{"id":"https://openalex.org/W7163564458","doi":"https://doi.org/10.3390/pharmaceutics18060696","title":"Putatively Identified Sarmentoside-B Removes Oligomerized Amyloid Peptide from Neurons by Inhibiting mTOR and Restoring Lysosomal Function, in In Vitro Alzheimer\u2019s Disease Model","display_name":"Putatively Identified Sarmentoside-B Removes Oligomerized Amyloid Peptide from Neurons by Inhibiting mTOR and Restoring Lysosomal Function, in In Vitro Alzheimer\u2019s Disease Model","publication_year":2026,"publication_date":"2026-06-04","ids":{"openalex":"https://openalex.org/W7163564458","doi":"https://doi.org/10.3390/pharmaceutics18060696","pmid":"https://pubmed.ncbi.nlm.nih.gov/42357312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13305706"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics18060696","doi":"https://doi.org/10.3390/pharmaceutics18060696","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18060696","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/pharmaceutics18060696","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114481625","display_name":"Bruna Rojas Froes","orcid":"https://orcid.org/0009-0007-0678-903X","observed_orcids":["https://orcid.org/0009-0007-0678-903X"]},"institutions":[{"id":"https://openalex.org/I81009624","display_name":"Universidade S\u00e3o Francisco","ror":"https://ror.org/045ae7j03","country_code":"BR","type":"education","lineage":["https://openalex.org/I81009624"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Rojas Fr\u00f3es","raw_affiliation_strings":["Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0009-0007-0678-903X","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil","institution_ids":["https://openalex.org/I81009624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137845045","display_name":"Juliana Guanaes Pina","orcid":"https://orcid.org/0009-0000-5159-3959","observed_orcids":["https://orcid.org/0009-0000-5159-3959"]},"institutions":[{"id":"https://openalex.org/I81009624","display_name":"Universidade S\u00e3o Francisco","ror":"https://ror.org/045ae7j03","country_code":"BR","type":"education","lineage":["https://openalex.org/I81009624"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana Guanaes Pina","raw_affiliation_strings":["Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0009-0000-5159-3959","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil","institution_ids":["https://openalex.org/I81009624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111085039","display_name":"Mariana da Mata Alves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana da Mata Alves","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica e Biof\u00edsica, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica e Biof\u00edsica, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026061398","display_name":"Alquiandra Stefani Ferreira Man\u00e7ano","orcid":"https://orcid.org/0000-0002-8423-8213","observed_orcids":["https://orcid.org/0000-0002-8423-8213"]},"institutions":[{"id":"https://openalex.org/I81009624","display_name":"Universidade S\u00e3o Francisco","ror":"https://ror.org/045ae7j03","country_code":"BR","type":"education","lineage":["https://openalex.org/I81009624"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alquiandra S. F. Man\u00e7ano","raw_affiliation_strings":["Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8423-8213","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil","institution_ids":["https://openalex.org/I81009624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078407381","display_name":"Fernanda Caldas Cardoso","orcid":"https://orcid.org/0000-0002-0068-9974","observed_orcids":["https://orcid.org/0000-0002-0068-9974"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fernanda C. Cardoso","raw_affiliation_strings":["Centre for Motor Neuron Disease Research, Faculty of Health, Medicine and Behavioural Sciences, Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0068-9974","affiliations":[{"raw_affiliation_string":"Centre for Motor Neuron Disease Research, Faculty of Health, Medicine and Behavioural Sciences, Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042183935","display_name":"Juliana Mozer Sciani","orcid":"https://orcid.org/0000-0001-7213-206X","observed_orcids":["https://orcid.org/0000-0001-7213-206X"]},"institutions":[{"id":"https://openalex.org/I81009624","display_name":"Universidade S\u00e3o Francisco","ror":"https://ror.org/045ae7j03","country_code":"BR","type":"education","lineage":["https://openalex.org/I81009624"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Juliana Mozer Sciani","raw_affiliation_strings":["Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7213-206X","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Produtos Naturais, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista 12916-900, SP, Brazil","institution_ids":["https://openalex.org/I81009624"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042183935"],"corresponding_institution_ids":["https://openalex.org/I81009624"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.6364,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84220011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"18","issue":"6","first_page":"696","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.753000020980835},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/lysosome-function","display_name":"lysosomal function","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9089999794960022},{"id":"https://openalex.org/keywords/eudendrium-carneum","display_name":"Eudendrium carneum","score":0.8840000033378601},{"id":"https://openalex.org/keywords/amyloid-plaque-clearance","display_name":"amyloid plaque clearance","score":0.843999981880188},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.734000027179718},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9067000150680542},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.6625999808311462},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5852000117301941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5791000127792358},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5515999794006348},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5011000037193298},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.498199999332428},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.48559999465942383},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4625000059604645},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.45730000734329224},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4431000053882599},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.4390000104904175},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C2780034444","wikidata":"https://www.wikidata.org/wiki/Q5052485","display_name":"Cathepsin L","level":4,"score":0.4291999936103821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42579999566078186},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.41929998993873596},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.40939998626708984},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3847000002861023},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.37790000438690186},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.37470000982284546},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.366100013256073},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.3181000053882599},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30000001192092896},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.2515000104904175},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics18060696","doi":"https://doi.org/10.3390/pharmaceutics18060696","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18060696","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:42357312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42357312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13305706","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13305706/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:85249f272e5d41ab830d15f2ceaa0fea","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/85249f272e5d41ab830d15f2ceaa0fea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 18, Iss 6, p 696 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics18060696","doi":"https://doi.org/10.3390/pharmaceutics18060696","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18060696","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6597247950","display_name":"Evaluation of molecules from marine animals in the modulation of autophagy-lysosomal system of neurons, with focus on neurodegenerative diseases","funder_award_id":"24/10076-9","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7951341759","display_name":null,"funder_award_id":"313402/2023-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G83810101","display_name":null,"funder_award_id":"2024/15252-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1495214424","https://openalex.org/W1966280414","https://openalex.org/W1970049339","https://openalex.org/W1978443989","https://openalex.org/W1986154972","https://openalex.org/W1999514044","https://openalex.org/W2025179174","https://openalex.org/W2043291430","https://openalex.org/W2048165147","https://openalex.org/W2087243986","https://openalex.org/W2144535585","https://openalex.org/W2161260889","https://openalex.org/W2315843281","https://openalex.org/W2321630106","https://openalex.org/W2405825843","https://openalex.org/W2807540667","https://openalex.org/W2906172143","https://openalex.org/W2907674688","https://openalex.org/W2983279517","https://openalex.org/W3159355990","https://openalex.org/W3185235264","https://openalex.org/W3215427361","https://openalex.org/W3216591159","https://openalex.org/W4205304555","https://openalex.org/W4210251879","https://openalex.org/W4280632366","https://openalex.org/W4295981397","https://openalex.org/W4298002541","https://openalex.org/W4380989783","https://openalex.org/W4382284149","https://openalex.org/W4386328067","https://openalex.org/W4388232516","https://openalex.org/W4389254179","https://openalex.org/W4390176391","https://openalex.org/W4391722782","https://openalex.org/W4401668782","https://openalex.org/W4403604650","https://openalex.org/W4403961319","https://openalex.org/W4405621945","https://openalex.org/W4410534304","https://openalex.org/W4411366425","https://openalex.org/W4415420528","https://openalex.org/W4416748715","https://openalex.org/W7125209967"],"related_works":["https://openalex.org/W2381214295","https://openalex.org/W3136785936","https://openalex.org/W1978817477","https://openalex.org/W2044948951","https://openalex.org/W4388157023","https://openalex.org/W4313200489","https://openalex.org/W2912663702","https://openalex.org/W7221716371","https://openalex.org/W3035119403","https://openalex.org/W4389335197"],"abstract_inverted_index":{"Background/Objectives:":[0],"Alzheimer\u2019s":[1],"disease":[2],"(AD)":[3],"is":[4,33],"characterized":[5,90],"by":[6,66,91,133,183,195,209,230],"beta-amyloid":[7],"(A\u03b2)":[8],"plaque":[9,138],"deposition,":[10],"which":[11],"impairs":[12],"several":[13],"cellular":[14],"processes,":[15],"including":[16],"autophagy.":[17],"Considering":[18],"the":[19,24,40,47,109,180,202],"multifactorial":[20],"nature":[21],"of":[22,26,43,61,124,204],"AD,":[23],"development":[25],"therapies":[27],"acting":[28],"on":[29,55],"alternative":[30],"molecular":[31,196],"targets":[32],"necessary.":[34],"In":[35],"this":[36,191],"study,":[37],"we":[38],"evaluated":[39,79,95,132],"neuroprotective":[41,71,156,225],"effect":[42],"a":[44,119],"molecule":[45,87],"from":[46],"hydrozoan":[48],"Eudendrium":[49],"carneum":[50,63],"and":[51,82,100,112,129,136,158,175,190],"investigated":[52],"its":[53,70,236],"impact":[54],"autophagy-related":[56,125,232],"pathways.":[57],"Methods:":[58],"The":[59,85,122,146],"secretion":[60],"E.":[62],"was":[64,94,106,116,131,140,193],"fractionated":[65],"RP-HPLC":[67],"according":[68],"to":[69,77],"activity":[72,115],"in":[73,97,164,213],"SH-SY5Y":[74],"cells":[75],"exposed":[76],"oA\u03b242,":[78],"using":[80,108,118,142],"LDH":[81],"MTT":[83],"assays.":[84],"purified":[86],"(named":[88],"EC5),":[89],"mass":[92],"spectrometry,":[93],"regarding":[96],"silico":[98],"toxicity":[99,161,229],"calcium":[101,166],"dynamics.":[102,170],"Neuronal":[103],"lysosomal":[104,173],"morphology":[105,174],"assessed":[107],"LysoTracker":[110],"probe,":[111],"cathepsin":[113,176],"D":[114,177],"determined":[117],"synthetic":[120],"substrate.":[121],"expression":[123],"proteins":[126],"(mTOR,":[127],"LAMP-1,":[128],"LC3B)":[130],"dot":[134],"blotting,":[135],"amyloid":[137,233],"clearance":[139,203],"quantified":[141],"Thioflavin-T":[143,210],"staining.":[144],"Results:":[145],"steroid":[147],"glycoside":[148],"putatively":[149,219],"identified":[150,220],"as":[151,207,221],"Sarmentoside":[152,222],"B":[153],"(EC5)":[154],"exhibited":[155],"effects":[157,226],"showed":[159],"no":[160],"or":[162,167],"alterations":[163],"neuronal":[165,215],"sodium":[168],"channel":[169],"EC5":[171,186],"restored":[172],"activity,":[178],"reversing":[179],"impairment":[181],"induced":[182],"oA\u03b242.":[184],"Furthermore,":[185],"reduced":[187,214],"mTOR":[188],"expression,":[189],"interaction":[192],"supported":[194],"docking":[197],"analysis.":[198],"Lysosomal":[199],"restoration":[200],"promoted":[201],"oA\u03b242":[205],"aggregates,":[206],"evidenced":[208],"staining,":[211],"resulting":[212],"death.":[216],"Conclusions:":[217],"EC5,":[218],"B,":[223],"exerts":[224],"against":[227],"oA\u03b242-induced":[228],"promoting":[231],"clearance,":[234],"highlighting":[235],"therapeutic":[237],"potential":[238],"for":[239],"AD.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-06-05T00:00:00"}