{"id":"https://openalex.org/W7164155604","doi":"https://doi.org/10.1212/wnl.0000000000217047","title":"Impact of LAMA5 Variants on Immune Cell Infiltration Using 2D Blood Brain Barrier Culture Model of Multiple Sclerosis (P2-18.004)","display_name":"Impact of LAMA5 Variants on Immune Cell Infiltration Using 2D Blood Brain Barrier Culture Model of Multiple Sclerosis (P2-18.004)","publication_year":2026,"publication_date":"2026-06-09","ids":{"openalex":"https://openalex.org/W7164155604","doi":"https://doi.org/10.1212/wnl.0000000000217047"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000217047","doi":"https://doi.org/10.1212/wnl.0000000000217047","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000217047","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054066035","display_name":"Aksel S\u0131va","orcid":"https://orcid.org/0000-0002-8340-6641","observed_orcids":["https://orcid.org/0000-0002-8340-6641"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aksel Siva","raw_affiliation_strings":["Istanbul University Cerrahpasa School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University Cerrahpasa School of Medicine","institution_ids":["https://openalex.org/I4210112471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092600371","display_name":"Umut Voyvoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umut Voyvoda","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138345967","display_name":"kerem cotuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"kerem cotuk","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138340369","display_name":"Hanbike Efe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanbike Efe","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087744747","display_name":"Sevim Naz Kar\u0131\u015f\u0131k","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sevim Naz Karisik","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138356947","display_name":"Meziyet Reda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meziyet Reda","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099169641","display_name":"Bet\u00fcl \u00c7akici","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betul Cakici","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127396016","display_name":"Elif \u00c7elik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Celik","raw_affiliation_strings":["Translational Medicine, Acibadem University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Acibadem University","institution_ids":["https://openalex.org/I322491407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066246686","display_name":"Ahmet Can Timu\u00e7in","orcid":"https://orcid.org/0000-0002-9483-3593","observed_orcids":["https://orcid.org/0000-0002-9483-3593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmet Can Timucin","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023016254","display_name":"Umut \u0130nci Onat","orcid":"https://orcid.org/0000-0003-4360-9310","observed_orcids":["https://orcid.org/0000-0003-4360-9310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umut \u0130nci Onat","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045459551","display_name":"Bade G\u00fcle\u00e7","orcid":"https://orcid.org/0000-0002-2340-4409","observed_orcids":["https://orcid.org/0000-0002-2340-4409"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bade Gulec","raw_affiliation_strings":["Istanbul University Cerrahpasa School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University Cerrahpasa School of Medicine","institution_ids":["https://openalex.org/I4210112471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005378034","display_name":"Melih T\u00fct\u00fcnc\u00fc","orcid":"https://orcid.org/0000-0002-9851-7002","observed_orcids":["https://orcid.org/0000-0002-9851-7002"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Melih Tutuncu","raw_affiliation_strings":["Istanbul University Cerrahpasa School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University Cerrahpasa School of Medicine","institution_ids":["https://openalex.org/I4210112471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062409928","display_name":"U\u011fur Uyguno\u011flu","orcid":"https://orcid.org/0000-0003-2866-4004","observed_orcids":["https://orcid.org/0000-0003-2866-4004"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ugur Uygunoglu","raw_affiliation_strings":["Istanbul University Cerrahpasa School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University Cerrahpasa School of Medicine","institution_ids":["https://openalex.org/I4210112471"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112372256","display_name":"Eda Turanli","orcid":"https://orcid.org/0000-0001-5876-0510","observed_orcids":["https://orcid.org/0000-0001-5876-0510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eda Turanli","raw_affiliation_strings":["molecular biology and genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"molecular biology and genetics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3944017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11_Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lama5","display_name":"LAMA5","score":0.9359999895095825},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8149999976158142},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.796999990940094},{"id":"https://openalex.org/keywords/familial-multiple-sclerosis","display_name":"familial multiple sclerosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/in-vitro-blood-brain-barrier-model","display_name":"in vitro blood-brain barrier model","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8392000198364258},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7232999801635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6183000206947327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5358999967575073},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5120999813079834},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4984999895095825},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C2778144876","wikidata":"https://www.wikidata.org/wiki/Q4955745","display_name":"Brain Cell","level":2,"score":0.39640000462532043},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3310999870300293},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.25870001316070557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000217047","doi":"https://doi.org/10.1212/wnl.0000000000217047","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000217047","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049009586","https://openalex.org/W2027286906","https://openalex.org/W2941320351","https://openalex.org/W2318892057","https://openalex.org/W2055950044","https://openalex.org/W2116842576","https://openalex.org/W2934045422","https://openalex.org/W4206951043","https://openalex.org/W3031331152","https://openalex.org/W2287869235"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,19,49,68,92,150,166,172,222,236,275,295,310,328,346,364,384,402,423,443,467,495,621,650,677,708,737,766],"impact":[4],"of":[5,32,67,152,184,224,278,297,312,330,348,366,386,404,425,445,469,497,516,529,623,642,652,669,679,696,700,710,725,729,739,754,758,768,783,787,800,805,818,835],"LAMA5":[6,80,96,225,229,265],"variants":[7,266],"identified":[8,100,267],"in":[9,26,39,73,79,101,129,160,192,221,268,281,309,327,345,363,383,401,422,442,466,494,620,649,676,707,736,765],"multiple":[10],"sclerosis":[11],"(MS)":[12],"families":[13],"on":[14,449,473,501,627,656,683,714,743,772],"immune":[15,45],"cell":[16,46,76],"infiltration":[17,234],"across":[18,91,165,235],"blood\u2013brain":[20],"barrier":[21,246],"(BBB)":[22],"using":[23,113,255],"a":[24,36,62,130,317,335,353,371,391,409,430,450,474,502,628,657,684,715,744,773],"2D":[25,132],"vitro":[27],"co-culture":[28,133],"model.":[29],"Background":[30],"Disruption":[31],"BBB":[33,213,279],"integrity":[34,214,280],"plays":[35],"central":[37,50],"role":[38],"MS":[40,102,241,525,814],"pathogenesis":[41,242],"by":[42,289],"facilitating":[43],"peripheral":[44,124],"entry":[47],"into":[48,106,274],"nervous":[51],"system,":[52],"leading":[53],"to":[54,148,180,240,263,554,560,566,572,578,583,588,594,600,606,612],"neuroinflammation":[55],"and":[56,87,118,141,157,163,187,197,215,219,248,291,539,796],"neurodegeneration.":[57],"Laminin":[58],"subunit":[59],"alpha-5":[60],"(LAMA5),":[61],"key":[63],"extracellular":[64],"matrix":[65],"component":[66],"BBB,":[69,237],"has":[70,305,323,341,359,379,397,418,438,462,490,519,532,552,558,564,570,576,581,586,592,598,604,610,616,645,672,703,732,761,790,808,821,838],"been":[71],"implicated":[72],"regulating":[74],"endothelial\u2013immune":[75],"interactions.":[77],"Variants":[78],"may":[81],"therefore":[82],"alter":[83],"adhesion":[84,162,218,250],"molecule":[85,251],"expression":[86,151,199],"promote":[88],"lymphocyte":[89,161,217,233],"migration":[90,136,170,220],"BBB.":[93,167],"Design/Methods":[94],"The":[95,228,514,527,537,640,667,698,727,756,785,803,816,833],"p.Thr3126Ile":[97,230],"missense":[98],"mutation,":[99],"families,":[103],"was":[104,137,146,176,189,200],"introduced":[105],"human":[107],"umbilical":[108],"vein":[109],"endothelial":[110,245],"cells":[111,127],"(HUVECs)":[112],"cytosine":[114],"base":[115],"editing.":[116],"Wild-type":[117],"mutant":[119,173,193],"HUVECs":[120],"were":[121,286],"co-cultured":[122],"with":[123,139],"blood":[125],"mononuclear":[126],"(PBMCs)":[128],"Transwell":[131],"system.":[134],"PBMC":[135,169],"induced":[138],"TNF\u03b1":[140],"IFN\u03b3":[142],"stimulation.":[143],"Quantitative":[144],"PCR":[145],"performed":[147],"assess":[149],"ICAM1,":[153,185],"VCAM1,":[154,186],"CLDN5,":[155],"ITGB1,":[156],"ITGAL\u2014genes":[158],"involved":[159],"transmigration":[164],"Results":[168],"through":[171,243],"HUVEC":[174],"monolayer":[175],"25%":[177],"higher":[178],"compared":[179],"wild-type":[181],"cells.":[182],"Expression":[183],"CLDN5":[188],"significantly":[190,201],"reduced":[191],"HUVECs,":[194],"whereas":[195],"ITGB1":[196],"ITGAL":[198],"increased":[202],"(p":[203],"<":[204],"0.05":[205],"for":[206,314,319,332,337,350,355,368,373,388,393,406,411,427,432,447,458,471,482,499,510,625,636,654,665,681,692,712,723,741,752,770,781],"all).":[207],"These":[208],"molecular":[209],"changes":[210],"indicate":[211],"compromised":[212],"enhanced":[216],"presence":[223],"variants.":[226],"Conclusions":[227],"variant":[231],"increases":[232],"potentially":[238],"contributing":[239],"impaired":[244],"function":[247],"dysregulated":[249],"expression.":[252],"Ongoing":[253],"studies":[254],"prime":[256],"editing":[257],"technology":[258],"will":[259],"extend":[260],"this":[261],"investigation":[262],"additional":[264],"familial":[269],"MS,":[270],"providing":[271],"translational":[272],"insights":[273],"genetic":[276],"regulation":[277],"neuroinflammatory":[282],"diseases.":[283],"Disclaimer:":[284],"Abstracts":[285],"not":[287,293],"reviewed":[288],"Neurology\u00ae":[290,298],"do":[292],"reflect":[294],"views":[296],"editors":[299],"or":[300,453,477,505,631,660,687,718,747,776],"staff.":[301],"Disclosure:":[302],"Dr.":[303,321,339,357,377,395,416,436,460,488,517,530,590,608],"Siva":[304,322,340,358,378,396,417,437,461,489,518,531],"received":[306,324,342,360,380,398,419,439,463,491,520,533,617,646,673,704,733,762,791,809,822,839],"personal":[307,325,343,361,381,399,420,440,464,492,618,647,674,705,734,763],"compensation":[308,326,344,362,382,400,421,441,465,493,619,648,675,706,735,764],"range":[311,329,347,365,385,403,424,444,468,496,622,651,678,709,738,767],"$500-$4,999":[313,331,349,367,387,405,426,446,470,498,624],"serving":[315,333,351,369,389,407,428,448,472,500,626,655,682,713,742,771],"as":[316,334,352,370,390,408,429],"Consultant":[318,336,354,372,392,410,431],"Novartis.":[320,666],"Roche.":[338,459],"Sanofi-Genzyme.":[356],"Biogen":[374,693],"-":[375,486,545],"TR.":[376,487],"Alexion.":[394],"Ali":[412],"Raif":[413],"Pharmaceuticals,":[414,434],"Turkiye.":[415,435],"Sanovel":[433,753],"Scientific":[451,475,503,538,629,658,685,716,745,774,795,828,845],"Advisory":[452,476,504,630,659,686,717,746,775],"Data":[454,478,506,632,661,688,719,748,777],"Safety":[455,479,507,633,662,689,720,749,778],"Monitoring":[456,480,508,634,663,690,721,750,779],"board":[457,481,509,635,664,691,722,751,780],"Abdi":[483],"Ibrahim":[484],"Ilac":[485],"Merck":[511],"Serono":[512],".":[513,639,832,849],"institution":[515,528,641,668,699,728,757,786,804,817,834],"research":[521,534,792,810,823,840],"support":[522,535,793,811,824,841],"from":[523,536,794,812,825,842],"Turkish":[524,813],"Society.":[526,815],"Technological":[540,797],"Research":[541,548,798,829,846],"Council":[542,799],"Of":[543],"Turkey":[544,638,801],"Health":[546],"Sciences":[547],"Grants.":[549],"Umut":[550],"Voyvoda":[551],"nothing":[553,559,565,571,577,582,587,593,599,605,611],"disclose.":[555,561,567,573,579,589,595,601,607,613],"Mr.":[556],"Cotuk":[557],"Ms.":[562,568],"Efe":[563],"Karisik":[569],"Miss":[574],"Reda":[575],"Author":[580],"discloseMiss":[584],"Celik":[585],"Timucin":[591],"Mrs.":[596],"Onat":[597],"Bade":[602],"Gulec":[603],"Tutuncu":[609],"Ugur":[614,643,670,701,730,759],"Uygunoglu":[615,644,671,702,731,760],"Roche":[637],"$0-$499":[653,680,711,740,769],"Idec/Gen":[694],"Pharma":[695],"Turkey.":[697,726,755,784],"Merck-Serono":[724],"Genveon":[782],"Eda":[788,806,819,836],"Turanli":[789,807,820,837],"(T\u00dcBITAK).":[802],"Acibadem":[826],"University":[827,844],"Projects":[830,847],"Commission":[831,848],"Istanbul":[843]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-06-11T00:00:00"}
