{"id":"https://openalex.org/W7163734026","doi":"https://doi.org/10.1007/s11033-026-12069-2","title":"HSP70-targeting TKD-functionalized smart micelles for membrane\u2212guided precision breast cancer therapy: a review","display_name":"HSP70-targeting TKD-functionalized smart micelles for membrane\u2212guided precision breast cancer therapy: a review","publication_year":2026,"publication_date":"2026-06-06","ids":{"openalex":"https://openalex.org/W7163734026","doi":"https://doi.org/10.1007/s11033-026-12069-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/42250130"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-026-12069-2","doi":"https://doi.org/10.1007/s11033-026-12069-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-026-12069-2","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109685640","display_name":"Manisha S. Jain","orcid":"https://orcid.org/0009-0001-1398-0568","observed_orcids":["https://orcid.org/0009-0001-1398-0568"]},"institutions":[{"id":"https://openalex.org/I4405285236","display_name":"Adichunchanagiri University","ror":"https://ror.org/051n8fq88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405285236"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manisha S. Jain","raw_affiliation_strings":["Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India","institution_ids":["https://openalex.org/I4405285236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138040827","display_name":"S. Rohith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285236","display_name":"Adichunchanagiri University","ror":"https://ror.org/051n8fq88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405285236"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"S. Rohith","raw_affiliation_strings":["Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India","institution_ids":["https://openalex.org/I4405285236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082112880","display_name":"Jeevan Gowda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285236","display_name":"Adichunchanagiri University","ror":"https://ror.org/051n8fq88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405285236"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jeevan Gowda","raw_affiliation_strings":["Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India","institution_ids":["https://openalex.org/I4405285236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019847016","display_name":"T. Mallamma","orcid":"https://orcid.org/0000-0002-9604-8898","observed_orcids":["https://orcid.org/0000-0002-9604-8898","https://orcid.org/0009-0000-3709-0247"]},"institutions":[{"id":"https://openalex.org/I4405285236","display_name":"Adichunchanagiri University","ror":"https://ror.org/051n8fq88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405285236"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"T. Mallamma","raw_affiliation_strings":["Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India. mallammareddy89@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India. mallammareddy89@gmail.com","institution_ids":["https://openalex.org/I4405285236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019847016","https://openalex.org/A5082112880","https://openalex.org/A5109685640","https://openalex.org/A5138040827"],"corresponding_institution_ids":["https://openalex.org/I4405285236"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.3475,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42919772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"53","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/membrane-bound-hsp70","display_name":"membrane-bound Hsp70","score":0.8679999709129333},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.5550000071525574},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8899999856948853},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6807000041007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6789000034332275},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5965999960899353},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.586899995803833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5426999926567078},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4796999990940094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4494999945163727},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4422999918460846},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42570000886917114},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.41780000925064087},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.39259999990463257},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3402000069618225},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33239999413490295},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-026-12069-2","doi":"https://doi.org/10.1007/s11033-026-12069-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-026-12069-2","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:42250130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42250130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W1971061361","https://openalex.org/W2003791117","https://openalex.org/W2073985854","https://openalex.org/W2104935252","https://openalex.org/W2151940597","https://openalex.org/W2181262244","https://openalex.org/W2191597244","https://openalex.org/W2342842685","https://openalex.org/W2344850880","https://openalex.org/W2421275313","https://openalex.org/W2423664568","https://openalex.org/W2486678718","https://openalex.org/W2492805479","https://openalex.org/W2768932688","https://openalex.org/W2772289170","https://openalex.org/W2794088236","https://openalex.org/W2794683780","https://openalex.org/W2806270978","https://openalex.org/W2890733148","https://openalex.org/W2912852543","https://openalex.org/W2970329262","https://openalex.org/W2990178572","https://openalex.org/W2995358496","https://openalex.org/W2999076572","https://openalex.org/W3010628223","https://openalex.org/W3012011334","https://openalex.org/W3015804616","https://openalex.org/W3041375481","https://openalex.org/W3044344005","https://openalex.org/W3045977938","https://openalex.org/W3105227577","https://openalex.org/W3106396660","https://openalex.org/W3113161474","https://openalex.org/W3136209092","https://openalex.org/W3152692115","https://openalex.org/W3170638641","https://openalex.org/W3199710068","https://openalex.org/W3210062227","https://openalex.org/W3215626020","https://openalex.org/W4200257923","https://openalex.org/W4210625950","https://openalex.org/W4220884535","https://openalex.org/W4240727293","https://openalex.org/W4280556061","https://openalex.org/W4283661738","https://openalex.org/W4285992810","https://openalex.org/W4292466583","https://openalex.org/W4293067507","https://openalex.org/W4295957247","https://openalex.org/W4295973382","https://openalex.org/W4297312287","https://openalex.org/W4297497350","https://openalex.org/W4300690180","https://openalex.org/W4309746155","https://openalex.org/W4309754188","https://openalex.org/W4313435873","https://openalex.org/W4317600205","https://openalex.org/W4320494162","https://openalex.org/W4321371901","https://openalex.org/W4321598135","https://openalex.org/W4323295468","https://openalex.org/W4353072310","https://openalex.org/W4361005365","https://openalex.org/W4365449016","https://openalex.org/W4381248948","https://openalex.org/W4385487393","https://openalex.org/W4385877957","https://openalex.org/W4386390703","https://openalex.org/W4386862229","https://openalex.org/W4389449503","https://openalex.org/W4391442556","https://openalex.org/W4392298786","https://openalex.org/W4392678894","https://openalex.org/W4393238235","https://openalex.org/W4394678848","https://openalex.org/W4398241291","https://openalex.org/W4399055235","https://openalex.org/W4400137948","https://openalex.org/W4400147911","https://openalex.org/W4400150254","https://openalex.org/W4400741193","https://openalex.org/W4400798205","https://openalex.org/W4402041802","https://openalex.org/W4402139103","https://openalex.org/W4403419774","https://openalex.org/W4405945348","https://openalex.org/W4406228597","https://openalex.org/W4407226369","https://openalex.org/W4408032454","https://openalex.org/W4408869289","https://openalex.org/W4408932417","https://openalex.org/W4408996307","https://openalex.org/W4409404456","https://openalex.org/W4409630345","https://openalex.org/W4409734715","https://openalex.org/W4409766318","https://openalex.org/W4409828387","https://openalex.org/W4410823541","https://openalex.org/W4410991540","https://openalex.org/W4411339103","https://openalex.org/W4412161798","https://openalex.org/W4412355336","https://openalex.org/W4412602752","https://openalex.org/W4412649000","https://openalex.org/W4412784959","https://openalex.org/W4413325724","https://openalex.org/W4413471047","https://openalex.org/W4414032782","https://openalex.org/W4414040459","https://openalex.org/W4414040491","https://openalex.org/W4416459332","https://openalex.org/W4417318007","https://openalex.org/W7116880350","https://openalex.org/W7117696738","https://openalex.org/W7134927443","https://openalex.org/W7139014375","https://openalex.org/W7142193414","https://openalex.org/W7155355700"],"related_works":["https://openalex.org/W2191597244","https://openalex.org/W4200257923","https://openalex.org/W4225830385","https://openalex.org/W1964384887","https://openalex.org/W4393986987","https://openalex.org/W7131830223","https://openalex.org/W4251425232","https://openalex.org/W7161773778","https://openalex.org/W2069954151","https://openalex.org/W3200422453"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-06-07T00:00:00"}
