{"id":"https://openalex.org/W7163746973","doi":"https://doi.org/10.1016/j.cca.2026.121154","title":"Urinary Exosomal ATF3 as a non-invasive biomarker for early detection of acute kidney injury","display_name":"Urinary Exosomal ATF3 as a non-invasive biomarker for early detection of acute kidney injury","publication_year":2026,"publication_date":"2026-06-06","ids":{"openalex":"https://openalex.org/W7163746973","doi":"https://doi.org/10.1016/j.cca.2026.121154","pmid":"https://pubmed.ncbi.nlm.nih.gov/42250676"},"language":"en","primary_location":{"id":"doi:10.1016/j.cca.2026.121154","doi":"https://doi.org/10.1016/j.cca.2026.121154","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2026.121154","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027318015","display_name":"Dilip Kumar Arya","orcid":"https://orcid.org/0000-0002-4087-3311","observed_orcids":["https://orcid.org/0000-0002-4087-3311"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]},{"id":"https://openalex.org/I4210161010","display_name":"Centre of Biomedical Research","ror":"https://ror.org/05xkqnm68","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210161010"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dilip Kumar Arya","raw_affiliation_strings":["Centre of BioMedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of BioMedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014, India","institution_ids":["https://openalex.org/I161370692","https://openalex.org/I4210161010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138049872","display_name":"Anupama Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupama Verma","raw_affiliation_strings":["Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049725660","display_name":"Rajeev Mishra","orcid":"https://orcid.org/0000-0002-7411-4022","observed_orcids":["https://orcid.org/0000-0002-7411-4022"]},"institutions":[{"id":"https://openalex.org/I229991691","display_name":"Chhatrapati Shahu Ji Maharaj University","ror":"https://ror.org/040qxz868","country_code":"IN","type":"education","lineage":["https://openalex.org/I229991691"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajeev Mishra","raw_affiliation_strings":["Department of Life Sciences & Biotechnology, CSJM University, Kanpur, Uttar Pradesh 208024, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences & Biotechnology, CSJM University, Kanpur, Uttar Pradesh 208024, India","institution_ids":["https://openalex.org/I229991691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004802831","display_name":"Elisabetta Mueller","orcid":"https://orcid.org/0000-0003-2533-2266","observed_orcids":["https://orcid.org/0000-0003-2533-2266"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabetta Mueller","raw_affiliation_strings":["Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078382644","display_name":"Narendra Verma","orcid":"https://orcid.org/0000-0003-1028-7204","observed_orcids":["https://orcid.org/0000-0003-1028-7204"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]},{"id":"https://openalex.org/I4210161010","display_name":"Centre of Biomedical Research","ror":"https://ror.org/05xkqnm68","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210161010"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narendra Verma","raw_affiliation_strings":["Centre of BioMedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: narendraverma@cbmr.res.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of BioMedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: narendraverma@cbmr.res.in","institution_ids":["https://openalex.org/I161370692","https://openalex.org/I4210161010","https://openalex.org/I99364266"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078382644"],"corresponding_institution_ids":["https://openalex.org/I161370692","https://openalex.org/I4210161010","https://openalex.org/I99364266"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22631877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"591","issue":null,"first_page":"121154","last_page":"121154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/urinary-exosomes","display_name":"urinary exosomes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/atf3","display_name":"ATF3","score":0.953000009059906},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.847000002861023},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7450000047683716},{"id":"https://openalex.org/keywords/kidney-injury-biomarkers","display_name":"kidney injury biomarkers","score":0.6840000152587891},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.4300000071525574},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.4429999887943268},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7495999932289124},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7204999923706055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6680999994277954},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6603999733924866},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5914000272750854},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5410000085830688},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.5357000231742859},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5267999768257141},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4316999912261963},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4171999990940094},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.36390000581741333},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.33629998564720154},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2779225474","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urinalysis","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.25519999861717224}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cca.2026.121154","doi":"https://doi.org/10.1016/j.cca.2026.121154","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2026.121154","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:42250676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42250676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1506555948","https://openalex.org/W1513067957","https://openalex.org/W1597058931","https://openalex.org/W1762620449","https://openalex.org/W1966590237","https://openalex.org/W1980218015","https://openalex.org/W2011081730","https://openalex.org/W2019442978","https://openalex.org/W2027414130","https://openalex.org/W2032418919","https://openalex.org/W2034615998","https://openalex.org/W2041439693","https://openalex.org/W2042773343","https://openalex.org/W2043575472","https://openalex.org/W2051931680","https://openalex.org/W2064561597","https://openalex.org/W2068979787","https://openalex.org/W2070692494","https://openalex.org/W2072718771","https://openalex.org/W2075596754","https://openalex.org/W2076265695","https://openalex.org/W2076740795","https://openalex.org/W2080535870","https://openalex.org/W2081359434","https://openalex.org/W2082883369","https://openalex.org/W2086981199","https://openalex.org/W2098296304","https://openalex.org/W2105284628","https://openalex.org/W2114461677","https://openalex.org/W2122537353","https://openalex.org/W2124663458","https://openalex.org/W2128832729","https://openalex.org/W2133442735","https://openalex.org/W2136347227","https://openalex.org/W2145221987","https://openalex.org/W2145339507","https://openalex.org/W2146081758","https://openalex.org/W2155886511","https://openalex.org/W2158748750","https://openalex.org/W2159114297","https://openalex.org/W2160767270","https://openalex.org/W2162392154","https://openalex.org/W2347116954","https://openalex.org/W2516370793","https://openalex.org/W2568883368","https://openalex.org/W2570610921","https://openalex.org/W2738491178","https://openalex.org/W2739394507","https://openalex.org/W2767766003","https://openalex.org/W2810395966","https://openalex.org/W2888556650","https://openalex.org/W2888749427","https://openalex.org/W2905047249","https://openalex.org/W2920816866","https://openalex.org/W2935609143","https://openalex.org/W2972811706","https://openalex.org/W2998552676","https://openalex.org/W2999710344","https://openalex.org/W3010255445","https://openalex.org/W3011850089","https://openalex.org/W3024682481","https://openalex.org/W3045256806","https://openalex.org/W3113043888","https://openalex.org/W3146487028","https://openalex.org/W3155253987","https://openalex.org/W3195950103","https://openalex.org/W3213135202","https://openalex.org/W4211223405","https://openalex.org/W4282021410","https://openalex.org/W4294953533","https://openalex.org/W4315628227","https://openalex.org/W4376133237","https://openalex.org/W4390724131","https://openalex.org/W4395052079","https://openalex.org/W4403454705","https://openalex.org/W4404708859","https://openalex.org/W4406454096","https://openalex.org/W4408002813","https://openalex.org/W4409358921","https://openalex.org/W4409516538"],"related_works":["https://openalex.org/W2076740795","https://openalex.org/W2568883368","https://openalex.org/W1988249798","https://openalex.org/W4282928780","https://openalex.org/W4396993885","https://openalex.org/W4317757210","https://openalex.org/W4307945760","https://openalex.org/W4313471891","https://openalex.org/W2126474322","https://openalex.org/W7140127117"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-07T00:00:00"}