":[639,651,662,674,685,696,708,720,733,744,755,766,777,998,1009,1020,1301,1312,1325,1336,1347,1359,1372,1383,1897,1909,1921,1933,1944,1960,1972,1984,1996],"research":[645,657,668,680,691,702,714,726,739,750,761,772,783,1004,1015,1026,1307,1318,1331,1342,1353,1365,1378,1389,1903,1915,1927,1939,1950,1966,1978,1990,2002],"support":[646,658,669,681,692,703,715,727,740,751,762,773,784,1005,1016,1027,1308,1319,1332,1343,1354,1366,1379,1390,1904,1916,1928,1940,1951,1967,1979,1991,2003],"RA":[671],"Pharma/UCB.":[672],"Horizon/Amgen.":[694],"Cartesian":[717,878,954,988,1070,1113,1120,1636],"Therapeutics.":[718,879,955,989,996,1114,1121,1299,1357,1637,1713,1970],"Janssen/Johnson":[729],"Immunovant.":[742],"Regeneron.":[753],"COUR.":[775],"Faculty":[803,821,839,857],"AcademicCME.":[805],"CMEO.":[823],"PER.":[841],"MedLive.":[859],"Durmus":[861],"disclose.":[865],"Jewell":[867,881,896,912,931,957,984,991,1001,1012,1023,1034,1050],"employee":[876,890,905,1083,1111],"University":[892],"Maryland.":[894],"Baltimore":[907,1029],"VA":[908,1030],"Medical":[909,1031],"Center.":[910,1032],"Kerna":[928],"Ventures.":[929],"$500,000-$999,999":[940],"officer":[945],"member":[947,1867,2021,2045],"Board":[950,977,2018],"Directors":[952],"Editor,":[971,973],"Associate":[972],"Editorial":[975],"Member":[978,1410],"Nature":[980],"Publishing":[981],"Group.":[982],"stock":[986,993,1068,1092,1118,1850,1860,1874,1882,1892],"Nodal":[995],"NIH.":[1007,1310,1412,1942],"JDRF.":[1018],"intellectual":[1037,1053],"property":[1038,1054],"interests":[1039,1055,2033,2058],"discovery":[1042,1058],"technology":[1044,1060],"relating":[1045,1061],"health":[1047,1063],"care.":[1048,1064],"Hafsa":[1065],"Kamboh":[1066],"Therapeutics,":[1071],"Inc.":[1072,1895],"Rybak":[1074,1089],"Marinus":[1085,1098],"Pharmaceuticals":[1086,1099],".":[1087,1100,1437,1919],"ownership":[1095],"interest":[1096],"Fedak":[1102,1116],"Mozaffar":[1123,1142,1160,1178,1196,1214,1234,1252,1276,1304,1315,1328,1339,1350,1362,1375,1386,1394],"Alexion":[1139,1486,1906],"Pharmaceuticals.":[1140,1462,1487,1907],"Sanofi-Genzyme.":[1176],"Amicus.":[1194],"Grifols.":[1212],"Astellas":[1230,1368],"Gene":[1231,1369],"Therapy.":[1232],"Bayer.":[1250],"Sarepta.":[1274],"Applied":[1298],"Muscular":[1321],"Dystrophy":[1322],"Association.":[1323],"Sanofi.":[1334],"Amicus":[1356],"Therpay.":[1370],"Cartesian.":[1381],"Cabaletta.":[1392],"Study":[1408],"Section":[1409],"Howard":[1414,1439,1464,1489,1515,1539,1564,1588,1614,1639,1664,1690,1715,1740,1765,1785,1805,1826,1846,1856,1870,1878,1888,1900,1912,1924,1936,1947,1963,1975,1987,1999,2009,2037],"argenx":[1436,1918],"Regeneron":[1461],"AMGEN":[1511],"(Horizon":[1512],"Therapeutics).":[1513],"Biohaven":[1561],"Ltd.":[1562],"CorEvitas.":[1586],"Merck":[1610,2005],"EMD":[1611,2006],"Serono.":[1612,2007],"H.":[1686],"Lundbeck":[1687],"A/S.":[1688],"Seismic":[1712],"UCB":[1737,1930],"Vor":[1762],"Biopharma.":[1763],"Academic":[1782],"CME.":[1783,1803,1824],"PeerView":[1802],"Platform":[1822],"Q":[1823],"MJH":[1843],"LifeSci.":[1844],"dividends.Dr.":[1855,1877,1887],"Pfizer":[1862],"dividends.":[1863],"An":[1864],"immediate":[1865],"family":[1866],"GlaxoSmithKline":[1876],"Bristol":[1884],"Myer":[1885],"Squbb":[1886],"AbbieVie":[1894],"Biosciences.":[1931],"Centers":[1953],"Disease":[1955],"Control/Research":[1956],"Triangle":[1957],"Institute.":[1958],"Cartestian":[1969],"Ad":[1993],"Scientiam.":[1994],"non-compensated":[2012,2040],"relationship":[2013,2041],"Advisiory":[2017],"member,":[2019],"Committee":[2020,2044],"Myasthenia":[2023],"Gravis":[2024],"Foundation":[2025],"America":[2027],"that":[2028,2053],"relevant":[2030,2055],"AAN":[2032,2057],"activities.":[2035,2060],"American":[2047],"Assoc":[2048],"Neuromuscular":[2049],"Electrodiagnostic":[2051],"Medicine":[2052]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-06-11T00:00:00"}