{"id":"https://openalex.org/W7163394499","doi":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","title":"The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion","display_name":"The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7163394499","doi":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","pmid":"https://pubmed.ncbi.nlm.nih.gov/42282770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13252371"},"language":"en","primary_location":{"id":"doi:10.1016/j.atherosclerosis.2026.121887","doi":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008013487","display_name":"Grigorios Panteloglou","orcid":"https://orcid.org/0000-0002-7672-7623","observed_orcids":["https://orcid.org/0000-0002-7672-7623"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Grigorios Panteloglou","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125002726","display_name":"J\u00e9r\u00f4me Robert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Robert","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135379563","display_name":"Marieke Smit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marieke Smit","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003398987","display_name":"Nicolette Huijkman","orcid":"https://orcid.org/0009-0001-8221-3178","observed_orcids":["https://orcid.org/0009-0001-8221-3178"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicolette Huijkman","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072637890","display_name":"Niels Kloosterhuis","orcid":"https://orcid.org/0009-0000-5500-3282","observed_orcids":["https://orcid.org/0009-0000-5500-3282"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Kloosterhuis","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046117875","display_name":"Christopher S. Law","orcid":"https://orcid.org/0009-0005-4516-3844","observed_orcids":["https://orcid.org/0009-0005-4516-3844"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Law","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Woods","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Woods","raw_affiliation_strings":["Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031437785","display_name":"Alaa Othman","orcid":"https://orcid.org/0000-0002-0092-5594","observed_orcids":["https://orcid.org/0000-0002-0092-5594"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257037","display_name":"Functional Genomics Center Zurich","ror":"https://ror.org/04tgr1802","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257037"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alaa Othman","raw_affiliation_strings":["Functional Genomics Center, University of Zurich and ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Center, University of Zurich and ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4405257037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060221179","display_name":"Marcus Edi Kleber","orcid":"https://orcid.org/0000-0003-0663-7275","observed_orcids":["https://orcid.org/0000-0003-0663-7275"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus E. Kleber","raw_affiliation_strings":["Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112054212","display_name":"Graciela Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Graciela E. Delgado","raw_affiliation_strings":["Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023815363","display_name":"Patrizia Tarugi","orcid":"https://orcid.org/0000-0001-6864-7853","observed_orcids":["https://orcid.org/0000-0001-6864-7853"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Tarugi","raw_affiliation_strings":["Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089952115","display_name":"Museer A. Lone","orcid":"https://orcid.org/0000-0001-9710-775X","observed_orcids":["https://orcid.org/0000-0001-9710-775X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Museer A. Lone","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073617969","display_name":"Justina Clarinda Wolters","orcid":"https://orcid.org/0000-0003-0066-3720","observed_orcids":["https://orcid.org/0000-0003-0066-3720"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Justina Clarinda Wolters","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063913582","display_name":"Antoine Rimbert","orcid":"https://orcid.org/0000-0002-2971-4926","observed_orcids":["https://orcid.org/0000-0002-2971-4926"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144168","display_name":"Institut du Thorax","ror":"https://ror.org/049kkt456","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210144168","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Rimbert","raw_affiliation_strings":["Nantes Universit\u00e9, CNRS, Inserm, l'institut du thorax, Nantes, F-44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, CNRS, Inserm, l'institut du thorax, Nantes, F-44000, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210144168","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044758435","display_name":"Anja Kerksiek","orcid":"https://orcid.org/0009-0002-6162-6106","observed_orcids":["https://orcid.org/0009-0002-6162-6106"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Kerksiek","raw_affiliation_strings":["Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037194416","display_name":"D. Luetjohann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter L\u00fctjohann","raw_affiliation_strings":["Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056391477","display_name":"Lucia Rohrer","orcid":"https://orcid.org/0000-0002-2167-0818","observed_orcids":["https://orcid.org/0000-0002-2167-0818","https://orcid.org/0009-0003-6681-7021"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lucia Rohrer","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028624448","display_name":"Paolo Zanoni","orcid":"https://orcid.org/0000-0001-9397-1989","observed_orcids":["https://orcid.org/0000-0001-9397-1989"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paolo Zanoni","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053327647","display_name":"Sofia Kakava","orcid":"https://orcid.org/0000-0003-3315-2361","observed_orcids":["https://orcid.org/0000-0003-3315-2361"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sofia Kakava","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137745757","display_name":"Stephanie Haeusler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephanie H\u00e4usler","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078689619","display_name":"Eveline Schlumpf","orcid":"https://orcid.org/0009-0000-5432-8552","observed_orcids":["https://orcid.org/0009-0000-5432-8552"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Eveline Schlumpf","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011244479","display_name":"Marta Futema","orcid":"https://orcid.org/0000-0002-2120-2088","observed_orcids":["https://orcid.org/0000-0002-2120-2088"]},"institutions":[{"id":"https://openalex.org/I4401726869","display_name":"City St George's, University of London","ror":"https://ror.org/047ybhc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta Futema","raw_affiliation_strings":["Cardiovascular and Genomics Research Institute, St George's School of Health and Medical Sciences, City St Georges University of London, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Genomics Research Institute, St George's School of Health and Medical Sciences, City St Georges University of London, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4401726869","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064235722","display_name":"Steve Eric Humphries","orcid":"https://orcid.org/0000-0002-8221-6547","observed_orcids":["https://orcid.org/0000-0002-8221-6547","https://orcid.org/0000-0002-4153-8785"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve E. Humphries","raw_affiliation_strings":["Institute of Cardiovascular Science, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033198329","display_name":"Janet S. Chou","orcid":"https://orcid.org/0000-0002-4610-2657","observed_orcids":["https://orcid.org/0000-0002-4610-2657"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Chou","raw_affiliation_strings":["Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048372741","display_name":"Winfried Maerz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Winfried M\u00e4rz","raw_affiliation_strings":["Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237","https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048379219","display_name":"Raif S. Geha","orcid":"https://orcid.org/0000-0002-6019-3751","observed_orcids":["https://orcid.org/0000-0002-6019-3751"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raif S. Geha","raw_affiliation_strings":["Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071460521","display_name":"Anthony K. Shum","orcid":"https://orcid.org/0000-0001-5139-4802","observed_orcids":["https://orcid.org/0000-0001-5139-4802"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony K. Shum","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013598309","display_name":"Jan Albert Kuivenhoven","orcid":"https://orcid.org/0000-0002-9346-2719","observed_orcids":["https://orcid.org/0000-0002-9346-2719"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Albert Kuivenhoven","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031086317","display_name":"Bart van de Sluis","orcid":"https://orcid.org/0000-0003-3039-4365","observed_orcids":["https://orcid.org/0000-0003-3039-4365"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart van de Sluis","raw_affiliation_strings":["Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027046285","display_name":"Arnold von Eckardstein","orcid":"https://orcid.org/0000-0002-1666-2266","observed_orcids":["https://orcid.org/0000-0002-1666-2266"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Arnold von Eckardstein","raw_affiliation_strings":["Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland. Electronic address: v.eckardstein@access.uzh.ch"],"raw_orcid":"https://orcid.org/0000-0002-1666-2266","affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, University of Zurich and University Hospital Zurich, Zurich, Switzerland. Electronic address: v.eckardstein@access.uzh.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5027046285"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":{"value":4020,"currency":"USD","value_usd":4020},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29815745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"421","issue":null,"first_page":"121887","last_page":"121887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.921999990940094},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ldl-uptake","display_name":"LDL uptake","score":0.7379999756813049},{"id":"https://openalex.org/keywords/apolipoprotein-b-secretion","display_name":"apolipoprotein B secretion","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/copa","display_name":"COPA","score":0.8100000023841858},{"id":"https://openalex.org/keywords/copb2","display_name":"COPB2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8090000152587891},{"id":"https://openalex.org/keywords/non-hdl-cholesterol","display_name":"non-HDL cholesterol","score":0.8149999976158142},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.41200000047683716},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C206912223","wikidata":"https://www.wikidata.org/wiki/Q21111963","display_name":"COPI","level":5,"score":0.7651000022888184},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7311000227928162},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6274999976158142},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.6158999800682068},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5971999764442444},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5227000117301941},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.5185999870300293},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4603999853134155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4528000056743622},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.4065999984741211},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.3982999920845032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39640000462532043},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.36000001430511475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.33379998803138733},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.32989999651908875},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3156999945640564},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29420000314712524},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.2540999948978424},{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.25060001015663147}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.1016/j.atherosclerosis.2026.121887","doi":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},{"id":"doi:10.64898/2026.05.30.728950","doi":"https://doi.org/10.64898/2026.05.30.728950","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.30.728950","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42282770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42282770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42667864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42667864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13252371","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13252371/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire/47bb9de3-0df0-47e3-ad6a-0950a441754c","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/47bb9de3-0df0-47e3-ad6a-0950a441754c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.sgul.ac.uk:118938","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","pdf_url":"https://openaccess.sgul.ac.uk/id/eprint/118938/1/1-s2.0-S0021915026012530-main.pdf","source":{"id":"https://openalex.org/S4306400552","display_name":"St George's Online Research Archive (St George's University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165862685","host_organization_name":"St George's, University of London","host_organization_lineage":["https://openalex.org/I165862685"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:HAL:hal-05706880v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05706880","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv : the preprint server for biology, 2026, &#x27E8;10.64898/2026.05.30.728950&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/805969","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/805969","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Atherosclerosis, 421","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-c-000805969","doi":"https://doi.org/10.3929/ethz-c-000805969","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000805969","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1016/j.atherosclerosis.2026.121887","doi":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2026.121887","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1084116739","display_name":null,"funder_award_id":"2015T068","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"},{"id":"https://openalex.org/G1779241766","display_name":"Translating disease to cardiovascular health","funder_award_id":"603091","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4580073235","display_name":"Mechanisms of a Novel Combined Immunodeficiency Caused by a Homozygous Mutation in COPG1","funder_award_id":"5r01ai139633-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000877674","display_name":"Unraveling the molecular mechanisms of impaired central tolerance in COPA syndrome","funder_award_id":"R01AI168299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309744","display_name":"Fondazione Cassa di Risparmio di Modena","ror":"https://ror.org/03cen5169"},{"id":"https://openalex.org/F4320318534","display_name":"Dutch Cardiovascular Alliance","ror":"https://ror.org/02e8s5y35"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321642","display_name":"Hartstichting","ror":"https://ror.org/05nxhgm70"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320327577","display_name":"SystemsX.ch","ror":"https://ror.org/02s09gf16"},{"id":"https://openalex.org/F4320328233","display_name":"Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338377","display_name":"FP7 Health","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7163394499.pdf","grobid_xml":"https://content.openalex.org/works/W7163394499.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1549397399","https://openalex.org/W1587595704","https://openalex.org/W1965876831","https://openalex.org/W1972476556","https://openalex.org/W1976292735","https://openalex.org/W1979701744","https://openalex.org/W1999804187","https://openalex.org/W2014137007","https://openalex.org/W2033341579","https://openalex.org/W2036516274","https://openalex.org/W2052357712","https://openalex.org/W2059145105","https://openalex.org/W2072031181","https://openalex.org/W2078540517","https://openalex.org/W2104602624","https://openalex.org/W2112323649","https://openalex.org/W2120043292","https://openalex.org/W2136359534","https://openalex.org/W2142811955","https://openalex.org/W2152311269","https://openalex.org/W2155991311","https://openalex.org/W2256016639","https://openalex.org/W2345206408","https://openalex.org/W2492345185","https://openalex.org/W2553056070","https://openalex.org/W2597883645","https://openalex.org/W2757992992","https://openalex.org/W2762925040","https://openalex.org/W2770926056","https://openalex.org/W2783941908","https://openalex.org/W2789459269","https://openalex.org/W2900678639","https://openalex.org/W2944400690","https://openalex.org/W2944940476","https://openalex.org/W2950719694","https://openalex.org/W3011622061","https://openalex.org/W3024448168","https://openalex.org/W3038787796","https://openalex.org/W3041705712","https://openalex.org/W3043341203","https://openalex.org/W3126431387","https://openalex.org/W3197941781","https://openalex.org/W3198898259","https://openalex.org/W3205644245","https://openalex.org/W3207662637","https://openalex.org/W3215247046","https://openalex.org/W4205823791","https://openalex.org/W4225141722","https://openalex.org/W4288447650","https://openalex.org/W4308195446","https://openalex.org/W4308679124","https://openalex.org/W4322496077","https://openalex.org/W4386861232","https://openalex.org/W4390579063","https://openalex.org/W4394908824","https://openalex.org/W4405047128","https://openalex.org/W4405100204","https://openalex.org/W4409119804","https://openalex.org/W4409317628","https://openalex.org/W4410830891","https://openalex.org/W4413020599","https://openalex.org/W4413639704"],"related_works":["https://openalex.org/W4413639704","https://openalex.org/W1984867098","https://openalex.org/W2078151137","https://openalex.org/W3116644041","https://openalex.org/W2052601297","https://openalex.org/W4412600137","https://openalex.org/W2045271633","https://openalex.org/W1977410465","https://openalex.org/W2182994768","https://openalex.org/W2085002947"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Decreased":[3],"removal":[4],"and":[5,58,83,103,114,117,133,148,155,170,203,217,231],"increased":[6,130,196],"production":[7],"of":[8,21,34,61,70,97,112,122,140,151,162,168,182,194,199,208,227],"apolipoprotein":[9],"B":[10],"(apoB)":[11],"containing":[12],"lipoproteins":[13],"cause":[14],"hypercholesterolemia,":[15],"a":[16,26],"major":[17],"causal":[18],"risk":[19],"factor":[20],"atherosclerotic":[22],"cardiovascular":[23],"disease.":[24],"By":[25],"genome-wide":[27],"siRNA":[28],"screen,":[29],"we":[30],"previously":[31],"identified":[32],"subunits":[33],"the":[35,55,59,123,163,197,206],"Coat":[36],"protein":[37],"I":[38],"(COPI)":[39],"complex":[40],"to":[41],"limit":[42],"low":[43],"density":[44],"lipoprotein":[45],"(LDL)":[46],"uptake":[47,111],"into":[48],"Huh-7":[49,106],"hepatocarcinoma":[50],"cells.":[51],"This":[52],"study":[53],"investigated":[54],"underlying":[56],"mechanism":[57],"role":[60],"impaired":[62],"COPI":[63,91,212,238],"function":[64,71],"for":[65],"hypercholesterolemia.":[66,190],"METHODS:":[67],"Targeted":[68],"loss":[69],"experiments":[72],"in":[73,81,105,109,201,205,229,241],"vitro":[74],"as":[75,77,127,129,220,222],"well":[76,128,221],"genetic":[78],"association":[79],"studies":[80],"humans":[82,242],"three":[84],"mouse":[85],"models":[86],"with":[87,144,189,245],"mutated":[88],"or":[89,165],"disrupted":[90],"genes":[92],"were":[93,142,185],"performed.":[94],"RESULTS:":[95],"Silencing":[96],"COPA,":[98],"COPB1,":[99],"COPB2,":[100],"ARCN1,":[101],"COPG1,":[102,171],"COPZ1":[104],"cells":[107],"resulted":[108],"decreased":[110],"LDL":[113,124],"aberrant":[115],"glycosylation":[116],"reduced":[118],"cell":[119],"surface":[120],"abundance":[121],"receptor":[125],"(LDLR)":[126],"apoB":[131,218],"secretion":[132,219],"cellular":[134],"lipid":[135,224],"storage.":[136],"Single":[137],"nucleotide":[138],"polymorphisms":[139],"ARCN1":[141,146],"associated":[143,244],"lower":[145],"expression":[147],"higher":[149,246],"levels":[150],"LDL-cholesterol.":[152],"While":[153],"patients":[154,188],"mice":[156,230],"carrying":[157],"rare":[158,177,236],"immunopathogenic":[159],"missense":[160],"variants":[161,178,240],"WD40-":[164],"appendage":[166],"domains":[167,181],"COPA":[169],"respectively,":[172],"had":[173],"normal":[174],"LDL-cholesterol":[175,247],"levels,":[176],"altering":[179],"other":[180],"these":[183],"proteins":[184],"enriched":[186],"among":[187],"The":[191,211],"hepatic":[192,223],"knockdown":[193],"Copg1":[195,228],"concentrations":[198],"nonHDL-cholesterol":[200],"plasma":[202],"triglycerides":[204],"liver":[207],"mice.":[209],"CONCLUSIONS:":[210],"coatomer":[213],"regulates":[214],"LDLR":[215],"activity":[216],"content.":[225],"Deficiency":[226],"some":[232],"but":[233],"not":[234],"all":[235],"damaging":[237],"gene":[239],"are":[243],"levels.":[248]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-06-04T00:00:00"}
